Differential response related to genotoxicity between eggplant (Solanum melanogena) skin aqueous extract and its main purified anthocyanin (delphinidin) in vivo

Food and Chemical Toxicology

Volumn 45, Issue 5, 2007, Pages 852-858

  Azevedo, Luciana ^a   Alves de Lima, Patrícia L ^b   Gomes, José C ^c   Stringheta, Paulo C ^c   Ribeiro, Daniel A ^d   Salvadori, Daisy M F ^b  

^a Centro Universitario Federal   (Brazil)

^b SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

^c FEDERAL UNIVERSITY OF VIÇOSA   (Brazil)

^d FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Anthocyanins; Antimutagenesis; Mice; Micronucleus test; Single cell gel (comet) assay

Indexed keywords

ANTHOCYANIN; CYCLOPHOSPHAMIDE; DELPHINIDIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; AQUEOUS SOLUTION; ARTICLE; AUBERGINE; CANCER INHIBITION; COMET ASSAY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ERYTHROCYTE; GENOTOXICITY; IN VIVO STUDY; MALE; MICRONUCLEUS TEST; MOUSE; MUTAGENICITY; NONHUMAN; STATISTICAL SIGNIFICANCE;

ANIMALS; ANTHOCYANINS; ANTIOXIDANTS; COMET ASSAY; CYCLOPHOSPHAMIDE; DOSE-RESPONSE RELATIONSHIP, DRUG; ERYTHROCYTES; MALE; MICE; MICRONUCLEUS TESTS; MUTAGENICITY TESTS; PLANT EXTRACTS; SOLANUM MELONGENA;

MUS; SOLANUM; SOLANUM MELONGENA;

EID: 33947415304     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fct.2006.11.004     Document Type: Article

References (40)

1. Afaq F., Saleem M., Krueger C.G., Reed J.D., and Mukhtar H. Anthocyanin- and hydrolyzable tannin-rich pomegranate fruit extract modulates MAPK and NF-kappaB pathways and inhibits skin tumorigenesis in CD-1 mice. Int. J. Cancer 113 (2005) 423-433
2. Bomser J.A., Singletary K.M., Wallig M.A., and Smith M.A. Inhibition of TPA-induced tumor promotion in CD-1 mouse epidermis by a polyphenolic fraction from grape seeds. Cancer Lett. 135 (1999) 151-157
3. Bonassi S., Hagmar L., Strömberg U., Montagud A.H., Tinerberg H., Forni A., Heikkila P., Wanders S., Wilhardt P., Hansteen I.L., Knudsen L.E., and Norppa H. For the European study group on cytogenetic biomarkers and health. Human micronucleus project. Cancer Res. 60 (2000) 1619-1625
4. Cao G., Sofic E., and Prior R.L. Antioxidant capacity of tea and common vegetables. J. Agr. Food Chem. 44 (1996) 3426-3431
5. Chiaradia, A.C.N. 1997. Determinação da estrutura de pigmentos de feijão e estudo da sua ação na qualidade protéica. Viçosa: UFV, 107p. PhD Thesis (Portuguese).
6. De Flora S., Izzotti A., D'Agostini F., Balansky R.M., Noonan D., and Albini A. Multiple points of intervention in the prevention of cancer and other mutation-related diseases. Mutat. Res. 480 (2001) 9-12
7. Glei M., Matuschek M., Steiner C., Bohm V., Persin C., and Pool-Zobel B.L. Initial in vitro toxicity testing of functional foods rich in catechins and anthocyanins in human cells. Toxicol. In Vitro. 17 (2003) 723-729
8. Hagiwara A., Yoshino H., and Ichihara T. Prevention by natural food anthocyanins, purple sweet potato color and red cabbage color of 2-amino-1-methyl-6-phenylimidazo[4,5-b] pyridine (PhIP)-associated colorectal carcinogenesis in rats initiated with 1,2-dimethylhydrazine. J. Toxicol. Sci. 27 (2002) 57-68
9. Hagmar L., Bonassi S., Strömberg U., Brogger A., Knudsen L.E., Norppa H., and Reuterwall C. Chromosomal aberrations in lymphocytes predict human cancer - a report from the European study group on cytogenetic biomarkers and health (ESCH). Cancer Res. 58 (1998) 4117-4121
10. Harborne J.B. In Comparative Biochemistry of the Flavonoids (1967), Academic Press, London
11. Hartmann A., Pfuhler S., Dennog C., Germdnik D., Pilger A., and Speit G. Exercise-induced DNA effects in human leukocytes are not accompanied by increase formation of 8-hydroxy-2-deoxyguanosine or induction of micronuclei. Free Radical Biol. Med. 24 (1998) 245-251
12. Hayashi M., Morita T., Kodama Y., Sofuni T., and Ishidate Jr. M. The micronucleus assay with mouse peripheral blood reticulocytes using acridine orange-coated slides. Mutat. Res. 245 (1990) 245-249
13. Hendry G.A.F., and Houghton J.D. Natural Food Colorants (1992), Editora Blackie and Son, New York 280 p.
14. Hou D.X. Potential mechanisms of cancer chemoprevention by anthocyanins. Ct Mol. Med. 3 (2003) 149-159
15. Hou D.X., Fujii M., Terahara N., and Yoshimoto M. Molecular mechanisms behind the chemopreventive effects of anthocyanidins. Biomed. Biotechnol. 5 (2004) 321-325
16. Hou D.X., Ose T., Lin S., Harazoro K., Imamura I., Kubo M., Uto T., Terahara N., Yoshimoto M., and Fujii M. Anthocyanidins induce apoptosis in human promyelocytic leukemia cells: structure-activity relationship and mechanisms involved. Int. J. Oncol. 23 (2003) 705-712
17. Joshi S.S., Kuszynski C.A., and Bagchi D. The cellular and molecular basis of health benefits of grape seed proanthocyanidin extract. Curr. Pharm. Biotechnol. 2 (2001) 187-200
18. Kamei H., Kojima T., and Hasegawa M. Suppression of tumor cell growth by anthocyanins in vitro. Cancer Invest. 13 (1995) 590-594
19. Kassie F., Parzefall W., and Knasmuller S. Single cell gel electrophoresis assay: a new technique for human biomonitoring studies. Mutat. Res. 463 (2000) 13-31
20. Katsube N., Iwashita K., Tsushida T., Yamaki K., and Kobori M. Induction of apoptosis in cancer cells by Bilberry (Vaccinium myrtillus) and the anthocyanins. J. Agr. Food Chem. 51 (2003) 68-75
21. Kuhnau J. The flavonoids. A class of semi-essential food components: their role in human nutrition. World Rev. Nutr. Diet 24 (1976) 117-191
22. Lazze M.C., Savio M., Pizzala R., Cazzalini O., Perucca P., Scovassi A.I., Stivala L.A., and Bianchi L. Anthocyanins induce cell cycle perturbations and apoptosis in different human cell lines. Carcinogenesis 25 (2004) 1427-1433
23. Macgregor J.T., Heddle J.A., Hite M., Margolin B.H., Ramel C., Salamone M.F., Tia R.R., and Wild D. Guidelines for the conduct of micronucleus assay in mammalian bone marrow erythrocytes. Mutat. Res. 189 (1987) 103-112
24. Manoharan K., and Banerjee M.R. β-Carotene reduces sister chromatid exchanges induced by chemical carcinogens in mouse mammary cells in organ culture. Cell Biol. Int. Rep. 9 (1985) 783-789
25. Matsumoto H., Inaba H., Kishi M., Tominaga S., Hirayama M., and Tsuda T. Orally administered delphinidin 3-rutinoside and cyanidin 3-rutinoside are directly absorbed in rats and humans and appear in the blood and the intact forms. J. Agr. Food Chem. 49 (2001) 1546-1551
26. Meiers S., Kemeny M., Weyand U., Gastpar R., von Angerer E., and Marko D. The anthocyanidins cyaniding and delphinidin are potent inhibitors of the epidermal growth-factor receptor. J. Agr. Food Chem. 49 (2001) 958-962
27. Miyazawa T., Nakagawa K., Kudo M., Muraishi K., and Someya K. Direct intestinal absorption of red fruit anthocyanins, cyaniding-3-glucoside and cyaniding-3,5-diglucoside, into rats and humans. J. Agr. Food Chem. 47 (1999) 1083-1091
28. Morais H., Ramos C., Forgács E., Cserháti T., and Oliveira J. Influence of storage conditions on the stability of monomeric anthocyanins studied by reversed-phase high-performance liquid chromatography. J. Chromatogr. B 770 (2002) 297-301
29. Morita T., Asano N., Awogi T., Sasaki Y.F., Sato S.I., Shimada H., Sutou S., Suzuki T., Wakata A., Sofuni T., and Hayashi M. Evaluation of the rodent micronucleus assay in the screening of IARC carcinogens (groups 1, 2A and 2B). The summary report of the 6th collaborative study by CSWGMT/JEMS.MMS. Mutat. Res. 389 (1997) 3-122
30. Ozela, E.F. 1996. Extração e identificação da estrutura de um pigmento de frutos de bertalha. Viçosa: UFV, 1996. 59p. Máster Thesis. (Portuguese).
31. Ravindra P.V., and Narayan M.S. Antioxidant activity of the anthocyanin from carrot (Daucus carota) callus culture. Int. J. Food Sci. Nutr. 54 (2003) 349-355
32. Schmid W. The micronucleus test. Mutat. Res. 31 (1975) 9-15
33. Singh N.P., McCoy M.T., Tice R.R., and Schneider E.I. A simple technique for quantification of low levels of DNA damage in individual cells. Exp. Cell Res. 175 (1988) 184-191
34. Speit G., and Hartmann A.A. Sensitive genotoxicity test for detection of DNA damage and repair. Methods Mol. Biol. 113 (1999) 203-212
35. Sporn M.B. Chemoprevention of cancer. Nature 272 (1978) 402-403
36. Tice R.R., Agurell E., Anderson D., Burlinson B., Hartmann A., Kobayashi H., Miyamae Y., Rojas E., Ryu J.C., and Sasaki Y.F. Single cell gel/comet assay: guidelines for in vitro and in vivo genetic toxicology testing. Environ. Mol. Mutag. 35 (2000) 206
37. Tsuda T., Shiga K., Oshhima K., Kawaskishi S., and Osawa T. Inhibition of lipid peroxidation and the active oxygen radical scavenging effect of anthocyanin pigments isolated from Phaseolus vulgaris. J. Biochem. Pharmacol. 52 (1996) 1033-1039
38. Wang H., Cao G., and Prior R.L. Oxygen radial absorbing capacity of anthocyanins. J. Agr. Food Chem. 45 (1997) 304-309
39. Wang H., Nair M.G., and Strasburg G.M. Antioxidant and anti-inflammatory activities of anthocyanins and their aglycon, cyaniding from tart cherries. J. Nat. Prod. 62 (1999) 294-296
40. Waters M.D., Brady A.L., Stack H.F., and Brockman H.E. Antimutagenicity profiles for some model compounds. Mutat. Res. 238 (1990) 57-85