Soya isoflavone supplementation enhances spatial working memory in men

British Journal of Nutrition

Volumn 102, Issue 9, 2009, Pages 1348-1354

  Thorp, Alicia A ^a,b   Sinn, Natalie ^a   Buckley, Jonathan D ^a   Coates, Alison M ^a   Howe, Peter R C ^a  

^a UNIVERSITY OF SOUTH AUSTRALIA   (Australia)

^b UNIVERSITY OF ADELAIDE   (Australia)

Author keywords

Cognitive performance; Diet; Phyto oestrogens; Sex differences

Indexed keywords

DAIDZEIN; ESTROGEN; GENISTEIN; ISOFLAVONE; PLACEBO; ISOFLAVONE DERIVATIVE;

ADULT; AGED; ARTICLE; ATTENTION; AUDITORY MEMORY; BRAIN FUNCTION; CLINICAL TRIAL; COGNITION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG ACTIVITY; EPISODIC MEMORY; HUMAN; HUMAN EXPERIMENT; MALE; MENTAL FUNCTION; NORMAL HUMAN; PLANNING; RANDOMIZED CONTROLLED TRIAL; SOYBEAN; SUPPLEMENTATION; VERBAL MEMORY; VOLUNTEER; WORKING MEMORY; DIET SUPPLEMENTATION; DRUG EFFECT; MIDDLE AGED; NEUROPSYCHOLOGICAL TEST; RECALL; SHORT TERM MEMORY;

ADULT; AGED; AGED, 80 AND OVER; COGNITION; CROSS-OVER STUDIES; DIETARY SUPPLEMENTS; DOUBLE-BLIND METHOD; HUMANS; ISOFLAVONES; MALE; MEMORY, SHORT-TERM; MENTAL RECALL; MIDDLE AGED; NEUROPSYCHOLOGICAL TESTS; SOYBEANS;

EID: 84950170959     PISSN: 00071145     EISSN: 14752662     Source Type: Journal    
DOI: 10.1017/S0007114509990201     Document Type: Article

References (66)

1. Kimura D (1999) Sex and Cognition. Cambridge, MA: The MIT Press.
2. Mann VA, Sasanuma S, Sakuma N, et al. (1990) Sex differences in cognitive abilities: a cross-cultural perspective. Neuropsychologia 28, 1063-1077.
3. Maccoby EE & Jacklin CN (1974) The Psychology of Sex Differences. Stanford, CA: Stanford University Press.
4. Collaer ML & Hines M (1995) Human behavioral sex differences: a role for gonadal hormones during early development? Psychol Bull 118, 55-107.
5. Silverman I & Phillips K (1998) The evolutionary psychology of spatial sex differences. In Handbook of Evolutionary Psychology: Ideas, Issues and Applications, pp. 595-611 [C Crawford and DL Krebs, editors]. Mahwah, NJ: Erlbaum.
6. Shughrue PJ, Lane MV & Merchenthaler I (1997) Comparative distribution of estrogen receptor-a and -b mRNA in the rat central nervous system. J Comp Neurol 388, 507-525.
7. Osterlund MK & Hurd YL (2001) Estrogen receptors in the human forebrain and the relation to neuropsychiatric disorders. Prog Neurobiol 64, 251-267.
8. Pau CY, Pau KY & Spies HG (1998) Putative estrogen receptor b and a mRNA expression in male and female rhesus macaques. Mol Cell Endocrinol 146, 59-68.
9. Otto T & Eichenbaum H (1992) Neuronal activity in the hippocampus during delayed non-match to sample performance in rats: evidence for hippocampal processing in recognition memory. Hippocampus 2, 323-334.
10. Loy R, Gerlach JL & McEwen BS (1988) Autoradiographic localization of estradiol-binding neurons in the rat hippocampal formation and entorhinal cortex. Brain Res 467, 245-251.
11. O'Keefe JA & Handa RJ (1990) Transient elevation of estrogen receptors in the neonatal rat hippocampus. Brain Res Dev Brain Res 57, 119-127.
12. Duff SJ & Hampson E (2000) A beneficial effect of estrogen on working memory in postmenopausal women taking hormone replacement therapy. Horm Behav 38, 262-276.
13. Maki PM, Zonderman AB&Resnick SM(2001) Enhanced verbal memory in nondemented elderly women receiving hormonereplacement therapy. Am J Psychiatry 158, 227-233.
14. Miles C, Green R, Sanders G, et al. (1998) Estrogen and memory in a transsexual population. Horm Behav 34, 199-208.
15. Lee YB, Lee HJ, Won MH, et al. (2004) Soy isoflavones improve spatial delayed matching-to-place performance and reduce cholinergic neuron loss in elderly male rats. J Nutr 134, 1827-1831.
16. File SE, Hartley DE, Alom N, et al. (2003) Soya phytoestrogens change cortical and hippocampal expression of BDNF mRNA in male rats. Neurosci Lett 338, 135-138.
17. Lephart ED, West TW, Weber KS, et al. (2002) Neurobehavioral effects of dietary soy phytoestrogens. Neurotoxicol Teratol 24, 5-16.
18. File SE, Hartley DE, Elsabagh S, et al. (2005) Cognitive improvement after 6 weeks of soya supplements in postmenopausal women is limited to frontal lobe function. Menopause 12, 193-201.
19. Duffy RH, Wiseman H & File SE (2003) Improved cognitive function in postmenopausal women after 12 weeks of consumption of a soya extract containing isoflavones. Pharmacol Biochem Behav 75, 721-729.
20. Kritz-Silverstein D, Von Mühlen D, Barrett-Connor E, et al. (2003) Isoflavones and cognitive function in older women: the SOy and Postmenopausal Health In Aging (SOPHIA) Study. Menopause 10, 196-202.
21. Kreijkamp-Kaspers S, Kok L, Bots ML, et al. (2005) Randomized controlled trial of the effects of soy protein containing isoflavones on vascular function in postmenopausal women. Am J Clin Nutr 81, 189-195. (Pubitemid 43073393)
22. Ho SC, Chan AS, Ho YP, et al. (2007) Effects of soy isoflavone supplementation on cognitive function in Chinese postmenopausal women: a double-blind, randomized, controlled trial. Menopause 14, 489-499.
23. White LR, Petrovitch H, Ross GW, et al. (2000) Brain aging and midlife tofu consumption. J Am Coll Nutr 19, 242-255.
24. Lund TD, West TW, Tian LY, et al. (2001) Visual spatial memory is enhanced in female rats (but inhibited in males) by dietary soy phytoestrogens. BMC Neurosci 2, 20.
25. Celec P, Ostatníková D, Hodosy J, et al. (2007) Increased one week soybean consumption affects spatial abilities but not sex hormone status in men. Int J Food Sci Nutr 58, 424-428.
26. Ostatníková D, Celec P, Hodosy J, et al. (2007) Short-term soybean intake and its effect on steroid sex hormones and cognitive abilities. Fertil Steril 88, 1632-1636.
27. File SE, Jarrett N, Fluck E, et al. (2001) Eating soya improves human memory. Psychopharmacology (Berl) 157, 430-436.
28. Duff SJ & Hampson E (2001) A sex difference on a novel spatial working memory task in humans. Brain Cogn 47, 470-493.
29. Ivison D (1977) The Wechsler Memory Scale: preliminary findings toward an Australian standardisation. Aust Psychol 12, 303-312.
30. Bleecker ML, Bolla-Wilson K, Agnew J, et al. (1988) Agerelated sex differences in verbal memory. J Clin Psychol 44, 403-411.
31. Geffen GM, Moar KJ, O'Hanlon AP, et al. (1990) The Auditory Verbal Learning Test (Rey): performance of 16 to 86 year olds of average intelligence. Clin Neuropsychol 4, 45-63.
32. Berenbaum SA, Baxter L, Seidenberg M, et al. (1997) Role of the hippocampus in sex differences in verbal memory: memory outcome following left anterior temporal lobectomy. Neuropsychology 11, 585-591.
33. Hay JC (2007) PsychLab Online: 2D Mental Rotation Task. http://pantherfile.uwm.edu/johnchay/index.htm?uniq = 1n12ul
34. Hogervorst E, Sadjimin T, Yesufu A, et al. (2008) High tofu intake is associated with worse memory in elderly Indonesian men and women. Dement Geriatr Cogn Disord 26, 50-57.
35. Courtney SM, Petit L, Maisog JM, et al. (1998) An area specialized for spatial working memory in human frontal cortex. Science 279, 1347-1351.
36. Bonsall RW, Zumpe D & Michael RP (1990) Comparisons of the nuclear uptake of [3H]-testosterone and its metabolites by the brains of male and female macaque fetuses at 122 days of gestation. Neuroendocrinology 51, 474-480.
37. Clark AS, MacLusky NJ & Goldman-Rakic PS (1988) Androgen binding and metabolism in the cerebral cortex of the developing rhesus monkey. Endocrinology 123, 932-940.
38. MacLusky NJ, Naftolin F & Goldman-Rakic PS (1986) Estrogen formation and binding in the cerebral cortex of the developing rhesus monkey. Proc Natl Acad Sci U S A 83, 513-516.
39. Bixo M, Bäckström T, Winblad B, et al. (1995) Estradiol and testosterone in specific regions of the human female brain in different endocrine states. J Steroid Biochem Mol Biol 55, 297-303.
40. Berman KF, Schmidt PJ, Rubinow DR, et al. (1997) Modulation of cognition-specific cortical activity by gonadal steroids: a positron-emission tomography study in women. Proc Natl Acad Sci U S A 94, 8836-8841.
41. Gamache PH, Maher TJ, Setchell KDR, et al. (1996) The transfer of non-steroidal dietary estrogens into brain. Soc Neurosci 22, 771-776.
42. Lephart ED, Thompson JM, Setchell KD, et al. (2000) Phytoestrogens decrease brain calcium-binding proteins but do not alter hypothalamic androgen metabolizing enzymes in adult male rats. Brain Res 859, 123-131.
43. Passingham RE (1985) Memory of monkeys (Macaca mulatta) with lesions in prefrontal cortex. Behav Neurosci 99, 3-21.
44. Owen A, Downes JJ, Sahakian BJ, et al. (1990) Planning and spatial working memory following frontal lobe lesions in man. Neuropsychologia 28, 1021-1034.
45. Owen AM, Sahakian BJ, Semple J, et al. (1995) Visuospatial short-term recognition memory and learning after temporal lobe excisions, frontal lobe excisions or amygdalohippocampectomy in man. Neuropsychologia 33, 1-24.
46. Owen AM, Evans AC & Petrides M (1996) Evidence for a twostage model of spatial working memory processing within the lateral frontal cortex: a positron emission tomography study. Cereb Cortex 6, 31-38.
47. Ruff RM, Light RH, Parker SB, et al. (1996) Benton Controlled Oral Word Association Test: reliability and updated norms. Arch Clin Neuropsychol 11, 329-338.
48. Sarno MT, Buonaguro A & Levita E (1985) Gender and recovery from aphasia after stroke. J Nerv Ment Dis 173, 605-609.
49. Zec RF, Andrise A, Vicari S, et al. (1990) A comparison of phonemic and sematic word fluency in Alzheimer patients and elderly controls (abstract). J Clin Exp Neuropsychol 12, 18.
50. Blum JE, Fosshage JL & Jarvik LF (1972) Intellectual changes and sex differences in octogenarians: a twenty year longitudinal study of aging. Dev Psychol 7, 178-187.
51. Kreijkamp-Kaspers S, Kok L, Grobbee DE, et al. (2004) Effect of soy protein containing isoflavones on cognitive function, bone mineral density, and plasma lipids in postmenopausal women: a randomized controlled trial. JAMA 292, 65-74.
52. Fournier LR, Ryan Borchers TA, Robison LM, et al. (2007) The effects of soy milk and isoflavone supplements on cognitive performance in healthy, postmenopausal women. J Nutr Health Aging 11, 155-164.
53. Bornstein RA (1985) Normative data on selected neuropsychological measures from a non clinical sample. J Clin Psychol 41, 651-659.
54. Kortte KB, Horner MD & Windham WK (2002) The Trail Making Test, part B: cognitive flexibility or ability to maintain set? Appl Neuropsychol 9, 106-109.
55. Gaudino EA, Geisler MW & Squires NK (1995) Construct validity in the Trail Making Test: what makes part B harder? J Clin Exp Neuropsychol 17, 529-535.
56. Luine VN, Richards ST, Wu VY, et al. (1998) Estradiol enhances learning and memory in a spatial memory task and effects levels of monoaminergic neurotransmitters. Horm Behav 34, 149-162.
57. Bimonte HA & Denenberg VH (1999) Estradiol facilitates performance as working memory load increases. Psychoneuroendocrinology 24, 161-173.
58. Berry B, McMahan R & Gallagher M (1997) Spatial learning and memory at defined points of the estrous cycle: effects on performance of a hippocampal-dependent task. Behav Neurosci 111, 267-274.
59. Williams CL & Meck WH (1991) The organizational effects of gonadal steroids on sexually dimorphic spatial ability. Psychoneuroendocrinology 16, 155-176.
60. Lephart ED (1996) A review of brain aromatase cytochrome P450. Brain Res Brain Res Rev 22, 1-26.
61. Isgor C & Sengelaub DR (1998) Prenatal gonadal steroids affect adult spatial behavior, CA1 and CA3 pyramidal cell morphology in rats. Horm Behav 34, 183-198.
62. Roof RL (1993) Neonatal exogenous testosterone modifies sex difference in radial arm and Morris water maze performance in prepubescent and adult rats. Behav Brain Res 53, 1-10.
63. Voyer D, Voyer S & Bryden MP (1995) Magnitude of sex differences in spatial abilities: a meta-analysis and consideration of critical variables. Psychol Bull 117, 250-270.
64. Fonda SJ, Bertrand R, O'Donnell A, et al. (2005) Age, hormones, and cognitive functioning among middle-aged and elderly men: cross-sectional evidence from the Massachusetts Male Aging Study. J Gerontol A Biol Sci Med Sci 60, 385-390.
65. Moffat SD, Zonderman AB, Metter EJ, et al. (2002) Longitudinal assessment of serum free testosterone concentration predicts memory performance and cognitive status in elderly men. J Clin Endocrinol Metab 87, 5001-5007.
66. Yaffe K, Liu LY, Zmuda J, et al. (2002) Sex hormones and cognitive function in older men. J Am Geriatr Soc 50, 707-712.