Cognitive improvement after 6 weeks of soy supplements in postmenopausal women is limited to frontal lobe function

Menopause

Volumn 12, Issue 2, 2005, Pages 193-201

  File, Sandra E ^a   Hartley, David E ^a   Elsabagh, Sarah ^a,b   Duffy, Rosanna ^a   Wiseman, Helen ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Frontal lobe; Hormone therapy; Memory; Menopausal symptoms; Soy

Indexed keywords

ISOFLAVONE; NOVASOY; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; ATTENTION; CLINICAL ARTICLE; CLINICAL TRIAL; COGNITION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORRELATION ANALYSIS; DIET SUPPLEMENTATION; DOUBLE BLIND PROCEDURE; DRUG EFFECT; FEMALE; FRONTAL LOBE; HORMONAL THERAPY; HUMAN; INTERMETHOD COMPARISON; LONG TERM MEMORY; MEMORY; MENOPAUSAL SYNDROME; MENOPAUSE; MENTAL FUNCTION; MOOD; PATIENT SELECTION; PERFORMANCE; PLANNING; POSTMENOPAUSE; QUESTIONNAIRE; RANDOMIZATION; RANDOMIZED CONTROLLED TRIAL; SHORT TERM MEMORY; SOMNOLENCE; SOYBEAN; STATISTICAL SIGNIFICANCE; SYMPTOM; TREATMENT OUTCOME;

AGED; COGNITION DISORDERS; DOUBLE-BLIND METHOD; DRUG ADMINISTRATION SCHEDULE; ESTROGEN REPLACEMENT THERAPY; FEMALE; FRONTAL LOBE; HUMANS; MIDDLE AGED; PHYTOESTROGENS; PHYTOTHERAPY; POSTMENOPAUSE; QUESTIONNAIRES; SOYBEAN PROTEINS; TREATMENT OUTCOME;

EID: 16244412623     PISSN: 10723714     EISSN: None     Source Type: Journal    
DOI: 10.1097/00042192-200512020-00014     Document Type: Article

References (46)

1. Makela S, Santti R, Salo L, McLachlan JA. Phytoestrogens are partial estrogen agonists in the adult male mouse. Environ Health Perspect 1995;103:123-127.
2. Stahl S, Chun TY, Gray WG. Phytoestrogens are estrogen agonists in an estrogen-responsive pituitary cell line. Toxicol Appl Pharmacol 1998;152:41-48.
3. Philips SM, Sherwin BB. Effects of estrogen on memory function in surgically menopausal women. Psychoneuroendocrinology 1992;17:485-495.
4. Jacobs DM, Tang MX, Stern Y, et al. Cognitive function in nondemented older women who took estrogen after menopause. Neurology 1998;50:368-373.
5. Duka T, Tasker R, McGowan JF. The effects of 3-week estrogen hormone replacement on cognition in elderly healthy females. Psychopharmacology 2000;149:129-139.
6. Albertazzi P, Natale V, Barbolini C, Teglio L, Di Micco R. The effect of tibolone versus continuous-combined norethisterone acetate and estradiol on memory, libido and mood of post-menopausal women: a pilot study Maturitas 2000;36:223-229.
7. Fluck E, File SE, Rymer J. Cognitive effects of ten years of hormone-replacement therapy with tibolone. J Clin Psychopharmacology 2002;22:62-67.
8. Ross JL, Roeltgen D, Feuillan P, Kushner H, Cutler GB Jr. Use of estrogen in young girls with Turner syndrome: effects on memory. Neurology 2000;54:164-170.
9. Miles C, Green R, Sanders G, Hines M. Estrogen and memory in a transsexual population. Norm Behav 1998;34:199-208.
10. Brinton RD, Chen S, Montoya M, Hsieh D, Minaya J. The estrogen replacement therapy of the Women's Health Initiative promotes the cellular mechanisms of memory and neuronal survival in neurons vulnerable to Alzheimer's disease. Maturitas 2000;34(suppl 2):S35-S52.
11. Kawas C, Resnick S, Morrison A, et al. A prospective study of estrogen replacement therapy and the risk of developing Alzheimer's disease: the Baltimore Longitudinal Study of Aging. Neurology 1997;48:1517-1521.
12. Paganini-Hill A, Henderson VW. Estrogen replacement therapy and risk of Alzheimer disease. Arch Intern Med 1996;156:2213-2217.
13. Tang MX, Jacobs D, Stern Y, et al. Effect of oestrogen during menopause on risk and age at onset of Alzheimer's disease. Lancet 1996;348:429-432.
14. Yaffe K, Sawaya G, Lieberburg I, Grady D. Estrogen therapy in postmenopausal women: effects on cognitive function and dementia. JAMA 1998;279:688-695.
15. Shumaker SA, Legault C, Rapp SR, et al. Estrogen plus progestin and the incidence of dementia and mild cognitive impairment in postmenopausal women: the Women's Health Initiative memory study: a randomized controlled trial. JAMA 2003;289:2651-2662.
16. Kronenberg F, Fugh-Berman A. Complementary and alternative medicine for menopausal symptoms: a review of randomized controlled trials. Ann Intern Med 2002;137:805-813.
17. Henderson VW. Isoflavones: food for thoughtful consideration. Menopause 2003;10:189-190.
18. Duffy R, Wiseman H, File SE. Improved cognitive function in post-menopausal women after 12 weeks of consumption of a soya extract containing isoflavones. Pharm Biochem Behav 2003;75:721-729.
19. Kritz-Silverstein D, Von Muhlen D, Barrett-Connor E, Bressel MA. Isoflavones and cognitive function in older women: the SOy and Postmenopausal Health In Aging (SOPHIA) Study. Menopause 2003;10:196-202.
20. File SE, Heard JE, Rymer J. Trough estradiol levels associated with cognitive impairment in postmenopausal women after 10 years of estradiol implants. Psychopharmacology 2002;161:107-112.
21. File SE, Jarrett N, Fluck E, Duffy R, Casey K, Wiseman H. Eating soya improves human memory. Psychopharmacology 2001;157:430-436.
22. Nelson HE, Willson JR. Restandardisation of the NART Against the WAIS-R. Windsor, UK: NFER-Nelson, 1991.
23. Greene JC. Constructing a standard climacteric scale. Maturitas 1998;29:25-31.
24. Zigmond AS, Snaith RP. The hospital and anxiety depression scale. Acta Psychiatr Scand 1983;67:361-370.
25. Johns MW. A new method for measuring daytime sleepiness - the Epworth Sleepiness Scale. Sleep 1991;14:540-545.
26. Johns MW. Reliability and factor-analysis of the Epworth Sleepiness Scale. Sleep 1992;15:376-381.
27. Bond AJ, Lader M. The use of analogue scales in rating subjective feelings. Br J Med Psychol 1974;47:211-218.
28. Owen AM, Sahakian BJ, Semple J, Polkey CE, Robbins TW. Visuospatial short-term recognition memory and learning after temporal lobe excisions, frontal lobe excisions or amygdalo-hippocampectomy in man. Neuropsychologica 1995;33:1-24.
29. Weschler D. Weschler Memory Scale-Revised. San Antonio, TX: Harcourt Brace Jovanovich, 1987.
30. Owen AM, Roberts AC, Polkey CE, Robbins TW. Extra-dimensional versus intra-dimensional set shifting performance following frontal lobe excisions, temporal lobe excisions or amygdalo-hippocampectomy in man. Neuropsychologica 1991;29:993-1006.
31. Owen AM, Downes JJ, Sahakian BJ, Polkey CE, Robbins TW. Planning and spatial working memory following frontal lobe lesions in man. Neuropsychologica 1990;28:1021-1034.
32. Spreen O, Strauss E. A Compendium of Neuropsychological Tests: Administrations Norms and Commentary. Oxford, UK: Oxford University Press, 1991.
33. Soules MR, Sherman S, Parrott E, et al. Executive summary: stages of reproductive aging workshop (STRAW) Park City, Utah, July, 2001. Menopause 2001;8:402-407.
34. Daum I, Graber S, Schugens MM, Mayes AR. Memory dysfunction of the frontal type in normal ageing. Neuroreport 1996;7:2625-2628.
35. Persad CC, Abeles N, Zacks RT, Denburg NL. Inhibitory changes after age 60 and their relationship to measures of attention and memory. J Gerontol B Psychol Sci Soc Sci 2002;57:P223-P232.
36. Brzezinski A and Debi A. Phytoestrogens: the 'natural' selective estrogen receptor modulators. Eur J Obstet Gynecol Reprod Biol 1999;85:47-51.
37. Kuiper GGJM, Lemmen JG, Carlsson BO, et al. Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor β. Endocrinology 1998;139:4252-4263.
38. Lephart ED, West TW, Weber KS, Rhees RW, et al. Neurobehavioral effects of dietary soy phytoestrogens. Neurotoxicol Teratol 2002;24:5-16.
39. Hartley DE, Edwards JE, Spiller CE, et al. The soya isoflavone content of rat diet can increase anxiety and stress hormone release in the male rat. Psychopharmacology 2003;167:46-53.
40. Forsling ML, Kallo I, Hartley DE, et al. Oestrogen receptor-β and neurohypophysial hormones: functional interaction and neuroanatomical localisation. Pharmacol Biochem Behav 2003; 76:535-542.
41. Isgor C, Shieh KR, Akil H, Watson SJ. Colocalization of estrogen beta-receptor messenger RNA with orphanin FQ, vasopressin and oxytocin in the rat hypothalamic paraventricular and supraoptic nuclei. Anat Embryol 2003;206:461-469.
42. Pau CY, Pau K-Y F, Spies HG. Putative estrogen receptor β and α mRNA expression in male and female rhesus macaques. Mol Cell Endocrinol 1998;146:59-68.
43. Pan Y, Anthony M, Clarkson TB. Effect of estradiol and soy phytoestrogens on choline acetyltransferase and nerve growth factor mRNAs in the frontal cortex and hippocampus of female rats. Soc Exp Biol Med 1999;221:118-125.
44. Pan Y, Anthony M, Clarkson TB. Evidence for up-regulation of brain-derived neurotrophic factor mRNA by soy phytoestrogens in the frontal cortex of retired breeder female rats. Neurosci Lett 1999;261:17-20.
45. File SE, Hartley DE, Alom N, Rattray M. Soya phytoestrogens change cortical and hippocampal expression of BDNF mRNA in male rats. Neurosci Lett 2003;338:135-138.
46. McEwen BS. Invited review: estrogens effects on the brain: multiple sites and molecular mechanisms. J Appl Physiol 2001;91:2785-2801.