The genomic and transcriptomic landscape of anaplastic thyroid cancer: Implications for therapy

BMC Cancer

Volumn 15, Issue 1, 2015, Pages

  Kasaian, Katayoon ^a   Wiseman, Sam M ^b   Walker, Blair A ^b   Schein, Jacqueline E ^a   Zhao, Yongjun ^a   Hirst, Martin ^a   Moore, Richard A ^a   Mungall, Andrew J ^a   Marra, Marco A ^a,c   Jones, Steven JM ^a,c,d,e  

^a BRITISH COLUMBIA CANCER AGENCY   (Canada)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^c UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^d SIMON FRASER UNIVERSITY   (Canada)

^e Department of Molecular Biology and Biochemistry ^*  (Canada)

Author keywords

Anaplastic thyroid carcinoma; Cell line; Epigenetic alterations; FGFR2 OGDH fusion; MKRN1 BRAF fusion; MTOR signaling pathway; SS18 SLC5A11 fusion; Therapy targets; Whole genome and transcriptome sequencing

Indexed keywords

ANTINEOPLASTIC AGENT; B RAF KINASE; BRM PROTEIN; E1A ASSOCIATED P300 PROTEIN; FIBROBLAST GROWTH FACTOR RECEPTOR; HISTONE DEACETYLASE 10; MAMMALIAN TARGET OF RAPAMYCIN; METHYL CPG BINDING PROTEIN 2; TRANSCRIPTOME; VASCULOTROPIN RECEPTOR;

ADULT; ANAPLASTIC THYROID CANCER; ANEUPLOIDY; ARTICLE; BCL11A GENE; BRAF GENE; CANCER THERAPY; CHROMOSOME 20Q; CHROMOSOME 5P; CONTROLLED STUDY; COPY NUMBER VARIATION; DNA MODIFICATION; DRUG TARGETING; EP300 GENE; EPIGENETICS; FGFR GENE; FGFR2 OGDH GENE; FUSION GENE; GENE DELETION; GENE DUPLICATION; GENE EXPRESSION; GENE FUSION; GENE LOSS; GENE MUTATION; GENE TARGETING; GENOMICS; HDAC10 GENE; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN GENOME; HUMAN TISSUE; KIT GENE; MALE; MECP2 GENE; MIDDLE AGED; MKRN1 BRAF GENE; PRIMARY TUMOR; PROTO ONCOGENE; RET GENE; SIGNAL TRANSDUCTION; SMARCA2 GENE; SS18 GENE; SS18 SLC5A11 GENE; THYROID CANCER CELL LINE; THYROID CARCINOMA; TISSUE SECTION; TRANSCRIPTOMICS; TUMOR SUPPRESSOR GENE; VEGFR GENE; CARCINOMA; COMPARATIVE STUDY; DNA SEQUENCE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETIC EPIGENESIS; GENETIC HETEROGENEITY; GENETIC VARIATION; GENETICS; MOLECULARLY TARGETED THERAPY; MUTATION; PROCEDURES; THYROID CARCINOMA, ANAPLASTIC; THYROID NEOPLASMS; TUMOR CELL LINE;

CARCINOMA; CELL LINE, TUMOR; EPIGENESIS, GENETIC; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; GENETIC HETEROGENEITY; GENETIC VARIATION; GENOMICS; HUMANS; MALE; MIDDLE AGED; MOLECULAR TARGETED THERAPY; MUTATION; SEQUENCE ANALYSIS, DNA; THYROID CARCINOMA, ANAPLASTIC; THYROID NEOPLASMS;

EID: 84950153131     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/s12885-015-1955-9     Document Type: Article

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