The National Lung Matrix Trial: Translating the biology of stratification in advanced non-small-cell lung cancer

Annals of Oncology

Volumn 26, Issue 12, 2015, Pages 2464-2469

  Middleton, G ^a,b   Crack, L R ^a   Popat, S ^c   Swanton, C ^d,e   Hollingsworth, S J ^f   Buller, R ^g   Walker, I ^h   Carr, T H ^f   Wherton, D ^a   Billingham, L J ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^b UNIVERSITY HOSPITALS BIRMINGHAM NHS FOUNDATION TRUST   (United Kingdom)

^c INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^d THE FRANCIS CRICK INSTITUTE   (United Kingdom)

^e UNIVERSITY COLLEGE LONDON   (United Kingdom)

^f ASTRAZENECA   (United Kingdom)

^g PFIZER INC   (United States)

^h IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

Author keywords

Adaptive trial design; National Lung Matrix Trial; Non small cell lung cancer; Stratified medicine; Umbrella Trial

Indexed keywords

ANTINEOPLASTIC AGENT; AZD 4547; AZD 5353; CRIZOTINIB; DOCETAXEL; OSIMERTINIB; PALBOCICLIB; SELUMETINIB; TUMOR MARKER; UNCLASSIFIED DRUG; VISTUSERTIB; 4-AMINO-N-(1-(4-CHLOROPHENYL)-3-HYDROXYPROPYL)-1-(7H-PYRROLO(2,3-D)PYRIMIDIN-4-YL)PIPERIDINE-4-CARBOXAMIDE; PROTEIN KINASE B; PYRIMIDINE DERIVATIVE; PYRROLE DERIVATIVE;

ADVANCED CANCER; ARTICLE; CANCER SCREENING; DRUG EFFICACY; GENOME ANALYSIS; HUMAN; MUTATIONAL ANALYSIS; NEXT GENERATION SEQUENCING; NON SMALL CELL LUNG CANCER; PRIORITY JOURNAL; ANTAGONISTS AND INHIBITORS; CARCINOMA, NON-SMALL-CELL LUNG; CLINICAL TRIAL; GENETICS; LUNG NEOPLASMS; MULTICENTER STUDY; PHASE 2 CLINICAL TRIAL; PROCEDURES; TRANSLATIONAL RESEARCH; TRENDS; TUMOR RECURRENCE; UNITED KINGDOM;

ANTINEOPLASTIC AGENTS; BIOMARKERS, TUMOR; CARCINOMA, NON-SMALL-CELL LUNG; HUMANS; LUNG NEOPLASMS; NEOPLASM RECURRENCE, LOCAL; PROTO-ONCOGENE PROTEINS C-AKT; PYRIMIDINES; PYRROLES; TRANSLATIONAL MEDICAL RESEARCH; UNITED KINGDOM;

EID: 84949944937     PISSN: 09237534     EISSN: 15698041     Source Type: Journal    
DOI: 10.1093/annonc/mdv394     Document Type: Article

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