-
1
-
-
84879302728
-
HIV-1 neutralizing antibodies: understanding nature's pathways
-
Mascola JR, Haynes BF. 2013. HIV-1 neutralizing antibodies: understanding nature's pathways. Immunol Rev 254:225-244. http://dx.doi.org/10.1111/imr.12075.
-
(2013)
Immunol Rev
, vol.254
, pp. 225-244
-
-
Mascola, J.R.1
Haynes, B.F.2
-
2
-
-
84883796903
-
Antibodies in HIV-1 vaccine development and therapy
-
Klein F, Mouquet H, Dosenovic P, Scheid JF, Scharf L, Nussenzweig MC. 2013. Antibodies in HIV-1 vaccine development and therapy. Science 341:1199-1204. http://dx.doi.org/10.1126/science.1241144.
-
(2013)
Science
, vol.341
, pp. 1199-1204
-
-
Klein, F.1
Mouquet, H.2
Dosenovic, P.3
Scheid, J.F.4
Scharf, L.5
Nussenzweig, M.C.6
-
3
-
-
84929896699
-
Antibody responses to envelope glycoproteins in HIV-1 infection
-
Burton DR, Mascola JR. 2015. Antibody responses to envelope glycoproteins in HIV-1 infection. Nat Immunol 16:571-576. http://dx.doi.org/10.1038/ni.3158.
-
(2015)
Nat Immunol
, vol.16
, pp. 571-576
-
-
Burton, D.R.1
Mascola, J.R.2
-
4
-
-
84909640954
-
Structure and immune recognition of trimeric pre-fusion HIV-1 Env
-
Pancera M, Zhou T, Druz A, Georgiev IS, Soto C, Gorman J, Huang J, Acharya P, Chuang GY, Ofek G, Stewart-Jones GB, Stuckey J, Bailer RT, Joyce MG, Louder MK, Tumba N, Yang Y, Zhang B, Cohen MS, Haynes BF, Mascola JR, Morris L, Munro JB, Blanchard SC, Mothes W, Connors M, Kwong PD. 2014. Structure and immune recognition of trimeric pre-fusion HIV-1 Env. Nature 514:455-461. http://dx.doi.org/10.1038/nature13808.
-
(2014)
Nature
, vol.514
, pp. 455-461
-
-
Pancera, M.1
Zhou, T.2
Druz, A.3
Georgiev, I.S.4
Soto, C.5
Gorman, J.6
Huang, J.7
Acharya, P.8
Chuang, G.Y.9
Ofek, G.10
Stewart-Jones, G.B.11
Stuckey, J.12
Bailer, R.T.13
Joyce, M.G.14
Louder, M.K.15
Tumba, N.16
Yang, Y.17
Zhang, B.18
Cohen, M.S.19
Haynes, B.F.20
Mascola, J.R.21
Morris, L.22
Munro, J.B.23
Blanchard, S.C.24
Mothes, W.25
Connors, M.26
Kwong, P.D.27
more..
-
5
-
-
84890859441
-
Cryo-EM structure of a fully glycosylated soluble cleaved HIV-1 envelope trimer
-
Lyumkis D, Julien JP, de Val N, Cupo A, Potter CS, Klasse PJ, Burton DR, Sanders RW, Moore JP, Carragher B, Wilson IA, Ward AB. 2013. Cryo-EM structure of a fully glycosylated soluble cleaved HIV-1 envelope trimer. Science 342:1484-1490. http://dx.doi.org/10.1126/science.1245627.
-
(2013)
Science
, vol.342
, pp. 1484-1490
-
-
Lyumkis, D.1
Julien, J.P.2
de Val, N.3
Cupo, A.4
Potter, C.S.5
Klasse, P.J.6
Burton, D.R.7
Sanders, R.W.8
Moore, J.P.9
Carragher, B.10
Wilson, I.A.11
Ward, A.B.12
-
6
-
-
84890858459
-
Crystal structure of a soluble cleaved HIV-1 envelope trimer
-
Julien JP, Cupo A, Sok D, Stanfield RL, Lyumkis D, Deller MC, Klasse PJ, Burton DR, Sanders RW, Moore JP, Ward AB, Wilson IA. 2013. Crystal structure of a soluble cleaved HIV-1 envelope trimer. Science 342: 1477-1483. http://dx.doi.org/10.1126/science.1245625.
-
(2013)
Science
, vol.342
, pp. 1477-1483
-
-
Julien, J.P.1
Cupo, A.2
Sok, D.3
Stanfield, R.L.4
Lyumkis, D.5
Deller, M.C.6
Klasse, P.J.7
Burton, D.R.8
Sanders, R.W.9
Moore, J.P.10
Ward, A.B.11
Wilson, I.A.12
-
7
-
-
84937469192
-
HIV-1 neutralizing antibodies induced by native-like envelope trimers
-
Sanders RW, van Gils MJ, Derking R, Sok D, Ketas TJ, Burger JA, Ozorowski G, Cupo A, Simonich C, Goo L, Arendt H, Kim HJ, Lee JH, Pugach P, Williams M, Debnath G, Moldt B, van Breemen MJ, Isik G, Medina-Ramirez M, Back JW, Koff WC, Julien JP, Rakasz EG, Seaman MS, Guttman M, Lee KK, Klasse PJ, LaBranche C, Schief WR, Wilson IA, Overbaugh J, Burton DR, Ward AB, Montefiori DC, Dean H, Moore JP. 2015. HIV-1 neutralizing antibodies induced by native-like envelope trimers. Science http://dx.doi.org/10.1126/science.aac4223.
-
(2015)
Science
-
-
Sanders, R.W.1
van Gils, M.J.2
Derking, R.3
Sok, D.4
Ketas, T.J.5
Burger, J.A.6
Ozorowski, G.7
Cupo, A.8
Simonich, C.9
Goo, L.10
Arendt, H.11
Kim, H.J.12
Lee, J.H.13
Pugach, P.14
Williams, M.15
Debnath, G.16
Moldt, B.17
van Breemen, M.J.18
Isik, G.19
Medina-Ramirez, M.20
Back, J.W.21
Koff, W.C.22
Julien, J.P.23
Rakasz, E.G.24
Seaman, M.S.25
Guttman, M.26
Lee, K.K.27
Klasse, P.J.28
LaBranche, C.29
Schief, W.R.30
Wilson, I.A.31
Overbaugh, J.32
Burton, D.R.33
Ward, A.B.34
Montefiori, D.C.35
Dean, H.36
Moore, J.P.37
more..
-
8
-
-
84934954773
-
Priming a broadly neutralizing antibody response to HIV-1 using a germlinetargeting immunogen
-
Jardine JG, Ota T, Sok D, Pauthner M, Kulp DW, Kalyuzhniy O, Skog PD, Thinnes TC, Bhullar D, Briney B, Menis S, Jones M, Kubitz M, Spencer S, Adachi Y, Burton DR, Schief WR, Nemazee D. 2015. Priming a broadly neutralizing antibody response to HIV-1 using a germlinetargeting immunogen. Science http://dx.doi.org/10.1126/science.aac5894.
-
(2015)
Science
-
-
Jardine, J.G.1
Ota, T.2
Sok, D.3
Pauthner, M.4
Kulp, D.W.5
Kalyuzhniy, O.6
Skog, P.D.7
Thinnes, T.C.8
Bhullar, D.9
Briney, B.10
Menis, S.11
Jones, M.12
Kubitz, M.13
Spencer, S.14
Adachi, Y.15
Burton, D.R.16
Schief, W.R.17
Nemazee, D.18
-
9
-
-
84934937791
-
Immunization for HIV-1 broadly neutralizing antibodies in human Ig knockin mice
-
Dosenovic P, von Boehmer L, Escolano A, Jardine J, Freund NT, Gitlin AD, McGuire AT, Kulp DW, Oliveira T, Scharf L, Pietzsch J, Gray MD, Cupo A, van Gils MJ, Yao KH, Liu C, Gazumyan A, Seaman MS, Bjorkman PJ, Sanders RW, Moore JP, Stamatatos L, Schief WR, Nussenzweig MC. 2015. Immunization for HIV-1 broadly neutralizing antibodies in human Ig knockin mice. Cell 161:1505-1515. http://dx.doi.org/10.1016/j.cell.2015.06.003.
-
(2015)
Cell
, vol.161
, pp. 1505-1515
-
-
Dosenovic, P.1
von Boehmer, L.2
Escolano, A.3
Jardine, J.4
Freund, N.T.5
Gitlin, A.D.6
McGuire, A.T.7
Kulp, D.W.8
Oliveira, T.9
Scharf, L.10
Pietzsch, J.11
Gray, M.D.12
Cupo, A.13
van Gils, M.J.14
Yao, K.H.15
Liu, C.16
Gazumyan, A.17
Seaman, M.S.18
Bjorkman, P.J.19
Sanders, R.W.20
Moore, J.P.21
Stamatatos, L.22
Schief, W.R.23
Nussenzweig, M.C.24
more..
-
10
-
-
84874561170
-
Neutralizing antibodies to HIV-1 induced by immunization
-
McCoy LE, Weiss RA. 2013. Neutralizing antibodies to HIV-1 induced by immunization. J Exp Med 210:209-223. http://dx.doi.org/10.1084/jem.20121827.
-
(2013)
J Exp Med
, vol.210
, pp. 209-223
-
-
McCoy, L.E.1
Weiss, R.A.2
-
11
-
-
84880295369
-
Advances in structure-based vaccine design
-
Kulp DW, Schief WR. 2013. Advances in structure-based vaccine design. Curr Opin Virol 3:322-331. http://dx.doi.org/10.1016/j.coviro.2013.05.010.
-
(2013)
Curr Opin Virol
, vol.3
, pp. 322-331
-
-
Kulp, D.W.1
Schief, W.R.2
-
12
-
-
84883187027
-
Broadly neutralizing antibodies and the search for an HIV-1 vaccine: the end of the beginning
-
Kwong PD, Mascola JR, Nabel GJ. 2013. Broadly neutralizing antibodies and the search for an HIV-1 vaccine: the end of the beginning. Nat Rev Immunol 13:693-701. http://dx.doi.org/10.1038/nri3516.
-
(2013)
Nat Rev Immunol
, vol.13
, pp. 693-701
-
-
Kwong, P.D.1
Mascola, J.R.2
Nabel, G.J.3
-
13
-
-
84928571820
-
History of passive antibody administration for prevention and treatment of infectious diseases
-
Graham BS, Ambrosino DM. 2015. History of passive antibody administration for prevention and treatment of infectious diseases. CurrOpinHIVAIDS 10:129-134. http://dx.doi.org/10.1097/COH.0000000000000154.
-
(2015)
CurrOpinHIVAIDS
, vol.10
, pp. 129-134
-
-
Graham, B.S.1
Ambrosino, D.M.2
-
14
-
-
84907971356
-
Enhanced potency of a broadly neutralizing HIV-1 antibody in vitro improves protection against lentiviral infection in vivo
-
Rudicell RS, Kwon YD, Ko SY, Pegu A, Louder MK, Georgiev IS, Wu X, Zhu J, Boyington JC, Chen X, Shi W, Yang ZY, Doria-Rose NA, McKee K, O'Dell S, Schmidt SD, Chuang GY, Druz A, Soto C, Yang Y, Zhang B, Zhou T, Todd JP, Lloyd KE, Eudailey J, Roberts KE, Donald BR, Bailer RT, Ledgerwood J, Program NCS, Mullikin JC, Shapiro L, Koup RA, Graham BS, Nason MC, Connors M, Haynes BF, Rao SS, Roederer M, Kwong PD, Mascola JR, Nabel GJ. 2014. Enhanced potency of a broadly neutralizing HIV-1 antibody in vitro improves protection against lentiviral infection in vivo. J Virol 88:12669-12682. http://dx.doi.org/10.1128/JVI.02213-14.
-
(2014)
J Virol
, vol.88
, pp. 12669-12682
-
-
Rudicell, R.S.1
Kwon, Y.D.2
Ko, S.Y.3
Pegu, A.4
Louder, M.K.5
Georgiev, I.S.6
Wu, X.7
Zhu, J.8
Boyington, J.C.9
Chen, X.10
Shi, W.11
Yang, Z.Y.12
Doria-Rose, N.A.13
McKee, K.14
O'Dell, S.15
Schmidt, S.D.16
Chuang, G.Y.17
Druz, A.18
Soto, C.19
Yang, Y.20
Zhang, B.21
Zhou, T.22
Todd, J.P.23
Lloyd, K.E.24
Eudailey, J.25
Roberts, K.E.26
Donald, B.R.27
Bailer, R.T.28
Ledgerwood, J.29
Program, N.C.S.30
Mullikin, J.C.31
Shapiro, L.32
Koup, R.A.33
Graham, B.S.34
Nason, M.C.35
Connors, M.36
Haynes, B.F.37
Rao, S.S.38
Roederer, M.39
Kwong, P.D.40
Mascola, J.R.41
Nabel, G.J.42
more..
-
15
-
-
84904497424
-
Neutralizing antibodies to HIV-1 envelope protect more effectively in vivo than those to the CD4 receptor
-
Pegu A, Yang ZY, Boyington JC, Wu L, Ko SY, Schmidt SD, McKee K, Kong WP, Shi W, Chen X, Todd JP, Letvin NL, Huang J, Nason MC, Hoxie JA, Kwong PD, Connors M, Rao SS, Mascola JR, Nabel GJ. 2014. Neutralizing antibodies to HIV-1 envelope protect more effectively in vivo than those to the CD4 receptor. Sci Transl Med 6:243ra288.
-
(2014)
Sci Transl Med
, vol.6
-
-
Pegu, A.1
Yang, Z.Y.2
Boyington, J.C.3
Wu, L.4
Ko, S.Y.5
Schmidt, S.D.6
McKee, K.7
Kong, W.P.8
Shi, W.9
Chen, X.10
Todd, J.P.11
Letvin, N.L.12
Huang, J.13
Nason, M.C.14
Hoxie, J.A.15
Kwong, P.D.16
Connors, M.17
Rao, S.S.18
Mascola, J.R.19
Nabel, G.J.20
more..
-
16
-
-
84907212727
-
Passive transfer of modest titers of potent and broadly neutralizing anti-HIV monoclonal antibodies block SHIV infection in macaques
-
Shingai M, Donau OK, Plishka RJ, Buckler-White A, Mascola JR, Nabel GJ, Nason MC, Montefiori D, Moldt B, Poignard P, Diskin R, Bjorkman PJ, Eckhaus MA, Klein F, Mouquet H, Cetrulo Lorenzi JC, Gazumyan A, Burton DR, Nussenzweig MC, Martin MA, Nishimura Y. 2014. Passive transfer of modest titers of potent and broadly neutralizing anti-HIV monoclonal antibodies block SHIV infection in macaques. J Exp Med 211:2061-2074. http://dx.doi.org/10.1084/jem.20132494.
-
(2014)
J Exp Med
, vol.211
, pp. 2061-2074
-
-
Shingai, M.1
Donau, O.K.2
Plishka, R.J.3
Buckler-White, A.4
Mascola, J.R.5
Nabel, G.J.6
Nason, M.C.7
Montefiori, D.8
Moldt, B.9
Poignard, P.10
Diskin, R.11
Bjorkman, P.J.12
Eckhaus, M.A.13
Klein, F.14
Mouquet, H.15
Cetrulo Lorenzi, J.C.16
Gazumyan, A.17
Burton, D.R.18
Nussenzweig, M.C.19
Martin, M.A.20
Nishimura, Y.21
more..
-
17
-
-
84885338257
-
HIV-1 suppression and durable control by combining single broadly neutralizing antibodies and antiretroviral drugs in humanized mice
-
Horwitz JA, Halper-Stromberg A, Mouquet H, Gitlin AD, Tretiakova A, Eisenreich TR, Malbec M, Gravemann S, Billerbeck E, Dorner M, Buning H, Schwartz O, Knops E, Kaiser R, Seaman MS, Wilson JM, Rice CM, Ploss A, Bjorkman PJ, Klein F, Nussenzweig MC. 2013. HIV-1 suppression and durable control by combining single broadly neutralizing antibodies and antiretroviral drugs in humanized mice. Proc Natl Acad Sci U S A 110:16538-16543. http://dx.doi.org/10.1073/pnas.1315295110.
-
(2013)
Proc Natl Acad Sci U S A
, vol.110
, pp. 16538-16543
-
-
Horwitz, J.A.1
Halper-Stromberg, A.2
Mouquet, H.3
Gitlin, A.D.4
Tretiakova, A.5
Eisenreich, T.R.6
Malbec, M.7
Gravemann, S.8
Billerbeck, E.9
Dorner, M.10
Buning, H.11
Schwartz, O.12
Knops, E.13
Kaiser, R.14
Seaman, M.S.15
Wilson, J.M.16
Rice, C.M.17
Ploss, A.18
Bjorkman, P.J.19
Klein, F.20
Nussenzweig, M.C.21
more..
-
18
-
-
84887627657
-
Antibody-mediated immunotherapy of macaques chronically infected with SHIV suppresses viraemia
-
Shingai M, Nishimura Y, Klein F, Mouquet H, Donau OK, Plishka R, Buckler-White A, Seaman M, Piatak M, Jr, Lifson JD, Dimitrov DS, Nussenzweig MC, Martin MA. 2013. Antibody-mediated immunotherapy of macaques chronically infected with SHIV suppresses viraemia. Nature 503:277-280.
-
(2013)
Nature
, vol.503
, pp. 277-280
-
-
Shingai, M.1
Nishimura, Y.2
Klein, F.3
Mouquet, H.4
Donau, O.K.5
Plishka, R.6
Buckler-White, A.7
Seaman, M.8
Piatak, M.9
Lifson, J.D.10
Dimitrov, D.S.11
Nussenzweig, M.C.12
Martin, M.A.13
-
19
-
-
84887626950
-
Therapeutic efficacy of potent neutralizing HIV-1-specific monoclonal antibodies in SHIVinfected rhesus monkeys
-
Barouch DH, Whitney JB, Moldt B, Klein F, Oliveira TY, Liu J, Stephenson KE, Chang HW, Shekhar K, Gupta S, Nkolola JP, Seaman MS, Smith KM, Borducchi EN, Cabral C, Smith JY, Blackmore S, Sanisetty S, Perry JR, Beck M, Lewis MG, Rinaldi W, Chakraborty AK, Poignard P, Nussenzweig MC, Burton DR. 2013. Therapeutic efficacy of potent neutralizing HIV-1-specific monoclonal antibodies in SHIVinfected rhesus monkeys. Nature 503:224-228.
-
(2013)
Nature
, vol.503
, pp. 224-228
-
-
Barouch, D.H.1
Whitney, J.B.2
Moldt, B.3
Klein, F.4
Oliveira, T.Y.5
Liu, J.6
Stephenson, K.E.7
Chang, H.W.8
Shekhar, K.9
Gupta, S.10
Nkolola, J.P.11
Seaman, M.S.12
Smith, K.M.13
Borducchi, E.N.14
Cabral, C.15
Smith, J.Y.16
Blackmore, S.17
Sanisetty, S.18
Perry, J.R.19
Beck, M.20
Lewis, M.G.21
Rinaldi, W.22
Chakraborty, A.K.23
Poignard, P.24
Nussenzweig, M.C.25
Burton, D.R.26
more..
-
20
-
-
84928405730
-
Viraemia suppressed in HIV-1-infected humans by broadly neutralizing antibody 3BNC117
-
Caskey M, Klein F, Lorenzi JC, Seaman MS, West AP, Jr, Buckley N, Kremer G, Nogueira L, Braunschweig M, Scheid JF, Horwitz JA, Shimeliovich I, Ben-Avraham S, Witmer-Pack M, Platten M, Lehmann C, Burke LA, Hawthorne T, Gorelick RJ, Walker BD, Keler T, Gulick RM, Fatkenheuer G, Schlesinger SJ, Nussenzweig MC. 2015. Viraemia suppressed in HIV-1-infected humans by broadly neutralizing antibody 3BNC117. Nature http://dx.doi.org/10.1038/nature14411.
-
(2015)
Nature
-
-
Caskey, M.1
Klein, F.2
Lorenzi, J.C.3
Seaman, M.S.4
West, A.P.5
Buckley, N.6
Kremer, G.7
Nogueira, L.8
Braunschweig, M.9
Scheid, J.F.10
Horwitz, J.A.11
Shimeliovich, I.12
Ben-Avraham, S.13
Witmer-Pack, M.14
Platten, M.15
Lehmann, C.16
Burke, L.A.17
Hawthorne, T.18
Gorelick, R.J.19
Walker, B.D.20
Keler, T.21
Gulick, R.M.22
Fatkenheuer, G.23
Schlesinger, S.J.24
Nussenzweig, M.C.25
more..
-
21
-
-
84946480939
-
Safety, pharmacokinetics, and neutralization of the broadly neutralizing HIV-1 human monoclonal antibody VRC01 in healthy adults
-
1 September
-
Ledgerwood JE, Coates E, Yamshchikov G, Saunders J, Holman L, Enama ME, DeZure A, Mohan S, Pandey J, Schwartz R, Hu Z, Koup RA, Capparelli E, Mascola JR, Graham BS. 1 September 2015. Safety, pharmacokinetics, and neutralization of the broadly neutralizing HIV-1 human monoclonal antibody VRC01 in healthy adults. Clin Exp Immunol http://dx.doi.org/10.1111/cei.12692.
-
(2015)
Clin Exp Immunol
-
-
Ledgerwood, J.E.1
Coates, E.2
Yamshchikov, G.3
Saunders, J.4
Holman, L.5
Enama, M.E.6
DeZure, A.7
Mohan, S.8
Pandey, J.9
Schwartz, R.10
Hu, Z.11
Koup, R.A.12
Capparelli, E.13
Mascola, J.R.14
Graham, B.S.15
-
22
-
-
84949866463
-
-
HIV Vaccines (X5):101, Keystone Symposia on Molecular and Cellular Biology
-
Lynch R, Boritz E, Coates E, Koup R, Ledgerwood J, Mascola J. 2015. Virologic impact of VRC01-infusion in HIV-1 infected subjects. HIV Vaccines (X5):101, Keystone Symposia on Molecular and Cellular Biology.
-
(2015)
Virologic impact of VRC01-infusion in HIV-1 infected subjects
-
-
Lynch, R.1
Boritz, E.2
Coates, E.3
Koup, R.4
Ledgerwood, J.5
Mascola, J.6
-
23
-
-
84922982202
-
Improving neutralization potency and breadth by combining broadly reactive HIV-1 antibodies targeting major neutralization epitopes
-
Kong R, Louder MK, Wagh K, Bailer RT, deCamp A, Greene K, Gao H, Taft JD, Gazumyan A, Liu C, Nussenzweig MC, Korber B, Montefiori DC, Mascola JR. 2015. Improving neutralization potency and breadth by combining broadly reactive HIV-1 antibodies targeting major neutralization epitopes. J Virol 89:2659-2671. http://dx.doi.org/10.1128/JVI.03136-14.
-
(2015)
J Virol
, vol.89
, pp. 2659-2671
-
-
Kong, R.1
Louder, M.K.2
Wagh, K.3
Bailer, R.T.4
deCamp, A.5
Greene, K.6
Gao, H.7
Taft, J.D.8
Gazumyan, A.9
Liu, C.10
Nussenzweig, M.C.11
Korber, B.12
Montefiori, D.C.13
Mascola, J.R.14
-
24
-
-
84922224963
-
Intra-spike crosslinking overcomes antibody evasion by HIV-1
-
Galimidi RP, Klein JS, Politzer MS, Bai S, Seaman MS, Nussenzweig MC, West AP, Jr, Bjorkman PJ. 2015. Intra-spike crosslinking overcomes antibody evasion by HIV-1. Cell 160:433-446. http://dx.doi.org/10.1016/j.cell.2015.01.016.
-
(2015)
Cell
, vol.160
, pp. 433-446
-
-
Galimidi, R.P.1
Klein, J.S.2
Politzer, M.S.3
Bai, S.4
Seaman, M.S.5
Nussenzweig, M.C.6
West, A.P.7
Bjorkman, P.J.8
-
25
-
-
84882404868
-
Bispecific antibodies directed to CD4 domain 2 and HIV envelope exhibit exceptional breadth and picomolar potency against HIV-1
-
Pace CS, Song R, Ochsenbauer C, Andrews CD, Franco D, Yu J, Oren DA, Seaman MS, Ho DD. 2013. Bispecific antibodies directed to CD4 domain 2 and HIV envelope exhibit exceptional breadth and picomolar potency against HIV-1. Proc Natl Acad Sci U S A 110:13540-13545. http://dx.doi.org/10.1073/pnas.1304985110.
-
(2013)
Proc Natl Acad Sci U S A
, vol.110
, pp. 13540-13545
-
-
Pace, C.S.1
Song, R.2
Ochsenbauer, C.3
Andrews, C.D.4
Franco, D.5
Yu, J.6
Oren, D.A.7
Seaman, M.S.8
Ho, D.D.9
-
26
-
-
84924375707
-
AAV-expressed eCD4-Ig provides durable protection from multiple SHIV challenges
-
Gardner MR, Kattenhorn LM, Kondur HR, von Schaewen M, Dorfman T, Chiang JJ, Haworth KG, Decker JM, Alpert MD, Bailey CC, Neale ES, Jr, Fellinger CH, Joshi VR, Fuchs SP, Martinez-Navio JM, Quinlan BD, Yao AY, Mouquet H, Gorman J, Zhang B, Poignard P, Nussenzweig MC, Burton DR, Kwong PD, Piatak M, Jr, Lifson JD, Gao G, Desrosiers RC, Evans DT, Hahn BH, Ploss A, Cannon PM, Seaman MS, Farzan M. 2015. AAV-expressed eCD4-Ig provides durable protection from multiple SHIV challenges. Nature 519:87-91. http://dx.doi.org/10.1038/nature14264.
-
(2015)
Nature
, vol.519
, pp. 87-91
-
-
Gardner, M.R.1
Kattenhorn, L.M.2
Kondur, H.R.3
von Schaewen, M.4
Dorfman, T.5
Chiang, J.J.6
Haworth, K.G.7
Decker, J.M.8
Alpert, M.D.9
Bailey, C.C.10
Neale, E.S.11
Fellinger, C.H.12
Joshi, V.R.13
Fuchs, S.P.14
Martinez-Navio, J.M.15
Quinlan, B.D.16
Yao, A.Y.17
Mouquet, H.18
Gorman, J.19
Zhang, B.20
Poignard, P.21
Nussenzweig, M.C.22
Burton, D.R.23
Kwong, P.D.24
Piatak, M.25
Lifson, J.D.26
Gao, G.27
Desrosiers, R.C.28
Evans, D.T.29
Hahn, B.H.30
Ploss, A.31
Cannon, P.M.32
Seaman, M.S.33
Farzan, M.34
more..
-
27
-
-
84904463520
-
Rational design and characterization of the novel, broad and potent bispecific HIV-1 neutralizing antibody iMabm36
-
Sun M, Pace CS, Yao X, Yu F, Padte NN, Huang Y, Seaman MS, Li Q, Ho DD. 2014. Rational design and characterization of the novel, broad and potent bispecific HIV-1 neutralizing antibody iMabm36. J Acquir Immune Defic Syndr 66:473-483. http://dx.doi.org/10.1097/QAI.0000000000000218.
-
(2014)
J Acquir Immune Defic Syndr
, vol.66
, pp. 473-483
-
-
Sun, M.1
Pace, C.S.2
Yao, X.3
Yu, F.4
Padte, N.N.5
Huang, Y.6
Seaman, M.S.7
Li, Q.8
Ho, D.D.9
-
28
-
-
79960592856
-
Immunoglobulin domain crossover as a generic approach for the production of bispecific IgG antibodies
-
Schaefer W, Regula JT, Bahner M, Schanzer J, Croasdale R, Durr H, Gassner C, Georges G, Kettenberger H, Imhof-Jung S, Schwaiger M, Stubenrauch KG, Sustmann C, Thomas M, Scheuer W, Klein C. 2011. Immunoglobulin domain crossover as a generic approach for the production of bispecific IgG antibodies. Proc Natl Acad Sci U S A 108:11187-11192.http://dx.doi.org/10.1073/pnas.1019002108.
-
(2011)
Proc Natl Acad Sci U S A
, vol.108
, pp. 11187-11192
-
-
Schaefer, W.1
Regula, J.T.2
Bahner, M.3
Schanzer, J.4
Croasdale, R.5
Durr, H.6
Gassner, C.7
Georges, G.8
Kettenberger, H.9
Imhof-Jung, S.10
Schwaiger, M.11
Stubenrauch, K.G.12
Sustmann, C.13
Thomas, M.14
Scheuer, W.15
Klein, C.16
-
29
-
-
77954920017
-
Rational design of envelope identifies broadly neutralizing human monoclonal antibodies to HIV-1
-
Wu X, Yang ZY, Li Y, Hogerkorp CM, Schief WR, Seaman MS, Zhou T, Schmidt SD, Wu L, Xu L, Longo NS, McKee K, O'Dell S, Louder MK, Wycuff DL, Feng Y, Nason M, Doria-Rose N, Connors M, Kwong PD, Roederer M, Wyatt RT, Nabel GJ, Mascola JR. 2010. Rational design of envelope identifies broadly neutralizing human monoclonal antibodies to HIV-1. Science 329:856-861. http://dx.doi.org/10.1126/science.1187659.
-
(2010)
Science
, vol.329
, pp. 856-861
-
-
Wu, X.1
Yang, Z.Y.2
Li, Y.3
Hogerkorp, C.M.4
Schief, W.R.5
Seaman, M.S.6
Zhou, T.7
Schmidt, S.D.8
Wu, L.9
Xu, L.10
Longo, N.S.11
McKee, K.12
O'Dell, S.13
Louder, M.K.14
Wycuff, D.L.15
Feng, Y.16
Nason, M.17
Doria-Rose, N.18
Connors, M.19
Kwong, P.D.20
Roederer, M.21
Wyatt, R.T.22
Nabel, G.J.23
Mascola, J.R.24
more..
-
30
-
-
84903757787
-
Transplanting supersites of HIV-1 vulnerability
-
Zhou T, Zhu J, Yang Y, Gorman J, Ofek G, Srivatsan S, Druz A, Lees CR, Lu G, Soto C, Stuckey J, Burton DR, Koff WC, Connors M, Kwong PD. 2014. Transplanting supersites of HIV-1 vulnerability. PLoS One 9:e99881. http://dx.doi.org/10.1371/journal.pone.0099881.
-
(2014)
PLoS One
, vol.9
-
-
Zhou, T.1
Zhu, J.2
Yang, Y.3
Gorman, J.4
Ofek, G.5
Srivatsan, S.6
Druz, A.7
Lees, C.R.8
Lu, G.9
Soto, C.10
Stuckey, J.11
Burton, D.R.12
Koff, W.C.13
Connors, M.14
Kwong, P.D.15
-
31
-
-
85018072556
-
Structure-based design of trimeric V1V2 antigens
-
Gorman J, Yang Y, Druz A, Baxa U, Kwong PD. 2014. Structure-based design of trimeric V1V2 antigens. AIDS Res Hum Retroviruses 30(S1): A1-A7. http://dx.doi.org/10.1089/aid.2014.5000.abstract.
-
(2014)
AIDS Res Hum Retroviruses
, vol.30
, pp. A1-A7
-
-
Gorman, J.1
Yang, Y.2
Druz, A.3
Baxa, U.4
Kwong, P.D.5
-
32
-
-
84884678235
-
A next-generation cleaved, soluble HIV-1 Env trimer, BG505 SOSIP.664 gp140, expresses multiple epitopes for broadly neutralizing but not non-neutralizing antibodies
-
Sanders RW, Derking R, Cupo A, Julien JP, Yasmeen A, de Val N, Kim HJ, Blattner C, de la Pena AT, Korzun J, Golabek M, de Los Reyes K, Ketas TJ, van Gils MJ, King CR, Wilson IA, Ward AB, Klasse PJ, Moore JP. 2013. A next-generation cleaved, soluble HIV-1 Env trimer, BG505 SOSIP.664 gp140, expresses multiple epitopes for broadly neutralizing but not non-neutralizing antibodies. PLoS Pathog 9:e1003618. http://dx.doi.org/10.1371/journal.ppat.1003618.
-
(2013)
PLoS Pathog
, vol.9
-
-
Sanders, R.W.1
Derking, R.2
Cupo, A.3
Julien, J.P.4
Yasmeen, A.5
de Val, N.6
Kim, H.J.7
Blattner, C.8
de la Pena, A.T.9
Korzun, J.10
Golabek, M.11
de Los Reyes, K.12
Ketas, T.J.13
van Gils, M.J.14
King, C.R.15
Wilson, I.A.16
Ward, A.B.17
Klasse, P.J.18
Moore, J.P.19
-
33
-
-
84880149399
-
Structural basis for diverse N-glycan recognition by HIV-1-neutralizing V1-V2-directed antibody PG16
-
Pancera M, Shahzad-Ul-Hussan S, Doria-Rose NA, McLellan JS, Bailer RT, Dai K, Loesgen S, Louder MK, Staupe RP, Yang Y, Zhang B, Parks R, Eudailey J, Lloyd KE, Blinn J, Alam SM, Haynes BF, Amin MN, Wang LX, Burton DR, Koff WC, Nabel GJ, Mascola JR, Bewley CA, Kwong PD. 2013. Structural basis for diverse N-glycan recognition by HIV-1-neutralizing V1-V2-directed antibody PG16. Nat Struct Mol Biol 20:804-813. http://dx.doi.org/10.1038/nsmb.2600.
-
(2013)
Nat Struct Mol Biol
, vol.20
, pp. 804-813
-
-
Pancera, M.1
Shahzad-Ul-Hussan, S.2
Doria-Rose, N.A.3
McLellan, J.S.4
Bailer, R.T.5
Dai, K.6
Loesgen, S.7
Louder, M.K.8
Staupe, R.P.9
Yang, Y.10
Zhang, B.11
Parks, R.12
Eudailey, J.13
Lloyd, K.E.14
Blinn, J.15
Alam, S.M.16
Haynes, B.F.17
Amin, M.N.18
Wang, L.X.19
Burton, D.R.20
Koff, W.C.21
Nabel, G.J.22
Mascola, J.R.23
Bewley, C.A.24
Kwong, P.D.25
more..
-
34
-
-
84907983318
-
Enhanced neonatal Fc receptor function improves protection against primate SHIV infection
-
Ko SY, Pegu A, Rudicell RS, Yang ZY, Joyce MG, Chen X, Wang K, Bao S, Kraemer TD, Rath T, Zeng M, Schmidt SD, Todd JP, Penzak SR, Saunders KO, Nason MC, Haase AT, Rao SS, Blumberg RS, Mascola JR, Nabel GJ. 2014. Enhanced neonatal Fc receptor function improves protection against primate SHIV infection. Nature 514:642-645. http://dx.doi.org/10.1038/nature13612.
-
(2014)
Nature
, vol.514
, pp. 642-645
-
-
Ko, S.Y.1
Pegu, A.2
Rudicell, R.S.3
Yang, Z.Y.4
Joyce, M.G.5
Chen, X.6
Wang, K.7
Bao, S.8
Kraemer, T.D.9
Rath, T.10
Zeng, M.11
Schmidt, S.D.12
Todd, J.P.13
Penzak, S.R.14
Saunders, K.O.15
Nason, M.C.16
Haase, A.T.17
Rao, S.S.18
Blumberg, R.S.19
Mascola, J.R.20
Nabel, G.J.21
more..
-
35
-
-
77954042425
-
Few and far between: how HIV may be evading antibody avidity
-
Klein JS, Bjorkman PJ. 2010. Few and far between: how HIV may be evading antibody avidity. PLoS Pathog 6:e1000908. http://dx.doi.org/10.1371/journal.ppat.1000908.
-
(2010)
PLoS Pathog
, vol.6
-
-
Klein, J.S.1
Bjorkman, P.J.2
-
36
-
-
66149132686
-
Examination of the contributions of size and avidity to the neutralization mechanisms of the anti-HIV antibodies b12 and 4E10
-
Klein JS, Gnanapragasam PN, Galimidi RP, Foglesong CP, West AP, Jr, Bjorkman PJ. 2009. Examination of the contributions of size and avidity to the neutralization mechanisms of the anti-HIV antibodies b12 and 4E10. Proc Natl Acad Sci U S A 106:7385-7390. http://dx.doi.org/10.1073/pnas.0811427106.
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 7385-7390
-
-
Klein, J.S.1
Gnanapragasam, P.N.2
Galimidi, R.P.3
Foglesong, C.P.4
West, A.P.5
Bjorkman, P.J.6
-
37
-
-
84893859920
-
Generation of bispecific IgG antibodies by structure-based design of an orthogonal Fab interface
-
Lewis SM, Wu X, Pustilnik A, Sereno A, Huang F, Rick HL, Guntas G, Leaver-Fay A, Smith EM, Ho C, Hansen-Estruch C, Chamberlain AK, Truhlar SM, Conner EM, Atwell S, Kuhlman B, Demarest SJ. 2014. Generation of bispecific IgG antibodies by structure-based design of an orthogonal Fab interface. Nat Biotechnol 32:191-198. http://dx.doi.org/10.1038/nbt.2797.
-
(2014)
Nat Biotechnol
, vol.32
, pp. 191-198
-
-
Lewis, S.M.1
Wu, X.2
Pustilnik, A.3
Sereno, A.4
Huang, F.5
Rick, H.L.6
Guntas, G.7
Leaver-Fay, A.8
Smith, E.M.9
Ho, C.10
Hansen-Estruch, C.11
Chamberlain, A.K.12
Truhlar, S.M.13
Conner, E.M.14
Atwell, S.15
Kuhlman, B.16
Demarest, S.J.17
-
38
-
-
84875542050
-
Efficient generation of stable bispecific IgG1 by controlled Fab-arm exchange
-
Labrijn AF, Meesters JI, de Goeij BE, van den Bremer ET, Neijssen J, van Kampen MD, Strumane K, Verploegen S, Kundu A, Gramer MJ, van Berkel PH, van de Winkel JG, Schuurman J, Parren PW. 2013. Efficient generation of stable bispecific IgG1 by controlled Fab-arm exchange. Proc Natl Acad Sci U S A 110:5145-5150. http://dx.doi.org/10.1073/pnas.1220145110.
-
(2013)
Proc Natl Acad Sci U S A
, vol.110
, pp. 5145-5150
-
-
Labrijn, A.F.1
Meesters, J.I.2
de Goeij, B.E.3
van den Bremer, E.T.4
Neijssen, J.5
van Kampen, M.D.6
Strumane, K.7
Verploegen, S.8
Kundu, A.9
Gramer, M.J.10
van Berkel, P.H.11
van de Winkel, J.G.12
Schuurman, J.13
Parren, P.W.14
-
39
-
-
84925321830
-
A novel antibody engineering strategy for making monovalent bispecific heterodimeric IgG antibodies by electrostatic steering mechanism
-
Liu Z, Leng EC, Gunasekaran K, Pentony M, Shen M, Howard M, Stoops J, Manchulenko K, Razinkov V, Liu H, Fanslow W, Hu Z, Sun N, Hasegawa H, Clark R, Foltz IN, Yan W. 2015. A novel antibody engineering strategy for making monovalent bispecific heterodimeric IgG antibodies by electrostatic steering mechanism. J Biol Chem 290:7535-7562.http://dx.doi.org/10.1074/jbc.M114.620260.
-
(2015)
J Biol Chem
, vol.290
, pp. 7535-7562
-
-
Liu, Z.1
Leng, E.C.2
Gunasekaran, K.3
Pentony, M.4
Shen, M.5
Howard, M.6
Stoops, J.7
Manchulenko, K.8
Razinkov, V.9
Liu, H.10
Fanslow, W.11
Hu, Z.12
Sun, N.13
Hasegawa, H.14
Clark, R.15
Foltz, I.N.16
Yan, W.17
-
40
-
-
84890667775
-
Ang-2-VEGF-A CrossMab, a novel bispecific human IgG1 antibody blocking VEGF-A and Ang-2 functions simultaneously, mediates potent antitumor, antiangiogenic, and antimetastatic efficacy
-
Kienast Y, Klein C, Scheuer W, Raemsch R, Lorenzon E, Bernicke D, Herting F, Yu S, The HH, Martarello L, Gassner C, Stubenrauch KG, Munro K, Augustin HG, Thomas M. 2013. Ang-2-VEGF-A CrossMab, a novel bispecific human IgG1 antibody blocking VEGF-A and Ang-2 functions simultaneously, mediates potent antitumor, antiangiogenic, and antimetastatic efficacy. Clin Cancer Res 19:6730-6740. http://dx.doi.org/10.1158/1078-0432.CCR-13-0081.
-
(2013)
Clin Cancer Res
, vol.19
, pp. 6730-6740
-
-
Kienast, Y.1
Klein, C.2
Scheuer, W.3
Raemsch, R.4
Lorenzon, E.5
Bernicke, D.6
Herting, F.7
Yu, S.8
The, H.H.9
Martarello, L.10
Gassner, C.11
Stubenrauch, K.G.12
Munro, K.13
Augustin, H.G.14
Thomas, M.15
-
41
-
-
84878566279
-
Inhibition of the HIV-1 spike by single-PG9/16-antibody binding suggests a coordinated-activation model for its three protomeric units
-
Löving R, Sjoberg M, Wu SR, Binley JM, Garoff H. 2013. Inhibition of the HIV-1 spike by single-PG9/16-antibody binding suggests a coordinated-activation model for its three protomeric units. J Virol 87:7000-7007. http://dx.doi.org/10.1128/JVI.00530-13.
-
(2013)
J Virol
, vol.87
, pp. 7000-7007
-
-
Löving, R.1
Sjoberg, M.2
Wu, S.R.3
Binley, J.M.4
Garoff, H.5
|