Cyanohydrin as an anchoring group for potent and selective inhibitors of enterovirus 71 3C protease

Journal of Medicinal Chemistry

Volumn 58, Issue 23, 2015, Pages 9414-9420

  Zhai, Yangyang ^a,b   Zhao, Xiangshuai ^a,b   Cui, Zhengjie ^a,b   Wang, Man ^a,b   Wang, Yaxin ^c   Li, Linfeng ^a,b   Sun, Qi ^d   Yang, Xi ^a,b   Zeng, Debin ^a,b   Liu, Ying ^a,b   Sun, Yuna ^e   Lou, Zhiyong ^c   Shang, Luqing ^a,b   Yin, Zheng ^a,b  

^a NANKAI UNIVERSITY   (China)

^b Tianjin Engineering Center of Micro Nano Biomaterials and Detection Treatment Technology   (China)

^c TSINGHUA UNIVERSITY   (China)

^d CENTRAL CHINA NORMAL UNIVERSITY   (China)

^e INSTITUTE OF GEOLOGY AND GEOPHYSICS   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ACETIC ACID ETHYL ESTER; ALDEHYDE; ALPHA HYDROXY AMIDE; ALPHA KETO AMIDE; AMIDE; ANTIVIRUS AGENT; CARBON; CARBOXYLIC ACID; CYANOHYDRIN; CYSTEINE PROTEINASE; DESS MARTIN PERIODINANE; ENTEROVIRUS 71 EC PROTEASE; ENZYME INHIBITOR; ESTER DERIVATIVE; HYDROCHLORIC ACID; RUPINTRIVIR; UNCLASSIFIED DRUG; VIRUS ENZYME; 3C PROTEASES; NITRILE; PROTEIN BINDING; VIRUS PROTEIN;

ANTIVIRAL ACTIVITY; ARTICLE; CHEMICAL REACTION KINETICS; CRYSTAL STRUCTURE; CRYSTALLIZATION; CYTOTOXICITY; CYTOTOXICITY ASSAY; DIASTEREOSELECTIVITY; DRUG SYNTHESIS; ELECTROPHILICITY; ENTEROVIRUS 71; ENZYME ACTIVITY; EPIMERIZATION; HUMAN; HYDROGEN BOND; MOLECULAR DOCKING; NONHUMAN; SARS CORONAVIRUS; STEREOCHEMISTRY; VIRUS REPLICATION; ANTAGONISTS AND INHIBITORS; CHEMISTRY; DRUG EFFECTS; ENTEROVIRUS A; ENTEROVIRUS INFECTIONS; ENZYMOLOGY; METABOLISM; VIROLOGY; X RAY CRYSTALLOGRAPHY;

ANTIVIRAL AGENTS; CRYSTALLOGRAPHY, X-RAY; CYSTEINE ENDOPEPTIDASES; ENTEROVIRUS A, HUMAN; ENTEROVIRUS INFECTIONS; HUMANS; MOLECULAR DOCKING SIMULATION; NITRILES; PROTEIN BINDING; VIRAL PROTEINS;

EID: 84949870603     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/acs.jmedchem.5b01013     Document Type: Article

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