Structures of Enterovirus 71 3C proteinase (strain E2004104-TW-CDC) and its complex with rupintrivir

Acta Crystallographica Section D: Biological Crystallography

Volumn 69, Issue 5, 2013, Pages 866-871

  Wu, Caiming ^a   Cai, Qixu ^a   Chen, Chen ^a   Li, Ning ^b   Peng, Xuanjia ^b   Cai, Yaxian ^b   Yin, Ke ^b   Chen, Xinsheng ^b   Wang, Xiaolong ^a   Zhang, Rongfu ^a   Liu, Lijie ^a   Chen, Shuhui ^b   Li, Jian ^b   Lin, Tianwei ^a  

^a XIAMEN UNIVERSITY   (China)

^b WUXI APPTEC   (China)

Author keywords

3C proteinases; drug design; Enterovirus; EV71; hand, foot and mouth disease; rupintrivir

Indexed keywords

2 PYRROLIDONE DERIVATIVE; 3C PROTEASES; ANTIVIRUS AGENT; CYSTEINE PROTEINASE; CYSTEINE PROTEINASE INHIBITOR; ISOXAZOLE DERIVATIVE; RUPINTRIVIR; VIRUS PROTEIN;

3C PROTEINASES; AMINO ACID SEQUENCE; ARTICLE; BINDING SITE; CELL LINE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; DRUG DESIGN; DRUG EFFECT; ENTEROVIRUS; ENZYME ACTIVE SITE; ENZYMOLOGY; EV71; HAND FOOT AND MOUTH DISEASE; HUMAN; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PROTEIN CONFORMATION; VIROLOGY; X RAY CRYSTALLOGRAPHY;

3C PROTEINASES; DRUG DESIGN; ENTEROVIRUS; EV71; HAND, FOOT AND MOUTH DISEASE; RUPINTRIVIR;

AMINO ACID SEQUENCE; ANTIVIRAL AGENTS; BINDING SITES; CATALYTIC DOMAIN; CELL LINE; CONSERVED SEQUENCE; CRYSTALLOGRAPHY, X-RAY; CYSTEINE ENDOPEPTIDASES; CYSTEINE PROTEINASE INHIBITORS; ENTEROVIRUS A, HUMAN; HUMANS; ISOXAZOLES; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN CONFORMATION; PYRROLIDINONES; VIRAL PROTEINS;

EID: 84877278432     PISSN: 09074449     EISSN: 13990047     Source Type: Journal    
DOI: 10.1107/S0907444913002862     Document Type: Article

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