SCOPUS 정보 검색 플랫폼

Volumn 108, Issue , 2016, Pages 334-346

Towards new 5-HT7 antagonists among arylsulfonamide derivatives of (aryloxy)ethyl-alkyl amines: Multiobjective based design, synthesis, and antidepressant and anxiolytic properties

(9) Canale, Vittorio a Kurczab, Rafa b Partyka, Anna a Sataa, Grzegorz b Ledna, Tomasz b Jastrzebska Wiesek, Magdalena a Wesoowska, Anna a Bojarski, Andrzej J b Zajdel, Pawel a

a JAGIELLONIAN UNIVERSITY MEDICAL COLLEGE (Poland)

b INSTITUTE OF PHARMACOLOGY (Poland)

Author keywords

5 HT7 antagonist; Anxiety; Depression; Forced swim test; Four plate test; Molecular docking; SB 269970; Screening of combinatorial library; Tail suspension test

Indexed keywords

1 METHYL N [1 [2 [(2 TERT BUTYL)PHENOXY]ETHYL]PIPERIDIN 4 YL] 1H PYRAZOLE 4 SULFONAMIDE; 1 METHYL N [8 [2 [2 (BIPHENYL 2 YLOXY)ETHYL] 8 AZABICYCLO[3.2.1]OCTAN 3YL] 1H PYRAZOLE 4 SULFONAMIDE; 3 CHLORO N [7 [2 [2 (BIPHENYL 2 YLOXY)]ETHYL] 2,7 DIAZABICYCLO[2.2.1]HEPTAN 2 YL] BENZENESULFONAMIDE; 3 CHLORO N [8 [2 (BIPHENYL 2 YLOXY)ETHYL] 8 AZABICYCLO[3.2.1]OCTAN 3YL] BENZENESULFONAMIDE; 3 FLUORO N [1 [2 (2 CYCLOPENTYLPHENOXY)ETHYL]PIPERIDIN 4 YL] BENZENESULFONAMIDE; 3 FLUORO N [1 [2 [(PROPAN 2 YL)PHENOXY]ETHYL] 8 AZABICYCLO[3.2.1]OCTAN 3 YL] BENZENESULFONAMIDE; 3 FLUORO N [1 [2 [(PROPAN 2 YL)PHENOXY]ETHYL]AZETIDIN 3 YL] BENZENESULFONAMIDE; 3 [2 [2 (4 METHYL 1 PIPERIDINYL)ETHYL] 1 PYRROLIDINESULFONYL]PHENOL; 4 FLUORO N [1 (2 PHENOXYETHYL)PIPERIDIN 4 YL] BENZENESULFONAMIDE; 4 FLUORO N [1 [2 (1,2 TOLYLOXY)ETHY]PIPERIDIN 4 YL] BENZENESULFONAMIDE; 4 FLUORO N [1 [2 (2 ISOPROPOXYPHENOXY)ETHYL]PIPERIDIN 4 YL] BENZENESULFONAMIDE; 4 FLUORO N [1 [2 (2 METHOXYPHENOXY)ETHYL]PIPERIDIN 4 YL] BENZENESULFONAMIDE; 4 FLUORO N [1 [2 (2,6 DIISOPROPYLPHENOXY)ETHYL]PIPERIDIN 4 YL] BENZENESULFONAMIDE; 4 FLUORO N [1 [2 [(PROPAN 2 YL)PHENOXY] ETHYL] 8 AZABICYCLO[3.2.1]OCTAN 3 YL] BENZENESULFONAMIDE; ANTIDEPRESSANT AGENT; ANXIOLYTIC AGENT; CITALOPRAM; DIAZEPAM; N [1 [2 [(PROPAN 2 YL)PHENOXY]ETHYL]PIPERIDIN 4 YL] PYRIDINE 3 SULFONAMIDE; SEROTONIN ANTAGONIST; UNCLASSIFIED DRUG; UNINDEXED DRUG; [1 [2 [(PROPAN 2 YL)PHENOXY]ETHYL]PIPERIDIN 4 YL] 3 (4 FLUOROPHENYL)UREA; AMINE; SEROTONIN 7 RECEPTOR; SEROTONIN RECEPTOR; SULFONAMIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIDEPRESSANT ACTIVITY; ANXIETY DISORDER; ARTICLE; BINDING AFFINITY; COMBINATORIAL LIBRARY; CONTROLLED STUDY; DEPRESSION; DRUG DESIGN; DRUG SYNTHESIS; FORCED SWIM TEST; FOUR-PLATE TEST; HUMAN; IN VITRO STUDY; LIGAND BINDING; MALE; MOLECULAR DOCKING; MOLECULAR MODEL; MOUSE; NONHUMAN; RAT; RECEPTOR BINDING ASSAY; SOLID PHASE SYNTHESIS; STRUCTURE ACTIVITY RELATION; TAIL SUSPENSION TEST; TRANQUILIZING ACTIVITY; ANIMAL; ANIMAL BEHAVIOR; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; HEK293 CELL LINE; METABOLISM; MOTOR ACTIVITY; SYNTHESIS;

AMINES; ANIMALS; ANTI-ANXIETY AGENTS; ANTIDEPRESSIVE AGENTS; BEHAVIOR, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; HEK293 CELLS; HUMANS; MICE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MOTOR ACTIVITY; RECEPTORS, SEROTONIN; SEROTONIN ANTAGONISTS; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

EID: 84949843834 PISSN: 02235234 EISSN: 17683254 Source Type: Journal
DOI: 10.1016/j.ejmech.2015.11.040 Document Type: Article

Times cited : (32)

References (48)

1
- 0027368668
- A novel adenylyl cyclase-activating serotonin receptor (5-HT7) implicated in the regulation of mammalian circadian rhythms
- T.W. Lovenberg, B.M. Baron, L. De Lecea, J.D. Miller, R.A. Prosser, M.A. Rea, P.E. Foye, M. Racke, A.L. Slone, B.W. Siegel, A novel adenylyl cyclase-activating serotonin receptor (5-HT7) implicated in the regulation of mammalian circadian rhythms, Neuron 11 (1993) 449-458.
- (1993) Neuron , vol.11 , pp. 449-458
- Lovenberg, T.W.¹ Baron, B.M.² De Lecea, L.³ Miller, J.D.⁴ Prosser, R.A.⁵ Rea, M.A.⁶ Foye, P.E.⁷ Racke, M.⁸ Slone, A.L.⁹ Siegel, B.W.¹⁰

2
- 23944516797
- 5-HT7 receptor is coupled to G alpha subunits of heterotrimeric G12-protein to regulate gene transcription and neuronal morphology
- E. Kvachnina, G. Liu, A. Dityatev, U. Renner, A. Dumuis, D.W. Richter, G. Dityateva, M. Schachner, T.A. Voyno-Yasenetskaya, E.G. Ponimaskin, 5-HT7 receptor is coupled to G alpha subunits of heterotrimeric G12-protein to regulate gene transcription and neuronal morphology, J. Neurosci. 25 (2005) 7821-7830.
- (2005) J. Neurosci. , vol.25 , pp. 7821-7830
- Kvachnina, E.¹ Liu, G.² Dityatev, A.³ Renner, U.⁴ Dumuis, A.⁵ Richter, D.W.⁶ Dityateva, G.⁷ Schachner, M.⁸ Voyno-Yasenetskaya, T.A.⁹ Ponimaskin, E.G.¹⁰

3
- 84949789758
- The serotonin 5-HT7 receptors: Two decades of research
- A. Matthys, G. Haegeman, K. Van Craenenbroeck, P. Vanhoenacker, The serotonin 5-HT7 receptors: two decades of research, Mol. Neurobiol. 230 (2011) 555-568.
- (2011) Mol. Neurobiol. , vol.230 , pp. 555-568
- Matthys, A.¹ Haegeman, G.² Van Craenenbroeck, K.³ Vanhoenacker, P.⁴

4
- 84939971807
- A. Nikiforuk, CNS Drugs 29 (2015) 265-275.
- (2015) CNS Drugs , vol.29 , pp. 265-275
- Nikiforuk, A.¹

5
- 33845741592
- Enhancement of the anti-immobility action of antidepressants by a selective 5-HT7 receptor antagonist in the forced swimming test in mice
- A. Wesolowska, E. Tatarczynska, A. Nikiforuk, E. Chojnacka-Wojcik, Enhancement of the anti-immobility action of antidepressants by a selective 5-HT7 receptor antagonist in the forced swimming test in mice, Eur. J. Pharmacol. 555 (2007) 43-47.
- (2007) Eur. J. Pharmacol. , vol.555 , pp. 43-47
- Wesolowska, A.¹ Tatarczynska, E.² Nikiforuk, A.³ Chojnacka-Wojcik, E.⁴

6
- 77549084645
- The 5-HT(7) receptor as a mediator and modulator of antidepressant-like behavior
- G. Sarkisyan, A.J. Roberts, P.B. Hedlund, The 5-HT(7) receptor as a mediator and modulator of antidepressant-like behavior, Behav. Brain Res. 209 (2010) 99-108.
- (2010) Behav. Brain Res. , vol.209 , pp. 99-108
- Sarkisyan, G.¹ Roberts, A.J.² Hedlund, P.B.³

7
- 79954597841
- Pharmacological blockade of 5-HT7 receptors as a putative fast acting antidepressant strategy
- O. Mnie-Filali, C. Faure, L. Lamb-as-Senas, M.M. El, H. Belblidia, E. Gondard, A. Etievant, H. Scarna, A. Didier, A. Berod, P. Blier, N. Haddjeri, Pharmacological blockade of 5-HT7 receptors as a putative fast acting antidepressant strategy, Neuropsychopharmacology 36 (2011) 1275-1288.
- (2011) Neuropsychopharmacology , vol.36 , pp. 1275-1288
- Mnie-Filali, O.¹ Faure, C.² Lamb-As-Senas, L.³ El, M.M.⁴ Belblidia, H.⁵ Gondard, E.⁶ Etievant, A.⁷ Scarna, H.⁸ Didier, A.⁹ Berod, A.¹⁰ Blier, P.¹¹ Haddjeri, N.¹²

8
- 67649452096
- Amisulpride is a potent 5-HT7 antagonist: Relevance for antidepressant actions in vivo
- A.I. Abbas, P.B. Hedlund, X.P. Huang, T.B. Tran, H.Y. Meltzer, B.L. Roth, Amisulpride is a potent 5-HT7 antagonist: relevance for antidepressant actions in vivo, Psychopharmacology 205 (2009) 119-128.
- (2009) Psychopharmacology , vol.205 , pp. 119-128
- Abbas, A.I.¹ Hedlund, P.B.² Huang, X.P.³ Tran, T.B.⁴ Meltzer, H.Y.⁵ Roth, B.L.⁶

9
- 84874353764
- The role of 5-HT7 receptor antagonism in the amelioration of MK-801-induced learning and memory deficits by the novel atypical antipsychotic drug lurasidone
- T. Horisawa, H. Nishikawa, S. Toma, A. Ikeda, M. Horiguchi, M. Ono, T. Ishiyama, M. Taiji, The role of 5-HT7 receptor antagonism in the amelioration of MK-801-induced learning and memory deficits by the novel atypical antipsychotic drug lurasidone, Behav. Brain Res. 244 (2013) 66-69.
- (2013) Behav. Brain Res. , vol.244 , pp. 66-69
- Horisawa, T.¹ Nishikawa, H.² Toma, S.³ Ikeda, A.⁴ Horiguchi, M.⁵ Ono, M.⁶ Ishiyama, T.⁷ Taiji, M.⁸

10
- 18244431670
- (R)-3,N-dimethyl-N-[1-methyl-3-(4-methyl-piperidin-1-yl) propyl] benzenesulfonamide: The first selective 5-HT7 receptor antagonist
- I.T. Forbes, S. Dabbs, D.M. Duckworth, A.J. Jennings, F.D. King, P.J. Lovell, A.M. Brown, L. Collin, J.J. Hagan, D.N. Middlemiss, G.J. Riley, D.R. Thomas, N. Upton, (R)-3,N-dimethyl-N-[1-methyl-3-(4-methyl-piperidin-1-yl) propyl] benzenesulfonamide: the first selective 5-HT7 receptor antagonist, J. Med. Chem. 41, 1998, 655-657.
- (1998) J. Med. Chem. , vol.41 , pp. 655-657
- Forbes, I.T.¹ Dabbs, S.² Duckworth, D.M.³ Jennings, A.J.⁴ King, F.D.⁵ Lovell, P.J.⁶ Brown, A.M.⁷ Collin, L.⁸ Hagan, J.J.⁹ Middlemiss, D.N.¹⁰ Riley, G.J.¹¹ Thomas, D.R.¹² Upton, N.¹³

11
- 10744231657
- SB-656104-A, a novel selective 5-HT7 receptor antagonist, modulates REM sleep in rats
- D.R. Thomas, S. Melotto, M. Massagrande, A.D. Gribble, P. Jeffrey, A.J. Stevens, N.J. Deeks, P.J. Eddershaw, S.H. Fenwick, G. Riley, T. Stean, C.M. Scott, M.J. Hill, D.N. Middlemiss, J.J. Hagan, G.W. Price, I.T. Forbes, SB-656104-A, a novel selective 5-HT7 receptor antagonist, modulates REM sleep in rats, Br. J. Pharmacol. 4 (2003) 705-714.
- (2003) Br. J. Pharmacol. , vol.4 , pp. 705-714
- Thomas, D.R.¹ Melotto, S.² Massagrande, M.³ Gribble, A.D.⁴ Jeffrey, P.⁵ Stevens, A.J.⁶ Deeks, N.J.⁷ Eddershaw, P.J.⁸ Fenwick, S.H.⁹ Riley, G.¹⁰ Stean, T.¹¹ Scott, C.M.¹² Hill, M.J.¹³ Middlemiss, D.N.¹⁴ Hagan, J.J.¹⁵ Price, G.W.¹⁶ Forbes, I.T.¹⁷

12
- 0037119746
- Tetrahydrothienopyridylbutyltetrahydrobenzindoles: New selective ligands of the 5-HT7 receptor
- C. Kikuchi, T. Hiranuma, M. Koyama, Tetrahydrothienopyridylbutyltetrahydrobenzindoles: new selective ligands of the 5-HT7 receptor, Bioorg. Med. Chem. Lett. 12 (2002) 2549-2552.
- (2002) Bioorg. Med. Chem. Lett. , vol.12 , pp. 2549-2552
- Kikuchi, C.¹ Hiranuma, T.² Koyama, M.³

13
- 43049113873
- (Phenylpiperazinyl-butyl)oxindoles as selective 5-HT7 receptor antagonists
- B. Volk, J. Bark-oczy, E. Hegedus, S. Udvari, I. Gacs-alyi, T. Mezei, K. Pallagi, H. Kompagne, G. Levay, A. Egyed, L.G.J. Harsing, M. Spedding, G. Simiq, (Phenylpiperazinyl-butyl)oxindoles as selective 5-HT7 receptor antagonists, J. Med. Chem. 51 (2008) 2522-2532.
- (2008) J. Med. Chem. , vol.51 , pp. 2522-2532
- Volk, B.¹ Barkoczy, J.² Hegedus, E.³ Udvari, S.⁴ Gacsalyi, I.⁵ Mezei, T.⁶ Pallagi, K.⁷ Kompagne, H.⁸ Levay, G.⁹ Egyed, A.¹⁰ Harsing, L.G.J.¹¹ Spedding, M.¹² Simiq, G.¹³

14
- 79955408540
- Novel benzo [b]thiophene derivatives as new potential antidepressants with rapid onset of action
- L. Berrade, B. Aisa, M.J. Ramirez, S. Galiano, S. Guccione, L.R. Moltzau, F.O. Levy, F. Nicoletti, G. Battaglia, G. Molinaro, I. Aldana, A. Monge, P. Perez-Silanes, Novel benzo [b]thiophene derivatives as new potential antidepressants with rapid onset of action, J. Med. Chem. 54 (2011) 3086-3090.
- (2011) J. Med. Chem. , vol.54 , pp. 3086-3090
- Berrade, L.¹ Aisa, B.² Ramirez, M.J.³ Galiano, S.⁴ Guccione, S.⁵ Moltzau, L.R.⁶ Levy, F.O.⁷ Nicoletti, F.⁸ Battaglia, G.⁹ Molinaro, G.¹⁰ Aldana, I.¹¹ Monge, A.¹² Perez-Silanes, P.¹³

15
- 84906939234
- Novel N-biphenyl-2-ylmethyl 2-methoxyphenylpiperazinylalkanamides as 5-HT7R antagonists for the treatment of depression
- Y. Kim, J. Tae, K. Lee, H. Rhim, I.H. Choo, H. Cho, W.K. Park, G. Keum, H. Choo, Novel N-biphenyl-2-ylmethyl 2-methoxyphenylpiperazinylalkanamides as 5-HT7R antagonists for the treatment of depression, Bioorg. Med. Chem. 22 (2014) 4587-4596.
- (2014) Bioorg. Med. Chem. , vol.22 , pp. 4587-4596
- Kim, Y.¹ Tae, J.² Lee, K.³ Rhim, H.⁴ Choo, I.H.⁵ Cho, H.⁶ Park, W.K.⁷ Keum, G.⁸ Choo, H.⁹

16
- 67749139773
- Sulfonamides with the N-alkyl-N0-dialkylguanidine moiety as 5-HT7 receptor ligands
- P. Zajdel, G. Subra, P. Verdie, E. Gabzdyl, A.J. Bojarski, B. Duszy-nska, J. Martinez, M. Pawowski, Sulfonamides with the N-alkyl-N0-dialkylguanidine moiety as 5-HT7 receptor ligands, Bioorg. Med. Chem. Lett. 19 (2009) 4827-4831.
- (2009) Bioorg. Med. Chem. Lett. , vol.19 , pp. 4827-4831
- Zajdel, P.¹ Subra, G.² Verdie, P.³ Gabzdyl, E.⁴ Bojarski, A.J.⁵ Duszy-Nska, B.⁶ Martinez, J.⁷ Pawowski, M.⁸

17
- 84920117960
- Towards novel 5-HT7 versus 5-HT1A receptor ligands among LCAPs with cyclic amino acid amide fragments: Design, synthesis, and antidepressant properties
- V. Canale, R. Kurczab, A. Partyka, G. Sataa, J. Witek, M. Jastrzebska-Wiesek, M. Pawowski, A.J. Bojarski, A. Wesoowska, P. Zajdel, Towards novel 5-HT7 versus 5-HT1A receptor ligands among LCAPs with cyclic amino acid amide fragments: design, synthesis, and antidepressant properties, Part II. Eur. J. Med. Chem. 92 (2015) 202-211.
- (2015) Part II. Eur. J. Med. Chem. , vol.92 , pp. 202-211
- Canale, V.¹ Kurczab, R.² Partyka, A.³ Sataa, G.⁴ Witek, J.⁵ Jastrzebska-Wiesek, M.⁶ Pawowski, M.⁷ Bojarski, A.J.⁸ Wesoowska, A.⁹ Zajdel, P.¹⁰

18
- 61649121755
- Benzimidazolone-based serotonin 5-HT1A or 5-HT7R ligands: Synthesis and biological evaluation
- E. Badarau, F. Suzenet, A.J. Bojarski, A.L. Fînaru, G. Guillaumet, Benzimidazolone-based serotonin 5-HT1A or 5-HT7R ligands: synthesis and biological evaluation, Bioorg. Med. Chem. Lett. 19 (2009) 1600-1603.
- (2009) Bioorg. Med. Chem. Lett. , vol.19 , pp. 1600-1603
- Badarau, E.¹ Suzenet, F.² Bojarski, A.J.³ Fînaru, A.L.⁴ Guillaumet, G.⁵

19
- 84906099546
- Structure-activity relationships and molecular modeling studies of novel arylpiperazinylalkyl 2-benzoxazolones and 2-benzothiazolones as 5-HT7 and 5-HT1A receptor ligands
- L. Salerno, V. Pittal-a, M.N. Modica, M.A. Siracusa, S. Intagliata, A. Cagnotto, M. Salmona, R. Kurczab, A.J. Bojarski, G. Romeo, Structure-activity relationships and molecular modeling studies of novel arylpiperazinylalkyl 2-benzoxazolones and 2-benzothiazolones as 5-HT7 and 5-HT1A receptor ligands, Eur. J. Med. Chem. 85 (2014) 716-726.
- (2014) Eur. J. Med. Chem. , vol.85 , pp. 716-726
- Salerno, L.¹ Pittal-A, V.² Modica, M.N.³ Siracusa, M.A.⁴ Intagliata, S.⁵ Cagnotto, A.⁶ Salmona, M.⁷ Kurczab, R.⁸ Bojarski, A.J.⁹ Romeo, G.¹⁰

20
- 84899058912
- Towards the development of 5-HT7 ligands combining serotonin-like and arylpiperazine moieties
- G. Spadoni, A. Bedini, S. Bartolucci, D. Pala, M. Mor, T. Riccioni, F. Borsini, W. Cabri, D. Celona, M. Marzi, G. Tarzia, S. Rivara, P. Minetti, Towards the development of 5-HT7 ligands combining serotonin-like and arylpiperazine moieties, Eur. J. Med. Chem. 80 (2014) 8-35.
- (2014) Eur. J. Med. Chem. , vol.80 , pp. 8-35
- Spadoni, G.¹ Bedini, A.² Bartolucci, S.³ Pala, D.⁴ Mor, M.⁵ Riccioni, T.⁶ Borsini, F.⁷ Cabri, W.⁸ Celona, D.⁹ Marzi, M.¹⁰ Tarzia, G.¹¹ Rivara, S.¹² Minetti, P.¹³

21
- 84898623523
- Synthesis, radiolabeling and in vivo evaluation of[11C](R)-1-[4-[2-(4-methoxyphenyl)phenyl]piperazin-1-yl]-3-(2-pyrazinyloxy)-2-propanol, a potential PET radioligand for the 5-HT7 receptor
- H.D. Hansen, E. Lacivita, P. Di Pilato, M.M. Herth, S. Lehel, A. Ettrup, V.L. Andersen, A. Dyssegaard, P. De Giorgio, R. Perrone, F. Berardi, N.A. Colabufo, M. Niso, G.M. Knudsen, M. Leopoldo, Synthesis, radiolabeling and in vivo evaluation of [11C](R)-1-[4-[2-(4-methoxyphenyl)phenyl]piperazin-1-yl]-3-(2-pyrazinyloxy)-2-propanol, a potential PET radioligand for the 5-HT7 receptor, Eur. J. Med. Chem. 79 (2014) 152-163.
- (2014) Eur. J. Med. Chem. , vol.79 , pp. 152-163
- Hansen, H.D.¹ Lacivita, E.² Di Pilato, P.³ Herth, M.M.⁴ Lehel, S.⁵ Ettrup, A.⁶ Andersen, V.L.⁷ Dyssegaard, A.⁸ De Giorgio, P.⁹ Perrone, R.¹⁰ Berardi, F.¹¹ Colabufo, N.A.¹² Niso, M.¹³ Knudsen, G.M.¹⁴ Leopoldo, M.¹⁵

22
- 84906097445
- The extracellular entrance provides selectivity to serotonin 5-HT7 receptor antagonists with antidepressant-like behavior in vivo
- R.A. Medina, H. V-azquez-Villa, J.C. G-omez-Tamayo, B. Benhamú, M. Martín-Fontecha, T. de la Fuente, G. Caltabiano, P.B. Hedlund, L. Pardo, M.L. L-opez-Rodríguez, The extracellular entrance provides selectivity to serotonin 5-HT7 receptor antagonists with antidepressant-like behavior in vivo, J. Med. Chem. 57 (2014) 6879-6884.
- (2014) J. Med. Chem. , vol.57 , pp. 6879-6884
- Medina, R.A.¹ Vazquez-Villa, H.² Gomez-Tamayo, J.C.³ Benhamú, B.⁴ Martín-Fontecha, M.⁵ De La Fuente, T.⁶ Caltabiano, G.⁷ Hedlund, P.B.⁸ Pardo, L.⁹ Lopez-Rodríguez, M.L.¹⁰

23
- 84864137323
- Translational evaluation of JNJ-18038683, a 5-hydroxytryptamine type 7 receptor antagonist, on rapid eye movement sleep and in major depressive disorder
- P. Bonaventure, C. Dugovic, M. Kramer, P. De Boer, J. Singh, S. Wilson, K. Bertelsen, J.N. Di, J. Shelton, L. Aluisio, L. Dvorak, I. Fraser, B. Lord, D. Nepomuceno, A. Ahnaou, W. Drinkenburg, W.Y. Chai, C. Dvorak, S. Sands, N. Carruthers, T.W. Lovenberg, Translational evaluation of JNJ-18038683, a 5-hydroxytryptamine type 7 receptor antagonist, on rapid eye movement sleep and in major depressive disorder, J. Pharmacol. Exp. Ther. 342 (2012) 429-440.
- (2012) J. Pharmacol. Exp. Ther. , vol.342 , pp. 429-440
- Bonaventure, P.¹ Dugovic, C.² Kramer, M.³ De Boer, P.⁴ Singh, J.⁵ Wilson, S.⁶ Bertelsen, K.⁷ Di, J.N.⁸ Shelton, J.⁹ Aluisio, L.¹⁰ Dvorak, L.¹¹ Fraser, I.¹² Lord, B.¹³ Nepomuceno, D.¹⁴ Ahnaou, A.¹⁵ Drinkenburg, W.¹⁶ Chai, W.Y.¹⁷ Dvorak, C.¹⁸ Sands, S.¹⁹ Carruthers, N.²⁰ Lovenberg, T.W.²¹ more..

24
- 84868002368
- The multiobjective based design, synthesis and evaluation of the arylsulfonamide/amide derivatives of aryloxyethyl-and arylthioethyl-piperidines and pyrrolidines as a novel class of potent 5-HT receptor antagonists
- P. Zajdel, R. Kurczab, K. Grychowska, G. Sataa, M. Pawowski, A.J. Bojarski, The multiobjective based design, synthesis and evaluation of the arylsulfonamide/amide derivatives of aryloxyethyl-and arylthioethyl-piperidines and pyrrolidines as a novel class of potent 5-HT receptor antagonists, Eur. J. Med. Chem. 56 (2012) 348-360.
- (2012) Eur. J. Med. Chem. , vol.56 , pp. 348-360
- Zajdel, P.¹ Kurczab, R.² Grychowska, K.³ Sataa, G.⁴ Pawowski, M.⁵ Bojarski, A.J.⁶

25
- 84936850528
- Arylsulfonamide derivatives of (aryloxy)ethyl-piperidines as selective 5-HT7 receptor antagonists and their psychotropic properties
- P. Zajdel, V. Canale, A. Partyka, K. Marciniec, G. Sataa, R. Kurczab, A. Siwek, M. Jastrzebska-Wiesek, A. Wesoowska, T. Kos, P. Popik, A.J. Bojarski, Arylsulfonamide derivatives of (aryloxy)ethyl-piperidines as selective 5-HT7 receptor antagonists and their psychotropic properties, Med. Chem. Comm. 6 (2015) 1272-1277.
- (2015) Med. Chem. Comm. , vol.6 , pp. 1272-1277
- Zajdel, P.¹ Canale, V.² Partyka, A.³ Marciniec, K.⁴ Sataa, G.⁵ Kurczab, R.⁶ Siwek, A.⁷ Jastrzebska-Wiesek, M.⁸ Wesoowska, A.⁹ Kos, T.¹⁰ Popik, P.¹¹ Bojarski, A.J.¹²

26
- 0027211828
- Structure-activity relationship studies of CNS agents. Part 9: 5-HT1A and 5-HT2 receptor affinity of some 2-and 3-substituted 1, 2, 3, 4-tetrahydro-beta-carbolines
- A.J. Bojarski, M.T. Cega, S. Charakchieva-Minol, M.J. Mokrosz, M. Ma-ckowiak, S. Misztal, J.L. Mokrosz, Structure-activity relationship studies of CNS agents. Part 9: 5-HT1A and 5-HT2 receptor affinity of some 2-and 3-substituted 1, 2, 3, 4-tetrahydro-beta-carbolines, Pharmazie 4 (1993) 89-94.
- (1993) Pharmazie , vol.4 , pp. 89-94
- Bojarski, A.J.¹ Cega, M.T.² Charakchieva-Minol, S.³ Mokrosz, M.J.⁴ Ma-Ckowiak, M.⁵ Misztal, S.⁶ Mokrosz, J.L.⁷

27
- 34548838847
- The influence of modifications in imide fragment structure on 5-HT(1A) and 5-HT(7) receptor affinity and in vivo pharmacological properties of some new 1-(m-trifluoromethylphenyl)piperazines
- M.H. Paluchowska, R. Bugno, B. Duszy-nska, E. Tatarczy-nska, A. Nikiforuk, T. Lenda, E. Chojnacka-W-ojcik, The influence of modifications in imide fragment structure on 5-HT(1A) and 5-HT(7) receptor affinity and in vivo pharmacological properties of some new 1-(m-trifluoromethylphenyl)piperazines, Bioorg. Med. Chem. 15 (2007) 7116-7125.
- (2007) Bioorg. Med. Chem. , vol.15 , pp. 7116-7125
- Paluchowska, M.H.¹ Bugno, R.² Duszynska, B.³ Tatarczynska, E.⁴ Nikiforuk, A.⁵ Lenda, T.⁶ Chojnacka-Wojcik, E.⁷

28
- 84857033235
- Quinoline-and isoquinoline-sulfonamide derivatives of LCAP as potent CNS multi-receptor-5-HT1A/5-HT2A/5-HT7 and D2/D3/D4-agents: The synthesis and pharmacological evaluation
- P. Zajdel, K. Marciniec, A. Ma-slankiewicz, G. Sataa, B. Duszy-nska, A.J. Bojarski, A. Partyka, M. Jastrzebska-Wiesek, D. Wr-obel, A. Wesoowska, M. Pawowski, Quinoline-and isoquinoline-sulfonamide derivatives of LCAP as potent CNS multi-receptor-5-HT1A/5-HT2A/5-HT7 and D2/D3/D4-agents: the synthesis and pharmacological evaluation, Bioorg. Med. Chem. 20 (2012) 1545-1556.
- (2012) Bioorg. Med. Chem. , vol.20 , pp. 1545-1556
- Zajdel, P.¹ Marciniec, K.² Maslankiewicz, A.³ Sataa, G.⁴ Duszynska, B.⁵ Bojarski, A.J.⁶ Partyka, A.⁷ Jastrzebska-Wiesek, M.⁸ Wrobel, D.⁹ Wesoowska, A.¹⁰ Pawowski, M.¹¹

29
- 0015861774
- Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction
- Y. Cheng, W.H. Prusoff, Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction, Biochem. Pharmacol. 22 (1973) 3099-3108.
- (1973) Biochem. Pharmacol. , vol.22 , pp. 3099-3108
- Cheng, Y.¹ Prusoff, W.H.²

30
- 0017651126
- Behavioral despair in mice: A primary screening test for antidepressants
- R.D. Porsolt, A. Bertin, M. Jalfre, Behavioral despair in mice: a primary screening test for antidepressants, Arch. Int. Pharmacodyn. Ther. 229 (1977) 327-336.
- (1977) Arch. Int. Pharmacodyn. Ther. , vol.229 , pp. 327-336
- Porsolt, R.D.¹ Bertin, A.² Jalfre, M.³

31
- 0021990491
- The tail suspension test: A new method for screening antidepressants in mice
- L. Steru, R. Chermat, B. Thierry, P. Simon, The tail suspension test: a new method for screening antidepressants in mice, Psychopharmacology 85 (1985) 367-370.
- (1985) Psychopharmacology , vol.85 , pp. 367-370
- Steru, L.¹ Chermat, R.² Thierry, B.³ Simon, P.⁴

32
- 0018268297
- Behavioural despair in rats: A new model sensitive to antidepressant treatments
- R.D. Porsolt, G. Anton, N. Blavet, M. Jalfre, Behavioural despair in rats: a new model sensitive to antidepressant treatments, Eur. J. Pharmacol. 47 (1978) 379-391.
- (1978) Eur. J. Pharmacol. , vol.47 , pp. 379-391
- Porsolt, R.D.¹ Anton, G.² Blavet, N.³ Jalfre, M.⁴

33
- 0015096075
- Evaluation of a rapid technique for detecting minor tranquilizers
- C. Aron, P. Simon, C. Larousse, J.R. Boissier, Evaluation of a rapid technique for detecting minor tranquilizers, Neuropharmacology 10 (1971) 459-469.
- (1971) Neuropharmacology , vol.10 , pp. 459-469
- Aron, C.¹ Simon, P.² Larousse, C.³ Boissier, J.R.⁴

34
- 84875223433
- Quinolinesulfonamides of aryloxy-/arylthio-ethyl piperidines: Influence of an arylether fragment on 5-HT1A/5-HT7 receptor selectivity
- K. Grychowska, K. Marciniec, V. Canale, M. Szymiec, G. Glanowski, G. Sataa, A. Ma-slankiewicz, M. Pawowski, A.J. Bojarski, P. Zajdel, Quinolinesulfonamides of aryloxy-/arylthio-ethyl piperidines: influence of an arylether fragment on 5-HT1A/5-HT7 receptor selectivity, Arch. Pharm. 346 (2013) 180-188.
- (2013) Arch. Pharm. , vol.346 , pp. 180-188
- Grychowska, K.¹ Marciniec, K.² Canale, V.³ Szymiec, M.⁴ Glanowski, G.⁵ Sataa, G.⁶ Maslankiewicz, A.⁷ Pawowski, M.⁸ Bojarski, A.J.⁹ Zajdel, P.¹⁰

35
- 0034070287
- Characterization of SB-269970-A, a selective 5-HT(7) receptor antagonist
- J.J. Hagan, G.W. Price, P. Jeffrey, N.J. Deeks, T. Stean, D. Piper, M.I. Smith, N. Upton, A.D. Medhurst, D.N. Middlemiss, G.J. Riley, P.J. Lovell, S.M. Bromidge, D.R. Thomas, Characterization of SB-269970-A, a selective 5-HT(7) receptor antagonist, Br. J. Pharmacol. 130 (2000) 539-548.
- (2000) Br. J. Pharmacol. , vol.130 , pp. 539-548
- Hagan, J.J.¹ Price, G.W.² Jeffrey, P.³ Deeks, N.J.⁴ Stean, T.⁵ Piper, D.⁶ Smith, M.I.⁷ Upton, N.⁸ Medhurst, A.D.⁹ Middlemiss, D.N.¹⁰ Riley, G.J.¹¹ Lovell, P.J.¹² Bromidge, S.M.¹³ Thomas, D.R.¹⁴

36
- 52049102696
- Influence of serotonin 5-HT(7) receptor blockade on the behavioral and neurochemical effects of imipramine in rats
- A. Wesoowska, M. Kowalska, Influence of serotonin 5-HT(7) receptor blockade on the behavioral and neurochemical effects of imipramine in rats, Pharmacol. Rep. 60 (2008) 464-474.
- (2008) Pharmacol. Rep. , vol.60 , pp. 464-474
- Wesoowska, A.¹ Kowalska, M.²

37
- 0023552933
- Selective agonists and antagonists for 5-hydroxytryptamine receptor subtypes, and interactions with yohimbine and FG 7142 using the elevated plus-maze test in the rat
- S. Pellow, A.L. Johnston, S.E. File, Selective agonists and antagonists for 5-hydroxytryptamine receptor subtypes, and interactions with yohimbine and FG 7142 using the elevated plus-maze test in the rat, J. Pharm. Pharmacol. 39 (1987) 917-928.
- (1987) J. Pharm. Pharmacol. , vol.39 , pp. 917-928
- Pellow, S.¹ Johnston, A.L.² File, S.E.³

38
- 0142216081
- The neurobiology and control of anxious states
- M.J. Millan, The neurobiology and control of anxious states, Prog. Neurobiol. 70 (2003) 83-244.
- (2003) Prog. Neurobiol. , vol.70 , pp. 83-244
- Millan, M.J.¹

39
- 33747075753
- Effect of the selective 5-HT7 receptor antagonist SB 269970 in animal models of anxiety and depression
- A. Wesoowska, A. Nikiforuk, K. Stachowicz, E. Tatarczy-nska, Effect of the selective 5-HT7 receptor antagonist SB 269970 in animal models of anxiety and depression, Neuropharmacology 51 (2006) 578-586.
- (2006) Neuropharmacology , vol.51 , pp. 578-586
- Wesoowska, A.¹ Nikiforuk, A.² Stachowicz, K.³ Tatarczynska, E.⁴

40
- 84855958018
- Modulatory effects of two novel agonists for serotonin receptor 7 on emotion motivation and circadian rhythm profiles in mice
- W. Adriani, D. Travaglini, E. Lacivita, L. Saso, M. Leopoldo, G. Laviola, Modulatory effects of two novel agonists for serotonin receptor 7 on emotion, motivation and circadian rhythm profiles in mice, Neuropharmacology 62 (2012) 833-842.
- (2012) Neuropharmacology , vol.62 , pp. 833-842
- Adriani, W.¹ Travaglini, D.² Lacivita, E.³ Saso, L.⁴ Leopoldo, M.⁵ Laviola, G.⁶

41
- 84902038397
- Persistent modification of forebrain networks and metabolism in rats following adolescent exposure to a 5-HT7 receptor agonist
- R. Canese, F. Zoratto, L. Altabella, P. Porcari, L. Mercurio, F. De Pasquale, E. Butti, G. Martino, E. Lacivita, M. Leopoldo, G. Laviola, W. Adriani, Persistent modification of forebrain networks and metabolism in rats following adolescent exposure to a 5-HT7 receptor agonist, Psychopharmacology 23 (2015) 275-289.
- (2015) Psychopharmacology , vol.23 , pp. 275-289
- Canese, R.¹ Zoratto, F.² Altabella, L.³ Porcari, P.⁴ Mercurio, L.⁵ De Pasquale, F.⁶ Butti, E.⁷ Martino, G.⁸ Lacivita, E.⁹ Leopoldo, M.¹⁰ Laviola, G.¹¹ Adriani, W.¹²

42
- 84949850511
- Experimental conditions for these assays are described online at
- The percentage of inhibition for b1, H1 and M1 receptors were evaluated at Eurofins Cerep. Experimental conditions for these assays are described online at www.cerep.fr.
- The Percentage of Inhibition for b1, H1 and M1 Receptors Were Evaluated at Eurofins Cerep

43
- 84949850512
- Schrodinger LLC, New York, NY
- CombiGlide, version 3.5, Schrodinger, LLC, New York, NY, 2014.
- (2014) CombiGlide, Version 3.5

44
- 84949850513
- Instant JChem 15.3.16.0 ChemAxon
- Instant JChem 15.3.16.0, 2015, ChemAxon (http://www.chemaxon.com).
- (2015)

45
- 84946568513
- Schrodinger LLC, New York, NY
- LigPrep, version 3.2, Schrodinger, LLC, New York, NY, 2014.
- (2014) LigPrep, Version 3.2

46
- 84946492002
- Schrodinger LLC, New York, NY
- QikProp, version 4.2, Schrodinger, LLC, New York, NY, 2014.
- (2014) QikProp, Version 4.2

47
- 84946566698
- Schrodinger LLC, New York, NY
- Glide, version 6.5, Schrodinger, LLC, New York, NY, 2014.
- (2014) Glide, Version 6.5

48
- 84949814587
- BIOVIA Inc., San Diego, CA, USA
- Discovery Studio 3.5, BIOVIA Inc., San Diego, CA, USA.
- Discovery Studio 3.5

* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.