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Volumn 20, Issue 4, 2012, Pages 1545-1556

Quinoline- and isoquinoline-sulfonamide derivatives of LCAP as potent CNS multi-receptor - 5-HT 1A/5-HT 2A/5-HT 7 and D 2/D 3/D 4 - Agents: The synthesis and pharmacological evaluation

(11) Zajdel, Paweł a Marciniec, Krzysztof b Maślankiewicz, Andrzej b Satała, Grzegorz c Duszyńska, Beata c Bojarski, Andrzej J c Partyka, Anna a Jastrzbska Wisek, Magdalena a Wróbel, Dagmara a Wesołowska, Anna a Pawłowski, MacIej a

a JAGIELLONIAN UNIVERSITY MEDICAL COLLEGE (Poland)

b MEDICAL UNIVERSITY OF SILESIA (Poland)

c INSTITUTE OF PHARMACOLOGY (Poland)

Author keywords

5 HT2A receptor antagonist; 5 HT7 receptor antagonist; Anxiety; D2 antagonist; Depression; Long chain arylpiperazines; Quinolinesulfonamides isoquinolinesulfonamides; Schizophrenia

Indexed keywords

4 [4 [2 [4 (4 CHLOROPHENYL) PIPERAZIN 1 YL] ETHYL] PIPERIDINE 1 SULFONYL] ISOQUINOLINE; ANTIDEPRESSANT AGENT; ANXIOLYTIC AGENT; CLOZAPINE; DIAZEPAM; DOPAMINE 2 RECEPTOR; DOPAMINE 3 RECEPTOR; DOPAMINE 4 RECEPTOR; DOPAMINE RECEPTOR AFFECTING AGENT; HALOPERIDOL; IMIPRAMINE; ISOQUINOLINESILFONAMIDE DERIVATIVE; N [3 [4 (3 CHLOROPHENYL) PIPERAZIN 1 YL] PROPYL] 3 QUINOLINESULFONAMIDE; N [3 [4 (4 CHLOROPHENYL) PIPERAZIN 1 YL] PROPYL] 3 QUINOLINESULFONAMIDE; N [3 [4 (4 CHLOROPHENYL) PIPERAZIN 1 YL] PROPYL] 4 ISOQUINOLINESULFONAMIDE; N [4 [4 (3 CHLOROPHENYL) PIPERAZIN 1 YL] BUTYL] 3 QUINOLINESULFONAMIDE; N [4 [4 (3 CHLOROPHENYL) PIPERAZIN 1 YL] BUTYL] 6 CHLORO 3 QUINOLINESULFONAMIDE; N [4 [4 (3 CHLOROPHENYL) PIPERAZIN 1 YL] BUTYL] 6 QUINOLINESULFONAMIDE; N [4 [4 (3 CHLOROPHENYL) PIPERAZIN 1 YL] BUTYL] 8 QUINOLINESULFONAMIDE; N [4 [4 (4 CHLOROPHENYL) PIPERAZIN 1 YL] BUTYL] 3 QUINOLINESULFONAMIDE; N [4 [4 (4 CHLOROPHENYL) PIPERAZIN 1 YL] BUTYL] 6 QUINOLINESULFONAMIDE; NAPHTHALENESULFONAMIDE DERIVATIVE; NEUROLEPTIC AGENT; QUINOLINE DERIVATIVE; SEROTONIN 1A RECEPTOR; SEROTONIN 2A RECEPTOR; SEROTONIN 7 RECEPTOR; SEROTONIN ANTAGONIST; SEROTONIN RECEPTOR AFFECTING AGENT; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANXIETY DISORDER; ARTICLE; CONTROLLED STUDY; DEPRESSION; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; FORCED SWIMMING TEST; HUMAN; HUMAN CELL; LOCOMOTION; MAZE TEST; MOUSE; NONHUMAN; RAT; SCHIZOPHRENIA; STRUCTURE ACTIVITY RELATION; TRANQUILIZING ACTIVITY;

ANIMALS; ANTIPSYCHOTIC AGENTS; CENTRAL NERVOUS SYSTEM; ISOQUINOLINES; MICE; PIPERAZINES; QUINOLINES; RATS; RECEPTOR, SEROTONIN, 5-HT1A; RECEPTOR, SEROTONIN, 5-HT2A; RECEPTORS, SEROTONIN; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

MUS; RATTUS;

EID: 84857033235 PISSN: 09680896 EISSN: 14643391 Source Type: Journal
DOI: 10.1016/j.bmc.2011.12.039 Document Type: Article

Times cited : (62)

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