메뉴 건너뛰기




Volumn 6, Issue NOV, 2015, Pages

Plasma 24-metabolite panel predicts preclinical transition to clinical stages of Alzheimer's disease

Author keywords

Alzheimer's disease; Biomarkers; Economics; Ethics; Lipids; Metabolomics; Risk assessment

Indexed keywords

ACYLCARNITINE; AMINO ACID; APOLIPOPROTEIN E4; ASPARAGINE; BIOLOGICAL MARKER; DECADIENYLCARNITINE; DECENOYLCARNITINE; DODECENOYLCARNITINE; HEXADECADIENYLCARNITINE; HYDROXYOCTADECENOYLCARNITINE; HYDROXYVALERYLCARNITINE; LYSOPHOSPHATIDYLCHOLINE; METHYLMALONYLCARNITINE; N(G),N(G) DIMETHYLARGININE; NONAYLCARNITINE; PHOSPHORYLCHOLINE; PROPIONYLCARNITINE; UNCLASSIFIED DRUG; VALERYLCARNITINE;

EID: 84949787003     PISSN: None     EISSN: 16642295     Source Type: Journal    
DOI: 10.3389/fneur.2015.00237     Document Type: Article
Times cited : (95)

References (65)
  • 1
    • 79956098248 scopus 로고    scopus 로고
    • Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease
    • Sperling RA, Aisen PS, Beckett LA, Bennett DA, Craft S, Fagan AM, et al. Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement (2011) 7:280-92. doi:10.1016/j.jalz.2011.03.003.
    • (2011) Alzheimers Dement , vol.7 , pp. 280-292
    • Sperling, R.A.1    Aisen, P.S.2    Beckett, L.A.3    Bennett, D.A.4    Craft, S.5    Fagan, A.M.6
  • 2
    • 84898447902 scopus 로고    scopus 로고
    • Plasma phospholipids identify antecedent memory impairment in older adults
    • Mapstone M, Cheema AK, Fiandaca MS, Zhong X, Mhyre TR, Macarthur LH, et al. Plasma phospholipids identify antecedent memory impairment in older adults. Nat Med (2014) 20:415-8. doi:10.1038/nm.3466.
    • (2014) Nat Med , vol.20 , pp. 415-418
    • Mapstone, M.1    Cheema, A.K.2    Fiandaca, M.S.3    Zhong, X.4    Mhyre, T.R.5    Macarthur, L.H.6
  • 3
    • 84902515726 scopus 로고    scopus 로고
    • The critical need for defining preclinical biomarkers in Alzheimer's disease
    • Fiandaca MS, Mapstone M, Cheema AK, FederoffHJ. The critical need for defining preclinical biomarkers in Alzheimer's disease. Alzheimers Dement (2014) 10:S195-211. doi:10.1016/j.jalz.2014.04.015.
    • (2014) Alzheimers Dement , vol.10 , pp. S195-S211
    • Fiandaca, M.S.1    Mapstone, M.2    Cheema, A.K.3    Federoff, H.J.4
  • 4
    • 0027457620 scopus 로고
    • Receiver-operating characteristic (ROC) plots: a fundamental evaluation tool in clinical medicine
    • Zweig MH, Campbell G. Receiver-operating characteristic (ROC) plots: a fundamental evaluation tool in clinical medicine. Clin Chem (1993) 39:561-77.
    • (1993) Clin Chem , vol.39 , pp. 561-577
    • Zweig, M.H.1    Campbell, G.2
  • 5
    • 84887232805 scopus 로고    scopus 로고
    • Evidence of altered phosphatidylcholine metabolism in Alzheimer's disease
    • Whiley L, Sen A, Heaton J, Proitsi P, Garcia-Gomez D, Leung R, et al. Evidence of altered phosphatidylcholine metabolism in Alzheimer's disease. Neurobiol Aging (2014) 35:271-8. doi:10.1016/j.neurobiolaging.2013.08.001.
    • (2014) Neurobiol Aging , vol.35 , pp. 271-278
    • Whiley, L.1    Sen, A.2    Heaton, J.3    Proitsi, P.4    Garcia-Gomez, D.5    Leung, R.6
  • 7
    • 0001287271 scopus 로고    scopus 로고
    • Regression shrinkage and selection via the lasso
    • Tibshirani R. Regression shrinkage and selection via the lasso. J R Stat Soc B (1996) 58:267-88.
    • (1996) J R Stat Soc B , vol.58 , pp. 267-288
    • Tibshirani, R.1
  • 9
    • 0037931319 scopus 로고    scopus 로고
    • Robustness against separation and outliers in logistic regression
    • Rousseeuw PJ, Christmann A. Robustness against separation and outliers in logistic regression. Comput Stat Data Anal (2003) 43:315-32. doi:10.1016/S0167-9473(02)00304-3.
    • (2003) Comput Stat Data Anal , vol.43 , pp. 315-332
    • Rousseeuw, P.J.1    Christmann, A.2
  • 10
    • 16244366026 scopus 로고
    • Index for rating diagnostic tests
    • Youden WJ. Index for rating diagnostic tests. Cancer (1950) 3:32-5. doi:10.1002/1097-0142(1950)3:1<32::AID-CNCR2820030106>3.0.CO;2-3.
    • (1950) Cancer , vol.3 , pp. 32-35
    • Youden, W.J.1
  • 13
    • 57749087174 scopus 로고    scopus 로고
    • Sample size for positive and negative predictive value in diagnostic research using case-control designs
    • Steinberg DM, Fine J, Chappell R. Sample size for positive and negative predictive value in diagnostic research using case-control designs. Biostatistics (2009) 10:94-105. doi:10.1093/biostatistics/kxn018.
    • (2009) Biostatistics , vol.10 , pp. 94-105
    • Steinberg, D.M.1    Fine, J.2    Chappell, R.3
  • 14
    • 84910005783 scopus 로고    scopus 로고
    • 2014 Alzheimer's disease facts and figures
    • Alzheimer's A. 2014 Alzheimer's disease facts and figures. Alzheimers Dement (2014) 10:e47-92. doi:10.1016/j.jalz.2014.02.001.
    • (2014) Alzheimers Dement , vol.10 , pp. e47-e92
    • Alzheimer's, A.1
  • 15
    • 84949777459 scopus 로고    scopus 로고
    • Altered plasma phospholipid composition in autosomal dominant Alzheimer's disease: a DIAN study
    • Chatterjee P, Lim WLF, Gupta VB, Sorhabi HR, Taddei K, Brown B, et al. Altered plasma phospholipid composition in autosomal dominant Alzheimer's disease: a DIAN study. Alzheimers Dement (2014) 10:260. doi:10.1016/j.jalz.2014.04.412.
    • (2014) Alzheimers Dement , vol.10 , pp. 260
    • Chatterjee, P.1    Lim, W.L.F.2    Gupta, V.B.3    Sorhabi, H.R.4    Taddei, K.5    Brown, B.6
  • 16
    • 84919742683 scopus 로고    scopus 로고
    • Using direct infusion mass spectrometry for serum metabolomics in Alzheimer's disease
    • Gonzalez-Dominguez R, Garcia-Barrera T, Gomez-Ariza JL. Using direct infusion mass spectrometry for serum metabolomics in Alzheimer's disease. Anal Bioanal Chem (2014) 406:7137-48. doi:10.1007/s00216-014-8102-3.
    • (2014) Anal Bioanal Chem , vol.406 , pp. 7137-7148
    • Gonzalez-Dominguez, R.1    Garcia-Barrera, T.2    Gomez-Ariza, J.L.3
  • 17
    • 84927928846 scopus 로고    scopus 로고
    • Plasma lipidomics analysis finds long chain cholesteryl esters to be associated with Alzheimer's disease
    • Proitsi P, Kim M, Whiley L, Pritchard M, Leung R, Soininen H, et al. Plasma lipidomics analysis finds long chain cholesteryl esters to be associated with Alzheimer's disease. Transl Psychiatry (2015) 5:e494. doi:10.1038/tp.2014.127.
    • (2015) Transl Psychiatry , vol.5
    • Proitsi, P.1    Kim, M.2    Whiley, L.3    Pritchard, M.4    Leung, R.5    Soininen, H.6
  • 19
    • 77049118002 scopus 로고    scopus 로고
    • Lipid alterations in lipid rafts from Alzheimer's disease human brain cortex
    • Martin V, Fabelo N, Santpere G, Puig B, Marin R, Ferrer I, et al. Lipid alterations in lipid rafts from Alzheimer's disease human brain cortex. J Alzheimers Dis (2010) 19:489-502. doi:10.3233/JAD-2010-1242.
    • (2010) J Alzheimers Dis , vol.19 , pp. 489-502
    • Martin, V.1    Fabelo, N.2    Santpere, G.3    Puig, B.4    Marin, R.5    Ferrer, I.6
  • 20
    • 84910609998 scopus 로고    scopus 로고
    • GDNF signaling implemented by GM1 ganglioside; failure in Parkinson's disease and GM1-deficient murine model
    • Hadaczek P, Wu G, Sharma N, Ciesielska A, Bankiewicz K, Davidow AL, et al. GDNF signaling implemented by GM1 ganglioside; failure in Parkinson's disease and GM1-deficient murine model. Exp Neurol (2015) 263:177-89. doi:10.1016/j.expneurol.2014.10.010.
    • (2015) Exp Neurol , vol.263 , pp. 177-189
    • Hadaczek, P.1    Wu, G.2    Sharma, N.3    Ciesielska, A.4    Bankiewicz, K.5    Davidow, A.L.6
  • 21
    • 84856072382 scopus 로고    scopus 로고
    • Comparative lipidomic analysis of mouse and human brain with Alzheimer disease
    • Chan RB, Oliveira TG, Cortes EP, Honig LS, DuffKE, Small SA, et al. Comparative lipidomic analysis of mouse and human brain with Alzheimer disease. J Biol Chem (2012) 287:2678-88. doi:10.1074/jbc. M111.274142.
    • (2012) J Biol Chem , vol.287 , pp. 2678-2688
    • Chan, R.B.1    Oliveira, T.G.2    Cortes, E.P.3    Honig, L.S.4    Duff, K.E.5    Small, S.A.6
  • 23
    • 0033791814 scopus 로고    scopus 로고
    • Membrane breakdown in acute and chronic neurodegeneration: focus on choline-containing phospholipids
    • Klein J. Membrane breakdown in acute and chronic neurodegeneration: focus on choline-containing phospholipids. J Neural Transm (2000) 107:1027-63. doi:10.1007/s007020070051.
    • (2000) J Neural Transm , vol.107 , pp. 1027-1063
    • Klein, J.1
  • 24
    • 80053334820 scopus 로고    scopus 로고
    • From brain to food: analysis of phosphatidylcholins, lyso-phosphatidylcholins and phosphatidylcholin-plasmalogens derivates in Alzheimer's disease human post mortem brains and mice model via mass spectrometry
    • Grimm MO, Grosgen S, Riemenschneider M, Tanila H, Grimm HS, Hartmann T. From brain to food: analysis of phosphatidylcholins, lyso-phosphatidylcholins and phosphatidylcholin-plasmalogens derivates in Alzheimer's disease human post mortem brains and mice model via mass spectrometry. J Chromatogr A (2011) 1218:7713-22. doi:10.1016/j.chroma.2011.07.073.
    • (2011) J Chromatogr A , vol.1218 , pp. 7713-7722
    • Grimm, M.O.1    Grosgen, S.2    Riemenschneider, M.3    Tanila, H.4    Grimm, H.S.5    Hartmann, T.6
  • 25
    • 84903640571 scopus 로고    scopus 로고
    • Metabolomic study of lipids in serum for biomarker discovery in Alzheimer's disease using direct infusion mass spectrometry
    • Gonzalez-Dominguez R, Garcia-Barrera T, Gomez-Ariza JL. Metabolomic study of lipids in serum for biomarker discovery in Alzheimer's disease using direct infusion mass spectrometry. J Pharm Biomed Anal (2014) 98:321-6. doi:10.1016/j.jpba.2014.05.023.
    • (2014) J Pharm Biomed Anal , vol.98 , pp. 321-326
    • Gonzalez-Dominguez, R.1    Garcia-Barrera, T.2    Gomez-Ariza, J.L.3
  • 26
    • 0034213298 scopus 로고    scopus 로고
    • Glycerophospholipids in brain: their metabolism, incorporation into membranes, functions, and involvement in neurological disorders
    • Farooqui AA, Horrocks LA, Farooqui T. Glycerophospholipids in brain: their metabolism, incorporation into membranes, functions, and involvement in neurological disorders. Chem Phys Lipids (2000) 106:1-29. doi:10.1016/S0009-3084(00)00128-6.
    • (2000) Chem Phys Lipids , vol.106 , pp. 1-29
    • Farooqui, A.A.1    Horrocks, L.A.2    Farooqui, T.3
  • 27
    • 0034500422 scopus 로고    scopus 로고
    • Fatty acid analysis of blood plasma of patients with Alzheimer's disease, other types of dementia, and cognitive impairment
    • Conquer JA, Tierney MC, Zecevic J, Bettger WJ, Fisher RH. Fatty acid analysis of blood plasma of patients with Alzheimer's disease, other types of dementia, and cognitive impairment. Lipids (2000) 35:1305-12. doi:10.1007/s11745-000-0646-3.
    • (2000) Lipids , vol.35 , pp. 1305-1312
    • Conquer, J.A.1    Tierney, M.C.2    Zecevic, J.3    Bettger, W.J.4    Fisher, R.H.5
  • 28
    • 0034912811 scopus 로고    scopus 로고
    • Essential polyunsaturated fatty acids and the barrier to the brain: the components of a model for transport
    • discussion 215-121
    • Edmond J. Essential polyunsaturated fatty acids and the barrier to the brain: the components of a model for transport. J Mol Neurosci (2001) 16:181-93; discussion 215-121.
    • (2001) J Mol Neurosci , vol.16 , pp. 181-193
    • Edmond, J.1
  • 29
    • 84922479473 scopus 로고    scopus 로고
    • Polyunsaturated fatty acids and their metabolites in brain function and disease
    • Bazinet RP, Laye S. Polyunsaturated fatty acids and their metabolites in brain function and disease. Nat Rev Neurosci (2014) 15:771-85. doi:10.1038/nrn3820.
    • (2014) Nat Rev Neurosci , vol.15 , pp. 771-785
    • Bazinet, R.P.1    Laye, S.2
  • 30
    • 0034912915 scopus 로고    scopus 로고
    • In vivo fatty acid incorporation into brain phosholipids in relation to plasma availability, signal transduction and membrane remodeling
    • discussion 279-284
    • Rapoport SI. In vivo fatty acid incorporation into brain phosholipids in relation to plasma availability, signal transduction and membrane remodeling. J Mol Neurosci (2001) 16:243-61; discussion 279-284.
    • (2001) J Mol Neurosci , vol.16 , pp. 243-261
    • Rapoport, S.I.1
  • 31
    • 0018385493 scopus 로고
    • Lipoprotein lipase and acid lipase activity in rabbit brain microvessels
    • Brecher P, Kuan HT. Lipoprotein lipase and acid lipase activity in rabbit brain microvessels. J Lipid Res (1979) 20:464-71.
    • (1979) J Lipid Res , vol.20 , pp. 464-471
    • Brecher, P.1    Kuan, H.T.2
  • 32
    • 0030972045 scopus 로고    scopus 로고
    • No evidence for direct incorporation of esterified palmitic acid from plasma into brain lipids of awake adult rat
    • Purdon D, Arai T, Rapoport S. No evidence for direct incorporation of esterified palmitic acid from plasma into brain lipids of awake adult rat. J Lipid Res (1997) 38:526-30.
    • (1997) J Lipid Res , vol.38 , pp. 526-530
    • Purdon, D.1    Arai, T.2    Rapoport, S.3
  • 33
    • 0034913114 scopus 로고    scopus 로고
    • Plasma free fatty acid and lipoproteins as sources of polyunsaturated fatty acid for the brain
    • discussion 215-121
    • Spector AA. Plasma free fatty acid and lipoproteins as sources of polyunsaturated fatty acid for the brain. J Mol Neurosci (2001) 16:159-65; discussion 215-121.
    • (2001) J Mol Neurosci , vol.16 , pp. 159-165
    • Spector, A.A.1
  • 34
    • 0028898743 scopus 로고
    • Coenzyme A-dependent cleavage of membrane phospholipids in several rat tissues: ATP-independent acyl-CoA synthesis and the generation of lysophospholipids
    • Sugiura T, Kudo N, Ojima T, Mabuchi-Itoh K, Yamashita A, Waku K. Coenzyme A-dependent cleavage of membrane phospholipids in several rat tissues: ATP-independent acyl-CoA synthesis and the generation of lysophospholipids. Biochim Biophys Acta (1995) 1255:167-76. doi:10.1016/0005-2760(94)00237-S.
    • (1995) Biochim Biophys Acta , vol.1255 , pp. 167-176
    • Sugiura, T.1    Kudo, N.2    Ojima, T.3    Mabuchi-Itoh, K.4    Yamashita, A.5    Waku, K.6
  • 35
    • 0030809527 scopus 로고    scopus 로고
    • Relation between free fatty acid and acyl-CoA concentrations in rat brain following decapitation
    • Deutsch J, Rapoport SI, Purdon AD. Relation between free fatty acid and acyl-CoA concentrations in rat brain following decapitation. Neurochem Res (1997) 22:759-65. doi:10.1023/A:1022030306359.
    • (1997) Neurochem Res , vol.22 , pp. 759-765
    • Deutsch, J.1    Rapoport, S.I.2    Purdon, A.D.3
  • 36
    • 0030946557 scopus 로고    scopus 로고
    • Changes in cerebral acyl-CoA concentrations following ischemia-reperfusion in awake gerbils
    • Rabin O, Deutsch J, Grange E, Pettigrew KD, Chang MC, Rapoport SI, et al. Changes in cerebral acyl-CoA concentrations following ischemia-reperfusion in awake gerbils. J Neurochem (1997) 68:2111-8. doi:10.1046/j.1471-4159.1997.68052111.x.
    • (1997) J Neurochem , vol.68 , pp. 2111-2118
    • Rabin, O.1    Deutsch, J.2    Grange, E.3    Pettigrew, K.D.4    Chang, M.C.5    Rapoport, S.I.6
  • 37
    • 0034988945 scopus 로고    scopus 로고
    • Delivery and turnover of plasma-derived essential PUFAs in mammalian brain
    • Rapoport SI, Chang MCJ, Spector AA. Delivery and turnover of plasma-derived essential PUFAs in mammalian brain. J Lipid Res (2001) 42:678-85.
    • (2001) J Lipid Res , vol.42 , pp. 678-685
    • Rapoport, S.I.1    Chang, M.C.J.2    Spector, A.A.3
  • 38
    • 0000749205 scopus 로고
    • The function of cytidine coenzymes in the biosynthesis of phospholipides
    • Kennedy EP, Weiss SB. The function of cytidine coenzymes in the biosynthesis of phospholipides. J Biol Chem (1956) 222:193-214.
    • (1956) J Biol Chem , vol.222 , pp. 193-214
    • Kennedy, E.P.1    Weiss, S.B.2
  • 39
    • 84889770932 scopus 로고    scopus 로고
    • Targeting synaptic dysfunction in Alzheimer's disease by administering a specific nutrient combination
    • van Wijk N, Broersen LM, De Wilde MC, Hageman RJ, Groenendijk M, Sijben JW, et al. Targeting synaptic dysfunction in Alzheimer's disease by administering a specific nutrient combination. J Alzheimers Dis (2014) 38:459-79. doi:10.3233/JAD-130998.
    • (2014) J Alzheimers Dis , vol.38 , pp. 459-479
    • van Wijk, N.1    Broersen, L.M.2    De Wilde, M.C.3    Hageman, R.J.4    Groenendijk, M.5    Sijben, J.W.6
  • 40
    • 84900312887 scopus 로고    scopus 로고
    • The effect of souvenaid on functional brain network organisation in patients with mild Alzheimer's disease: a randomised controlled study
    • de Waal H, Stam CJ, Lansbergen MM, Wieggers RL, Kamphuis PJ, Scheltens P, et al. The effect of souvenaid on functional brain network organisation in patients with mild Alzheimer's disease: a randomised controlled study. PLoS One (2014) 9:e86558. doi:10.1371/journal.pone.0086558.
    • (2014) PLoS One , vol.9
    • de Waal, H.1    Stam, C.J.2    Lansbergen, M.M.3    Wieggers, R.L.4    Kamphuis, P.J.5    Scheltens, P.6
  • 41
    • 84942509989 scopus 로고    scopus 로고
    • Antiphospholipid autoantibodies as blood biomarkers for detection of early stage Alzheimer's disease
    • McIntyre JA, Ramsey CJ, Gitter BD, Saykin AJ, Wagenknecht DR, Hyslop PA, et al. Antiphospholipid autoantibodies as blood biomarkers for detection of early stage Alzheimer's disease. Autoimmunity (2015) 48(5):344-51. doi:10.3109/08916934.2015.1008464.
    • (2015) Autoimmunity , vol.48 , Issue.5 , pp. 344-351
    • McIntyre, J.A.1    Ramsey, C.J.2    Gitter, B.D.3    Saykin, A.J.4    Wagenknecht, D.R.5    Hyslop, P.A.6
  • 42
    • 71749085455 scopus 로고    scopus 로고
    • Acylcarnitines: role in brain
    • Jones LL, Mcdonald DA, Borum PR. Acylcarnitines: role in brain. Prog Lipid Res (2010) 49:61-75. doi:10.1016/j.plipres.2009.08.004.
    • (2010) Prog Lipid Res , vol.49 , pp. 61-75
    • Jones, L.L.1    Mcdonald, D.A.2    Borum, P.R.3
  • 44
    • 0016209777 scopus 로고
    • Psychiatric symptoms associated with L-asparaginase administration
    • Holland J, Fasanello S, Onuma T. Psychiatric symptoms associated with L-asparaginase administration. J Psychiatr Res (1974) 10:105-13. doi:10.1016/0022-3956(74)90030-2.
    • (1974) J Psychiatr Res , vol.10 , pp. 105-113
    • Holland, J.1    Fasanello, S.2    Onuma, T.3
  • 45
    • 0015008112 scopus 로고
    • Studies on the utilization of asparagine by mouse leukemia cells
    • Ubuka T, Meister A. Studies on the utilization of asparagine by mouse leukemia cells. J Natl Cancer Inst (1971) 46:291-8.
    • (1971) J Natl Cancer Inst , vol.46 , pp. 291-298
    • Ubuka, T.1    Meister, A.2
  • 46
    • 0019377631 scopus 로고
    • Synthesis and processing of asparagine-linked oligosaccharides
    • Hubbard SC, Ivatt RJ. Synthesis and processing of asparagine-linked oligosaccharides. Annu Rev Biochem (1981) 50:555-83. doi:10.1146/annurev.bi.50.070181.003011.
    • (1981) Annu Rev Biochem , vol.50 , pp. 555-583
    • Hubbard, S.C.1    Ivatt, R.J.2
  • 47
    • 84885758467 scopus 로고    scopus 로고
    • Deficiency of asparagine synthetase causes congenital microcephaly and a progressive form of encephalopathy
    • Ruzzo EK, Capo-Chichi JM, Ben-Zeev B, Chitayat D, Mao H, Pappas AL, et al. Deficiency of asparagine synthetase causes congenital microcephaly and a progressive form of encephalopathy. Neuron (2013) 80:429-41. doi:10.1016/j.neuron.2013.08.013.
    • (2013) Neuron , vol.80 , pp. 429-441
    • Ruzzo, E.K.1    Capo-Chichi, J.M.2    Ben-Zeev, B.3    Chitayat, D.4    Mao, H.5    Pappas, A.L.6
  • 48
    • 79953296231 scopus 로고    scopus 로고
    • The therapeutic potential of targeting endogenous inhibitors of nitric oxide synthesis
    • Leiper J, Nandi M. The therapeutic potential of targeting endogenous inhibitors of nitric oxide synthesis. Nat Rev Drug Discov (2011) 10:277-91. doi:10.1038/nrd3358.
    • (2011) Nat Rev Drug Discov , vol.10 , pp. 277-291
    • Leiper, J.1    Nandi, M.2
  • 49
    • 65249119330 scopus 로고    scopus 로고
    • Plasma asymmetric dimethylarginine and incidence of cardiovascular disease and death in the community
    • Boger RH, Sullivan LM, Schwedhelm E, Wang TJ, Maas R, Benjamin EJ, et al. Plasma asymmetric dimethylarginine and incidence of cardiovascular disease and death in the community. Circulation (2009) 119:1592-600. doi:10.1161/CIRCULATIONAHA.108.838268.
    • (2009) Circulation , vol.119 , pp. 1592-1600
    • Boger, R.H.1    Sullivan, L.M.2    Schwedhelm, E.3    Wang, T.J.4    Maas, R.5    Benjamin, E.J.6
  • 50
    • 0035425503 scopus 로고    scopus 로고
    • Nitric oxide synthases: structure, function and inhibition
    • Alderton WK, Cooper CE, Knowles RG. Nitric oxide synthases: structure, function and inhibition. Biochem J (2001) 357:593-615. doi:10.1042/0264-6021:3570593.
    • (2001) Biochem J , vol.357 , pp. 593-615
    • Alderton, W.K.1    Cooper, C.E.2    Knowles, R.G.3
  • 51
    • 39349090970 scopus 로고    scopus 로고
    • NO/cGMP-dependent modulation of synaptic transmission
    • Feil R, Kleppisch T. NO/cGMP-dependent modulation of synaptic transmission. Handb Exp Pharmacol (2008) 184:529-60. doi:10.1007/978-3-540-74805-2_16.
    • (2008) Handb Exp Pharmacol , vol.184 , pp. 529-560
    • Feil, R.1    Kleppisch, T.2
  • 52
    • 47949116906 scopus 로고    scopus 로고
    • Asymmetrical dimethylarginine is increased in plasma and decreased in cerebrospinal fluid of patients with Alzheimer's disease
    • Arlt S, Schulze F, Eichenlaub M, Maas R, Lehmbeck JT, Schwedhelm E, et al. Asymmetrical dimethylarginine is increased in plasma and decreased in cerebrospinal fluid of patients with Alzheimer's disease. Dement Geriatr Cogn Disord (2008) 26:58-64. doi:10.1159/000144026.
    • (2008) Dement Geriatr Cogn Disord , vol.26 , pp. 58-64
    • Arlt, S.1    Schulze, F.2    Eichenlaub, M.3    Maas, R.4    Lehmbeck, J.T.5    Schwedhelm, E.6
  • 53
    • 84928114518 scopus 로고    scopus 로고
    • The cerebral circulation: function and dysfunction in Alzheimer's disease
    • Hamel E. The cerebral circulation: function and dysfunction in Alzheimer's disease. J Cardiovasc Pharmacol (2014) 65:317-24. doi:10.1097/FJC.0000000000000177.
    • (2014) J Cardiovasc Pharmacol , vol.65 , pp. 317-324
    • Hamel, E.1
  • 54
    • 0032469313 scopus 로고    scopus 로고
    • Taking a count: the evaluation of genetic testing
    • Hall J, Viney R, Haas M. Taking a count: the evaluation of genetic testing. Aust N Z J Public Health (1998) 22:754-8. doi:10.1111/j.1467-842X.1998.tb01488.x.
    • (1998) Aust N Z J Public Health , vol.22 , pp. 754-758
    • Hall, J.1    Viney, R.2    Haas, M.3
  • 55
    • 1442276551 scopus 로고    scopus 로고
    • The hazards of early recognition of dementia: a risk assessment
    • Lliffe S, Manthorpe J. The hazards of early recognition of dementia: a risk assessment. Aging Ment Health (2004) 8:99-105. doi:10.1080/13607860410001649653.
    • (2004) Aging Ment Health , vol.8 , pp. 99-105
    • Lliffe, S.1    Manthorpe, J.2
  • 57
    • 58249093641 scopus 로고    scopus 로고
    • Economic methods for valuing the outcomes of genetic testing: beyond cost-effectiveness analysis
    • Grosse SD, Wordsworth S, Payne K. Economic methods for valuing the outcomes of genetic testing: beyond cost-effectiveness analysis. Genet Med (2008) 10:648-54. doi:10.1097/GIM.0b013e3181837217.
    • (2008) Genet Med , vol.10 , pp. 648-654
    • Grosse, S.D.1    Wordsworth, S.2    Payne, K.3
  • 58
    • 84965172390 scopus 로고    scopus 로고
    • Dementia risk and financial decision making by older households: the impact of information
    • Hsu JW, Willis R. Dementia risk and financial decision making by older households: the impact of information. J Hum Cap (2013) 2013:45. doi:10.2139/ssrn.2339225.
    • (2013) J Hum Cap , vol.2013 , pp. 45
    • Hsu, J.W.1    Willis, R.2
  • 59
    • 0034086974 scopus 로고    scopus 로고
    • Assessing financial capacity in patients with Alzheimer disease: a conceptual model and prototype instrument
    • Marson DC, Sawrie SM, Snyder S, McinturffB, Stalvey T, Boothe A, et al. Assessing financial capacity in patients with Alzheimer disease: a conceptual model and prototype instrument. Arch Neurol (2000) 57:877-84. doi:10.1001/archneur.57.6.877.
    • (2000) Arch Neurol , vol.57 , pp. 877-884
    • Marson, D.C.1    Sawrie, S.M.2    Snyder, S.3    Mcinturff, B.4    Stalvey, T.5    Boothe, A.6
  • 60
    • 44649111224 scopus 로고    scopus 로고
    • Declining financial capacity in patients with mild Alzheimer disease: a one-year longitudinal study
    • Martin R, Griffith HR, Belue K, Harrell L, Zamrini E, Anderson B, et al. Declining financial capacity in patients with mild Alzheimer disease: a one-year longitudinal study. Am J Geriatr Psychiatry (2008) 16:209-19. doi:10.1097/JGP.0b013e318157cb00.
    • (2008) Am J Geriatr Psychiatry , vol.16 , pp. 209-219
    • Martin, R.1    Griffith, H.R.2    Belue, K.3    Harrell, L.4    Zamrini, E.5    Anderson, B.6
  • 61
    • 70349655698 scopus 로고    scopus 로고
    • Declining financial capacity in mild cognitive impairment: a 1-year longitudinal study
    • Triebel KL, Martin R, Griffith HR, Marceaux J, Okonkwo OC, Harrell L, et al. Declining financial capacity in mild cognitive impairment: a 1-year longitudinal study. Neurology (2009) 73:928-34. doi:10.1212/WNL.0b013e3181b87971.
    • (2009) Neurology , vol.73 , pp. 928-934
    • Triebel, K.L.1    Martin, R.2    Griffith, H.R.3    Marceaux, J.4    Okonkwo, O.C.5    Harrell, L.6
  • 62
    • 84898042637 scopus 로고    scopus 로고
    • How are we going to live with Alzheimer's disease?
    • Karlawish J. How are we going to live with Alzheimer's disease? Health Aff(Millwood) (2014) 33:541-6. doi:10.1377/hlthaff.2014.0089.
    • (2014) Health Aff(Millwood) , vol.33 , pp. 541-546
    • Karlawish, J.1
  • 63
    • 84898038424 scopus 로고    scopus 로고
    • Alzheimer's disease legislation and policy-now and in the future
    • Hoffman D. Alzheimer's disease legislation and policy-now and in the future. Health Aff(Millwood) (2014) 33:561-5. doi:10.1377/hlthaff.2013.1223.
    • (2014) Health Aff(Millwood) , vol.33 , pp. 561-565
    • Hoffman, D.1
  • 64
    • 84949917720 scopus 로고    scopus 로고
    • Presidential Commission for the Study of Bioethical Issues Report
    • Ethics, and Society, Washington, DC: US Dept Health and Human Services
    • Guttman A, Wagner JW, Allen AL, Arras JD, Atkinson BF, Farahany NA, et al. Presidential Commission for the Study of Bioethical Issues Report, GRAY MATTERS-Integrative Approaches for Neuroscience, Ethics, and Society. Washington, DC: US Dept Health and Human Services (2014). http://www.bioethics.gov/sites/default/files/Gray%20Matters%20Vol%201.pdf.
    • (2014) GRAY MATTERS-Integrative Approaches for Neuroscience
    • Guttman, A.1    Wagner, J.W.2    Allen, A.L.3    Arras, J.D.4    Atkinson, B.F.5    Farahany, N.A.6
  • 65
    • 79959193198 scopus 로고    scopus 로고
    • Genetic counseling and testing for Alzheimer disease: joint practice guidelines of the American College of Medical Genetics and the National Society of Genetic Counselors
    • Goldman JS, Hahn SE, Catania JW, Larusse-Eckert S, Butson MB, Rumbaugh M, et al. Genetic counseling and testing for Alzheimer disease: joint practice guidelines of the American College of Medical Genetics and the National Society of Genetic Counselors. Genet Med (2011) 13:597-605. doi:10.1097/GIM.0b013e31821d69b8.
    • (2011) Genet Med , vol.13 , pp. 597-605
    • Goldman, J.S.1    Hahn, S.E.2    Catania, J.W.3    Larusse-Eckert, S.4    Butson, M.B.5    Rumbaugh, M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.