메뉴 건너뛰기




Volumn 7, Issue 4, 2015, Pages 2397-2414

Anti-tumor immunity in head and neck cancer: Understanding the evidence, how tumors escape and immunotherapeutic approaches

Author keywords

Adaptive immunity; Antigenicity; Checkpoint inhibitors; Immunogenicity; Immunosuppression; Immunotherapy; Innate immunity; Syngeneic mouse models; Tumor antigen; Vaccines

Indexed keywords

CETUXIMAB; TADALAFIL; TUMOR VACCINE;

EID: 84949778471     PISSN: None     EISSN: 20726694     Source Type: Journal    
DOI: 10.3390/cancers7040900     Document Type: Review
Times cited : (59)

References (110)
  • 1
    • 0027853037 scopus 로고
    • Murine Pam 212 cutaneous squamous cell carcinoma is nonimmunogenic in normal syngeneic hosts and resistant to immune effector mechanisms
    • [PubMed]
    • Chen, Z.; Rosten, S.I.; Lord, E.M.; Gaspari, A.A. Murine Pam 212 cutaneous squamous cell carcinoma is nonimmunogenic in normal syngeneic hosts and resistant to immune effector mechanisms. Reg. Immunol. 1993, 5, 285–292. [PubMed]
    • (1993) Reg. Immunol , vol.5 , pp. 285-292
    • Chen, Z.1    Rosten, S.I.2    Lord, E.M.3    Gaspari, A.A.4
  • 2
    • 0031450588 scopus 로고    scopus 로고
    • Expression of B7-1 by Pam 212 squamous cell carcinoma enhances tumor cell interactions with dendritic epidermal cells but does not affect in vivo tumor growth
    • [CrossRef] [PubMed]
    • Yeh, K.Y.; Chen, Z.; Nasir, A.; Ohsuga, Y.; Takashima, A.; Lord, E.M.; Gaspari, A.A. Expression of B7-1 by Pam 212 squamous cell carcinoma enhances tumor cell interactions with dendritic epidermal cells but does not affect in vivo tumor growth. J. Investig. Dermatol. 1997, 109, 728–733. [CrossRef] [PubMed]
    • (1997) J. Investig. Dermatol , vol.109 , pp. 728-733
    • Yeh, K.Y.1    Chen, Z.2    Nasir, A.3    Ohsuga, Y.4    Takashima, A.5    Lord, E.M.6    Gaspari, A.A.7
  • 3
    • 0030612750 scopus 로고    scopus 로고
    • Metastatic variants derived following in vivo tumor progression of an in vitro transformed squamous cell carcinoma line acquire a differential growth advantage requiring tumor-host interaction
    • [CrossRef] [PubMed]
    • Chen, Z.; Smith, C.W.; Kiel, D.; vanWaes, C. Metastatic variants derived following in vivo tumor progression of an in vitro transformed squamous cell carcinoma line acquire a differential growth advantage requiring tumor-host interaction. Clin. Exp. Metastasis 1997, 15, 527–537. [CrossRef] [PubMed]
    • (1997) Clin. Exp. Metastasis , vol.15 , pp. 527-537
    • Chen, Z.1    Smith, C.W.2    Kiel, D.3    Vanwaes, C.4
  • 4
    • 0033565516 scopus 로고    scopus 로고
    • The host environment promotes the constitutive activation of nuclear factor-kappaB and proinflammatory cytokine expression during metastatic tumor progression of murine squamous cell carcinoma
    • [PubMed]
    • Dong, G.; Chen, Z.; Kato, T.; van Waes, C. The host environment promotes the constitutive activation of nuclear factor-kappaB and proinflammatory cytokine expression during metastatic tumor progression of murine squamous cell carcinoma. Cancer Res. 1999, 59, 3495–3504. [PubMed]
    • (1999) Cancer Res , vol.59 , pp. 3495-3504
    • Dong, G.1    Chen, Z.2    Kato, T.3    Van Waes, C.4
  • 5
    • 0032425625 scopus 로고    scopus 로고
    • The host environment promotes the development of primary and metastatic squamous cell carcinomas that constitutively express proinflammatory cytokines IL-1a, IL-6, GM-CSF, and KC
    • [CrossRef] [PubMed]
    • Smith, C.W.; Chen, Z.; Dong, G.; Loukinova, E.; Pegram, M.Y.; Nicholas-Figueroa, L.; van Waes, C. The host environment promotes the development of primary and metastatic squamous cell carcinomas that constitutively express proinflammatory cytokines IL-1a, IL-6, GM-CSF, and KC. Clin. Exp. Metastasis 1998, 16, 655–664. [CrossRef] [PubMed]
    • (1998) Clin. Exp. Metastasis , vol.16 , pp. 655-664
    • Smith, C.W.1    Chen, Z.2    Dong, G.3    Loukinova, E.4    Pegram, M.Y.5    Nicholas-Figueroa, L.6    Van Waes, C.7
  • 6
    • 4344694684 scopus 로고    scopus 로고
    • Metastatic squamous cell carcinoma cells that overexpress c-Met exhibit enhanced angiogenesis factor expression, scattering and metastasis in response to hepatocyte growth factor
    • [CrossRef] [PubMed]
    • Dong, G.; Lee, T.L.; Yeh, N.T.; Geoghegan, J.; van Waes, C.; Chen, Z. Metastatic squamous cell carcinoma cells that overexpress c-Met exhibit enhanced angiogenesis factor expression, scattering and metastasis in response to hepatocyte growth factor. Oncogene 2004, 23, 6199–6208. [CrossRef] [PubMed]
    • (2004) Oncogene , vol.23 , pp. 6199-6208
    • Dong, G.1    Lee, T.L.2    Yeh, N.T.3    Geoghegan, J.4    Van Waes, C.5    Chen, Z.6
  • 7
    • 0034691757 scopus 로고    scopus 로고
    • Growth regulated oncogene-alpha expression by murine squamous cell carcinoma promotes tumor growth, metastasis, leukocyte infiltration and angiogenesis by a host CXC receptor-2 dependent mechanism
    • [CrossRef] [PubMed]
    • Loukinova, E.; Dong, G.; Enamorado-Ayalya, I.; Thomas, G.R.; Chen, Z.; Schreiber, H.; van Waes, C. Growth regulated oncogene-alpha expression by murine squamous cell carcinoma promotes tumor growth, metastasis, leukocyte infiltration and angiogenesis by a host CXC receptor-2 dependent mechanism. Oncogene 2000, 19, 3477–3486. [CrossRef] [PubMed]
    • (2000) Oncogene , vol.19 , pp. 3477-3486
    • Loukinova, E.1    Dong, G.2    Enamorado-Ayalya, I.3    Thomas, G.R.4    Chen, Z.5    Schreiber, H.6    Van Waes, C.7
  • 8
    • 0035545892 scopus 로고    scopus 로고
    • Expression of proangiogenic chemokine Gro 1 in low and high metastatic variants of Pam murine squamous cell carcinoma is differentially regulated by IL-1a, EGF and TGF-b1 through NF-kB dependent and independent mechanisms
    • [CrossRef] [PubMed]
    • Loukinova, E.; Chen, Z.; vanWaes, C.; Dong, G. Expression of proangiogenic chemokine Gro 1 in low and high metastatic variants of Pam murine squamous cell carcinoma is differentially regulated by IL-1a, EGF and TGF-b1 through NF-kB dependent and independent mechanisms. Int. J. Cancer 2001, 94, 637–644. [CrossRef] [PubMed]
    • (2001) Int. J. Cancer , vol.94 , pp. 637-644
    • Loukinova, E.1    Chen, Z.2    Vanwaes, C.3    Dong, G.4
  • 9
    • 0035874877 scopus 로고    scopus 로고
    • Molecular profiling of transformed and metastatic murine squamous carcinoma cells by differential display and cDNA microarray reveals altered expression of multiple genes related to growth, apoptosis, angiogenesis, and the NF-kB signal pathway
    • [PubMed]
    • Dong, G.; Loukinova, E.; Chen, Z.; Gangi, L.; Chanturita, T.I.; Liu, E.T.; vanWaes, C. Molecular profiling of transformed and metastatic murine squamous carcinoma cells by differential display and cDNA microarray reveals altered expression of multiple genes related to growth, apoptosis, angiogenesis, and the NF-kB signal pathway. Cancer Res. 2001, 61, 4797–4808. [PubMed]
    • (2001) Cancer Res , vol.61 , pp. 4797-4808
    • Dong, G.1    Loukinova, E.2    Chen, Z.3    Gangi, L.4    Chanturita, T.I.5    Liu, E.T.6    Vanwaes, C.7
  • 10
    • 4644313276 scopus 로고    scopus 로고
    • Nuclear factor-kB is an important modulator of the altered gene expression profile and malignant phenotype in squamous cell carcinoma
    • [CrossRef] [PubMed]
    • Loercher, A.; Lee, T.L.; Ricker, J.L.; Howard, A.; Geoghegen, J.; Chen, Z.; Sunwoo, J.B.; Sitcheran, R.; Chuang, E.Y.; Mitchell, J.B., et al. Nuclear factor-kB is an important modulator of the altered gene expression profile and malignant phenotype in squamous cell carcinoma. Cancer Res. 2004, 64, 6511–6523. [CrossRef] [PubMed]
    • (2004) Cancer Res , vol.64 , pp. 6511-6523
    • Loercher, A.1    Lee, T.L.2    Ricker, J.L.3    Howard, A.4    Geoghegen, J.5    Chen, Z.6    Sunwoo, J.B.7    Sitcheran, R.8    Chuang, E.Y.9    Mitchell, J.B.10
  • 11
    • 84949920081 scopus 로고    scopus 로고
    • Squamous cell carcinoma expressing proinflammatory cytokines produce T helper 1 unresponsivenenss and increased myeloid and T helper 2 type cytokine responses
    • Prevention and Therapy of Head and Neck Cancer, McLean, VA, USA, 9–13 October
    • Gill, R.C.Z.; Nejad-Sattarri, M.; Loos, B.; Park, C.; Yeh, N.T.; Kass, E.; van Waes, C. Squamous cell carcinoma expressing proinflammatory cytokines produce T helper 1 unresponsivenenss and increased myeloid and T helper 2 type cytokine responses. In Proceedings of the 6th ResearchWorkshop on Biology, Prevention and Therapy of Head and Neck Cancer, McLean, VA, USA, 9–13 October 2002.
    • (2002) Proceedings of the 6Th Researchworkshop on Biology
    • Gill, R.C.Z.1    Nejad-Sattarri, M.2    Loos, B.3    Park, C.4    Yeh, N.T.5    Kass, E.6    Van Waes, C.7
  • 12
    • 0033046904 scopus 로고    scopus 로고
    • Decreased expression of CD80 is a marker for increased tumorigenicity in a new murine model of oral squamous-cell carcinoma
    • CrossRef
    • Thomas, G.R.; Chen, Z.; Oechsli, M.N.; Hendler, F.J.; van Waes, C. Decreased expression of CD80 is a marker for increased tumorigenicity in a new murine model of oral squamous-cell carcinoma. Int. J. Cancer 1999, 82, 377–384. [CrossRef]
    • (1999) Int. J. Cancer , vol.82 , pp. 377-384
    • Thomas, G.R.1    Chen, Z.2    Oechsli, M.N.3    Hendler, F.J.4    Van Waes, C.5
  • 13
    • 0034114552 scopus 로고    scopus 로고
    • IL-12- and IL-2-induced tumor regression in a new murine model of oral squamous-cell carcinoma is promoted by expression of the CD80 co-stimulatory molecule and interferon-
    • CrossRef
    • Thomas, G.R.; Chen, Z.; Enamorado, I.; Bancroft, C.; vanWaes, C. IL-12- and IL-2-induced tumor regression in a new murine model of oral squamous-cell carcinoma is promoted by expression of the CD80 co-stimulatory molecule and interferon-. Int. J. Cancer 2000, 86, 368–374. [CrossRef]
    • (2000) Int. J. Cancer , vol.86 , pp. 368-374
    • Thomas, G.R.1    Chen, Z.2    Enamorado, I.3    Bancroft, C.4    Vanwaes, C.5
  • 14
    • 0742269447 scopus 로고    scopus 로고
    • Cytokines IL-1a, IL-6, and GM-CSF constitutively secreted by oral squamous carcinoma induce down-regulation of CD80 costimulatory molecule expression: Restoration by interferon gamma
    • [CrossRef] [PubMed]
    • Thomas, G.R.; Chen, Z.; Leukinova, E.; van Waes, C.; Wen, J. Cytokines IL-1a, IL-6, and GM-CSF constitutively secreted by oral squamous carcinoma induce down-regulation of CD80 costimulatory molecule expression: Restoration by interferon gamma. Cancer Immunol. Immunother. 2004, 53, 33–40. [CrossRef] [PubMed]
    • (2004) Cancer Immunol. Immunother , vol.53 , pp. 33-40
    • Thomas, G.R.1    Chen, Z.2    Leukinova, E.3    Van Waes, C.4    Wen, J.5
  • 15
    • 84923197605 scopus 로고    scopus 로고
    • Comprehensive genomic characterization of head and neck squamous cell carcinomas
    • Cancer Genome Atlas Network
    • Cancer Genome Atlas Network. Comprehensive genomic characterization of head and neck squamous cell carcinomas. Nature 2015, 517, 576–582.
    • (2015) Nature , vol.517 , pp. 576-582
  • 16
    • 48549102989 scopus 로고    scopus 로고
    • The p53 homologue DNp63a interacts with the nuclear factor-kB pathway to modulate epithelial cell growth
    • [CrossRef] [PubMed]
    • King, K.E.; Ponnamperuma, R.M.; Allen, C.; Lu, H.; Duggal, P.; Chen, Z.; van Waes, C.; Weinberg, W.C. The p53 homologue DNp63a interacts with the nuclear factor-kB pathway to modulate epithelial cell growth. Cancer Res. 2008, 68, 5122–5131. [CrossRef] [PubMed]
    • (2008) Cancer Res , vol.68 , pp. 5122-5131
    • King, K.E.1    Ponnamperuma, R.M.2    Allen, C.3    Lu, H.4    Duggal, P.5    Chen, Z.6    Van Waes, C.7    Weinberg, W.C.8
  • 17
    • 80155126633 scopus 로고    scopus 로고
    • TNF-k promotes c-REL/DeltaNp63alpha interaction and TAp73 dissociation from key genes that mediate growth arrest and apoptosis in head and neck cancer
    • [CrossRef] [PubMed]
    • Lu, H.; Yang, X.; Duggal, P.; Allen, C.T.; Yan, B.; Cohen, J.; Nottingham, L.; Romano, R.A.; Sinha, S.; King, K.E., et al. TNF-k promotes c-REL/DeltaNp63alpha interaction and TAp73 dissociation from key genes that mediate growth arrest and apoptosis in head and neck cancer. Cancer Res. 2011, 71, 6867–6877. [CrossRef] [PubMed]
    • (2011) Cancer Res , vol.71 , pp. 6867-6877
    • Lu, H.1    Yang, X.2    Duggal, P.3    Allen, C.T.4    Yan, B.5    Cohen, J.6    Nottingham, L.7    Romano, R.A.8    Sinha, S.9    King, K.E.10
  • 18
    • 79956083467 scopus 로고    scopus 로고
    • DNp63 versatilely regulates a Broad NF-kB gene program and promotes squamous epithelial proliferation, migration, and inflammation
    • [CrossRef] [PubMed]
    • Yang, X.; Lu, H.; Yan, B.; Romano, R.A.; Bian, Y.; Friedman, J.; Duggal, P.; Allen, C.; Chuang, R.; Ehsanian, R., et al. DNp63 versatilely regulates a Broad NF-kB gene program and promotes squamous epithelial proliferation, migration, and inflammation. Cancer Res. 2011, 71, 3688–3700. [CrossRef] [PubMed]
    • (2011) Cancer Res , vol.71 , pp. 3688-3700
    • Yang, X.1    Lu, H.2    Yan, B.3    Romano, R.A.4    Bian, Y.5    Friedman, J.6    Duggal, P.7    Allen, C.8    Chuang, R.9    Ehsanian, R.10
  • 19
    • 84892380785 scopus 로고    scopus 로고
    • Epidermal overexpression of transgenic DNp63 promotes type 2 immune and myeloid inflammatory responses and hyperplasia via NF-kB activation
    • [CrossRef] [PubMed]
    • Du, J.; Romano, R.A.; Si, H.; Mattox, A.; Bian, Y.; Yang, X.; Sinha, S.; van Waes, C.; Chen, Z. Epidermal overexpression of transgenic DNp63 promotes type 2 immune and myeloid inflammatory responses and hyperplasia via NF-kB activation. J. Pathol. 2014, 232, 356–368. [CrossRef] [PubMed]
    • (2014) J. Pathol , vol.232 , pp. 356-368
    • Du, J.1    Romano, R.A.2    Si, H.3    Mattox, A.4    Bian, Y.5    Yang, X.6    Sinha, S.7    Van Waes, C.8    Chen, Z.9
  • 20
    • 0035953308 scopus 로고    scopus 로고
    • IFNgamma and lymphocytes prevent primary tumour development and shape tumour immunogenicity
    • [CrossRef] [PubMed]
    • Shankaran, V.; Ikeda, H.; Bruce, A.T.; White, J.M.; Swanson, P.E.; Old, L.J.; Schreiber, R.D. IFNgamma and lymphocytes prevent primary tumour development and shape tumour immunogenicity. Nature 2001, 410, 1107–1111. [CrossRef] [PubMed]
    • (2001) Nature , vol.410 , pp. 1107-1111
    • Shankaran, V.1    Ikeda, H.2    Bruce, A.T.3    White, J.M.4    Swanson, P.E.5    Old, L.J.6    Schreiber, R.D.7
  • 23
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • [CrossRef] [PubMed]
    • Hanahan, D.; Weinberg, R.A. Hallmarks of cancer: The next generation. Cell 2011, 144, 646–674. [CrossRef] [PubMed]
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 24
  • 25
    • 84255191129 scopus 로고    scopus 로고
    • The clinical implications of antitumor immunity in head and neck cancer
    • [CrossRef] [PubMed]
    • Allen, C.T.; Judd, N.P.; Bui, J.D.; Uppaluri, R. The clinical implications of antitumor immunity in head and neck cancer. Laryngoscope 2012, 122, 144–157. [CrossRef] [PubMed]
    • (2012) Laryngoscope , vol.122 , pp. 144-157
    • Allen, C.T.1    Judd, N.P.2    Bui, J.D.3    Uppaluri, R.4
  • 28
    • 84908251881 scopus 로고    scopus 로고
    • Genomic and bioinformatic profiling of mutational neoepitopes reveals new rules to predict anticancer immunogenicity
    • [CrossRef] [PubMed]
    • Duan, F.; Duitama, J.; Al Seesi, S.; Ayres, C.M.; Corcelli, S.A.; Pawashe, A.P.; Blanchard, T.; McMahon, D.; Sidney, J.; Sette, A., et al. Genomic and bioinformatic profiling of mutational neoepitopes reveals new rules to predict anticancer immunogenicity. J. Exp. Med. 2014, 211, 2231–2248. [CrossRef] [PubMed]
    • (2014) J. Exp. Med , vol.211 , pp. 2231-2248
    • Duan, F.1    Duitama, J.2    Al Seesi, S.3    Ayres, C.M.4    Corcelli, S.A.5    Pawashe, A.P.6    Blanchard, T.7    McMahon, D.8    Sidney, J.9    Sette, A.10
  • 29
    • 84899061145 scopus 로고    scopus 로고
    • Exomics and immunogenics: Bridging mutational load and immune checkpoints efficacy
    • [CrossRef] [PubMed]
    • Champiat, S.; Ferte, C.; Lebel-Binay, S.; Eggermont, A.; Soria, J.C. Exomics and immunogenics: Bridging mutational load and immune checkpoints efficacy. Oncoimmunology 2014, 3, e27817. [CrossRef] [PubMed]
    • (2014) Oncoimmunology , vol.3
    • Champiat, S.1    Ferte, C.2    Lebel-Binay, S.3    Eggermont, A.4    Soria, J.C.5
  • 30
    • 0036852191 scopus 로고    scopus 로고
    • Natural selection of tumor variants in the generation of “tumor escape” phenotypes
    • [CrossRef] [PubMed]
    • Khong, H.T.; Restifo, N.P. Natural selection of tumor variants in the generation of “tumor escape” phenotypes. Nat. Immunol. 2002, 3, 999–1005. [CrossRef] [PubMed]
    • (2002) Nat. Immunol , vol.3 , pp. 999-1005
    • Khong, H.T.1    Restifo, N.P.2
  • 31
    • 0036852241 scopus 로고    scopus 로고
    • Cancer immunoediting: From immunosurveillance to tumor escape
    • [CrossRef] [PubMed]
    • Dunn, G.P.; Bruce, A.T.; Ikeda, H.; Old, L.J.; Schreiber, R.D. Cancer immunoediting: From immunosurveillance to tumor escape. Nat. Immunol. 2002, 3, 991–998. [CrossRef] [PubMed]
    • (2002) Nat. Immunol , vol.3 , pp. 991-998
    • Dunn, G.P.1    Bruce, A.T.2    Ikeda, H.3    Old, L.J.4    Schreiber, R.D.5
  • 33
    • 0003135066 scopus 로고
    • The treatment of inoperable sarcoma by bacterial toxins (The mixed toxins of the Streptococcus erysipelas and the Bacillus prodigiosus)
    • [PubMed]
    • Coley, W.B. The treatment of inoperable sarcoma by bacterial toxins (the mixed toxins of the Streptococcus erysipelas and the Bacillus prodigiosus). Proc. R. Soc. Med. 1910, 3, 1–48. [PubMed]
    • (1910) Proc. R. Soc. Med , vol.3 , pp. 1-48
    • Coley, W.B.1
  • 34
    • 84920516915 scopus 로고    scopus 로고
    • Tumor infiltrating lymphocytes (TIL) and prognosis in oral cavity squamous carcinoma: A preliminary study
    • [CrossRef] [PubMed]
    • Wolf, G.T.; Chepeha, D.B.; Bellile, E.; Nguyen, A.; Thomas, D.; McHugh, J. Tumor infiltrating lymphocytes (TIL) and prognosis in oral cavity squamous carcinoma: A preliminary study. Oral. Oncol. 2015, 51, 90–95. [CrossRef] [PubMed]
    • (2015) Oral. Oncol , vol.51 , pp. 90-95
    • Wolf, G.T.1    Chepeha, D.B.2    Bellile, E.3    Nguyen, A.4    Thomas, D.5    McHugh, J.6
  • 36
    • 84892946785 scopus 로고    scopus 로고
    • Tumour-infiltrating lymphocytes predict response to definitive chemoradiotherapy in head and neck cancer
    • [CrossRef] [PubMed]
    • Balermpas, P.; Michel, Y.; Wagenblast, J.; Seitz, O.; Weiss, C.; Rodel, F.; Rodel, C.; Fokas, E. Tumour-infiltrating lymphocytes predict response to definitive chemoradiotherapy in head and neck cancer. Br. J. Cancer 2014, 110, 501–509. [CrossRef] [PubMed]
    • (2014) Br. J. Cancer , vol.110 , pp. 501-509
    • Balermpas, P.1    Michel, Y.2    Wagenblast, J.3    Seitz, O.4    Weiss, C.5    Rodel, F.6    Rodel, C.7    Fokas, E.8
  • 38
    • 84944255998 scopus 로고    scopus 로고
    • CD8+ tumour-infiltrating lymphocytes in relation to HPV status and clinical outcome in patients with head and neck cancer after postoperative chemoradiotherapy: A multicentre study of the German Cancer Consortium Radiation Oncology Group (DKTK-ROG)
    • [CrossRef] [PubMed]
    • Balermpas, P.; Rodel, F.; Rodel, C.; Krause, M.; Linge, A.; Lohaus, F.; Baumann, M.; Tinhofer, I.; Budach, V.; Gkika, E., et al. CD8+ tumour-infiltrating lymphocytes in relation to HPV status and clinical outcome in patients with head and neck cancer after postoperative chemoradiotherapy: A multicentre study of the German Cancer Consortium Radiation Oncology Group (DKTK-ROG). Int. J. Cancer 2015. [CrossRef] [PubMed]
    • (2015) Int. J. Cancer
    • Balermpas, P.1    Rodel, F.2    Rodel, C.3    Krause, M.4    Linge, A.5    Lohaus, F.6    Baumann, M.7    Tinhofer, I.8    Budach, V.9    Gkika, E.10
  • 39
    • 1642577616 scopus 로고
    • Immune surveillance against virus-induced tumors and nonrejectability of spontaneous tumors: Contrasting consequences of host versus tumor evolution
    • [CrossRef] [PubMed]
    • Klein, G.; Klein, E. Immune surveillance against virus-induced tumors and nonrejectability of spontaneous tumors: Contrasting consequences of host versus tumor evolution. Proc. Natl. Acad. Sci. USA 1977, 74, 2121–2125. [CrossRef] [PubMed]
    • (1977) Proc. Natl. Acad. Sci. USA , vol.74 , pp. 2121-2125
    • Klein, G.1    Klein, E.2
  • 40
    • 84924388105 scopus 로고    scopus 로고
    • Intra-tumor genetic heterogeneity and mortality in head and neck cancer: Analysis of data from the Cancer Genome Atlas
    • [CrossRef] [PubMed]
    • Mroz, E.A.; Tward, A.D.; Hammon, R.J.; Ren, Y.; Rocco, J.W. Intra-tumor genetic heterogeneity and mortality in head and neck cancer: Analysis of data from the Cancer Genome Atlas. PLoS Med. 2015, 12, e1001786. [CrossRef] [PubMed]
    • (2015) Plos Med , vol.12
    • Mroz, E.A.1    Tward, A.D.2    Hammon, R.J.3    Ren, Y.4    Rocco, J.W.5
  • 41
    • 46949109577 scopus 로고    scopus 로고
    • Immunogenicity of premalignant lesions is the primary cause of general cytotoxic T lymphocyte unresponsiveness
    • [CrossRef] [PubMed]
    • Willimsky, G.; Czeh, M.; Loddenkemper, C.; Gellermann, J.; Schmidt, K.; Wust, P.; Stein, H.; Blankenstein, T. Immunogenicity of premalignant lesions is the primary cause of general cytotoxic T lymphocyte unresponsiveness. J. Exp. Med. 2008, 205, 1687–1700. [CrossRef] [PubMed]
    • (2008) J. Exp. Med , vol.205 , pp. 1687-1700
    • Willimsky, G.1    Czeh, M.2    Loddenkemper, C.3    Gellermann, J.4    Schmidt, K.5    Wust, P.6    Stein, H.7    Blankenstein, T.8
  • 42
    • 42349112060 scopus 로고    scopus 로고
    • Loss of CTL function among high-avidity tumor-specific CD8+ T cells following tumor infiltration
    • [CrossRef] [PubMed]
    • Janicki, C.N.; Jenkinson, S.R.; Williams, N.A.; Morgan, D.J. Loss of CTL function among high-avidity tumor-specific CD8+ T cells following tumor infiltration. Cancer Res. 2008, 68, 2993–3000. [CrossRef] [PubMed]
    • (2008) Cancer Res , vol.68 , pp. 2993-3000
    • Janicki, C.N.1    Jenkinson, S.R.2    Williams, N.A.3    Morgan, D.J.4
  • 43
    • 33845193274 scopus 로고    scopus 로고
    • On the definition of a criterion of immunogenicity
    • [CrossRef] [PubMed]
    • Pradeu, T.; Carosella, E.D. On the definition of a criterion of immunogenicity. Proc. Natl. Acad. Sci. USA 2006, 103, 17858–17861. [CrossRef] [PubMed]
    • (2006) Proc. Natl. Acad. Sci. USA , vol.103 , pp. 17858-17861
    • Pradeu, T.1    Carosella, E.D.2
  • 45
    • 84893637182 scopus 로고    scopus 로고
    • STING-dependent cytosolic DNA sensing pathways
    • [CrossRef] [PubMed]
    • Barber, G.N. STING-dependent cytosolic DNA sensing pathways. Trends Immunol. 2014, 35, 88–93. [CrossRef] [PubMed]
    • (2014) Trends Immunol , vol.35 , pp. 88-93
    • Barber, G.N.1
  • 46
    • 84859883741 scopus 로고    scopus 로고
    • Cancer and innate immune system interactions: Translational potentials for cancer immunotherapy
    • [CrossRef] [PubMed]
    • Liu, Y.; Zeng, G. Cancer and innate immune system interactions: Translational potentials for cancer immunotherapy. J. Immunother. 2012, 35, 299–308. [CrossRef] [PubMed]
    • (2012) J. Immunother , vol.35 , pp. 299-308
    • Liu, Y.1    Zeng, G.2
  • 47
    • 84929583365 scopus 로고    scopus 로고
    • Targeting Toll-like receptor 2 inhibits growth of head and neck squamous cell carcinoma
    • [CrossRef] [PubMed]
    • Farnebo, L.; Shahangian, A.; Lee, Y.; Shin, J.H.; Scheeren, F.A.; Sunwoo, J.B. Targeting Toll-like receptor 2 inhibits growth of head and neck squamous cell carcinoma. Oncotarget 2015, 6, 9897–9907. [CrossRef] [PubMed]
    • (2015) Oncotarget , vol.6 , pp. 9897-9907
    • Farnebo, L.1    Shahangian, A.2    Lee, Y.3    Shin, J.H.4    Scheeren, F.A.5    Sunwoo, J.B.6
  • 48
    • 33746075583 scopus 로고    scopus 로고
    • Immune escape associated with functional defects in antigen-processing machinery in head and neck cancer
    • [CrossRef] [PubMed]
    • Ferris, L.R.; Whiteside, T.L.; Ferrone, S. Immune escape associated with functional defects in antigen-processing machinery in head and neck cancer. Clin. Cancer Res. 2006, 12, 3890–3895. [CrossRef] [PubMed]
    • (2006) Clin. Cancer Res , vol.12 , pp. 3890-3895
    • Ferris, L.R.1    Whiteside, T.L.2    Ferrone, S.3
  • 49
    • 33748987908 scopus 로고    scopus 로고
    • Cancer despite immunosurveillance: Immunoselection and immunosubversion
    • [CrossRef] [PubMed]
    • Zitvogel, L.; Tesniere, A.; Kroemer, G. Cancer despite immunosurveillance: Immunoselection and immunosubversion. Nat. Rev. Immunol. 2006, 6, 715–727. [CrossRef] [PubMed]
    • (2006) Nat. Rev. Immunol , vol.6 , pp. 715-727
    • Zitvogel, L.1    Tesniere, A.2    Kroemer, G.3
  • 50
    • 84901290212 scopus 로고    scopus 로고
    • Releasing pressure in tumors: What do we know so far and where do we go from here? A review
    • [CrossRef] [PubMed]
    • Ariffin, A.B.; Forde, P.F.; Jahangeer, S.; Soden, D.M.; Hinchion, J. Releasing pressure in tumors: What do we know so far and where do we go from here? A review. Cancer Res. 2014, 74, 2655–2662. [CrossRef] [PubMed]
    • (2014) Cancer Res , vol.74 , pp. 2655-2662
    • Ariffin, A.B.1    Forde, P.F.2    Jahangeer, S.3    Soden, D.M.4    Hinchion, J.5
  • 51
    • 84991455944 scopus 로고    scopus 로고
    • Immune consequences of decreasing tumor vasculature with antiangiogenic tyrosine kinase inhibitors in combination with therapeutic vaccines
    • [CrossRef] [PubMed]
    • Farsaci, B.; Donahue, R.N.; Coplin, M.A.; Grenga, I.; Lepone, L.M.; Molinolo, A.A.; Hodge, J.W. Immune consequences of decreasing tumor vasculature with antiangiogenic tyrosine kinase inhibitors in combination with therapeutic vaccines. Cancer Immunol. Res. 2014, 2, 1090–1102. [CrossRef] [PubMed]
    • (2014) Cancer Immunol. Res , vol.2 , pp. 1090-1102
    • Farsaci, B.1    Donahue, R.N.2    Coplin, M.A.3    Grenga, I.4    Lepone, L.M.5    Molinolo, A.A.6    Hodge, J.W.7
  • 53
    • 35148881028 scopus 로고    scopus 로고
    • Drug resistance and the solid tumor microenvironment
    • [CrossRef] [PubMed]
    • Tredan, O.; Galmarini, C.M.; Patel, K.; Tannock, I.F. Drug resistance and the solid tumor microenvironment. J. Natl. Cancer Inst. 2007, 99, 1441–1454. [CrossRef] [PubMed]
    • (2007) J. Natl. Cancer Inst , vol.99 , pp. 1441-1454
    • Tredan, O.1    Galmarini, C.M.2    Patel, K.3    Tannock, I.F.4
  • 54
    • 84941587271 scopus 로고    scopus 로고
    • Immune consequences of tyrosine kinase inhibitors that synergize with cancer immunotherapy
    • CrossRef
    • Kwilas, A.R.; Donahue, R.N.; Tsang, K.Y.; Hodge, J.W. Immune consequences of tyrosine kinase inhibitors that synergize with cancer immunotherapy. Cancer Cell Microenviron. 2015, 2. [CrossRef]
    • (2015) Cancer Cell Microenviron
    • Kwilas, A.R.1    Donahue, R.N.2    Tsang, K.Y.3    Hodge, J.W.4
  • 56
    • 0035421326 scopus 로고    scopus 로고
    • Hepatocyte growth factor/scatter factor-induced activation of MEK and PI3K signal pathways contributes to expression of proangiogenic cytokines interleukin-8 and vascular endothelial growth factor in head and neck squamous cell carcinoma
    • [PubMed]
    • Dong, G.; Chen, Z.; Li, Z.Y.; Yeh, N.T.; Bancroft, C.C.; van Waes, C. Hepatocyte growth factor/scatter factor-induced activation of MEK and PI3K signal pathways contributes to expression of proangiogenic cytokines interleukin-8 and vascular endothelial growth factor in head and neck squamous cell carcinoma. Cancer Res. 2001, 61, 5911–5918. [PubMed]
    • (2001) Cancer Res , vol.61 , pp. 5911-5918
    • Dong, G.1    Chen, Z.2    Li, Z.Y.3    Yeh, N.T.4    Bancroft, C.C.5    Van Waes, C.6
  • 57
    • 61349100687 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells as regulators of the immune system
    • [CrossRef] [PubMed]
    • Gabrilovich, I.D.; Nagaraj, S. Myeloid-derived suppressor cells as regulators of the immune system. Nat. Rev. Immunol. 2009, 9, 162–174. [CrossRef] [PubMed]
    • (2009) Nat. Rev. Immunol , vol.9 , pp. 162-174
    • Gabrilovich, I.D.1    Nagaraj, S.2
  • 59
    • 84887512876 scopus 로고    scopus 로고
    • CXCR2-expressing myeloid-derived suppressor cells are essential to promote colitis-associated tumorigenesis
    • [CrossRef] [PubMed]
    • Katoh, H.; Wang, D.; Daikoku, T.; Sun, H.; Dey, S.K.; Dubois, R.N. CXCR2-expressing myeloid-derived suppressor cells are essential to promote colitis-associated tumorigenesis. Cancer Cell 2013, 24, 631–644. [CrossRef] [PubMed]
    • (2013) Cancer Cell , vol.24 , pp. 631-644
    • Katoh, H.1    Wang, D.2    Daikoku, T.3    Sun, H.4    Dey, S.K.5    Dubois, R.N.6
  • 60
    • 84857219446 scopus 로고    scopus 로고
    • Monocytic CCR2+ myeloid-derived suppressor cells promote immune escape by limiting activated CD8 T-cell infiltration into the tumor microenvironment
    • [CrossRef] [PubMed]
    • Lesokhin, A.M.; Hohl, T.M.; Kitano, S.; Cortez, C.; Hirschhorn-Cymerman, D.; Avogadri, F.; Rizzuto, G.A.; Lazarus, J.J.; Pamer, E.G.; Houghton, A.N., et al. Monocytic CCR2+ myeloid-derived suppressor cells promote immune escape by limiting activated CD8 T-cell infiltration into the tumor microenvironment. Cancer Res. 2012, 72, 876–886. [CrossRef] [PubMed]
    • (2012) Cancer Res , vol.72 , pp. 876-886
    • Lesokhin, A.M.1    Hohl, T.M.2    Kitano, S.3    Cortez, C.4    Hirschhorn-Cymerman, D.5    Avogadri, F.6    Rizzuto, G.A.7    Lazarus, J.J.8    Pamer, E.G.9    Houghton, A.N.10
  • 62
    • 0034551670 scopus 로고    scopus 로고
    • Identification of a CD11b+/Gr-1+/CD31+ myeloid progenitor capable of activating or suppressing CD8+ T cells
    • [PubMed]
    • Bronte, V.; Apolloni, E.; Cabrelle, A.; Ronca, R.; Serafini, P.; Zamboni, P.; Restifo, N.P.; Zanovello, P. Identification of a CD11b+/Gr-1+/CD31+ myeloid progenitor capable of activating or suppressing CD8+ T cells. Blood 2000, 96, 3838–3846. [PubMed]
    • (2000) Blood , vol.96 , pp. 3838-3846
    • Bronte, V.1    Apolloni, E.2    Cabrelle, A.3    Ronca, R.4    Serafini, P.5    Zamboni, P.6    Restifo, N.P.7    Zanovello, P.8
  • 65
    • 1342324748 scopus 로고    scopus 로고
    • Depletion of CXCR2 inhibits tumor growth and angiogenesis in a murine model of lung cancer
    • [CrossRef] [PubMed]
    • Keane, M.P.; Belperio, J.A.; Xue, Y.Y.; Burdick, M.D.; Strieter, R.M. Depletion of CXCR2 inhibits tumor growth and angiogenesis in a murine model of lung cancer. J. Immunol. 2004, 172, 2853–2360. [CrossRef] [PubMed]
    • (2004) J. Immunol , vol.172 , pp. 2360-2853
    • Keane, M.P.1    Belperio, J.A.2    Xue, Y.Y.3    Burdick, M.D.4    Strieter, R.M.5
  • 66
    • 84907484156 scopus 로고    scopus 로고
    • CSF1/CSF1R blockade reprograms tumor-infiltrating macrophages and improves response to T-cell checkpoint immunotherapy in pancreatic cancer models
    • [CrossRef] [PubMed]
    • Zhu, Y.; Knolhoff, B.L.; Meyer, M.A.; Nywening, T.M.; West, B.L.; Luo, J.; Wang-Gillam, A.; Goedegebuure, S.P.; Linehan, D.C.; DeNardo, D.G. CSF1/CSF1R blockade reprograms tumor-infiltrating macrophages and improves response to T-cell checkpoint immunotherapy in pancreatic cancer models. Cancer Res. 2014, 74, 5057–5069. [CrossRef] [PubMed]
    • (2014) Cancer Res , vol.74 , pp. 5057-5069
    • Zhu, Y.1    Knolhoff, B.L.2    Meyer, M.A.3    Nywening, T.M.4    West, B.L.5    Luo, J.6    Wang-Gillam, A.7    Goedegebuure, S.P.8    Linehan, D.C.9    Denardo, D.G.10
  • 68
    • 0030979282 scopus 로고    scopus 로고
    • Increased recurrence and metastasis in patients whose primary head and neck squamous cell carcinomas secreted granulocyte-macrophage colony-stimulating factor and contained CD34+ natural suppressor cells
    • CrossRef
    • Young, M.R.; Wright, M.A.; Lozano, Y.; Prechel, M.M.; Benefield, J.; Leonetti, J.P.; Collins, S.L.; Petruzzelli, G.J. Increased recurrence and metastasis in patients whose primary head and neck squamous cell carcinomas secreted granulocyte-macrophage colony-stimulating factor and contained CD34+ natural suppressor cells. Int. J. Cancer 1997, 74, 69–74. [CrossRef]
    • (1997) Int. J. Cancer , vol.74 , pp. 69-74
    • Oung, M.R.1    Wright, M.A.2    Lozano, Y.3    Prechel, M.M.4    Benefield, J.5    Leonetti, J.P.6    Collins, S.L.7    Petruzzelli, G.J.8
  • 69
    • 84907029151 scopus 로고    scopus 로고
    • Noncanonical NF-kB activation mediates STAT3-stimulated IDO upregulation in myeloid-derived suppressor cells in breast cancer
    • [CrossRef] [PubMed]
    • Yu, J.; Wang, Y.; Yan, F.; Zhang, P.; Li, H.; Zhao, H.; Yan, C.; Yan, F.; Ren, X. Noncanonical NF-kB activation mediates STAT3-stimulated IDO upregulation in myeloid-derived suppressor cells in breast cancer. J. Immunol. 2014, 193, 2574–2586. [CrossRef] [PubMed]
    • (2014) J. Immunol , vol.193 , pp. 2574-2586
    • Yu, J.1    Wang, Y.2    Yan, F.3    Zhang, P.4    Li, H.5    Zhao, H.6    Yan, C.7    Yan, F.8    Ren, X.9
  • 70
    • 84904406680 scopus 로고    scopus 로고
    • Tumor-associated macrophages: From mechanisms to therapy
    • [CrossRef] [PubMed]
    • Noy, R.; Pollard, J.W. Tumor-associated macrophages: From mechanisms to therapy. Immunity 2014, 41, 49–61. [CrossRef] [PubMed]
    • (2014) Immunity , vol.41 , pp. 49-61
    • Noy, R.1    Pollard, J.W.2
  • 72
    • 84873412294 scopus 로고    scopus 로고
    • Tumor-associated macrophages and the profile of inflammatory cytokines in oral squamous cell carcinoma
    • [CrossRef] [PubMed]
    • Costa, N.L.; Valadares, M.C.; Souza, P.P.; Mendonca, E.F.; Oliveira, J.C.; Silva, T.A.; Batista, A.C. Tumor-associated macrophages and the profile of inflammatory cytokines in oral squamous cell carcinoma. Oral. Oncol. 2013, 49, 216–223. [CrossRef] [PubMed]
    • (2013) Oral. Oncol , vol.49 , pp. 216-223
    • Costa, N.L.1    Valadares, M.C.2    Souza, P.P.3    Mendonca, E.F.4    Oliveira, J.C.5    Silva, T.A.6    Batista, A.C.7
  • 73
    • 22144439081 scopus 로고    scopus 로고
    • Tumor antigen-specific T helper cells in cancer immunity and immunotherapy
    • [CrossRef] [PubMed]
    • Knutson, L.K.; Disis, M.L. Tumor antigen-specific T helper cells in cancer immunity and immunotherapy. Cancer Immunol. Immunother. 2005, 54, 721–728. [CrossRef] [PubMed]
    • (2005) Cancer Immunol. Immunother , vol.54 , pp. 721-728
    • Knutson, L.K.1    Disis, M.L.2
  • 74
    • 84887832812 scopus 로고    scopus 로고
    • Intratumoral regulatory T cells upregulate immunosuppressive molecules in head and neck cancer patients
    • [CrossRef] [PubMed]
    • Jie, H.B.; Gildener-Leapman, N.; Li, J.; Srivastava, R.M.; Gibson, S.P.; Whiteside, T.L.; Ferris, R.L. Intratumoral regulatory T cells upregulate immunosuppressive molecules in head and neck cancer patients. Br. J. Cancer 2013, 109, 2629–2635. [CrossRef] [PubMed]
    • (2013) Br. J. Cancer , vol.109 , pp. 2629-2635
    • Jie, H.B.1    Gildener-Leapman, N.2    Li, J.3    Srivastava, R.M.4    Gibson, S.P.5    Whiteside, T.L.6    Ferris, R.L.7
  • 75
    • 34547655923 scopus 로고    scopus 로고
    • A unique subset of CD4+CD25highFoxp3+ T cells secreting interleukin-10 and transforming growth factor-beta1 mediates suppression in the tumor microenvironment
    • [CrossRef] [PubMed]
    • Strauss, L.; Bergmann, C.; Szczepanski, M.; Gooding, W.; Johnson, J.T.; Whiteside, T.L. A unique subset of CD4+CD25highFoxp3+ T cells secreting interleukin-10 and transforming growth factor-beta1 mediates suppression in the tumor microenvironment. Clin. Cancer Res. 2007, 13, 4345–4354. [CrossRef] [PubMed]
    • (2007) Clin. Cancer Res , vol.13 , pp. 4345-4354
    • Strauss, L.1    Bergmann, C.2    Szczepanski, M.3    Gooding, W.4    Johnson, J.T.5    Whiteside, T.L.6
  • 76
    • 33847183114 scopus 로고    scopus 로고
    • Increase in circulating Foxp3+CD4+CD25high regulatory T cells in nasopharyngeal carcinoma patients
    • [CrossRef] [PubMed]
    • Lau, K.M.; Cheng, S.H.; Lo, K.W.; Lee, S.A.; Woo, J.K.; van Hasselt, C.A.; Lee, S.P.; Rickinson, A.B.; Ng, M.H. Increase in circulating Foxp3+CD4+CD25high regulatory T cells in nasopharyngeal carcinoma patients. Br. J. Cancer 2007, 96, 617–622. [CrossRef] [PubMed]
    • (2007) Br. J. Cancer , vol.96 , pp. 617-622
    • Lau, K.M.1    Cheng, S.H.2    Lo, K.W.3    Lee, S.A.4    Woo, J.K.5    Van Hasselt, C.A.6    Lee, S.P.7    Rickinson, A.B.8    Ng, M.H.9
  • 77
    • 16244409219 scopus 로고    scopus 로고
    • Characteristics of CD4+CD25+ regulatory T cells in the peripheral circulation of patients with head and neck cancer
    • [CrossRef] [PubMed]
    • Schaefer, C.; Kim, G.G.; Albers, A.; Hoermann, K.; Myers, E.N.; Whiteside, T.L. Characteristics of CD4+CD25+ regulatory T cells in the peripheral circulation of patients with head and neck cancer. Br. J. Cancer 2005, 92, 913–920. [CrossRef] [PubMed]
    • (2005) Br. J. Cancer , vol.92 , pp. 913-920
    • Schaefer, C.1    Kim, G.G.2    Albers, A.3    Hoermann, K.4    Myers, E.N.5    Whiteside, T.L.6
  • 78
    • 84862306564 scopus 로고    scopus 로고
    • Characterization of the evolution of immune phenotype during the development and progression of squamous cell carcinoma of the head and neck
    • [CrossRef] [PubMed]
    • De Costa, A.M.; Schuyler, C.A.; Walker, D.D.; Young, M.R. Characterization of the evolution of immune phenotype during the development and progression of squamous cell carcinoma of the head and neck. Cancer Immunol. Immunother. 2012, 61, 927–939. [CrossRef] [PubMed]
    • (2012) Cancer Immunol. Immunother , vol.61 , pp. 927-939
    • De Costa, A.M.1    Schuyler, C.A.2    Walker, D.D.3    Young, M.R.4
  • 79
    • 24344436369 scopus 로고    scopus 로고
    • Sporadic immunogenic tumours avoid destruction by inducing T-cell tolerance
    • [CrossRef] [PubMed]
    • Willimsky, G.; Blankenstein, T. Sporadic immunogenic tumours avoid destruction by inducing T-cell tolerance. Nature 2005, 437, 141–146. [CrossRef] [PubMed]
    • (2005) Nature , vol.437 , pp. 141-146
    • Willimsky, G.1    Blankenstein, T.2
  • 80
    • 44349150012 scopus 로고    scopus 로고
    • Inhibitory B7-family molecules in the tumour microenvironment
    • [CrossRef] [PubMed]
    • Zou, W.; Chen, L. Inhibitory B7-family molecules in the tumour microenvironment. Nat. Rev. Immunol. 2008, 8, 467–477. [CrossRef] [PubMed]
    • (2008) Nat. Rev. Immunol , vol.8 , pp. 467-477
    • Zou, W.1    Chen, L.2
  • 81
    • 18544380239 scopus 로고    scopus 로고
    • Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion
    • [CrossRef] [PubMed]
    • Dong, H.; Strome, S.E.; Salomao, D.R.; Tamura, H.; Hirano, F.; Flies, D.B.; Roche, P.C.; Lu, J.; Zhu, G.; Tamada, K., et al. Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion. Nat. Med. 2002, 8, 793–800. [CrossRef] [PubMed]
    • (2002) Nat. Med , vol.8 , pp. 793-800
    • Dong, H.1    Strome, S.E.2    Salomao, D.R.3    Tamura, H.4    Hirano, F.5    Flies, D.B.6    Roche, P.C.7    Lu, J.8    Zhu, G.9    Tamada, K.10
  • 82
    • 84928062583 scopus 로고    scopus 로고
    • Immune checkpoint blockade: A common denominator approach to cancer therapy
    • [CrossRef] [PubMed]
    • Topalian, L.S.; Drake, C.G.; Pardoll, D.M. Immune checkpoint blockade: A common denominator approach to cancer therapy. Cancer Cell 2015, 27, 450–461. [CrossRef] [PubMed]
    • (2015) Cancer Cell , vol.27 , pp. 450-461
    • Topalian, L.S.1    Drake, C.G.2    Pardoll, D.M.3
  • 83
    • 84883863501 scopus 로고    scopus 로고
    • Up-regulation of PD-L1, IDO, and Tregs in the melanoma tumor microenvironment is driven by CD8+ T cells
    • [CrossRef] [PubMed]
    • Spranger, S.; Spaapen, R.M.; Zha, Y.; Williams, J.; Meng, Y.; Ha, T.T.; Gajewski, T.F. Up-regulation of PD-L1, IDO, and Tregs in the melanoma tumor microenvironment is driven by CD8+ T cells. Sci. Trans. Med. 2013, 5. [CrossRef] [PubMed]
    • (2013) Sci. Trans. Med
    • Spranger, S.1    Spaapen, R.M.2    Zha, Y.3    Williams, J.4    Meng, Y.5    Ha, T.T.6    Gajewski, T.F.7
  • 84
    • 84859128199 scopus 로고    scopus 로고
    • Colocalization of inflammatory response with B7-h1 expression in human melanocytic lesions supports an adaptive resistance mechanism of immune escape
    • [CrossRef] [PubMed]
    • Taube, J.M.; Anders, R.A.; Young, G.D.; Xu, H.; Sharma, R.; McMiller, T.L.; Chen, S.; Klein, A.P.; Pardoll, D.M.; Topalian, S.L., et al. Colocalization of inflammatory response with B7-h1 expression in human melanocytic lesions supports an adaptive resistance mechanism of immune escape. Sci. Trans. Med. 2012, 4. [CrossRef] [PubMed]
    • (2012) Sci. Trans. Med
    • Taube, J.M.1    Anders, R.A.2    Young, G.D.3    Xu, H.4    Sharma, R.5    McMiller, T.L.6    Chen, S.7    Klein, A.P.8    Pardoll, D.M.9    Topalian, S.L.10
  • 85
    • 84858766182 scopus 로고    scopus 로고
    • The blockade of immune checkpoints in cancer immunotherapy
    • [CrossRef] [PubMed]
    • Pardoll, D.M. The blockade of immune checkpoints in cancer immunotherapy. Nat. Rev. Cancer 2012, 12, 252–264. [CrossRef] [PubMed]
    • (2012) Nat. Rev. Cancer , vol.12 , pp. 252-264
    • Pardoll, D.M.1
  • 89
    • 84943143291 scopus 로고    scopus 로고
    • Current Status and Future Directions of the Immune Checkpoint Inhibitors Ipilimumab, Pembrolizumab, and Nivolumab in Oncology
    • [CrossRef] [PubMed]
    • Barbee, M.S.; Ogunniyi, A.; Horvat, T.Z.; Dang, T.O. Current Status and Future Directions of the Immune Checkpoint Inhibitors Ipilimumab, Pembrolizumab, and Nivolumab in Oncology. Ann. Pharmacother. 2015, 49, 907–937. [CrossRef] [PubMed]
    • (2015) Ann. Pharmacother , vol.49 , pp. 907-937
    • Barbee, M.S.1    Ogunniyi, A.2    Horvat, T.Z.3    Dang, T.O.4
  • 90
    • 84920666147 scopus 로고    scopus 로고
    • Tadalafil reduces myeloid-derived suppressor cells and regulatory T cells and promotes tumor immunity in patients with head and neck squamous cell carcinoma
    • [CrossRef] [PubMed]
    • Weed, D.T.; Vella, J.L.; Reis, I.M.; De la Fuente, A.C.; Gomez, C.; Sargi, Z.; Nazarian, R.; Califano, J.; Borrello, I.; Serafini, P. Tadalafil reduces myeloid-derived suppressor cells and regulatory T cells and promotes tumor immunity in patients with head and neck squamous cell carcinoma. Clin. Cancer Res. 2015, 21, 39–48. [CrossRef] [PubMed]
    • (2015) Clin. Cancer Res , vol.21 , pp. 39-48
    • Weed, D.T.1    Vella, J.L.2    Reis, I.M.3    De La Fuente, A.C.4    Gomez, C.5    Sargi, Z.6    Nazarian, R.7    Califano, J.8    Borrello, I.9    Serafini, P.10
  • 91
    • 84872484656 scopus 로고    scopus 로고
    • CXCR2: From Bench to Bedside
    • [CrossRef] [PubMed]
    • Stadtmann, A.; Zarbock, A. CXCR2: From Bench to Bedside. Front. Immunol. 2012, 3, 263. [CrossRef] [PubMed]
    • (2012) Front. Immunol , vol.3
    • Stadtmann, A.1    Zarbock, A.2
  • 92
    • 84903390248 scopus 로고    scopus 로고
    • DMXAA causes tumor site-specific vascular disruption in murine non-small cell lung cancer, and like the endogenous non-canonical cyclic dinucleotide STING agonist, 2131-cGAMP, induces M2 macrophage repolarization
    • [CrossRef] [PubMed]
    • Downey, C.M.; Aghaei, M.; Schwendener, R.A.; Jirik, F.R. DMXAA causes tumor site-specific vascular disruption in murine non-small cell lung cancer, and like the endogenous non-canonical cyclic dinucleotide STING agonist, 2131-cGAMP, induces M2 macrophage repolarization. PLoS ONE 2014, 9, e99988. [CrossRef] [PubMed]
    • (2014) Plos ONE , vol.9
    • Downey, C.M.1    Aghaei, M.2    Schwendener, R.A.3    Jirik, F.R.4
  • 93
    • 84904061702 scopus 로고    scopus 로고
    • Attenuated reprograms M2-polarized tumor-associated macrophages in ovarian cancer leading to iNOS-mediated tumor cell lysis
    • [CrossRef] [PubMed]
    • Lizotte, P.H.; Baird, J.R.; Stevens, C.A.; Lauer, P.; Green, W.R.; Brockstedt, D.G.; Fiering, S.N. Attenuated reprograms M2-polarized tumor-associated macrophages in ovarian cancer leading to iNOS-mediated tumor cell lysis. Oncoimmunology 2014, 3, e28926. [CrossRef] [PubMed]
    • (2014) Oncoimmunology , vol.3
    • Lizotte, P.H.1    Baird, J.R.2    Stevens, C.A.3    Lauer, P.4    Green, W.R.5    Brockstedt, D.G.6    Fiering, S.N.7
  • 94
    • 78650956146 scopus 로고    scopus 로고
    • Anti-tumour synergy of cytotoxic chemotherapy and anti-CD40 plus CpG-ODN immunotherapy through repolarization of tumour-associated macrophages
    • [CrossRef] [PubMed]
    • Buhtoiarov, I.N.; Sondel, P.M.; Wigginton, J.M.; Buhtoiarova, T.N.; Yanke, E.M.; Mahvi, D.A.; Rakhmilevich, A.L. Anti-tumour synergy of cytotoxic chemotherapy and anti-CD40 plus CpG-ODN immunotherapy through repolarization of tumour-associated macrophages. Immunology 2011, 132, 226–239. [CrossRef] [PubMed]
    • (2011) Immunology , vol.132 , pp. 226-239
    • Buhtoiarov, I.N.1    Sondel, P.M.2    Wigginton, J.M.3    Buhtoiarova, T.N.4    Yanke, E.M.5    Mahvi, D.A.6    Rakhmilevich, A.L.7
  • 95
    • 84901349978 scopus 로고    scopus 로고
    • Oral tolerance to cancer can be abrogated by T regulatory cell inhibition
    • [CrossRef] [PubMed]
    • Whelan, M.C.; Casey, G.; Larkin, J.O.; Guinn, B.A.; O'Sullivan, G.C.; Tangney, M. Oral tolerance to cancer can be abrogated by T regulatory cell inhibition. PLoS ONE 2014, 9, e97602. [CrossRef] [PubMed]
    • (2014) Plos ONE , vol.9
    • Whelan, M.C.1    Casey, G.2    Larkin, J.O.3    Guinn, B.A.4    O'sullivan, G.C.5    Tangney, M.6
  • 97
    • 84860188105 scopus 로고    scopus 로고
    • Therapeutic cancer vaccines: Current status and moving forward
    • [CrossRef] [PubMed]
    • Schlom, J. Therapeutic cancer vaccines: Current status and moving forward. J. Natl. Cancer Inst. 2012, 104, 599–613. [CrossRef] [PubMed]
    • (2012) J. Natl. Cancer Inst , vol.104 , pp. 599-613
    • Schlom, J.1
  • 99
    • 84925511280 scopus 로고    scopus 로고
    • A phase I dose escalation trial of MAGE-A3- and HPV16-specific peptide immunomodulatory vaccines in patients with recurrent/metastatic (RM) squamous cell carcinoma of the head and neck (SCCHN)
    • [CrossRef] [PubMed]
    • Zandberg, D.P.; Rollins, S.; Goloubeva, O.; Morales, R.E.; Tan, M.; Taylor, R.; Wolf, J.S.; Schumaker, L.M.; Cullen, K.J.; Zimrin, A., et al. A phase I dose escalation trial of MAGE-A3- and HPV16-specific peptide immunomodulatory vaccines in patients with recurrent/metastatic (RM) squamous cell carcinoma of the head and neck (SCCHN). Cancer Immunol. Immunother. 2015, 64, 367–379. [CrossRef] [PubMed]
    • (2015) Cancer Immunol. Immunother , vol.64 , pp. 367-379
    • Zandberg, D.P.1    Rollins, S.2    Goloubeva, O.3    Morales, R.E.4    Tan, M.5    Taylor, R.6    Wolf, J.S.7    Schumaker, L.M.8    Cullen, K.J.9    Zimrin, A.10
  • 101
    • 84921029675 scopus 로고    scopus 로고
    • Phase II clinical trial of multiple peptide vaccination for advanced head and neck cancer patients revealed induction of immune responses and improved OS
    • [CrossRef] [PubMed]
    • Yoshitake, Y.; Fukuma, D.; Yuno, A.; Hirayama, M.; Nakayama, H.; Tanaka, T.; Nagata, M.; Takamune, Y.; Kawahara, K.; Nakagawa, Y., et al. Phase II clinical trial of multiple peptide vaccination for advanced head and neck cancer patients revealed induction of immune responses and improved OS. Clin. Cancer Res. 2015, 21, 312–321. [CrossRef] [PubMed]
    • (2015) Clin. Cancer Res , vol.21 , pp. 312-321
    • Yoshitake, Y.1    Fukuma, D.2    Yuno, A.3    Hirayama, M.4    Nakayama, H.5    Tanaka, T.6    Nagata, M.7    Takamune, Y.8    Kawahara, K.9    Nakagawa, Y.10
  • 102
    • 84928759208 scopus 로고    scopus 로고
    • Adoptive cell transfer as personalized immunotherapy for human cancer
    • [CrossRef] [PubMed]
    • Rosenberg, A.S.; Restifo, N.P. Adoptive cell transfer as personalized immunotherapy for human cancer. Science 2015, 348, 62–68. [CrossRef] [PubMed]
    • (2015) Science , vol.348 , pp. 62-68
    • Rosenberg, A.S.1    Restifo, N.P.2
  • 103
    • 84880733312 scopus 로고    scopus 로고
    • Cell transfer for cancer immunotherapy in the era of synthetic biology
    • [CrossRef] [PubMed]
    • Kalos, M.; June, C.H. Adoptive T cell transfer for cancer immunotherapy in the era of synthetic biology. Immunity 2013, 39, 49–60. [CrossRef] [PubMed]
    • (2013) Immunity , vol.39 , pp. 49-60
    • Kalos, M.1    June, C.H.2    Adoptive, T.3
  • 104
    • 84907210011 scopus 로고    scopus 로고
    • Activated cytotoxic T-lymphocyte immunotherapy is effective for advanced oral and maxillofacial cancers
    • [CrossRef] [PubMed]
    • Ohtani, T.; Yamada, Y.; Furuhashi, A.; Ohmura, Y.; Nakamura, S.; Kato, H.; Yoshikawa, K.; Kazaoka, Y. Activated cytotoxic T-lymphocyte immunotherapy is effective for advanced oral and maxillofacial cancers. Int. J. Oncol. 2014, 45, 2051–2207. [CrossRef] [PubMed]
    • (2014) Int. J. Oncol , vol.45 , pp. 2051-2207
    • Ohtani, T.1    Yamada, Y.2    Furuhashi, A.3    Ohmura, Y.4    Nakamura, S.5    Kato, H.6    Yoshikawa, K.7    Kazaoka, Y.8
  • 105
    • 80051745944 scopus 로고    scopus 로고
    • Cetuximab therapy for head and neck squamous cell carcinoma: A systematic review of the data. Otolaryngol
    • [CrossRef] [PubMed]
    • Reeves, T.D.; Hill, E.G.; Armeson, K.E.; Gillespie, M.B. Cetuximab therapy for head and neck squamous cell carcinoma: A systematic review of the data. Otolaryngol. Head Neck Surg. 2011, 144, 676–684. [CrossRef] [PubMed]
    • (2011) Head Neck Surg , vol.144 , pp. 676-684
    • Reeves, T.D.1    Hill, E.G.2    Armeson, K.E.3    Gillespie, M.B.4
  • 106
    • 84877096819 scopus 로고    scopus 로고
    • Cetuximab-activated natural killer and dendritic cells collaborate to trigger tumor antigen-specific T-cell immunity in head and neck cancer patients
    • [CrossRef] [PubMed]
    • Srivastava, R.M.; Lee, S.C.; Andrade Filho, P.A.; Lord, C.A.; Jie, H.B.; Davidson, H.C.; Lopez-Albaitero, A.; Gibson, S.P.; Gooding, W.E.; Ferrone, S., et al. Cetuximab-activated natural killer and dendritic cells collaborate to trigger tumor antigen-specific T-cell immunity in head and neck cancer patients. Clin. Cancer Res. 2013, 19, 1858–1872. [CrossRef] [PubMed]
    • (2013) Clin. Cancer Res , vol.19 , pp. 1858-1872
    • Srivastava, R.M.1    Lee, S.C.2    Andrade Filho, P.A.3    Lord, C.A.4    Jie, H.B.5    Davidson, H.C.6    Lopez-Albaitero, A.7    Gibson, S.P.8    Gooding, W.E.9    Ferrone, S.10
  • 107
    • 84909595006 scopus 로고    scopus 로고
    • Tumor antigen-specific monoclonal antibodies and induction of T-cell immunity
    • [CrossRef] [PubMed]
    • Trivedi, S.; Jie, H.B.; Ferris, R.L. Tumor antigen-specific monoclonal antibodies and induction of T-cell immunity. Semin. Oncol. 2014, 41, 678–684. [CrossRef] [PubMed]
    • (2014) Semin. Oncol , vol.41 , pp. 678-684
    • Trivedi, S.1    Jie, H.B.2    Ferris, R.L.3
  • 110
    • 84907521155 scopus 로고    scopus 로고
    • A phase iB study of MK-3475 in patients with human papillomavirus (HPV)-associated and non-HPV-associated head and neck (H/N) cancer, ASCO Annual Meeting Abstracts
    • Seiwert, T.Y.; Burtness, B.; Weiss, J.; Gluck, I.; Eder, P.J.; Pai, S.; Dolled-Filhart, M.; Emancipator, K.; Pathiraja, K.; Gause, C., et al. A phase iB study of MK-3475 in patients with human papillomavirus (HPV)-associated and non-HPV-associated head and neck (H/N) cancer, ASCO Annual Meeting Abstracts. J. Clin. Oncol. 2014, 32, 6011.
    • (2014) J. Clin. Oncol , vol.32 , pp. 6011
    • Seiwert, T.Y.1    Burtness, B.2    Weiss, J.3    Gluck, I.4    Eder, P.J.5    Pai, S.6    Dolled-Filhart, M.7    Emancipator, K.8    Pathiraja, K.9    Gause, C.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.