-
1
-
-
84901605375
-
Understanding how cystic fibrosis mutations disrupt CFTR function: From single molecules to animal models
-
1:CAS:528:DC%2BC2cXntFygu7Y%3D 24727426
-
Wang Y, Wrennall JA, Cai Z, Li H, Sheppard DN (2014) Understanding how cystic fibrosis mutations disrupt CFTR function: from single molecules to animal models. Int J Biochem Cell Biol 52:47-57
-
(2014)
Int J Biochem Cell Biol
, vol.52
, pp. 47-57
-
-
Wang, Y.1
Wrennall, J.A.2
Cai, Z.3
Li, H.4
Sheppard, D.N.5
-
2
-
-
0034917716
-
The human ATP-binding cassette (ABC) transporter superfamily
-
1:CAS:528:DC%2BD3MXltFaitL0%3D 11435397
-
Dean M, Rzhetsky A, Alikmets R (2001) The human ATP-binding cassette (ABC) transporter superfamily. Genome Res 11:1156-1166
-
(2001)
Genome Res
, vol.11
, pp. 1156-1166
-
-
Dean, M.1
Rzhetsky, A.2
Alikmets, R.3
-
3
-
-
42049096734
-
CLC-0 and CFTR: Chloride channels evolved from transporters
-
1:CAS:528:DC%2BD1cXls1Khs7o%3D 18391167
-
Chen T-Y, Hwang T-C (2008) CLC-0 and CFTR: chloride channels evolved from transporters. Physiol Rev 88:351-387
-
(2008)
Physiol Rev
, vol.88
, pp. 351-387
-
-
Chen, T.-Y.1
Hwang, T.-C.2
-
4
-
-
57749106719
-
Evolutionary and functional divergence between the cystic fibrosis transmembrane conductance regulator and related ATP-binding cassette transporters
-
1:CAS:528:DC%2BD1cXhsV2rtL3F 19020075
-
Jordan IK, Kota KC, Cui G, Thompson CH, McCarty NA (2008) Evolutionary and functional divergence between the cystic fibrosis transmembrane conductance regulator and related ATP-binding cassette transporters. Proc Natl Acad Sci USA 105:18865-18870
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 18865-18870
-
-
Jordan, I.K.1
Kota, K.C.2
Cui, G.3
Thompson, C.H.4
McCarty, N.A.5
-
5
-
-
84874710058
-
Cystic fibrosis transmembrane conductance regulator (ABCC7) structure
-
23378596 3552343
-
Hunt JF, Wang C, Ford RC (2013) Cystic fibrosis transmembrane conductance regulator (ABCC7) structure. Cold Spring Harb Perspect Med 3:a009514
-
(2013)
Cold Spring Harb Perspect Med
, vol.3
-
-
Hunt, J.F.1
Wang, C.2
Ford, R.C.3
-
6
-
-
84874669588
-
The CFTR ion channel: Gating, regulation, and anion permeation
-
23284076 3530039
-
Hwang T-C, Kirk KL (2013) The CFTR ion channel: gating, regulation, and anion permeation. Cold Spring Harb Perspect Med 3:a009498
-
(2013)
Cold Spring Harb Perspect Med
, vol.3
-
-
Hwang, T.-C.1
Kirk, K.L.2
-
7
-
-
84893088864
-
Functional architecture of the CFTR chloride channel
-
1:CAS:528:DC%2BC2cXht1Oqsbo%3D 24341413
-
Linsdell P (2014) Functional architecture of the CFTR chloride channel. Mol Membr Biol 31:1-16
-
(2014)
Mol Membr Biol
, vol.31
, pp. 1-16
-
-
Linsdell, P.1
-
8
-
-
67349185408
-
Ion channels versus ion pumps: The principal difference, in principle
-
1:CAS:528:DC%2BD1MXjvV2ksrk%3D 19339978 2742554
-
Gadsby DC (2009) Ion channels versus ion pumps: the principal difference, in principle. Nat Rev Mol Cell Biol 10:344-352
-
(2009)
Nat Rev Mol Cell Biol
, vol.10
, pp. 344-352
-
-
Gadsby, D.C.1
-
9
-
-
84911394318
-
Conformational changes opening and closing the CFTR chloride channel: Insights from cysteine scanning mutagenesis
-
25367045
-
El Hiani Y, Linsdell P (2014) Conformational changes opening and closing the CFTR chloride channel: insights from cysteine scanning mutagenesis. Biochem Cell Biol 92:481-488
-
(2014)
Biochem Cell Biol
, vol.92
, pp. 481-488
-
-
El Hiani, Y.1
Linsdell, P.2
-
10
-
-
84928493859
-
Full-open and closed CFTR channels, with lateral tunnels from the cytoplasm and an alternative position of the F508 region, as revealed by molecular dynamics
-
1:CAS:528:DC%2BC2cXhs12ntbjJ 25287046
-
Mornon J-P, Hoffmann B, Jonic S, Lehn P, Callebaut I (2015) Full-open and closed CFTR channels, with lateral tunnels from the cytoplasm and an alternative position of the F508 region, as revealed by molecular dynamics. Cell Mol Life Sci 72:1377-1403
-
(2015)
Cell Mol Life Sci
, vol.72
, pp. 1377-1403
-
-
Mornon, J.-P.1
Hoffmann, B.2
Jonic, S.3
Lehn, P.4
Callebaut, I.5
-
11
-
-
84943189754
-
Cystic fibrosis transmembrane conductance regulator (CFTR): Closed and open state channel models
-
1:CAS:528:DC%2BC2MXhsFagurvO 26229102 4645605
-
Corradi V, Vergani P, Tieleman DP (2015) Cystic fibrosis transmembrane conductance regulator (CFTR): closed and open state channel models. J Biol Chem 290:22891-22906
-
(2015)
J Biol Chem
, vol.290
, pp. 22891-22906
-
-
Corradi, V.1
Vergani, P.2
Tieleman, D.P.3
-
12
-
-
0032169499
-
Channel-lining residues in the M3 membrane-spanning segment of the cystic fibrosis transmembrane conductance regulator
-
1:CAS:528:DyaK1cXltV2rtrk%3D 9724537
-
Akabas MH (1998) Channel-lining residues in the M3 membrane-spanning segment of the cystic fibrosis transmembrane conductance regulator. Biochemistry 37:12233-12240
-
(1998)
Biochemistry
, vol.37
, pp. 12233-12240
-
-
Akabas, M.H.1
-
13
-
-
11244339684
-
Direct comparison of the functional roles played by different transmembrane regions in the cystic fibrosis transmembrane conductance regulator chloride channel pore
-
1:CAS:528:DC%2BD2cXhtFeis73I 15504721
-
Ge N, Muise CN, Gong X, Linsdell P (2004) Direct comparison of the functional roles played by different transmembrane regions in the cystic fibrosis transmembrane conductance regulator chloride channel pore. J Biol Chem 279:55283-55289
-
(2004)
J Biol Chem
, vol.279
, pp. 55283-55289
-
-
Ge, N.1
Muise, C.N.2
Gong, X.3
Linsdell, P.4
-
14
-
-
84858633600
-
Cystic fibrosis transmembrane conductance regulator: A molecular model defines the architecture of the anion conduction path and locates a "bottleneck" in the pore
-
1:CAS:528:DC%2BC38XisFalsb4%3D 22352759 3316148
-
Norimatsu Y, Ivetac A, Alexander C, Kirkham J, O'Donnell N, Dawson DC, Sansom MS (2012) Cystic fibrosis transmembrane conductance regulator: a molecular model defines the architecture of the anion conduction path and locates a "bottleneck" in the pore. Biochemistry 51:2199-2212
-
(2012)
Biochemistry
, vol.51
, pp. 2199-2212
-
-
Norimatsu, Y.1
Ivetac, A.2
Alexander, C.3
Kirkham, J.4
O'Donnell, N.5
Dawson, D.C.6
Sansom, M.S.7
-
15
-
-
84934924925
-
The fifth transmembrane segment of cystic fibrosis transmembrane conductance regulator contributes to its anion permeation pathway
-
1:CAS:528:DC%2BC2MXptFajs70%3D 26024338
-
Zhang J, Hwang T-C (2015) The fifth transmembrane segment of cystic fibrosis transmembrane conductance regulator contributes to its anion permeation pathway. Biochemistry 54:3839-3850
-
(2015)
Biochemistry
, vol.54
, pp. 3839-3850
-
-
Zhang, J.1
Hwang, T.-C.2
-
16
-
-
84936810152
-
Functional architecture of the cytoplasmic entrance to the cystic fibrosis transmembrane conductance regulator chloride channel pore
-
25944907
-
El Hiani Y, Linsdell P (2015) Functional architecture of the cytoplasmic entrance to the cystic fibrosis transmembrane conductance regulator chloride channel pore. J Biol Chem 290:15855-15865
-
(2015)
J Biol Chem
, vol.290
, pp. 15855-15865
-
-
El Hiani, Y.1
Linsdell, P.2
-
17
-
-
33750222000
-
In vivo phosphorylation of CFTR promotes formation of a nucleotide-binding domain heterodimer
-
1:CAS:528:DC%2BD28XhtVyktb%2FF 17036051 1618097
-
Mense M, Vergani P, White DM, Altberg G, Nairn AC, Gadsby DC (2006) In vivo phosphorylation of CFTR promotes formation of a nucleotide-binding domain heterodimer. EMBO J 25:4728-4739
-
(2006)
EMBO J
, vol.25
, pp. 4728-4739
-
-
Mense, M.1
Vergani, P.2
White, D.M.3
Altberg, G.4
Nairn, A.C.5
Gadsby, D.C.6
-
18
-
-
70350336877
-
Cysteine-independent inhibition of the CFTR chloride channel by the cysteine-reactive reagent sodium (2-sulphonatoethyl) methanethiosulphonate
-
1:CAS:528:DC%2BD1MXhtVChu7fO 19466983 2737665
-
Li M-S, Demsey AFA, Qi J, Linsdell P (2009) Cysteine-independent inhibition of the CFTR chloride channel by the cysteine-reactive reagent sodium (2-sulphonatoethyl) methanethiosulphonate. Br J Pharmacol 157:1065-1071
-
(2009)
Br J Pharmacol
, vol.157
, pp. 1065-1071
-
-
Li, M.-S.1
Demsey, A.F.A.2
Qi, J.3
Linsdell, P.4
-
19
-
-
80755139374
-
Functional differences in pore properties between wild-type and cysteine-less forms of the CFTR chloride channel
-
1:CAS:528:DC%2BC3MXht1antbnJ 21796426
-
Holstead RG, Li M-S, Linsdell P (2011) Functional differences in pore properties between wild-type and cysteine-less forms of the CFTR chloride channel. J Membr Biol 243:15-23
-
(2011)
J Membr Biol
, vol.243
, pp. 15-23
-
-
Holstead, R.G.1
Li, M.-S.2
Linsdell, P.3
-
20
-
-
77957761417
-
Changes in accessibility of cytoplasmic substances to the pore associated with activation of the cystic fibrosis transmembrane conductance regulator chloride channel
-
20675380 2952214
-
El Hiani Y, Linsdell P (2010) Changes in accessibility of cytoplasmic substances to the pore associated with activation of the cystic fibrosis transmembrane conductance regulator chloride channel. J Biol Chem 285:32126-32140
-
(2010)
J Biol Chem
, vol.285
, pp. 32126-32140
-
-
El Hiani, Y.1
Linsdell, P.2
-
21
-
-
77956237499
-
Dual roles of the sixth transmembrane segment of the CFTR chloride channel in gating and permeation
-
1:CAS:528:DC%2BC3cXhtF2rtrnI 20805575 2931150
-
Bai Y, Li M, Hwang T-C (2010) Dual roles of the sixth transmembrane segment of the CFTR chloride channel in gating and permeation. J Gen Physiol 136:293-309
-
(2010)
J Gen Physiol
, vol.136
, pp. 293-309
-
-
Bai, Y.1
Li, M.2
Hwang, T.-C.3
-
22
-
-
79961146667
-
Alignment of transmembrane regions in the cystic fibrosis transmembrane conductance regulator chloride channel pore
-
1:CAS:528:DC%2BC3MXhtV2qtrnL 21746847 3149817
-
Wang W, El Hiani Y, Linsdell P (2011) Alignment of transmembrane regions in the cystic fibrosis transmembrane conductance regulator chloride channel pore. J Gen Physiol 138:165-178
-
(2011)
J Gen Physiol
, vol.138
, pp. 165-178
-
-
Wang, W.1
El Hiani, Y.2
Linsdell, P.3
-
23
-
-
80054724207
-
Functional arrangement of the 12th transmembrane region in the CFTR chloride channel based on functional investigation of a cysteine-less variant
-
1:CAS:528:DC%2BC3MXhtFCmurnF 21796338
-
Qian F, El Hiani Y, Linsdell P (2011) Functional arrangement of the 12th transmembrane region in the CFTR chloride channel based on functional investigation of a cysteine-less variant. Pflügers Arch 462:559-571
-
(2011)
Pflügers Arch
, vol.462
, pp. 559-571
-
-
Qian, F.1
El Hiani, Y.2
Linsdell, P.3
-
24
-
-
84896690825
-
Relative contribution of different transmembrane segments to the CFTR chloride channel pore
-
1:CAS:528:DC%2BC3sXht12isr%2FE 23955087
-
Wang W, El Hiani Y, Rubaiy HN, Linsdell P (2014) Relative contribution of different transmembrane segments to the CFTR chloride channel pore. Pflügers Arch 466:477-490
-
(2014)
Pflügers Arch
, vol.466
, pp. 477-490
-
-
Wang, W.1
El Hiani, Y.2
Rubaiy, H.N.3
Linsdell, P.4
-
25
-
-
84861116440
-
Role of the juxtamembrane region of cytoplasmic loop 3 in the gating and conductance of the cystic fibrosis transmembrane conductance regulator chloride channel
-
22545782 3381012
-
El Hiani Y, Linsdell P (2012) Role of the juxtamembrane region of cytoplasmic loop 3 in the gating and conductance of the cystic fibrosis transmembrane conductance regulator chloride channel. Biochemistry 51:3971-3981
-
(2012)
Biochemistry
, vol.51
, pp. 3971-3981
-
-
El Hiani, Y.1
Linsdell, P.2
-
26
-
-
80555127440
-
Structural basis for the channel function of a degraded ABC transporter, CFTR (ABCC7)
-
1:CAS:528:DC%2BC3MXhsFCrsLvE 22042986 3206304
-
Bai Y, Li M, Hwang T-C (2011) Structural basis for the channel function of a degraded ABC transporter, CFTR (ABCC7). J Gen Physiol 138:495-507
-
(2011)
J Gen Physiol
, vol.138
, pp. 495-507
-
-
Bai, Y.1
Li, M.2
Hwang, T.-C.3
-
27
-
-
84874150515
-
Cysteine scanning of CFTR's first transmembrane segment reveals its plausible roles in gating and permeation
-
1:CAS:528:DC%2BC3sXivFOqtLg%3D 23442957 3576531
-
Gao X, Bai Y, Hwang T-C (2013) Cysteine scanning of CFTR's first transmembrane segment reveals its plausible roles in gating and permeation. Biophys J 104:786-797
-
(2013)
Biophys J
, vol.104
, pp. 786-797
-
-
Gao, X.1
Bai, Y.2
Hwang, T.-C.3
|