Dysregulation of glucose homeostasis following chronic exogenous administration of leptin in healthy sprague-dawley rats

Journal of Clinical and Diagnostic Research

Volumn 9, Issue 12, 2015, Pages 6-9

  Wjidan, Khalil ^a   Ibrahim, Effendi ^a   Caszo, Brinnell ^b   Gnanou, Justin ^b   Singh, Harbindarjeet ^a  

^a UNIVERSITI TEKNOLOGI MARA   (Malaysia)

^b NATIONAL DEFENCE UNIVERSITY OF MALAYSIA   (Malaysia)

Author keywords

Glucose homeostasis; GLUT 4; Hyperinsulinaemia; Hyperleptinaemia; Insulin receptor

Indexed keywords

GLUCOSE; GLUCOSE TRANSPORTER 4; INSULIN; INSULIN RECEPTOR; LEPTIN; MESSENGER RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; GLUCOSE HOMEOSTASIS; GLUCOSE TOLERANCE; HYPERINSULINEMIA; HYPERLEPTINEMIA; INJECTION; MALE; MUSCLE BIOPSY; NONHUMAN; RAT; REAL TIME POLYMERASE CHAIN REACTION; SKELETAL MUSCLE;

EID: 84949746614     PISSN: 2249782X     EISSN: 0973709X     Source Type: Journal    
DOI: 10.7860/JCDR/2015/15594.7003     Document Type: Article

References (18)

1. Kahn SE, Hull RL, Utzschneide KM. Mechanisms linking obesity to insulin resistance and type 2 diabetes. Nature. 2006;444:840-46.
2. Qatanani M, Lazar MA. Mechanisms of obesity-associated insulin resistance: many choices on the menu. Genes Dev. 2007;21(12):1443-55.
3. Galletti F, D’Elia L, De Palma D, Russo O, Barba G, Siani A, et al. Hyperleptinaemia is associated with hypertension, systemic inflammation and insulin resistance in overweight but not in normal weight men. Nutr Metab Cardiovasc Dis. 2012;22(3):300-06.
4. Marroquí L, Gonzalez A, Ñeco P, Caballero-Garrido E, Vieira E, Ripoll C, et al. Role of leptin in the pancreatic β-cell: effects and signaling pathways. J Mol Endocrinol. 2012;49(1):R9-17.
5. Ceddia RB. Direct metabolic regulation in skeletal muscle and fat tissue by leptin: implications for glucose and fatty acids homeostasis. Int J Obes (Lond). 2005;29(10):1175-83.
6. Sáinz N, Rodríguez A, Catalán V, Becerril S, Ramírez B, Lancha A, et al. Leptin reduces the expression and increases the phosphorylation of the negative regulators of GLUT4 traffic TBC1D1 and TBC1D4 in muscle of ob/ob mice. PLoS One. 2012;7(1):e29389.
7. Farhana K, Effendi I, Caszo B, Satar NA, Singh HJ. Exercise prevents leptin-induced increase in blood pressure in Sprague-Dawley rats. J Physiol Biochem. 2014;70(2):417-23.
8. Vandesompele J, De Preter K, Pattyn F, Poppe B, Van Roy N, De Paepe A, et al. Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol. 2002;3(7):R34.
9. Kuehnen P, Laubner K, Raile K, Schofl C, Jakob F, Pilz I, et al. Protein phosphatase 1 (PP-1)-dependent inhibition of insulin secretion by leptin in INS-1 pancreatic b-cells and human pancreatic islets. Endocrinology. 2011;152(5):1800-08.
10. Seufert J, Kieffer TJ, Habener JF. Leptin inhibits insulin gene transcription and reverses hyperinsulinaemia in leptin-deficient ob/ob mice. Proc Natl Acad Sci. 1999;96(2):674-79.
11. Meek TH, Morton GJ. Leptin, diabetes, and the brain. Indian J of Endocrinol Metab. 2012;16(3):S534-42.
12. Park S, Ahn IS, Kim da S. Central infusion of leptin improves insulin resistance and suppresses b-cell function, but not b-cell mass, primarily through the sympathetic nervous system in a type 2 diabetic rat model. Life Sci. 2010;86(23-24):854-62.
13. Seufert J, Kieffer TJ, Leech CA, Holz GG, Moritz W, Ricordi C, et al. Leptin suppression of insulin secretion and gene expression in human pancreatic islets: implications for the development of adipogenic diabetes mellitus. J Clin Endocrinol Metab. 1999;84:670-76.
14. Chen PC, Kryukova YN, Shyng SL. Leptin regulates KATP channel trafficking in pancreatic β-cells by a signaling mechanism involving AMP-activated protein kinase (AMPK) and cAMP-dependent protein kinase (PKA). J Biol Chem. 2013; 288(47):34098-109.
15. Kahn SE, Cooper ME, Del Prato S. Pathophysiology and treatment of type 2 diabetes: perspectives on the past, present, and future. Lancet. 2014;383 (9922):1068-83.
16. Yaspelkis BB, Singh MK, Krisan AD, Collins DE, Kwong CC, Bernard JR, et al. Chronic leptin treatment enhances insulin-stimulated glucose disposal in skeletal muscle of high-fat fed rodents. Life Sci. 2004;74(14):1801-16.
17. Foley K, Boguslavsky S, Klip A. Endocytosis, recycling, and regulated exocytosis of glucose transporter 4. Biochemistry. 2011;50(15):3048-61.
18. Zeng J, Patterson BW, Klein S, Martin DR, Dagogo-Jack S, Kohrt WM, et al. Whole body leptin kinetics and renal metabolism in vivo. Am J Physiol. 1997; 273:E1102-06.