Peroxisome proliferator-activated receptor alpha, PPARα, directly regulates transcription of cytochrome P450 CYP2C8

Frontiers in Pharmacology

Volumn 6, Issue NOV, 2015, Pages

  Thomas, Maria ^a,b   Winter, Stefan ^a,b   Klumpp, Britta ^a,b   Turpeinen, Miia ^a,b,d   Klein, Kathrin ^a,b   Schwab, Matthias ^a,b,c   Zanger, Ulrich M ^a,b  

^a DR MARGARETE FISCHER BOSCH INSTITUTE OF CLINICAL PHARMACOLOGY   (Germany)

^b UNIVERSITY OF TÜBINGEN   (Germany)

^c UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

^d MEDICAL RESEARCH CENTER OULU   (Finland)

Author keywords

Chromatin immunoprecipitation; Diet drug interaction; Drug metabolism; Genotype phenotype correlation; HepaRG cells; Nuclear receptors; Transcriptional regulation; WNT catenin

Indexed keywords

BETA CATENIN; BILIRUBIN; CYTOCHROME P450 2C8; CYTOCHROME P450 3A4; GAMMA GLUTAMYLTRANSFERASE; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; WNT PROTEIN;

ADULT; ARTICLE; BILIRUBIN BLOOD LEVEL; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; CYP2C8 GENE; DOWN REGULATION; ENZYME ACTIVITY; FEMALE; GAMMA GLUTAMYL TRANSFERASE BLOOD LEVEL; GEL MOBILITY SHIFT ASSAY; GENE; GENE EXPRESSION REGULATION; GENE IDENTIFICATION; GENE SILENCING; GENETIC ASSOCIATION; GENETIC VARIABILITY; HUMAN; HUMAN CELL; HUMAN TISSUE; INTRACELLULAR SIGNALING; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; PHENOTYPE; PPAR ALPHA GENE; PROMOTER REGION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; RECEPTOR BINDING; SINGLE NUCLEOTIDE POLYMORPHISM; TRANSCRIPTION INITIATION; TRANSCRIPTION INITIATION SITE; TRANSCRIPTION REGULATION;

EID: 84949741133     PISSN: None     EISSN: 16639812     Source Type: Journal    
DOI: 10.3389/fphar.2015.00261     Document Type: Article

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