Two-year whey protein supplementation did not enhance muscle mass and physical function in well-nourished healthy older postmenopausal women

Journal of Nutrition

Volumn 145, Issue 11, 2015, Pages 2520-2526

  Zhu, Kun ^a,b   Kerr, Deborah A ^c   Meng, Xingqiong ^d   Devine, Amanda ^e   Solah, Vicky ^c   Binns, Colin W ^c   Prince, Richard L ^a,b  

^a SIR CHARLES GAIRDNER HOSPITAL   (Australia)

^b UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^c CURTIN UNIVERSITY   (Australia)

^d FLINDERS UNIVERSITY   (Australia)

^e EDITH COWAN UNIVERSITY   (Australia)

Author keywords

Muscle mass; Muscle strength; Older women; Physical function; Whey protein

Indexed keywords

MILK PROTEIN; NITROGEN; PLACEBO; PROTEIN INTAKE; WHEY PROTEIN;

AGED; ANTHROPOMETRY; ARM MUSCLE; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DIET SUPPLEMENTATION; DOUBLE BLIND PROCEDURE; DUAL ENERGY X RAY ABSORPTIOMETRY; FEMALE; FOLLOW UP; GASTROCNEMIUS MUSCLE; GRIP STRENGTH; HUMAN; LEG MUSCLE; MUSCLE MASS; NITROGEN URINE LEVEL; NORMAL HUMAN; PARALLEL DESIGN; PHYSICAL ACTIVITY; PHYSICAL MOBILITY; POSTMENOPAUSE; PROSPECTIVE STUDY; PROTEIN INTAKE; RANDOMIZED CONTROLLED TRIAL; SKELETAL MUSCLE; ADMINISTRATION AND DOSAGE; AGING; BODY MASS; CALORIC INTAKE; DIETARY SUPPLEMENT; DRUG EFFECTS; HAND STRENGTH; METABOLISM; MOTOR ACTIVITY; PHOTON ABSORPTIOMETRY; URINE; VERY ELDERLY;

ABSORPTIOMETRY, PHOTON; AGED; AGED, 80 AND OVER; AGING; BODY MASS INDEX; DIETARY PROTEINS; DIETARY SUPPLEMENTS; DOUBLE-BLIND METHOD; ENERGY INTAKE; FEMALE; FOLLOW-UP STUDIES; HAND STRENGTH; HUMANS; MOTOR ACTIVITY; MUSCLE, SKELETAL; NITROGEN; POSTMENOPAUSE; WHEY PROTEINS;

EID: 84949673792     PISSN: 00223166     EISSN: 15416100     Source Type: Journal    
DOI: 10.3945/jn.115.218297     Document Type: Article

References (37)

1. Borst SE. Interventions for sarcopenia and muscle weakness in older people. Age Ageing 2004;33:548-55.
2. Carmeli E, Coleman R, Reznick AZ. The biochemistry of aging muscle. Exp Gerontol 2002;37:477-89.
3. Fujita S, Volpi E. Amino acids and muscle loss with aging. J Nutr 2006;136 Suppl:277S-80S.
4. Volpi E, Ferrando AA, Yeckel CW, Tipton KD, Wolfe RR. Exogenous amino acids stimulate net muscle protein synthesis in the elderly. J Clin Invest 1998;101:2000-7.
5. Solerte SB, Gazzaruso C, Bonacasa R, Rondanelli M, Zamboni M, Basso C, Locatelli E, Schifino N, Giustina A, Fioravanti M. Nutritional supplements with oral amino acid mixtures increases whole-body lean mass and insulin sensitivity in elderly subjects with sarcopenia. Am J Cardiol 2008;101 11A:69E-77E.
6. Dillon EL, Sheffield-Moore M, Paddon-Jones D, Gilkison C, Sanford AP, Casperson SL, Jiang J, Chinkes DL, Urban RJ. Amino acid supplementation increases lean body mass, basal muscle protein synthesis, and insulin-like growth factor-I expression in older women. J Clin Endocrinol Metab 2009;94:1630-7.
7. Bonjour JP, Schurch MA, Chevalley T, Ammann P, Rizzoli R. Protein intake, IGF-1 and osteoporosis. Osteoporos Int 1997;7 Suppl 3:S36-42.
8. Castaneda C, Gordon PL, Fielding RA, Evans WJ, Crim MC. Marginal protein intake results in reduced plasma IGF-I levels and skeletal muscle fiber atrophy in elderly women. J Nutr Health Aging 2000;4:85-90.
9. Asp ML, Richardson JR, Collene AL, Droll KR, Belury MA. Dietary protein and beef consumption predict for markers of muscle mass and nutrition status in older adults. J Nutr Health Aging 2012;16:784-90.
10. Valenzuela RE, Ponce JA, Morales-Figueroa GG, Muro KA, Carreon VR, Alemán-Mateo H. Insufficient amounts and inadequate distribution of dietary protein intake in apparently healthy older adults in a developing country: implications for dietary strategies to prevent sarcopenia. Clin Interv Aging 2013;8:1143-8.
11. Houston DK, Nicklas BJ, Ding J, Harris TB, Tylavsky FA, Newman AB, Lee JS, Sahyoun NR, Visser M, Kritchevsky SB. Dietary protein intake is associated with lean mass change in older, community-dwelling adults: the Health, Aging, and Body Composition (Health ABC) Study. Am J Clin Nutr 2008;87:150-5.
12. Meng X, Zhu K, Devine A, Kerr DA, Binns CW, Prince RL. A 5-year cohort study of the effects of high protein intake on lean mass and BMC in elderly postmenopausal women. J Bone Miner Res 2009;24:1827-34.
13. Alemán-Mateo H, Macias L, Esparza-Romero J, Astiazaran-Garcia H, Blancas AL. Physiological effects beyond the significant gain in muscle mass in sarcopenic elderly men: evidence from a randomized clinical trial using a protein-rich food. Clin Interv Aging 2012;7:225-34.
14. Bouillanne O, Curis E, Hamon-Vilcot B, Nicolis I, Chretien P, Schauer N, Vincent JP, Cynober L, Aussel C. Impact of protein pulse feeding on lean mass in malnourished and at-risk hospitalized elderly patients: a randomized controlled trial. Clin Nutr 2013;32:186-92.
15. Alemán-Mateo H, Carreon VR, Macias L, Astiazaran-Garcia H, Gallegos-Aguilar AC, Enriquez JR. Nutrient-rich dairy proteins improve appendicular skeletal muscle mass and physical performance, and attenuate the loss of muscle strength in older men and women subjects: a single-blind randomized clinical trial. Clin Interv Aging 2014;9:1517-25.
16. Zhu K, Meng X, Kerr DA, Devine A, Solah V, Binns CW, Prince RL. The effects of a two-year randomized, controlled trial of whey protein supplementation on bone structure, IGF-1, and urinary calcium excretion in older postmenopausal women. J Bone Miner Res 2011;26:2298-306.
17. Hodgson JM, Zhu K, Lewis JR, Kerr D, Meng X, Solah V, Devine A, Binns CW, Woodman RJ, Prince RL. Long-term effects of a proteinenriched diet on blood pressure in older women. Br J Nutr 2012;107:1664-72.
18. Schulz KF, Altman DG, Moher D, Group C. CONSORT 2010 statement: updated guidelines for reporting parallel group randomised trials. BMJ 2010;340:c332.
19. Stewart A, Marfell-Jones MJ, Olds TS, de Ridder H. International standards for anthropometric assessment, 2011. International Society for the Advancement of Kinanthropometry, Adelaide, SA, Australia.
20. Hammond KA. Dietary and clinical assessment. In: Mahan LK, Escott-Stump S, eds. Krause's Food, Nutrition & Diet Therapy. Philadelphia: Elsevier; 2004. p. 407-35.
21. Podsiadlo D, Richardson S. The timed "Up & Go": a test of basic functional mobility for frail elderly persons. J Am Geriatr Soc 1991;39:142-8.
22. Department of Community Services and Health. NUTTAB 99 Database, 1999. Australian Government Publishing Service, Canberra, Australia.
23. McClements DJ. Analysis of food products, 2003 [Internet]. Version current 24 October 2003 [cited 2015 May 7]. Available from: http://people.umass.edu/~mcclemen/581Toppage.html.
24. Carlson TH. Laboratory data in nutrition assessment: assessment of protein-energy status. In: Mahan LK, Escott-Stump S, eds. Krause's Food, Nutrition and Diet Therapy. Philadelphia: Elsevier; 2004. p. 439-42.
25. Gibson RS. Principles of nutritional assessment, 2005. Oxford University Press, Oxford, United Kingdom.
26. Craig CL, Marshall AL, Sjostrom M, Bauman AE, Booth ML, Ainsworth BE, Pratt M, Ekelund U, Yngve A, Sallis JF, et al. International physical activity questionnaire: 12-country reliability and validity. Med Sci Sports Exerc 2003;35:1381-95.
27. Prince RL, Devine A, Dhaliwal SS, Dick IM. Effects of calcium supplementation on clinical fracture and bone structure: results of a 5-year, double-blind, placebo-controlled trial in elderly women. Arch Intern Med 2006;166:869-75.
28. Britt H. A new coding tool for computerised clinical systems in primary care-ICPC plus. Aust Fam Physician 1997;26 Suppl 2:S79-82.
29. National Health and Medical Research Council (Australia). New Zealand. Ministry of Health., Australia. Dept. of Health and Ageing. Nutrient reference values for Australia and New Zealand: including recommended dietary intakes, 2006. National Health and Medical Research Council, Canberra, ACT, Australia, pp 29-33.
30. World Health Organization. Protein and amino acid requirements in human nutrition. WHO Technical Report Series 935, 2007. World Health Organization.
31. Dangin M, Guillet C, Garcia-Rodenas C, Gachon P, Bouteloup-Demange C, Reiffers-Magnani K, Fauquant J, Ballevre O, Beaufrere B. The rate of protein digestion affects protein gain differently during aging in humans. J Physiol 2003;549:635-44.
32. Volpi E, Kobayashi H, Sheffield-Moore M, Mittendorfer B, Wolfe RR. Essential amino acids are primarily responsible for the amino acid stimulation of muscle protein anabolism in healthy elderly adults. Am J Clin Nutr 2003;78:250-8.
33. Paddon-Jones D, Sheffield-Moore M, Zhang XJ, Volpi E, Wolf SE, Aarsland A, Ferrando AA, Wolfe RR. Amino acid ingestion improves muscle protein synthesis in the young and elderly. Am J Physiol Endocrinol Metab 2004;286:E321-8.
34. Symons TB, Schutzler SE, Cocke TL, Chinkes DL, Wolfe RR, Paddon-Jones D. Aging does not impair the anabolic response to a protein-rich meal. Am J Clin Nutr 2007;86:451-6.
35. Cermak NM, Res PT, de Groot LC, Saris WH, van Loon LJ. Protein supplementation augments the adaptive response of skeletal muscle to resistance-type exercise training: a meta-analysis. Am J Clin Nutr 2012;96:1454-64.
36. Daly RM, O'Connell SL, Mundell NL, Grimes CA, Dunstan DW, Nowson CA. Protein-enriched diet, with the use of lean red meat, combined with progressive resistance training enhances lean tissue mass and muscle strength and reduces circulating IL-6 concentrations in elderly women: a cluster randomized controlled trial. Am J Clin Nutr 2014;99:899-910.
37. Taaffe DR, Sipila S, Cheng S, Puolakka J, Toivanen J, Suominen H. The effect of hormone replacement therapy and/or exercise on skeletal muscle attenuation in postmenopausal women: a yearlong intervention. Clin Physiol Funct Imaging 2005;25:297-304.