The effects of a two-year randomized, controlled trial of whey protein supplementation on bone structure, IGF-1, and urinary calcium excretion in older postmenopausal women

Journal of Bone and Mineral Research

Volumn 26, Issue 9, 2011, Pages 2298-2306

  Zhu, Kun ^a,b   Meng, Xingqiong ^c   Kerr, Deborah A ^c   Devine, Amanda ^d   Solah, Vicky ^c   Binns, Colin W ^c   Prince, Richard L ^a,b  

^a SIR CHARLES GAIRDNER HOSPITAL   (Australia)

^b UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^c CURTIN UNIVERSITY   (Australia)

^d EDITH COWAN UNIVERSITY   (Australia)

Author keywords

BONE STRUCTURE; IGF 1; OLDER WOMEN; PROTEIN; URINARY CALCIUM

Indexed keywords

CALCIUM; MILK PROTEIN; SOMATOMEDIN C;

AGED; ARTICLE; BONE DENSITY; BONE MASS; BONE STRENGTH; BONE STRUCTURE; CALCIUM EXCRETION; CALCIUM URINE LEVEL; DIET SUPPLEMENTATION; DOUBLE BLIND PROCEDURE; FEMALE; FEMUR NECK; HUMAN; HUMAN EXPERIMENT; POSTMENOPAUSE; PROTEIN BLOOD LEVEL; RANDOMIZED CONTROLLED TRIAL;

AGED; AGED, 80 AND OVER; BONE AND BONES; BONE DENSITY; CALCIUM; DIET; DIETARY SUPPLEMENTS; ENERGY METABOLISM; FEMALE; FEMUR NECK; FOOD; HIP; HUMANS; INSULIN-LIKE GROWTH FACTOR I; MILK PROTEINS; POSTMENOPAUSE; TOMOGRAPHY, X-RAY COMPUTED;

EID: 80052004698     PISSN: 08840431     EISSN: 15234681     Source Type: Journal    
DOI: 10.1002/jbmr.429     Document Type: Article

References (27)

1. Barzel US, Massey LK,. Excess dietary protein can adversely affect bone. J Nutr. 1998; 128: 1051-1053. (Pubitemid 28280209)
2. Roughead ZK, Johnson LK, Lykken GI, Hunt JR,. Controlled high meat diets do not affect calcium retention or indices of bone status in healthy postmenopausal women. J Nutr. 2003; 133: 1020-1026. (Pubitemid 36407119)
3. Kerstetter JE, O'Brien KO, Caseria DM, Wall DE, Insogna KL,. The impact of dietary protein on calcium absorption and kinetic measures of bone turnover in women. J Clin Endocrinol Metab. 2005; 90: 26-31. (Pubitemid 40116629)
4. Hunt JR, Johnson LK, Fariba Roughead ZK,. Dietary protein and calcium interact to influence calcium retention: a controlled feeding study. Am J Clin Nutr. 2009; 89: 1357-1365.
5. Kerstetter JE, O'Brien KO, Insogna KL,. Dietary protein, calcium metabolism, and skeletal homeostasis revisited. Am J Clin Nutr. 2003; 78: 584S-592S. (Pubitemid 40012553)
6. Schurch MA, Rizzoli R, Slosman D, Vadas L, Vergnaud P, Bonjour JP,. Protein supplements increase serum insulin-like growth factor-I levels and attenuate proximal femur bone loss in patients with recent hip fracture. A randomized, double-blind, placebo-controlled trial. Ann Intern Med. 1998; 128: 801-809. (Pubitemid 28267712)
7. Heaney RP, McCarron DA, Dawson-Hughes B, et al. Dietary changes favorably affect bone remodeling in older adults. J Am Diet Assoc. 1999; 99: 1228-1233. (Pubitemid 29480614)
8. Metz JA, Anderson JJB, Gallagher PN,. Intakes of calcium, phosphorus, and protein, and physical-activity level are related to radial bone mass in young adult women. Am J Clin Nutr. 1993; 58: 537-542. (Pubitemid 23307413)
9. Feskanich D, Willett WC, Stampfer MJ, Colditz GA,. Protein consumption and bone fractures in women. Am J Epidemiol. 1996; 143: 472-479. (Pubitemid 26085077)
10. Whiting SJ, Boyle JL, Thompson A, Mirwald RL, Faulkner RA,. Dietary protein, phosphorus and potassium are beneficial to bone mineral density in adult men consuming adequate dietary calcium. J Am Coll Nutr. 2002; 21: 402-409.
11. Hannan MT, Tucker KL, Dawson-Hughes B, Cupples LA, Felson DT, Kiel DP,. Effect of dietary protein on bone loss in elderly men and women: the Framingham Osteoporosis Study. J Bone Miner Res. 2000; 15: 2504-2512.
12. Promislow JHE, Goodman-Gruen D, Slymen DJ, Barrett-Connor E,. Protein consumption and bone mineral density in the elderly: the Rancho Bernardo Study. Am J Epidemiol. 2002; 155: 636-644. (Pubitemid 34246096)
13. Devine A, Dick IM, Islam AF, Dhaliwal SS, Prince RL,. Protein consumption is an important predictor of lower limb bone mass in elderly women. Am J Clin Nutr. 2005; 81: 1423-1428. (Pubitemid 41710248)
14. Munger RG, Cerhan JR, Chiu BC,. Prospective study of dietary protein intake and risk of hip fracture in postmenopausal women. Am J Clin Nutr. 1999; 69: 147-152. (Pubitemid 29031265)
15. Wengreen HJ, Munger RG, Cutler DR, Corcoran CD, Zhang J, Sassano NE,. Dietary protein intake and risk of osteoporotic hip fracture in elderly residents of Utah. J Bone Miner Res. 2004; 19: 537-545. (Pubitemid 41071212)
16. Darling AL, Millward DJ, Torgerson DJ, Hewitt CE, Lanham-New SA,. Dietary protein and bone health: a systematic review and meta-analysis. Am J Clin Nutr. 2009; 90: 1674-1692.
17. Tengstrand B, Cederholm T, Soderqvist A, Tidermark J,. Effects of protein-rich supplementation and nandrolone on bone tissue after a hip fracture. Clin Nutr. 2007; 26: 460-465. (Pubitemid 47103081)
18. Dawson-Hughes B,. Interaction of dietary calcium and protein in bone health in humans. J Nutr. 2003; 133: 852S-854S. (Pubitemid 36268368)
19. Frassetto LA, Lanham-New SA, Macdonald HM, et al. Standardizing terminology for estimating the diet-dependent net acid load to the metabolic system. J Nutr. 2007; 137: 1491-1492. (Pubitemid 46855491)
20. New SA, MacDonald HM, Campbell MK, et al. Lower estimates of net endogenous non-carbonic acid production are positively associated with indexes of bone health in premenopausal and perimenopausal women. Am J Clin Nutr. 2004; 79: 131-138. (Pubitemid 41132074)
21. Prince RL, Devine A, Dhaliwal SS, Dick IM,. Effects of calcium supplementation on clinical fracture and bone structure: results of a 5-year, double-blind, placebo-controlled trial in elderly women. Arch Intern Med. 2006; 166: 869-875.
22. Britt H,. A new coding tool for computerised clinical systems in primary care-ICPC plus. Aust Fam Physician. 1997; 26 (Suppl 2): S79-82.
23. National Health and Medical Research Council (Australia)., New Zealand. Ministry of Health., Australia. Dept. of Health and Ageing. Nutrient reference values for Australia and New Zealand: including recommended dietary intakes. [Canberra, A.C.T.: National Health and Medical Research Council], 2006.
24. Organization WH,. Protein and amino acid requirements in human nutrition. WHO Technical Report Series 935: World Health Organization, 2007.
25. Giustina A, Mazziotti G, Canalis E,. Growth hormone, insulin-like growth factors, and the skeleton. Endocr Rev. 2008; 29: 535-559.
26. Perrini S, Laviola L, Carreira MC, Cignarelli A, Natalicchio A, Giorgino F,. The GH/IGF1 axis and signaling pathways in the muscle and bone: mechanisms underlying age-related skeletal muscle wasting and osteoporosis. J Endocrinol. 2010; 205: 201-210.
27. Cadogan J, Eastell R, Jones N, Barker ME,. Milk intake and bone mineral acquisition in adolescent girls: randomised, controlled intervention trial. Bmj. 1997; 315: 1255-1260. (Pubitemid 27488731)