Safety of Intravenous Thrombolysis among Stroke Patients Taking New Oral Anticoagulants - Case Series and Systematic Review of Reported Cases

Journal of Stroke and Cerebrovascular Diseases

Volumn 24, Issue 12, 2015, Pages 2685-2693

  Shahjouei, Shima ^a   Tsivgoulis, Georgios ^b,c,d   Bavarsad Shahripour, Reza ^e   Jones, G Morgan ^f   Alexandrov, Andrei V ^b   Zand, Ramin ^b  

^a TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^c NATIONAL AND KAPODISTRIAN UNIVERSITY OF ATHENS   (Greece)

^d ST ANNE S UNIVERSITY HOSPITAL   (Czech Republic)

^e University of Alabama at Birmingham   (United States)

^f UNIVERSITY OF TENNESSEE COLLEGE OF PHARMACY   (United States)

Author keywords

Acute ischemic stroke; acute stroke therapy; anticoagulants; intracerebral hemorrhage; new oral anticoagulants; thrombolysis; tPA

Indexed keywords

ANTICOAGULANT AGENT; APIXABAN; DABIGATRAN; RIVAROXABAN; TISSUE PLASMINOGEN ACTIVATOR; FIBRINOLYTIC AGENT;

BLEEDING; BLOOD CLOT LYSIS; BRAIN HEMORRHAGE; CEREBROVASCULAR ACCIDENT; DISEASE SEVERITY; DRUG SAFETY; ECCHYMOSIS; EUROPE; HEMATURIA; HUMAN; MULTICENTER STUDY (TOPIC); PRIORITY JOURNAL; REVIEW; RISK ASSESSMENT; STROKE PATIENT; SYSTEMATIC REVIEW; UNITED STATES; ADVERSE EFFECTS; AGED; BRAIN ISCHEMIA; CASE REPORT; FEMALE; FIBRINOLYTIC THERAPY; MALE; MIDDLE AGED; STROKE; TREATMENT OUTCOME; VERY ELDERLY;

AGED; AGED, 80 AND OVER; ANTICOAGULANTS; BRAIN ISCHEMIA; FEMALE; FIBRINOLYTIC AGENTS; HUMANS; MALE; MIDDLE AGED; STROKE; THROMBOLYTIC THERAPY; TISSUE PLASMINOGEN ACTIVATOR; TREATMENT OUTCOME;

EID: 84949637950     PISSN: 10523057     EISSN: 15328511     Source Type: Journal    
DOI: 10.1016/j.jstrokecerebrovasdis.2015.07.021     Document Type: Article

References (43)

1. D. Capodanno, P. Capranzano, G. Giacchi, and et al. Novel oral anticoagulants versus warfarin in non-valvular atrial fibrillation: a meta-analysis of 50,578 patients Int J Cardiol 167 2013 1237 1241
2. V. Lee, J.J. Conners, and S. Prabhakaran Response to the letter by Lee et al J Stroke Cerebrovasc Dis 22 2013 894
3. W. Pfeilschifter, M. Abruscato, S. Hövelmann, and et al. Thrombolysis in a stroke patient on dabigatran anticoagulation: case report and synopsis of published cases Case Rep Neurol 5 2013 56 61
4. M. Palladino, L. Thomson, B. Swift, and et al. Implementing the new oral anticoagulants into the hospital formulary Am J Hematol 87 2012 S127 S132
5. S.J. Connolly, M.D. Ezekowitz, S. Yusuf, and et al. Dabigatran versus warfarin in patients with atrial fibrillation N Engl J Med 361 2009 1139 1151
6. N. Wahlgren, N. Ahmed, A. Dávalos, and et al. Thrombolysis with alteplase for acute ischaemic stroke in the Safe Implementation of Thrombolysis in Stroke-Monitoring Study (SITS-MOST): an observational study Lancet 369 2007 275 282
7. T.M. Hemmen, K.S. Rapp, J.A. Emond, and et al. Analysis of the National Institute of Neurological Disorders and Stroke tissue plasminogen activator studies following European Cooperative Acute Stroke Study III patient selection criteria J Stroke Cerebrovasc Dis 19 2010 290 293
8. G.J. Hankey Unanswered questions and research priorities to optimise stroke prevention in atrial fibrillation with the new oral anticoagulants J Thromb Haemost 111 2014 808 816
9. G.J. Hankey, B. Norrving, W. Hacke, and et al. Management of acute stroke in patients taking novel oral anticoagulants Int J Stroke 9 2014 627 632
10. Xian Y., Liang L., E.E. Smith, and et al. Risks of intracranial hemorrhage among patients with acute ischemic stroke receiving warfarin and treated with intravenous tissue plasminogen activator JAMA 307 2012 2600 2608
11. E.C. Jauch, J.L. Saver, H.P. Adams, and et al. Guidelines for the early management of patients with acute ischemic stroke: a guideline for healthcare professionals from the American Heart Association/American Stroke Association Stroke 44 2013 870 947
12. A. Folyovich, V. Varga, K.A. Béres-Molnár, and et al. Dilemma of indication for thrombolysis in a patient with acute ischemic stroke treated with a novel oral anticoagulant J Stroke Cerebrovasc Dis 23 2014 580 582
13. M.M. Kawiorski, A. Alonso-Canovas, A. de Felipe Mimbrera, and et al. Successful intravenous thrombolysis in acute ischaemic stroke in a patient on rivaroxaban treatment J Thromb Haemost 111 2014 557 558
14. H. Heidbuchel, P. Verhamme, M. Alings, and et al. EHRA practical guide on the use of new oral anticoagulants in patients with non-valvular atrial fibrillation: executive summary Eur Heart J 34 2013 2094 2106
15. E. Tabata, M. Yasaka, Y. Wakugawa, and et al. Recombinant Tissue-type Plasminogen Activator (rt-PA) therapy in an acute stroke patient taking dabigatran etexilate: a case report and literature review Intern Med 53 2014 1506
16. S.T.S. Troke, and S.T.G. Roup Tissue plasminogen activator for acute ischemic stroke N Engl J Med 333 1995 1581 1587
17. The NINDS t-PA Stroke Study Group Intracerebral hemorrhage after intravenous t-pa therapy for ischemic stroke Stroke 28 1997 2109 2118
18. W. Hacke, M. Kaste, C. Fieschi, and et al. Intravenous thrombolysis with recombinant tissue plasminogen activator for acute hemispheric stroke. The European Cooperative Acute Stroke Study (ECASS) JAMA 274 1995 1017 1025
19. Anon, and IBM Corp IBM SPSS Statistics for Windows, Version 22.0 2013 IBM Corp Armonk, NY
20. J. Inaishi, S. Nogawa, Y. Mano, and et al. Successful thrombolysis without hemorrhage in a patient with cardioembolic stroke under dabigatran treatment- A case report and review of literature Rinsho Shinkeigaku 54 2014 238 240
21. I. Casado Naranjo, J.C. Portilla-Cuenca, P.E. Jiménez Caballero, and et al. Fatal intracerebral hemorrhage associated with administration of recombinant tissue plasminogen activator in a stroke patient on treatment with dabigatran Cerebrovasc Dis 32 2011 614 615
22. S. Jayathissa, J. Gommans, and P. Harper Stroke thrombolysis in patients taking dabigatran Intern Med J 43 2013 826 828
23. R. Govindarajan, and N. Galvez Is intravenous recombinant tissue plasminogen activator (r-tPA) safe in patients on Dabigatran? Intern Med J 7 2014 21 22
24. M. Kate, A. Szkotak, A. Witt, and et al. Proposed approach to thrombolysis in dabigatran-treated patients presenting with ischemic stroke J Stroke Cerebrovasc Dis 23 2014 1351 1355
25. K. Bornkamm, and A. Harloff Safe intravenous thrombolysis in acute stroke despite treatment with rivaroxaban J Clin Neurosci 21 2014 2012 2013
26. D.J. Seiffge, C. Traenka, H. Gensicke, and et al. Intravenous thrombolysis in stroke patients receiving rivaroxaban Eur J Neurol 21 2014 e3 e4
27. V.H. Lee, J.J. Conners, and S. Prabhakaran Intravenous thrombolysis in a stroke patient taking dabigatran J Stroke Cerebrovasc Dis 21 2012 916 e11-2
28. R.-J. Van Hooff, K. Nieboer, A. De Smedt, and et al. Intravenous thrombolysis with recombinant tissue plasminogen activator for acute ischemic stroke in a patient treated with rivaroxaban Clin Neurol Neurosurg 122 2014 133 134
29. E. Tabata, M. Yasaka, Y. Wakugawa, and et al. Recombinant Tissue type Pl as minogen Activator (rt-PA) therapy in an acute stroke patient taking dabigatran etexilate: a case report and literature review Intern Med 53 2014 1515 1517
30. N. Sangha, R. El Khoury, V. Misra, and et al. Acute ischemic stroke treated with intravenous tissue plasminogen activator in a patient taking dabigatran with radiographic evidence of recanalization J Stroke Cerebrovasc Dis 21 2012 917 e5-8
31. S. Kimura, T. Ogata, J. Fukae, and et al. Revascularization for acute ischemic stroke is safe for rivaroxaban users J Stroke Cerebrovasc Dis 10 2014 1 5
32. T. Steiner, M. Böhm, M. Dichgans, and et al. Recommendations for the emergency management of complications associated with new direct oral anticoagulants (DOAC) Apixaban, Dabigatran, and Rivaroxaban Clin Res Cardiol 102 2013 399 412
33. I. Rybinnik, M.T. Mullen, S. Messe, and et al. Treatment of acute stroke in patients on dabigatran: a survey of US stroke specialists J Stroke Cerebrovasc Dis 22 2013 1312 1316
34. L. Breuer, J. Ringwald, S. Schwab, and et al. Ischemic stroke in an obese patient receiving dabigatran N Engl J Med 368 2013 2440 2442
35. M.J. Alberts, R.A. Bernstein, G.V. Naccarelli, and et al. Using dabigatran in patients with stroke: a practical guide for clinicians Stroke 43 2012 271 279
36. I. Plener, S. Sadry, L. Mozessohn, and et al. Management of severe dabigatran-related hemorrhage: case report, considerations for management, and recommendations Can J Hosp Pharm 67 2014 43 47
37. C.-E. Dempfle, and M.G. Hennerici Fibrinolytic treatment of acute ischemic stroke for patients on new oral anticoagulant drugs Cerebrovasc Dis 32 2011 616 619
38. F.D. Testai Intravenous thrombolysis in a stroke patient taking dabigatran J Stroke Cerebrovasc Dis 22 2013 894
39. G. Lippi, D. Ardissino, R. Quintavalla, and et al. Urgent monitoring of direct oral anticoagulants in patients with atrial fibrillation: a tentative approach based on routine laboratory tests J Thromb Thrombolysis 38 2014 269 274
40. L. Kellert, M. Sykora, C. Gumbinger, and et al. Blood pressure variability after intravenous thrombolysis in acute stroke does not predict intracerebral hemorrhage but poor outcome Cerebrovasc Dis 33 2012 135 140
41. D. Tanne, S.E. Kasner, A.M. Demchuk, and et al. Markers of increased risk of intracerebral hemorrhage after intravenous recombinant tissue plasminogen activator therapy for acute ischemic stroke in clinical practice: the Multicenter rt-PA Stroke Survey Circulation 105 2002 1679 1685
42. A.J. Neal, B.C. Campbell V, A. Chandratheva, and et al. Intravenous thrombolysis for acute ischaemic stroke in the setting of rivaroxaban use J Clin Neurosci 21 2014 2013 2015
43. R. Brouns, R.-J. Van Hooff, A. De Smedt, and et al. Acute stroke management in patients taking dabigatran CNS Neurosci Ther 18 2012 616 622