Recombinant tissue-type plasminogen activator (rt-PA) therapy in an acute stroke patient taking dabigatran etexilate: A case report and literature review

Internal Medicine

Volumn 53, Issue 14, 2014, Pages 1515-1517

  Tabata, Emi ^a,b   Yasaka, Masahiro ^a   Wakugawa, Yoshiyuki ^a   Okada, Yasushi ^a  

^a NATIONAL HOSPITAL ORGANIZATION KYUSHU MEDICAL CENTER   (Japan)

^b SAGA UNIVERSITY   (Japan)

Author keywords

Activated partial thromboplastin time (APTT); Dabigatran; Recombinant tissue type plasminogen activator (rt PA) therapy

Indexed keywords

ALTEPLASE; DABIGATRAN ETEXILATE; BENZIMIDAZOLE DERIVATIVE; BLOOD CLOTTING FACTOR 10A INHIBITOR; FIBRINOLYTIC AGENT; PRODRUG; PYRIDINE DERIVATIVE; RECOMBINANT PROTEIN; TISSUE PLASMINOGEN ACTIVATOR;

AGED; ARTICLE; BRAIN INFARCTION; BRAIN ISCHEMIA; CAROTID ARTERY OBSTRUCTION; CAROTID ENDARTERECTOMY; CAROTID ULTRASONOGRAPHY; CASE REPORT; CEREBROVASCULAR ACCIDENT; COMPUTED TOMOGRAPHIC ANGIOGRAPHY; DYSARTHRIA; ECHOGRAPHY; HEMIPARESIS; HUMAN; MAGNETIC RESONANCE ANGIOGRAPHY; MALE; NATIONAL INSTITUTES OF HEALTH STROKE SCALE; PARTIAL THROMBOPLASTIN TIME; BLOOD; DOSE RESPONSE; DRUG COMBINATION; FIBRINOLYTIC THERAPY; PROCEDURES; TIME;

AGED; BENZIMIDAZOLES; BRAIN INFARCTION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG THERAPY, COMBINATION; FACTOR XA INHIBITORS; FIBRINOLYTIC AGENTS; HUMANS; MALE; PARTIAL THROMBOPLASTIN TIME; PRODRUGS; PYRIDINES; RECOMBINANT PROTEINS; THROMBOLYTIC THERAPY; TIME FACTORS; TISSUE PLASMINOGEN ACTIVATOR;

EID: 84904294590     PISSN: 09182918     EISSN: 13497235     Source Type: Journal    
DOI: 10.2169/internalmedicine.53.1506     Document Type: Article

References (8)

1. Sangha N, El Khoury R, Misra V, Lopez G. Acute ischemic stroke treated with intravenous tissue plasminogen activator in a patient taking dabigatran with radiographic evidence of recanalization. J Stroke Cerebrovasc Dis 21: 917.e5-917.e8, 2012.
2. Marrone LC, Marrone AC. Thrombolysis in an ischemic stroke patient on dabigatran anticoagulation: a case report. Cerebrovasc Dis 34: 246-247, 2012.
3. Lee VH, Conners JJ, Prabhakaran S. Intravenous thrombolysis in a stroke patient taking dabigatran. J Stroke Cerebrovasc Dis 21: 916.e11-916.e12, 2012.
4. Casado Naranjo I, Portilla-Cuenca JC, Jiménez Caballero PE, Calle Escobar ML, Romero Sevilla RM. Fatal intracerebral hemorrhage associated with administration of recombinant tissue plasminogen activator in a stroke patient on treatment with dabigatran. Cerebrovasc Dis 32: 614-615, 2011.
5. De Smedt A, De Raedt S, Nieboer K, De Keyser J, Brouns R. Intravenous thrombolysis with recombinant tissue plasminogen activator in a stroke patient treated with dabigatran. Cerebrovasc Dis 30: 533-534, 2010.
6. Matute MC, Guillán M, García-Caldentey J, et al. Thrombolysis treatment for acute ischaemic stroke in a patient on treatment with dabigatran. Thromb Haemost 106: 178-179, 2011.
7. Inaishi J, Nogawa S, Mano Y, Yoshizaki T, Okada S. Successful thrombolysis without hemorrhage in a patient with cardioembolic stroke under dabigatran treatment-a case report and review of literature. Rinsho Shinkeigaku (Clinical Neurology) 54: 238-240, 2014 (in Jpanese, Abstract in English).
8. Hayashi M, Iwafuchi S, Kimura J, et al Intravenous thrombolysis with rt-PA in a stroke patient treated with dabigatran. 37th annual meeting of the Japan Stroke Society, April 2012, Fukuoka, Japan.