Thrombolysis in a stroke patient on dabigatran anticoagulation: Case report and synopsis of published cases

Case Reports in Neurology

Volumn 5, Issue 1, 2013, Pages 56-61

  Pfeilschifter, Waltraud ^a   Abruscato, Mario ^b   Hövelmann, Susanne ^b   Baas, Horst ^b  

^a UNIVERSITY HOSPITAL FRANKFURT   (Germany)

^b Klinikum Hanau   (Germany)

Author keywords

Anticoagulation; Atrial fibrillation; Fibrinolytic; Hemorrhage; Stroke; Thrombolysis

Indexed keywords

ALTEPLASE; BC THROMBIN REAGENT; CREATININE; DABIGATRAN; FLECAINIDE; PATHROMBIN SL; RIVAROXABAN; THROMBOPLASTIN; UNCLASSIFIED DRUG; ACETYLSALICYLIC ACID; DABIGATRAN ETEXILATE;

AGED; ANTICOAGULANT THERAPY; ARTICLE; BLOOD CLOT LYSIS; CARDIOVASCULAR EQUIPMENT; CASE REPORT; CLINICAL FEATURE; COAGUMETER; COMPUTED TOMOGRAPHIC ANGIOGRAPHY; CREATININE BLOOD LEVEL; FEMALE; FOLLOW UP; HEART PALPITATION; HUMAN; HYPERTENSION; INTERNATIONAL NORMALIZED RATIO; MEDICATION COMPLIANCE; NATIONAL INSTITUTES OF HEALTH STROKE SCALE; OCCLUSIVE CEREBROVASCULAR DISEASE; PAROXYSMAL HEART ATRIUM FIBRILLATION; PARTIAL THROMBOPLASTIN TIME; PRIORITY JOURNAL; RECANALIZATION; SIDE EFFECT; STROKE PATIENT; SYMPTOM; THROMBIN TIME; ANTICOAGULATION; BRAIN INFARCTION; COMPUTER ASSISTED TOMOGRAPHY; ECCHYMOSIS; HEART ATRIUM FIBRILLATION; MALE; TRANSTHORACIC ECHOCARDIOGRAPHY;

EID: 84877994800     PISSN: None     EISSN: 1662680X     Source Type: Journal    
DOI: 10.1159/000350570     Document Type: Article

References (16)

1. Connolly SJ, Ezekowitz MD, Yusuf S, Eikelboom J, Oldgren J, Parekh A, Pogue J, Reilly PA, Themeles E, Varrone J, Wang S, Alings M, Xavier D, Zhu J, Diaz R, Lewis BS, Darius H, Diener HC, Joyner CD, Wallentin L; RE-LY Steering Committee and Investigators: Dabigatran versus warfarin in patients with atrial fibrillation. N Engl J Med 2009;361:1139-1151.
2. Patel MR, Mahaffey KW, Garg J, Pan G, Singer DE, Hacke W, Breithardt G, Halperin JL, Hankey GJ, Piccini JP, Becker RC, Nessel CC, Paolini JF, Berkowitz SD, Fox KA, Califf RM; ROCKET AF Investigators: Rivaroxaban versus warfarin in nonvalvular atrial fibrillation. N Engl J Med 2011;365:883-891.
3. Granger CB, Alexander JH, McMurray JJ, Lopes RD, Hylek EM, Hanna M, Al-Khalidi HR, Ansell J, Atar D, Avezum A, Bahit MC, Diaz R, Easton JD, Ezekowitz JA, Flaker G, Garcia D, Geraldes M, Gersh BJ, Golitsyn S, Goto S, Hermosillo AG, Hohnloser SH, Horowitz J, Mohan P, Jansky P, Lewis BS, Lopez-Sendon JL, Pais P, Parkhomenko A, Verheugt FW, Zhu J, Wallentin L; ARISTOTLE Committees and Investigators: Apixaban versus warfarin in patients with atrial fibrillation. N Engl J Med 2011;365:981-992.
4. Capodanno D, Capranzano P, Giacchi G, Calvi V, Tamburino C: Novel oral anticoagulants versus warfarin in non-valvular atrial fibrillation: A meta-analysis of 50, 578 patients. Int J Cardiol 2012, E-pub ahead of print.
5. van Ryn J, Stangier J, Haertter S, Liesenfeld KH, Wienen W, Feuring M, Clemens A: Dabigatran etexilate-a novel, reversible, oral direct thrombin inhibitor: interpretation of coagulation assays and reversal of anticoagulant activity. Thromb Haemost 2010;103:1116-1127.
6. Chong CA, Chiu L: Dabigatran and acute stroke thrombolysis. Cerebrovasc Dis 2010;30:202.
7. Casado Naranjo I, Portilla-Cuenca JC, Jiménez Caballero PE, Calle Escobar ML, Romero Sevilla RM: Fatal intracerebral hemorrhage associated with administration of recombinant tissue plasminogen activator in a stroke patient on treatment with dabigatran. Cerebrovasc Dis 2011;32:614-615.
8. De Smedt A, De Raedt S, Nieboer K, De Keyser J, Brouns R: Intravenous thrombolysis with recombinant tissue plasminogen activator in a stroke patient treated with dabigatran. Cerebrovasc Dis 2010;30:533-534.
9. Matute MC, Guillán M, García-Caldentey J, Buisan J, Aparicio M, Masjuan J, Alonso de Leciñana M: Thrombolysis treatment for acute ischaemic stroke in a patient on treatment with dabigatran. Thromb Haemost 2011;106:178-179.
10. Sangha N, El Khoury R, Misra V, Lopez G: Acute ischemic stroke treated with intravenous tissue plasminogen activator in a patient taking dabigatran with radiographic evidence of recanalization. J Stroke Cerebrovasc Dis 2012;21:917.e5-e8.
11. Marrone LC, Marrone AC: Thrombolysis in an ischemic stroke patient on dabigatran anticoagulation: a case report. Cerebrovasc Dis 2012;34:246-247.
12. Lee VH, Conners JJ, Prabhakaran S: Intravenous thrombolysis in a stroke patient taking dabigatran. J Stroke Cerebrovasc Dis 2012;21:916.e11-e12.
13. Mani H, Hesse C, Stratmann G, Lindhoff-Last E: Rivaroxaban differentially influences ex vivo global coagulation assays based on the administration time. Thromb Haemost 2011;106:156-164.
14. Pfeilschifter W, Bohmann F, Baumgarten P, Mittelbronn M, Pfeilschifter J, Lindhoff-Last E, Steinmetz H, Foerch C: Thrombolysis with recombinant tissue plasminogen activator under dabigatran anticoagulation in experimental stroke. Ann Neurol 2012;71:624-633.
15. Bohmann F, Mirceska A, Pfeilschifter J, Lindhoff-Last E, Steinmetz H, Foerch C, Pfeilschifter W: No influence of dabigatran anticoagulation on hemorrhagic transformation in an experimental model of ischemic stroke. PLoS One 2012;7:e40804.
16. Gliem M, Hermsen D, van Rooijen N, Hartung HP, Jander S: Secondary intracerebral hemorrhage due to early initiation of oral anticoagulation after ischemic stroke: an experimental study in mice. Stroke 2012;43:3352-3357.