Successful thrombolysis without hemorrhage in a patient with cardioembolic stroke under dabigatran treatment - A case report and review of literature

Clinical Neurology

Volumn 54, Issue 3, 2014, Pages 238-240

  Inaishi, Jun ^a   Nogawa, Shigeru ^a   Mano, Yoshinori ^a   Yoshizaki, Takahito ^a   Okada, Satoshi ^a  

^a TOKYO DENTAL COLLEGE   (Japan)

Author keywords

Alteplase; Cardioembolic stroke; Dabigatran; Novel oral anticoalgulants; Rt PA

Indexed keywords

ALTEPLASE; DABIGATRAN; ANTITHROMBIN; BENZIMIDAZOLE DERIVATIVE; BETA ALANINE; RECOMBINANT PROTEIN; TISSUE PLASMINOGEN ACTIVATOR;

AGED; ARTICLE; BLOOD CLOT LYSIS; BRAIN HEMORRHAGE; CARDIOEMBOLIC STROKE; CASE REPORT; DIFFUSION WEIGHTED IMAGING; DYSARTHRIA; FIBRINOLYTIC THERAPY; FRONTAL GYRUS; HEART ATRIUM FIBRILLATION; HEART FAILURE; HEMIPARESIS; HUMAN; MALE; NATIONAL INSTITUTES OF HEALTH STROKE SCALE; PARTIAL THROMBOPLASTIN TIME; RANKIN SCALE; ANALOGS AND DERIVATIVES; ATRIAL FIBRILLATION; INTRAVENOUS DRUG ADMINISTRATION; STROKE; TIME; TREATMENT OUTCOME;

AGED; ANTITHROMBINS; ATRIAL FIBRILLATION; BENZIMIDAZOLES; BETA-ALANINE; DIFFUSION MAGNETIC RESONANCE IMAGING; HUMANS; INFUSIONS, INTRAVENOUS; MALE; PARTIAL THROMBOPLASTIN TIME; RECOMBINANT PROTEINS; STROKE; THROMBOLYTIC THERAPY; TIME FACTORS; TISSUE PLASMINOGEN ACTIVATOR; TREATMENT OUTCOME;

EID: 84896528346     PISSN: 0009918X     EISSN: None     Source Type: Journal    
DOI: 10.5692/clinicalneurol.54.238     Document Type: Article

References (9)

1. Connolly SJ, Ezekowitz MD, Yusuf S, et al Dabigatran versus warfarin in patients with atrial fibrillation. N Engl J Med 2009;361:1139-1151.
2. De Smedt A., De Raedt S, Nieboer K, et al Intravenous thrombolysis with recombinant tissue plasminogen activator in a stroke patient treated with dabigatran. Cerebrovasc Dis 2010; 30:533-534.
3. Matute MC, Guillan M, Garcia-Caldentey J, et al Thrombolysis treatment for acute ischaemic stroke in a patient on treatment with dabigatran. Thromb Haemost 2011;106:178-179.
4. Casado Naranjo I., Portilla-Cuenca JC, Jimenez Caballero PE, et al Fatal intracerebral hemorrhage associated with administration of recombinant tissue plasminogen activator in a stroke patient on treatment with dabigatran. Cerebrovasc Dis 2011;32: 614-615.
5. Lee VH, Conners JJ, Prabhakaran S. Intravenous thrombolysis in a stroke patient taking dabigatran. J Stroke Cerebrovasc Dis 2012;21:916e11-12.
6. Sangha N, El Khoury R, Misra V, et al Acute ischemic stroke treated with intravenous tissue plasminogen activator in a patient taking dabigatran with radiographic evidence of recanalization. J Stroke Cerebrovasc Dis 2012;21:917 e5-8.
7. Marrone LC, Marrone AC Thrombolysis in an ischemic stroke patient on dabigatran anticoagulation: a case report. Cerebrovasc Dis 2012;34:246-247.
8. Ammollo CT, Semeraro F, Incampo F., et al Dabigatran enhances clot susceptibility to fibrinolysis by mechanisms dependent on and independent of thrombin-activatable fibrinolysis inhibitor. J Thromb Haemost 2010;8:790-798.
9. Pfeilschifter W, Bohmann F, Baumgarten P., et al Thrombolysis with recombinant tissue plasminogen activator under dabigatran anticoagulation in experimental stroke. Ann Neurol 2012;71: 624-633.