Large-Scale Conformational Dynamics Control H5N1 Influenza Polymerase PB2 Binding to Importin α

Journal of the American Chemical Society

Volumn 137, Issue 48, 2015, Pages 15122-15134

  Delaforge, Elise ^a,b,c   Milles, Sigrid ^a,b,c   Bouvignies, Guillaume ^a,b,c   Bouvier, Denis ^a,b,c,d,e   Boivin, Stephane ^a,d,e   Salvi, Nicola ^a,b,c   Maurin, Damien ^a,b,c   Martel, Anne ^f   Round, Adam ^e   Lemke, Edward A ^g   Ringkjøbing Jensen, Malene ^a,b,c   Hart, Darren J ^a,d,e   Blackledge, Martin ^a,b,c  

^a UNIV GRENOBLE ALPES   (France)

^b CEA GRENOBLE   (France)

^c INSTITUT DE BIOLOGIE STRUCTURALE   (France)

^d CNRS   (France)

^e EUROPEAN MOLECULAR BIOLOGY LABORATORY   (France)

^f INSTITUT LAUE LANGEVIN   (France)

^g EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION ANALYSIS; BINDING ENERGY; CHEMICAL BONDS; CONFORMATIONS; ENERGY TRANSFER; FORSTER RESONANCE ENERGY TRANSFER; NEUTRON SCATTERING; NUCLEAR MAGNETIC RESONANCE; POLYMERS; TEMPERATURE DISTRIBUTION; X RAY SCATTERING;

CHEMICAL EXCHANGE SATURATION TRANSFER; CONFORMATIONAL DYNAMICS; CONFORMATIONAL EQUILIBRIUM; CONFORMATIONAL FLEXIBILITY; CONFORMATIONAL SELECTION; CRYSTALLOGRAPHIC STRUCTURE; TEMPERATURE DEPENDENCE; TEMPERATURE DEPENDENT DYNAMICS;

INTERFACE STATES;

KARYOPHERIN ALPHA; PB2 PROTEIN; UNCLASSIFIED DRUG; VIRUS PROTEIN; KARYOPHERIN; PB2 PROTEIN, INFLUENZA VIRUS; PROTEIN BINDING; SOLUTION AND SOLUBILITY;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; ENTHALPY; ENTROPY; FLUORESCENCE RESONANCE ENERGY TRANSFER; INFLUENZA A VIRUS (H5N1); MOLECULAR DYNAMICS; NEUTRON SCATTERING; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN STRUCTURE; PROTON NUCLEAR MAGNETIC RESONANCE; TEMPERATURE DEPENDENCE; X RAY CRYSTALLOGRAPHY; CHEMISTRY; ENZYMOLOGY; METABOLISM; PROTEIN CONFORMATION; SOLUTION AND SOLUBILITY;

CRYSTALLOGRAPHY, X-RAY; FLUORESCENCE RESONANCE ENERGY TRANSFER; INFLUENZA A VIRUS, H5N1 SUBTYPE; KARYOPHERINS; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEIN BINDING; PROTEIN CONFORMATION; SOLUTIONS; VIRAL PROTEINS;

EID: 84949591315     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/jacs.5b07765     Document Type: Article

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