PB2 mutations D701N and S714R promote adaptation of an influenza H5N1 virus to a mammalian host

Journal of Virology

Volumn 88, Issue 16, 2014, Pages 8735-8742

  Czudai Matwich, Volker ^a   Otte, Anna ^b   Matrosovich, Mikhail ^a   Gabriel, Gülsah ^b   Klenk, Hans Dieter ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

^b LEIBNIZ INSTITUTE FOR EXPERIMENTAL VIROLOGY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; ISOLEUCINE; NUCLEOTIDYLTRANSFERASE; PROTEIN PB2; SERINE; UNCLASSIFIED DRUG;

ADAPTATION; AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; HOST PATHOGEN INTERACTION; HUMAN; HUMAN CELL; INFLUENZA VIRUS A H5N1; MOUSE; MUTATION; NONHUMAN; PRIORITY JOURNAL; VIROGENESIS; VIRUS RECOMBINANT; VIRUS REPLICATION; VIRUS VIRULENCE;

ADAPTATION, PHYSIOLOGICAL; ANIMALS; DOGS; HEK293 CELLS; HUMANS; INFLUENZA A VIRUS, H5N1 SUBTYPE; INFLUENZA, HUMAN; MADIN DARBY CANINE KIDNEY CELLS; MAMMALS; MICE; MICE, INBRED BALB C; MUTATION; ORTHOMYXOVIRIDAE INFECTIONS; RNA REPLICASE; VIRAL PROTEINS;

EID: 84904870654     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.00422-14     Document Type: Article

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