The myeloperoxidase-derived oxidant hypothiocyanous acid inhibits protein tyrosine phosphatases via oxidation of key cysteine residues

Free Radical Biology and Medicine

Volumn 90, Issue , 2016, Pages 195-205

  Cook, Naomi L ^a   Moeke, Cassidy H ^a,b   Fantoni, Luca I ^a   Pattison, David I ^a,b   Davies, Michael J ^a,b,c  

^a HEART RESEARCH INSTITUTE   (Australia)

^b UNIVERSITY OF SYDNEY   (Australia)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Inflammation; Myeloperoxidase; Phosphorylation; Protein oxidation; Protein tyrosine phosphatases; Sulfenic acid; Thiol

Indexed keywords

5,5 DIMETHYL 1,3 CYCLOHEXANEDIONE; CD45 ANTIGEN; CYSTEINE; HYPOTHIOCYANOUS ACID; LEUKOCYTE ANTIGEN; MYELOPEROXIDASE; OXIDIZING AGENT; PHOSPHOTRANSFERASE; PROTEIN TYROSINE PHOSPHATASE; PROTEIN TYROSINE PHOSPHATASE SHP 1; SULFENIC ACID DERIVATIVE; THIOCYANIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CELL LYSATE; CONTROLLED STUDY; ENZYME ACTIVITY; HUMAN; HUMAN CELL; LIQUID CHROMATOGRAPHY; MACROPHAGE; MASS SPECTROMETRY; OXIDATION; PEPTIDE MAPPING; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; T LYMPHOCYTE; WESTERN BLOTTING; AMINO ACID SEQUENCE; ANTAGONISTS AND INHIBITORS; CELL CULTURE; METABOLISM; MOLECULAR GENETICS; OXIDATION REDUCTION REACTION;

AMINO ACID SEQUENCE; CELLS, CULTURED; CYSTEINE; HUMANS; MOLECULAR SEQUENCE DATA; OXIDATION-REDUCTION; PROTEIN TYROSINE PHOSPHATASES; THIOCYANATES;

EID: 84949570876     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2015.11.025     Document Type: Article

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