Profiles of microRNA networks in intestinal epithelial cells in a mouse model of colitis

Scientific Reports

Volumn 5, Issue , 2015, Pages

  Lee, Juneyoung ^a   Park, Eun Jeong ^a,d   Yuki, Yoshikazu ^a   Ahmad, Shandar ^b   Mizuguchi, Kenji ^b   Ishii, Ken J ^b,c   Shimaoka, Motomu ^d   Kiyono, Hiroshi ^a,e  

^a UNIVERSITY OF TOKYO   (Japan)

^b NATIONAL INSTITUTE OF BIOMEDICAL INNOVATION   (Japan)

^c OSAKA UNIVERSITY   (Japan)

^d MIE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^e JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

MICRORNA; TRANSCRIPTOME;

ANIMAL; ANTIBODY SPECIFICITY; COLITIS; COLON; DISEASE MODEL; EPITHELIUM CELL; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE REGULATORY NETWORK; GENETICS; INFLAMMATORY BOWEL DISEASE; INTESTINE MUCOSA; METABOLISM; MOUSE; PATHOLOGY; SMALL INTESTINE;

ANIMALS; COLITIS; COLON; DISEASE MODELS, ANIMAL; EPITHELIAL CELLS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE REGULATORY NETWORKS; INFLAMMATORY BOWEL DISEASES; INTESTINAL MUCOSA; INTESTINE, SMALL; MICE; MICRORNAS; ORGAN SPECIFICITY; TRANSCRIPTOME;

EID: 84949570870     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep18174     Document Type: Article

References (60)

1. Antoni, L., Nuding, S., Wehkamp, J. & Stange, E. F. Intestinal barrier in inflammatory bowel disease. World journal of gastroenterology: WJG 20, 1165-1179 (2014).
2. Kagnoff, M. F. The intestinal epithelium is an integral component of a communications network. J Clin Invest 124, 2841-2843 (2014).
3. Bartel, D. P. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116, 281-297 (2004).
4. Pekow, J. R. & Kwon, J. H. MicroRNAs in inflammatory bowel disease. Inflamm Bowel Dis 18, 187-193 (2012).
5. Fakhoury, M., Negrulj, R., Mooranian, A. & Al-Salami, H. Inflammatory bowel disease: clinical aspects and treatments. Journal of inflammation research 7, 113-120 (2014).
6. Vowinkel, T. et al. Impact of dextran sulfate sodium load on the severity of inflammation in experimental colitis. Digestive diseases and sciences 49, 556-564 (2004).
7. Hong, M. Y. et al. Differential response to DNA damage may explain different cancer susceptibility between small and large intestine. Experimental biology and medicine 230, 464-471 (2005).
8. Wu, F. et al. Identification of microRNAs associated with ileal and colonic Crohn's disease. Inflamm Bowel Dis 16, 1729-1738 (2010).
9. Friedman, R. C., Farh, K. K., Burge, C. B. & Bartel, D. P. Most mammalian mRNAs are conserved targets of microRNAs. Genome research 19, 92-105 (2009).
10. Chen, Y. A., Tripathi, L. P. & Mizuguchi, K. TargetMine, an integrated data warehouse for candidate gene prioritisation and target discovery. PloS one 6, e17844 (2011).
11. Josse, C. et al. Identification of a microRNA landscape targeting the PI3K/Akt signaling pathway in inflammation-induced colorectal carcinogenesis. Am J Physiol Gastrointest Liver Physiol 306, G229-243 (2014).
12. MacFie, T. S. et al. DUOX2 and DUOXA2 form the predominant enzyme system capable of producing the reactive oxygen species H2O2 in active ulcerative colitis and are modulated by 5-aminosalicylic acid. Inflamm Bowel Dis 20, 514-524 (2014).
13. Hong, F., Wu, B. X. & Li, Z. Molecular regulation of macrophages in unleashing cancer-related inflammation. Oncoimmunology 3, e27659 (2014).
14. Byrnes, J. J. et al. Effects of the ACE2 inhibitor GL1001 on acute dextran sodium sulfate-induced colitis in mice. Inflamm Res 58, 819-827 (2009).
15. Cattaneo, E. et al. Preinvasive colorectal lesion transcriptomes correlate with endoscopic morphology (polypoid vs. nonpolypoid). EMBO molecular medicine 3, 334-347 (2011).
16. Jaschke, A. et al. The GTPase ARFRP1 controls the lipidation of chylomicrons in the Golgi of the intestinal epithelium. Human molecular genetics 21, 3128-3142 (2012).
17. Ajuebor, M. N., Kunkel, S. L. & Hogaboam, C. M. The role of CCL3/macrophage inflammatory protein-1alpha in experimental colitis. European journal of pharmacology 497, 343-349 (2004).
18. Schenk, M., Bouchon, A., Seibold, F. & Mueller, C. TREM-1-expressing intestinal macrophages crucially amplify chronic inflammation in experimental colitis and inflammatory bowel diseases. J Clin Invest 117, 3097-3106 (2007).
19. Somasundaram, R. et al. Linking risk conferring mutations in NCF4 to functional consequences in Crohn's disease. Gut 61, 1097; author reply 1097-1098 (2012).
20. Egesten, A. et al. The proinflammatory CXC-chemokines GRO-alpha/CXCL1 and MIG/CXCL9 are concomitantly expressed in ulcerative colitis and decrease during treatment with topical corticosteroids. International journal of colorectal disease 22, 1421-1427 (2007).
21. Muise, A. M. et al. NADPH oxidase complex and IBD candidate gene studies: identification of a rare variant in NCF2 that results in reduced binding to RAC2. Gut 61, 1028-1035 (2012).
22. Jiang, H. R. et al. Influence of Slc11a1 (formerly Nramp1) on DSS-induced colitis in mice. Journal of leukocyte biology 85, 703-710 (2009).
23. Becker, S. et al. Overexpression of CD97 in intestinal epithelial cells of transgenic mice attenuates colitis by strengthening adherens junctions. PloS one 5, e8507 (2010).
24. Hasler, R. et al. Alterations of pre-mRNA splicing in human inflammatory bowel disease. European journal of cell biology 90, 603-611 (2011).
25. Uza, N. et al. SR-PSOX/CXCL16 plays a critical role in the progression of colonic inflammation. Gut 60, 1494-1505 (2011).
26. Zhou, J. S. et al. Prevention of lipopolysaccharide-induced microangiopathy by gp49B1: evidence for an important role for gp49B1 expression on neutrophils. J Exp Med 198, 1243-1251 (2003).
27. Wilson, G. J. et al. The C-type lectin receptor CLECSF8/CLEC4D is a key component of anti-mycobacterial immunity. Cell host & microbe 17, 252-259 (2015).
28. Kovacs, M. et al. The Src family kinases Hck, Fgr, and Lyn are critical for the generation of the in vivo inflammatory environment without a direct role in leukocyte recruitment. J Exp Med 211, 1993-2011 (2014).
29. Castellanos-Rubio, A. et al. Angiogenesis-related gene expression analysis in celiac disease. Autoimmunity 45, 264-270 (2012).
30. Sadik, C. D., Kim, N. D., Alekseeva, E. & Luster, A. D. IL-17RA signaling amplifies antibody-induced arthritis. PloS one 6, e26342 (2011).
31. Koller, F. L., Hwang, D. G., Dozier, E. A. & Fingleton, B. Epithelial interleukin-4 receptor expression promotes colon tumor growth. Carcinogenesis 31, 1010-1017 (2010).
32. Sanchez-Martinez, D. et al. All-trans retinoic acid (ATRA) induces miR-23a expression, decreases CTSC expression and granzyme B activity leading to impaired NK cell cytotoxicity. The international journal of biochemistry & cell biology 49, 42-52 (2014).
33. Wells, C. A. et al. The macrophage-inducible C-type lectin, mincle, is an essential component of the innate immune response to Candida albicans. J Immunol 180, 7404-7413 (2008).
34. Brown, V. K. et al. Multiple components of the B cell antigen receptor complex associate with the protein tyrosine phosphatase, CD45. The Journal of biological chemistry 269, 17238-17244 (1994).
35. Deuring, J. J. et al. Impeded protein folding and function in active inflammatory bowel disease. Biochem Soc Trans 39, 1107-1111 (2011).
36. Ricanek, P. et al. Reduced expression of aquaporins in human intestinal mucosa in early stage inflammatory bowel disease. Clinical and experimental gastroenterology 8, 49-67 (2015).
37. Hsieh, S. Y. et al. Comparative proteomic studies on the pathogenesis of human ulcerative colitis. Proteomics 6, 5322-5331 (2006).
38. Wen, T. et al. Carbonic anhydrase IV is expressed on IL-5-activated murine eosinophils. J Immunol 192, 5481-5489 (2014).
39. Mueller-Ortiz, S. L. et al. Targeted disruption of the gene encoding the murine small subunit of carboxypeptidase N (CPN1) causes susceptibility to C5a anaphylatoxin-mediated shock. J Immunol 182, 6533-6539 (2009).
40. Ly, N. P. et al. Netrin-1 inhibits leukocyte migration in vitro and in vivo. Proc Natl Acad Sci USA 102, 14729-14734 (2005).
41. Temesi, G. et al. Novel genes in Human Asthma Based on a Mouse Model of Allergic Airway Inflammation and Human Investigations. Allergy, asthma & immunology research 6, 496-503 (2014).
42. Zhang, H. et al. STIM1 calcium sensor is required for activation of the phagocyte oxidase during inflammation and host defense. Blood 123, 2238-2249 (2014).
43. Nedvetzki, S. et al. RHAMM, a receptor for hyaluronan-mediated motility, compensates for CD44 in inflamed CD44-knockout mice: a different interpretation of redundancy. Proc Natl Acad Sci USA 101, 18081-18086 (2004).
44. Meyer, M. S. et al. Genetic variation in RNASEL associated with prostate cancer risk and progression. Carcinogenesis 31, 1597-1603 (2010).
45. Toiyama, Y. et al. DPEP1, expressed in the early stages of colon carcinogenesis, affects cancer cell invasiveness. Journal of gastroenterology 46, 153-163 (2011).
46. Zang, Z. J. et al. Exome sequencing of gastric adenocarcinoma identifies recurrent somatic mutations in cell adhesion and chromatin remodeling genes. Nature genetics 44, 570-574 (2012).
47. Orchard-Webb, D. J., Lee, T. C., Cook, G. P. & Blair, G. E. CUB domain containing protein 1 (CDCP1) modulates adhesion and motility in colon cancer cells. BMC cancer 14, 754 (2014).
48. Stenling, R., Lindberg, J., Rutegard, J. & Palmqvist, R. Altered expression of CK7 and CK20 in preneoplastic and neoplastic lesions in ulcerative colitis. APMIS: acta pathologica, microbiologica, et immunologica Scandinavica 115, 1219-1226 (2007).
49. Speckmann, B. et al. Intestinal selenoprotein P in epithelial cells and in plasma cells. Archives of biochemistry and biophysics 541, 30-36 (2014).
50. Giovannetti, E. et al. High-throughput microRNA (miRNAs) arrays unravel the prognostic role of MiR-211 in pancreatic cancer. PloS one 7, e49145 (2012).
51. Kiesler, P., Fuss, I. J. & Strober, W. Experimental Models of Inflammatory Bowel Diseases. Cell Mol Gastroenterol Hepatol 1, 154-170 (2015).
52. Xavier, R. J. & Podolsky, D. K. Unravelling the pathogenesis of inflammatory bowel disease. Nature 448, 427-434 (2007).
53. Dieleman, L. A. et al. Dextran sulfate sodium-induced colitis occurs in severe combined immunodeficient mice. Gastroenterology 107, 1643-1652 (1994).
54. Bowcutt, R. et al. Heterogeneity across the murine small and large intestine. World journal of gastroenterology: WJG 20, 15216-15232 (2014).
55. Kaser, A., Niederreiter, L. & Blumberg, R. S. Genetically determined epithelial dysfunction and its consequences for microflora-host interactions. Cell Mol Life Sci 68, 3643-3649 (2011).
56. Archanioti, P. et al. Micro-RNAs as regulators and possible diagnostic bio-markers in inflammatory bowel disease. Journal of Crohn's & colitis 5, 520-524 (2011).
57. Hubenthal, M. et al. Sparse Modeling Reveals miRNA Signatures for Diagnostics of Inflammatory Bowel Disease. PloS one 10, e0140155 (2015).
58. Fasseu, M. et al. Identification of restricted subsets of mature microRNA abnormally expressed in inactive colonic mucosa of patients with inflammatory bowel disease. PloS one 5, e13160 (2010).
59. Morey, J. S., Ryan, J. C. & Van Dolah, F. M. Microarray validation: factors influencing correlation between oligonucleotide microarrays and real-time PCR. Biological procedures online 8, 175-193 (2006).
60. Qian, Y. et al. The adaptor Act1 is required for interleukin 17-dependent signaling associated with autoimmune and inflammatory disease. Nat Immunol 8, 247-256 (2007).