G12V and G12A KRAS mutations are associated with poor outcome in patients with metastatic colorectal cancer treated with bevacizumab

Tumor Biology

Volumn 37, Issue 5, 2016, Pages 6823-6830

  Fiala, Ondrej ^a   Buchler, Tomas ^a   Mohelnikova Duchonova, Beatrice ^b   Melichar, Bohuslav ^b   Matejka, Vit Martin ^a   Holubec, Lubos ^a   Kulhankova, Jana ^a   Bortlicek, Zbynek ^c   Bartouskova, Marie ^b   Liska, Vaclav ^a   Topolcan, Ondrej ^a   Sedivcova, Monika ^d   Finek, Jindrich ^a  

^a CHARLES UNIVERSITY   (Czech Republic)

^b PALACKÝ UNIVERSITY   (Czech Republic)

^c MASARYK UNIVERSITY   (Czech Republic)

^d Czech Republic Bioptic Laboratory   (Czech Republic)

Author keywords

Bevacizumab; Chemotherapy; Colorectal cancer; KRAS; Mutation

Indexed keywords

BEVACIZUMAB; CAPECITABINE; FLUOROURACIL; FOLINIC ACID; IRINOTECAN; OXALIPLATIN; CODON; RAS PROTEIN;

ADULT; AGED; ARTICLE; CANCER PROGNOSIS; CANCER SURVIVAL; FEMALE; GENE MUTATION; GENETIC ASSOCIATION; HUMAN; MAJOR CLINICAL STUDY; MALE; METASTATIC COLORECTAL CANCER; ONCOGENE K RAS; OVERALL SURVIVAL; PRIORITY JOURNAL; PROGRESSION FREE SURVIVAL; RISK FACTOR; SURVIVAL TIME; VERY ELDERLY; WILD TYPE; ALLELE; CODON; COLORECTAL NEOPLASMS; GENETICS; KAPLAN MEIER METHOD; METASTASIS; MIDDLE AGED; MORTALITY; MULTIMODALITY CANCER THERAPY; MUTATION; PATHOLOGY; PROGNOSIS; PROPORTIONAL HAZARDS MODEL; RETREATMENT; TREATMENT OUTCOME;

ADULT; AGED; AGED, 80 AND OVER; ALLELES; BEVACIZUMAB; CODON; COLORECTAL NEOPLASMS; COMBINED MODALITY THERAPY; FEMALE; HUMANS; KAPLAN-MEIER ESTIMATE; MALE; MIDDLE AGED; MUTATION; NEOPLASM METASTASIS; PROGNOSIS; PROPORTIONAL HAZARDS MODELS; RAS PROTEINS; RETREATMENT; TREATMENT OUTCOME;

EID: 84949567612     PISSN: 10104283     EISSN: 14230380     Source Type: Journal    
DOI: 10.1007/s13277-015-4523-7     Document Type: Article

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