메뉴 건너뛰기




Volumn 30, Issue 3, 2013, Pages

KRAS as prognostic biomarker in metastatic colorectal cancer patients treated with bevacizumab: A pooled analysis of 12 published trials

Author keywords

Bevacizumab; Colorectal cancer; KRAS; Predictive factor; Prognosis

Indexed keywords

BEVACIZUMAB; CAPECITABINE; CAPECITABINE PLUS OXALIPLATIN; FLUOROURACIL; FOLINIC ACID; IRINOTECAN; K RAS PROTEIN; MITOMYCIN; OXALIPLATIN; ANGIOGENESIS INHIBITOR; KRAS PROTEIN, HUMAN; MONOCLONAL ANTIBODY; ONCOPROTEIN; RAS PROTEIN; TUMOR MARKER;

EID: 84879590699     PISSN: 13570560     EISSN: 1559131X     Source Type: Journal    
DOI: 10.1007/s12032-013-0650-4     Document Type: Review
Times cited : (42)

References (38)
  • 1
    • 84866241598 scopus 로고    scopus 로고
    • Is K-ras gene mutation a prognostic factor for colorectal cancer: A systematic review and meta-analysis
    • Ren J, Li G, Ge J, Li X, Zhao Y. Is K-ras gene mutation a prognostic factor for colorectal cancer: a systematic review and meta-analysis. Dis Colon Rectum. 2012;55(8):913-23.
    • (2012) Dis Colon Rectum , vol.55 , Issue.8 , pp. 913-923
    • Ren, J.1    Li, G.2    Ge, J.3    Li, X.4    Zhao, Y.5
  • 2
    • 0035863495 scopus 로고    scopus 로고
    • K-ras and p16 aberrations confer poor prognosis in human colorectal cancer
    • Esteller M, González S, Risques RA, et al. K-ras and p16 aberrations confer poor prognosis in human colorectal cancer. J Clin Oncol. 2001;19:299-304.
    • (2001) J Clin Oncol , vol.19 , pp. 299-304
    • Esteller, M.1    González, S.2    Risques, R.A.3
  • 3
    • 0032032984 scopus 로고    scopus 로고
    • The type of K-ras mutation determines prognosis in colorectal cancer
    • Cerottini JP, Caplin S, Saraga E, Givel JC, Benhattar J. The type of K-ras mutation determines prognosis in colorectal cancer. Am J Surg. 1998;175(3):198-202.
    • (1998) Am J Surg , vol.175 , Issue.3 , pp. 198-202
    • Cerottini, J.P.1    Caplin, S.2    Saraga, E.3    Givel, J.C.4    Benhattar, J.5
  • 5
    • 0035444798 scopus 로고    scopus 로고
    • Kirsten ras mutations in patients with colorectal cancer: The 'RASCAL II' study
    • Andreyev HJ, Norman AR, Cunningham D, et al. Kirsten ras mutations in patients with colorectal cancer: the 'RASCAL II' study. Br J Cancer. 2001;85:692-6.
    • (2001) Br J Cancer , vol.85 , pp. 692-696
    • Andreyev, H.J.1    Norman, A.R.2    Cunningham, D.3
  • 6
    • 0032521205 scopus 로고    scopus 로고
    • Ki-ras mutation and p53 overexpression predict the clinical behavior of colorectal cancer: A Southwest oncology group study
    • Ahnen DJ, Feigl P, Quan G, et al. Ki-ras mutation and p53 overexpression predict the clinical behavior of colorectal cancer: a Southwest Oncology Group study. Cancer Res. 1998;58:1149-58.
    • (1998) Cancer Res , vol.58 , pp. 1149-1158
    • Ahnen, D.J.1    Feigl, P.2    Quan, G.3
  • 7
    • 77957205044 scopus 로고    scopus 로고
    • Predictive and prognostic value of KRAS mutations in metastatic colorectal cancer patients treated with cetuximab: A metaanalysis of 22 studies
    • Qiu LX, Mao C, Zhang J, Zhu XD, Liao RY, Xue K, Li J, Chen Q. Predictive and prognostic value of KRAS mutations in metastatic colorectal cancer patients treated with cetuximab: a metaanalysis of 22 studies. Eur J Cancer. 2010;46(15):2781-7.
    • (2010) Eur J Cancer , vol.46 , Issue.15 , pp. 2781-2787
    • Qiu, L.X.1    Mao, C.2    Zhang, J.3    Zhu, X.D.4    Liao, R.Y.5    Xue, K.6    Li, J.7    Chen, Q.8
  • 8
    • 84862026304 scopus 로고    scopus 로고
    • Addition of cetuximab to chemotherapy as first-line treatment for KRAS wild-type metastatic colorectal cancer: Pooled analysis of the CRYSTAL and OPUS randomised clinical trials
    • Bokemeyer C, Van Cutsem E, Rougier P, Ciardiello F, Heeger S, Schlichting M, Celik I, Köhne CH. Addition of cetuximab to chemotherapy as first-line treatment for KRAS wild-type metastatic colorectal cancer: pooled analysis of the CRYSTAL and OPUS randomised clinical trials. Eur J Cancer. 2012;48(10):1466-75.
    • (2012) Eur J Cancer , vol.48 , Issue.10 , pp. 1466-1475
    • Bokemeyer, C.1    Van Cutsem, E.2    Rougier, P.3    Ciardiello, F.4    Heeger, S.5    Schlichting, M.6    Celik, I.7    Köhne, C.H.8
  • 9
    • 84864444473 scopus 로고    scopus 로고
    • The predictive value of single nucleotide polymorphisms in the VEGF system to the efficacy of firstline treatment with bevacizumab plus chemotherapy in patients with metastatic colorectal cancer: Results from the Nordic ACT trial
    • Hansen TF, Christensen Rd, Andersen RF, Garm Spindler KL, Johnsson A, Jakobsen A. The predictive value of single nucleotide polymorphisms in the VEGF system to the efficacy of firstline treatment with bevacizumab plus chemotherapy in patients with metastatic colorectal cancer: results from the Nordic ACT trial. Int J Colorectal Dis. 2012;27(6):715-20.
    • (2012) Int J Colorectal Dis , vol.27 , Issue.6 , pp. 715-720
    • Hansen, T.F.1    Christensen, R.2    Andersen, R.F.3    Garm Spindler, K.L.4    Johnsson, A.5    Jakobsen, A.6
  • 13
    • 78649484648 scopus 로고    scopus 로고
    • Circulating endothelial cells and endothelial progenitors as predictive markers of clinical response to bevacizumab-based first-line treatment in advanced colorectal cancer patients
    • Ronzoni M, Manzoni M, Mariucci S, Loupakis F, Brugnatelli S, Bencardino K, Rovati B, Tinelli C, Falcone A, Villa E, Danova M. Circulating endothelial cells and endothelial progenitors as predictive markers of clinical response to bevacizumab-based first-line treatment in advanced colorectal cancer patients. Ann Oncol. 2010;21(12):2382-9.
    • (2010) Ann Oncol , vol.21 , Issue.12 , pp. 2382-2389
    • Ronzoni, M.1    Manzoni, M.2    Mariucci, S.3    Loupakis, F.4    Brugnatelli, S.5    Bencardino, K.6    Rovati, B.7    Tinelli, C.8    Falcone, A.9    Villa, E.10    Danova, M.11
  • 14
    • 79951673901 scopus 로고    scopus 로고
    • Hypertension and overall survival in metastatic colorectal cancer patients treated with bevacizumab-containing chemotherapy
    • Österlund P, Soveri LM, Isoniemi H, Poussa T, Alanko T, Bono P. Hypertension and overall survival in metastatic colorectal cancer patients treated with bevacizumab-containing chemotherapy. Br J Cancer. 2011;104(4):599-604.
    • (2011) Br J Cancer , vol.104 , Issue.4 , pp. 599-604
    • Österlund, P.1    Soveri, L.M.2    Isoniemi, H.3    Poussa, T.4    Alanko, T.5    Bono, P.6
  • 17
    • 61449202998 scopus 로고    scopus 로고
    • The clinical benefit of bevacizumab in metastatic colorectal cancer is independent of K-ras mutation status: Analysis of a phase III study of bevacizumab with chemotherapy in previously untreated metastatic colorectal cancer
    • Hurwitz HI, Yi J, Ince W, Novotny WF, Rosen O. The clinical benefit of bevacizumab in metastatic colorectal cancer is independent of K-ras mutation status: analysis of a phase III study of bevacizumab with chemotherapy in previously untreated metastatic colorectal cancer. Oncologist. 2009;14(1):22-8.
    • (2009) Oncologist , vol.14 , Issue.1 , pp. 22-28
    • Hurwitz, H.I.1    Yi, J.2    Ince, W.3    Novotny, W.F.4    Rosen, O.5
  • 18
    • 0032583387 scopus 로고    scopus 로고
    • Extracting summary statistics to perform meta-analyses of the published literature for survival endpoints
    • Parmar MK, Torri V, Stewart L. Extracting summary statistics to perform meta-analyses of the published literature for survival endpoints. Stat Med. 1998;17:2815-34.
    • (1998) Stat Med , vol.17 , pp. 2815-2834
    • Parmar, M.K.1    Torri, V.2    Stewart, L.3
  • 19
    • 34547450763 scopus 로고    scopus 로고
    • Practical methods for incorporating summary time-to-event data into meta-analysis
    • Tierney JF, Stewart LA, Ghersi D, Burdett S, Sydes MR. Practical methods for incorporating summary time-to-event data into meta-analysis. Trials. 2007;8:16.
    • (2007) Trials , vol.8 , pp. 16
    • Tierney, J.F.1    Stewart, L.A.2    Ghersi, D.3    Burdett, S.4    Sydes, M.R.5
  • 21
    • 84868501969 scopus 로고    scopus 로고
    • Prognostic value of KRAS genotype in metastatic colorectal cancer (MCRC) patients treated with intensive triplet chemotherapy plus bevacizumab (FIr-B/FOx) according to extension of metastatic disease
    • Bruera G, Cannita K, Di Giacomo D, Lamy A, Troncone G, Dal Mas A, Coletti G, Frébourg T, Sabourin JC, Tosi M, Ficorella C, Ricevuto E. Prognostic value of KRAS genotype in metastatic colorectal cancer (MCRC) patients treated with intensive triplet chemotherapy plus bevacizumab (FIr-B/FOx) according to extension of metastatic disease. BMC Med. 2012;10:135.
    • (2012) BMC Med , vol.10 , pp. 135
    • Bruera, G.1    Cannita, K.2    Di Giacomo, D.3    Lamy, A.4    Troncone, G.5    Dal Mas, A.6    Coletti, G.7    Frébourg, T.8    Sabourin, J.C.9    Tosi, M.10    Ficorella, C.11    Ricevuto, E.12
  • 24
    • 79960149283 scopus 로고    scopus 로고
    • Impact of KRAS and BRAF gene mutation status on outcomes from the phase III AGITG MAX trial of capecitabine alone or in combination with bevacizumab and mitomycin in advanced colorectal cancer
    • Price TJ, Hardingham JE, Lee CK, Weickhardt A, Townsend AR, Wrin JW, Chua A, Shivasami A, Cummins MM, Murone C, Tebbutt NC. Impact of KRAS and BRAF gene mutation status on outcomes from the phase III AGITG MAX trial of capecitabine alone or in combination with bevacizumab and mitomycin in advanced colorectal cancer. J Clin Oncol. 2011;29(19):2675-82.
    • (2011) J Clin Oncol , vol.29 , Issue.19 , pp. 2675-2682
    • Price, T.J.1    Hardingham, J.E.2    Lee, C.K.3    Weickhardt, A.4    Townsend, A.R.5    Wrin, J.W.6    Chua, A.7    Shivasami, A.8    Cummins, M.M.9    Murone, C.10    Tebbutt, N.C.11
  • 26
    • 78650608306 scopus 로고    scopus 로고
    • Erratum in, Dec 23
    • Erratum in: N Engl J Med. 2010 Dec 23;363(26):2573.
    • (2010) N Engl J Med , vol.363 , Issue.26 , pp. 2573
  • 29
    • 84892440002 scopus 로고    scopus 로고
    • KRAS and BRAF mutational analyses in a phase II trial of first-line FOLFOXIRI plus bevacizumab (BV) in metastatic colorectal cancer (mCRC) patients (pts)
    • Salvatore L, Loupakis F, Fontanini G, et al. KRAS and BRAF mutational analyses in a phase II trial of first-line FOLFOXIRI plus bevacizumab (BV) in metastatic colorectal cancer (mCRC) patients (pts). Eur J Cancer. 2009;2(suppl 7):339.
    • (2009) Eur J Cancer , vol.2 , Issue.SUPPL. 7 , pp. 339
    • Salvatore, L.1    Loupakis, F.2    Fontanini, G.3
  • 30
    • 79960146442 scopus 로고    scopus 로고
    • Impact of kras status on survival in patients (pts.) with metastatic colorectal cancer (mcrc) undergoing bevacizumab (bev) containing chemotherapy regimen-analysis of the aio colorectal cancer study group
    • Reinacher-Schick AC, Arnold D, Kubicka S, et al. Impact of kras status on survival in patients (pts.) with metastatic colorectal cancer (mcrc) undergoing bevacizumab (bev) containing chemotherapy regimen-analysis of the aio colorectal cancer study group. Ann Oncol. 2010;21(suppl 8):190.
    • (2010) Ann Oncol , vol.21 , Issue.SUPPL. 8 , pp. 190
    • Reinacher-Schick, A.C.1    Arnold, D.2    Kubicka, S.3
  • 31
    • 84892445720 scopus 로고    scopus 로고
    • Clinical outcomes of bevacizumab used in community oncology metastatic colorectal cancer (mcrc) patients with confirmed kras-status
    • Cartwright T, Yim YM, Yu E, et al. Clinical outcomes of bevacizumab used in community oncology metastatic colorectal cancer (mcrc) patients with confirmed kras-status. Ann Oncol. 2012;23(suppl 4):99.
    • (2012) Ann Oncol , vol.23 , Issue.SUPPL. 4 , pp. 99
    • Cartwright, T.1    Yim, Y.M.2    Yu, E.3
  • 32
    • 80051791807 scopus 로고    scopus 로고
    • Wt kras and gene expression levels of VEGFR2, EGFR, and ERCC-1 associated with progression-free survival (PFS) in patients (pts) with metastatic colorectal cancer (mCRC) treated with first-line 5-FU or capecitabine with oxaliplatin and bevacizumab (FOLFOX/BV or XELOX/BV)
    • abstr. 4056
    • El-Khoueiry AB, Pohl A, Danenberg K, et al. Wt Kras and gene expression levels of VEGFR2, EGFR, and ERCC-1 associated with progression-free survival (PFS) in patients (pts) with metastatic colorectal cancer (mCRC) treated with first-line 5-FU or capecitabine with oxaliplatin and bevacizumab (FOLFOX/BV or XELOX/BV). J Clin Oncol. 2009;15(suppl 5):abstr 4056.
    • (2009) J Clin Oncol , vol.15 , Issue.SUPPL. 5
    • El-Khoueiry, A.B.1    Pohl, A.2    Danenberg, K.3
  • 33
    • 60549118166 scopus 로고    scopus 로고
    • Arterial hypertension correlates with clinical outcome in colorectal cancer patients treated with firstline bevacizumab
    • Scartozzi M, Galizia E, Chiorrini S, Giampieri R, Berardi R, Pierantoni C, Cascinu S. Arterial hypertension correlates with clinical outcome in colorectal cancer patients treated with firstline bevacizumab. Ann Oncol. 2009;20(2):227-30.
    • (2009) Ann Oncol , vol.20 , Issue.2 , pp. 227-230
    • Scartozzi, M.1    Galizia, E.2    Chiorrini, S.3    Giampieri, R.4    Berardi, R.5    Pierantoni, C.6    Cascinu, S.7
  • 36
    • 0042972556 scopus 로고    scopus 로고
    • Ras modulates Myc activity to repress thrombospondin-1 expression and increase tumor angiogenesis
    • Watnick RS, Cheng Y-N, Rangarajan A, Ince TA, Weinberg RA. Ras modulates Myc activity to repress thrombospondin-1 expression and increase tumor angiogenesis. Cancer Cell. 2003;3:219-31.
    • (2003) Cancer Cell , vol.3 , pp. 219-231
    • Watnick, R.S.1    Cheng, Y.-N.2    Rangarajan, A.3    Ince, T.A.4    Weinberg, R.A.5
  • 37
    • 0037154738 scopus 로고    scopus 로고
    • Effect of p53 status on tumor response to antiangiogenic therapy
    • Yu JL, Rak JW, Coomber BL, Hicklin DJ, Kerbel RS. Effect of p53 status on tumor response to antiangiogenic therapy. Science. 2002;295:1526-8.
    • (2002) Science , vol.295 , pp. 1526-1528
    • Yu, J.L.1    Rak, J.W.2    Coomber, B.L.3    Hicklin, D.J.4    Kerbel, R.S.5
  • 38
    • 84871562117 scopus 로고    scopus 로고
    • Correlation of progression-free and postprogression survival with overall survival in advanced colorectal cancer
    • Petrelli F, Barni S. Correlation of progression-free and postprogression survival with overall survival in advanced colorectal cancer. Ann Oncol. 2013;24(1):186-92.
    • (2013) Ann Oncol , vol.24 , Issue.1 , pp. 186-192
    • Petrelli, F.1    Barni, S.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.