Metabolic changes in serum metabolome in response to a meal

European Journal of Nutrition

Volumn 56, Issue 2, 2017, Pages 671-681

  Shrestha, Aahana ^a   Müllner, Elisabeth ^a   Poutanen, Kaisa ^b,c   Mykkänen, Hannu ^b   Moazzami, Ali A ^a  

^a SWEDISH UNIVERSITY OF AGRICULTURAL SCIENCES   (Sweden)

^b UNIVERSITY OF EASTERN FINLAND   (Finland)

^c VTT TECHNICAL RESEARCH CENTRE OF FINLAND   (Finland)

Author keywords

Acylcarnitine; Amino acid; Glycolytic products; Insulin; Metabolomics; Phosphatidylcholine; Postprandial changes

Indexed keywords

ACYLCARNITINE; AMINO ACID; CITRIC ACID; INSULIN; ISOLEUCINE; KETONE BODY; LEUCINE; LYSOPHOSPHATIDYLCHOLINE; METHIONINE; PHOSPHATIDYLCHOLINE; PHOSPHOLIPID; SUCCINIC ACID; CARBOHYDRATE DIET; CARNITINE; FAT INTAKE; GLUCOSE BLOOD LEVEL; PROTEIN INTAKE;

ADULT; ARTICLE; CATABOLISM; CONTROLLED STUDY; CUCUMBER; DIET RESTRICTION; ENERGY RESOURCE; FATTY ACID OXIDATION; FEMALE; GLYCOLYSIS; HUMAN; HUMAN EXPERIMENT; INSULIN RESPONSE; LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY; MEAL; METABOLISM; METABOLITE; METABOLOME; METABOLOMICS; NORMAL HUMAN; POSTPRANDIAL STATE; PROTON NUCLEAR MAGNETIC RESONANCE; WHEAT; ADMINISTRATION AND DOSAGE; AGED; ANALOGS AND DERIVATIVES; ANALYSIS; BLOOD; BREAD; CARBOHYDRATE DIET; DIETARY FIBER; ENERGY METABOLISM; FAT INTAKE; GLUCOSE BLOOD LEVEL; MIDDLE AGED; PHYSIOLOGY; POSTMENOPAUSE; PROTEIN INTAKE;

AGED; AMINO ACIDS; BLOOD GLUCOSE; BREAD; CARNITINE; DIETARY CARBOHYDRATES; DIETARY FATS; DIETARY FIBER; DIETARY PROTEINS; ENERGY METABOLISM; FASTING; FEMALE; GLYCOLYSIS; HUMANS; INSULIN; KETONE BODIES; LEUCINE; MEALS; METABOLOME; MIDDLE AGED; PHOSPHOLIPIDS; POSTMENOPAUSE; POSTPRANDIAL PERIOD; TRITICUM;

EID: 84949560084     PISSN: 14366207     EISSN: 14366215     Source Type: Journal    
DOI: 10.1007/s00394-015-1111-y     Document Type: Article

References (42)

1. Zhao X, Peter A, Fritsche J, Elcnerova M, Fritsche A, Häring HU, Schleicher ED, Xu G, Lehmann R (2009) Changes of the plasma metabolome during an oral glucose tolerance test: is there more than glucose to look at? Am J Physiol: Endocrinol Metab 296(2):E384–E393
2. Shaham O, Wei R, Wang TJ, Ricciardi C, Lewis GD, Vasan RS, Carr SA, Thadhani R, Gerszten RE, Mootha VK (2008) Metabolic profiling of the human response to a glucose challenge reveals distinct axes of insulin sensitivity. Mol Syst Biol 4:214
3. Ho JE, Larson MG, Vasan RS, Ghorbani A, Cheng S, Rhee EP, Florez JC, Clish CB, Gerszten RE, Wang TJ (2013) Metabolite profiles during oral glucose challenge. Diabetes 62(8):2689–2698
4. Wang TJ, Larson MG, Vasan RS, Cheng S, Rhee EP, McCabe E, Lewis GD, Fox CS, Jacques PF, Fernandez C, O’Donnell CJ, Carr SA, Mootha VK, Florez JC, Souza A, Melander O, Clish CB, Gerszten RE (2011) Metabolite profiles and the risk of developing diabetes. Nat Med 17(4):448–453
5. Aronoff SL, Berkowitz K, Shreiner B, Want L (2004) Glucose metabolism and regulation: beyond insulin and glucagon. Diabetes Spectr 17(3):183–190. doi:10.2337/diaspect.17.3.183
6. Nicholson JK, Wilson ID (2003) Understanding ‘global’ systems biology: metabonomics and the continuum of metabolism. Nat Rev Drug Discov 2(8):668–676
7. Spégel P, Danielsson APH, Bacos K, Nagorny CLF, Moritz T, Mulder H, Filipsson K (2010) Metabolomic analysis of a human oral glucose tolerance test reveals fatty acids as reliable indicators of regulated metabolism. Metabolomics 6(1):56–66
8. Node K, Inoue T (2009) Postprandial hyperglycemia as an etiological factor in vascular failure. Cardiovasc Diabetol 8:23
9. Cavalot F, Petrelli A, Traversa M, Bonomo K, Fiora E, Conti M, Anfossi G, Costa G, Trovati M (2006) Postprandial blood glucose is a stronger predictor of cardiovascular events than fasting blood glucose in type 2 diabetes mellitus, particularly in women: lessons from the San Luigi Gonzaga diabetes study. J Clin Endocrinol Metab 91(3):813–819
10. Parkin CG, Brooks N (2002) Is postprandial glucose control important? Is it practical in primary care settings? Clin Diabetes 20(2):71–76. doi:10.2337/diaclin.20.2.71
11. Gannon MC, Nuttall FQ, Lane JT, Burmeister LA (1992) Metabolic response to cottage cheese or egg white protein, with or without glucose, in type II diabetic subjects. Metabolism 41(10):1137–1145
12. Nuttall F, Gannon M (2004) Metabolic response of people with type 2 diabetes to a high protein diet. Nutr Metab 1(1):6
13. Berger S, Vongaraya M (1966) Insulin response to ingested protein in diabetes. Diabetes 15:303–306
14. Van Loon LJC, Kruijshoop M, Menheere PPCA, Wagenmakers AJM, Saris WHM, Keizer HA (2003) Amino acid ingestion strongly enhances insulin secretion in patients with long-term type 2 diabetes. Diabetes Care 26(3):625–630
15. Gannon M, Nuttall F, Neil B, Westphal S (1988) The insulin and glucose responses to meals of glucose plus various proteins in type 2 diabetic subjects. Metabolism 37:1081–1088
16. Moazzami AA, Shrestha A, Morrison DA, Poutanen K, Mykkänen H (2014) Metabolomics reveals differences in postprandial responses to breads and fasting metabolic characteristics associated with postprandial insulin demand in postmenopausal women. J Nutr 144(6):807–814. doi:10.3945/jn.113.188912
17. Alberti KGMM, Zimmet PZ (1998) Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus. Provisional report of a WHO consultation. Diabet Med 15(7):539–553
18. Illig T, Gieger C, Zhai G, Römisch-Margl W, Wang-Sattler R, Prehn C, Altmaier E, Kastenmüller G, Kato BS, Mewes HW, Meitinger T, De Angelis MH, Kronenberg F, Soranzo N, Wichmann HE, Spector TD, Adamski J, Suhre K (2010) A genome-wide perspective of genetic variation in human metabolism. Nat Genet 42(2):137–141
19. Wang-Sattler R, Yu Z, Herder C, Messias AC, Floegel A, He Y, Heim K, Campillos M, Holzapfel C, Thorand B, Grallert H, Xu T, Bader E, Huth C, Mittelstrass K, Döring A, Meisinger C, Gieger C, Prehn C, Roemisch-Margl W, Carstensen M, Xie L, Yamanaka-Okumura H, Xing G, Ceglarek U, Thiery J, Giani G, Lickert H, Lin X, Li Y, Boeing H, Joost H-G, de Angelis MH, Rathmann W, Suhre K, Prokisch H, Peters A, Meitinger T, Roden M, Wichmann HE, Pischon T, Adamski J, Illig T (2012) Novel biomarkers for pre-diabetes identified by metabolomics. Mol Syst Biol. doi:10.1038/msb.2012.43
20. Liebich HM, Forst C (1984) Hydroxycarboxylic and oxocarboxylic acids in urine: products from branched-chain amino acid degradation and from ketogenesis. J Chromatogr: Biomed Appl 309(2):225–242
21. Foster DW (2012) Malonyl-CoA: the regulator of fatty acid synthesis and oxidation. J Clin Investig 122(6):1958–1959
22. Vanhove JLK, Zhang W, Kahler SG, Roe CR, Chen YT, Terada N, Chace DH, Iafolla AK, Ding JH, Millington DS (1993) Medium-chain acyl-coa dehydrogenase (Mcad) deficiency: diagnosis by acylcarnitine analysis in blood. Am J Hum Genet 52(5):958–966
23. Krug S, Kastenmüller G, Stückler F, Rist MJ, Skurk T, Sailer M, Raffler J, Römisch-Margl W, Adamski J, Prehn C, Frank T, Engel KH, Hofmann T, Luy B, Zimmermann R, Moritz F, Schmitt-Kopplin P, Krumsiek J, Kremer W, Huber F, Oeh U, Theis FJ, Szymczak W, Hauner H, Suhre K, Daniel H (2012) The dynamic range of the human metabolome revealed by challenges. FASEB J 26(6):2607–2619
24. Cole LK, Vance JE, Vance DE (2012) Phosphatidylcholine biosynthesis and lipoprotein metabolism. Biochimica et Biophysica Acta (BBA): Mol Cell Biol Lipids 1821(5):754–761. doi:10.1016/j.bbalip.2011.09.009
25. Floegel A, Stefan N, Yu Z, Mühlenbruch K, Drogan D, Joost HG, Fritsche A, Häring HU, De Angelis MH, Peters A, Roden M, Prehn C, Wang-Sattler R, Illig T, Schulze MB, Adamski J, Boeing H, Pischon T (2013) Identification of serum metabolites associated with risk of type 2 diabetes using a targeted metabolomic approach. Diabetes 62(2):639–648
26. Dashti M, Kulik W, Hoek F, Veerman EC, Peppelenbosch MP, Rezaee F (2011) A Phospholipidomic analysis of all defined human plasma lipoproteins. Sci Rep 1. http://www.nature.com/srep/2011/111107/srep00139/abs/srep00139.html#supplementary-information
27. Ogita K, Ai M, Tanaka A, Ito Y, Hirano T, Yoshino G, Shimokado K (2008) Serum concentration of small dense low-density lipoprotein-cholesterol during oral glucose tolerance test and oral fat tolerance test. Clin Chim Acta 387(1–2):36–41
28. Frayn KN (2002) Insulin resistance, impaired postprandial lipid metabolism and abdominal obesity. A deadly triad. Med Princ Pract 11(SUPPL. 2):31–40
29. Zhao X, Peter A, Fritsche J, Elcnerova M, Fritsche A, Haring H, Schleicher E, Xu G, Lehmann R (2009) Changes of the plasma metabolome during an oral glucose tolerance test: is there more than glucose to look at? Am J Physiol Endocrinol Metab 296:E384–E393
30. Tai ES, Tan MLS, Stevens RD, Low YL, Muehlbauer MJ, Goh DLM, Ilkayeva OR, Wenner BR, Bain JR, Lee JJM, Lim SC, Khoo CM, Shah SH, Newgard CB (2010) Insulin resistance is associated with a metabolic profile of altered protein metabolism in Chinese and Asian-Indian men. Diabetologia 53(4):757–767
31. McCormack SE, Shaham O, McCarthy MA, Deik AA, Wang TJ, Gerszten RE, Clish CB, Mootha VK, Grinspoon SK, Fleischman A (2013) Circulating branched-chain amino acid concentrations are associated with obesity and future insulin resistance in children and adolescents. Pediatric Obes 8(1):52–61. doi:10.1111/j.2047-6310.2012.00087.x
32. Pereira S, Marliss EB, Morais JA, Chevalier S, Gougeon R (2008) Insulin resistance of protein metabolism in type 2 diabetes. Diabetes 57(1):56–63. doi:10.2337/db07-0887
33. Fukagawa NK, Minaker KL, Rowe JW, Goodman MN, Matthews DE, Bier DM, Young VR (1985) Insulin-mediated reduction of whole body protein breakdown. Dose-response effects on leucine metabolism in postabsorptive men. J Clin Investig 76(6):2306–2311
34. Mihalik SJ, Goodpaster BH, Kelley DE, Chace DH, Vockley J, Toledo FGS, DeLany JP (2010) Increased levels of plasma acylcarnitines in obesity and type 2 diabetes and identification of a marker of glucolipotoxicity. Obesity 18(9):1695–1700. doi:10.1038/oby.2009.510
35. Garvey WT, Kwon S, Zheng D, Shaughnessy S, Wallace P, Hutto A, Pugh K, Jenkins AJ, Klein RL, Liao Y (2003) Effects of insulin resistance and type 2 diabetes on lipoprotein subclass particle size and concentration determined by nuclear magnetic resonance. Diabetes 52(2):453–462. doi:10.2337/diabetes.52.2.453
36. Wiesner P, Leidl K, Boettcher A, Schmitz G, Liebisch G (2009) Lipid profiling of FPLC-separated lipoprotein fractions by electrospray ionization tandem mass spectrometry. J Lipid Res 50(3):574–585. doi:10.1194/jlr.D800028-JLR200
37. Rahmouni K, Morgan DA, Morgan GM, Mark AL, Haynes WG (2005) Role of selective leptin resistance in diet-induced obesity hypertension. Diabetes 54(7):2012–2018
38. Heimbürger O, Lönnqvist F, Danielsson A, Nordenström J, Stenvinkel P (1997) Serum immunoreactive leptin concentration and its relation to the body fat content in chronic renal failure. J Am Soc Nephrol 8(9):1423–1430
39. Pelleymounter MA, Cullen MJ, Healy D, Hecht R, Winters D, McCaleb M (1998) Efficacy of exogenous recombinant murine leptin in lean and obese 10- to 12-mo-old female CD-1 mice. Am J Physiol: Regul Integr Comp Physiol 275(4):R950–R959
40. Paul Z, Allison H, Margery N, Myrlene S, de Maximilian C, Jason M, Andrew M, John L, Gregory C, George A, Gary D (1996) Serum leptin concentration, obesity, and insulin resistance in Western Samoans: cross sectional study. BMJ 313:965–969
41. Zuo H, Shi Z, Yuan B, Dai Y, Wu G, Hussain A (2013) Association between serum leptin concentrations and insulin resistance: a population-based study from China. PLoS ONE 8(1):e54615
42. Zimmet P, Hodge A, Nicolson M, Staten M, De Courten M, Moore J, Morawiecki A, Lubina J, Collier G, Alberti G, Dowse G (1996) Serum leptin concentration, obesity, and insulin resistance in Western Samoans: cross sectional study. Br Med J 313(7063):965–969