Distinct effects of methylseleninic acid versus selenite on apoptosis, cell cycle, and protein kinase pathways in DU145 human prostate cancer cells

Molecular Cancer Therapeutics

Volumn 1, Issue 12, 2002, Pages 1059-1066

  Jiang, Cheng ^a,c   Wang, Zaisen ^a   Ganther, Howard ^b   Lü, Junxuan ^a,c  

^a UNIVERSITY OF COLORADO   (United States)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

^c UNIVERSITY OF MINNESOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CDKN1A PROTEIN, HUMAN; CELL CYCLE PROTEIN; CYCLIN DEPENDENT KINASE INHIBITOR 1A; CYCLIN DEPENDENT KINASE INHIBITOR 1B; CYCLINE; DNA FRAGMENT; METHYLSELENIC ACID; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE 9; MITOGEN ACTIVATED PROTEIN KINASE P38; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; ORGANOSELENIUM DERIVATIVE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE; SELENIUM; SODIUM SELENITE; STRESS ACTIVATED PROTEIN KINASE 1; SUPEROXIDE; TUMOR SUPPRESSOR PROTEIN;

APOPTOSIS; ARTICLE; CELL CULTURE; CELL CYCLE; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CELL DEATH; COMPARATIVE STUDY; DRUG EFFECT; HUMAN; IMMUNOBLOTTING; MALE; METABOLISM; PHOSPHORYLATION; PROSTATE TUMOR; TIME;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL CYCLE; CELL CYCLE PROTEINS; CELL DEATH; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLIN-DEPENDENT KINASE INHIBITOR P27; CYCLINS; DNA FRAGMENTATION; G1 PHASE; HUMANS; IMMUNOBLOTTING; MALE; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASE 8; MITOGEN-ACTIVATED PROTEIN KINASE 9; MITOGEN-ACTIVATED PROTEIN KINASES; ORGANOSELENIUM COMPOUNDS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; POLY(ADP-RIBOSE) POLYMERASES; PROSTATIC NEOPLASMS; PROTEIN KINASES; S PHASE; SELENIUM; SODIUM SELENITE; SUPEROXIDES; TIME FACTORS; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEINS;

EID: 1242312903     PISSN: 15357163     EISSN: 15388514     Source Type: Journal    
DOI: None     Document Type: Article

References (37)

1. Clark, L. C., Combs, G. F., Jr., Turnbull, B. W., Slate, E. H., Chalker, D. K., Chow, J., Davis, L. S., Glover, R. A., Graham, G. F., Gross, E. G., et al. Effects of selenium supplementation for cancer prevention in patients with carcinoma of the skin. A randomized controlled trial. Nutritional Prevention of Cancer Study Group. J. Am. Med. Assoc., 276: 1957-1963, 1996. (Pubitemid 26427723)
2. Yu, S. Y., Zhu, Y. J., and Li, W. G. Protective role of selenium against hepatitis B virus and primary liver cancer in Qidong. Biol. Trace Elem. Res., 56: 117-124, 1997. (Pubitemid 27198254)
3. Ip, C., and Ganther, H. E. Activity of methylated forms of selenium in cancer prevention. Cancer Res., 50: 1206-1211, 1990. (Pubitemid 20084012)
4. Ip, C., Hayes, C., Budnick, R. M., and Ganther, H. E. Chemical form of selenium, critical metabolites, and cancer prevention. Cancer Res., 51: 595-600, 1991.
5. Ip, C. Lessons from basic research in selenium and cancer prevention. J. Nutr., 128: 1845-1854, 1998. (Pubitemid 28509845)
6. Lü, J., Jiang, C., Kaeck, M., Ganther, H., Vadhanavikit, S., Ip, C., and Thompson, H. Dissociation of the genotoxic and growth inhibitory effects of selenium. Biochem. Pharmacol., 252: 7392-7394, 1995.
7. Lü, J., Pei, H., Ip, C., Lisk, D., Ganther, H., and Thompson, H. J. Effect of an aqueous extract of selenium enriched garlic on in vitro markers and in vivo efficacy in cancer prevention. Carcinogenesis (Lond.), 17: 1903-1907, 1996. (Pubitemid 26325381)
8. Kaeck, M., Lü, J., Strange, R., Ip, C., Ganther, H., and Thompson, H. J. Differential induction of growth arrest inducible genes by selenium compounds. Biochem. Pharmacol., 53: 921-926, 1997. (Pubitemid 27224271)
9. Lü, J. X. Apoptosis and angiogenesis in cancer prevention by selenium. In: American Institute for Cancer Research (ed.), Nutrition and Cancer Prevention, pp. 131-145. New York: Kluwer/Plenum Publishers, 2000.
10. Sinha, R., Said, T. K., and Medina, D. Organic and inorganic selenium compounds inhibit mouse mammary cell growth in vitro by different cellular pathways. Cancer Lett., 107: 277-284, 1996. (Pubitemid 26382001)
11. Ganther, H. E. Pathways of selenium metabolism including respiratory excretory products. J. Am. Coll. Toxicol., 5: 1-5, 1986. (Pubitemid 16063578)
12. Jiang, C. Wang, Z. Ganther, H., and Lü, J. X. Caspases as key executors of methyl selenium induced apoptosis (anoikis) of DU145 human prostate cancer cells. Cancer Res., 61: 3062-3070, 2001. (Pubitemid 32691955)
13. Kim, T., Jung, U., Cho, D. Y., and Chung, A. S. Se-methylselenocysteine induces apoptosis through caspase activation in HL-60 cells. Carcinogenesis (Lond.), 22: 559-565, 2001. (Pubitemid 32288655)
14. Wang, Z. C., Jiang, H., Ganther, H., and Lü, J. X. Anti-mitogenic and pro-apoptotic activities of methylseleninic acid in vascular endothelial cells and associated effects on PI3K-AKT. ERK, JNK and p38MAPK signaling. Cancer Res., 61: 7171-7178, 2001. (Pubitemid 32946511)
15. Jiang, C., Ganther, H., and Lü, J. X. Monomethyl selenium-specific inhibition of MMP-2 and VEGF expression: implications for angiogenic switch regulation. Mol. Carcinog., 29: 236-250, 2000. (Pubitemid 32052668)
16. Tang, D. G., Li, L., Chopra, D. P., and Porter, A. T. Extended survivability of prostate cancer cells in the absence of trophic factors: increased proliferation, evasion of apoptosis, and the role of apoptosis proteins. Cancer Res., 58: 3466-3479, 1998. (Pubitemid 28371092)
17. Marte, B. M., and Downward, J. PKB/Akt: connecting phosphoinositide 3-kinase to cell survival and beyond. Trends Biochem. Sci., 22: 355-358, 1997.
18. Katso, R., Okkenhaug, K., Ahmadi, K., White, S., Timms, J., Waterfield, M. D. Cellular function of phosphoinositide 3-kinases: implications for development, homeostasis, and cancer. Annu. Rev. Cell Dev. Biol., 17: 615-675, 2001. (Pubitemid 33096187)
19. Wang, Z., Jiang, C., and Lü, J. Induction of caspase-mediated apoptosis and cell-cycle G1 arrest by selenium metabolite methylselenol. Mol. Carcinog., 34: 113-120, 2002. (Pubitemid 34747321)
20. Davis, R. J. MAPKs: new JNK expands the group. Trends Biochem. Sci., 19: 470-473, 1994. (Pubitemid 24342759)
21. Leppa, S., and Bohmann, D. Diverse functions of JNK signaling and c-Jun in stress response and apoptosis. Oncogene, 18: 6158-6162, 1999.
22. Cross, T. G., Scheel-Toellner, D., Henriquez, N. V., Deacon, E., Salmon, M., and Lord, J. M. Serine/threonine protein kinases and apoptosis. Exp. Cell Res., 256: 34-41, 2000. (Pubitemid 30211164)
23. 1 phase cell cycle machinery. Bioessays, 22: 818-826, 2000.
24. Sherr, C. J. The Pezcoller lecture: cancer cell cycles revisited. Cancer Res., 60: 3689-3695, 2000. (Pubitemid 32204552)
25. Xia, Z., Dickens, M., Raingeaud, J., Davis, R. J., and Greenberg, M. E. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science (Wash. DC), 270: 1326-1331, 1995.
26. Jiang, C., Jiang, W., Ip, C., Ganther, H., and Lü, J. X. Selenium-induced inhibition of angiogenesis in mammary cancer at chemopreventive levels of intake. Mol. Carcinog., 26: 213-225, 1999.
27. Sinha, R., Unni, E., Ganther, H. E., and Medina, D. Methylseleninic acid, a potent growth inhibitor of synchronized mouse mammary epithelial tumor cells in vitro. Biochem. Pharmacol., 61: 311-317, 2001. (Pubitemid 32126669)
28. Lü, J., Kaeck, M., Jiang, C., Wilson, A. C., and Thompson, H. J. Selenite induction of DNA strand breaks and apoptosis in mouse leukemic L1210 cells. Biochem. Pharmacol., 47: 1531-1535, 1994. (Pubitemid 24167263)
29. Zhong, W., and Oberley, T. D. Redox-mediated effects of selenium on apoptosis and cell cycle in the LNCaP human prostate cancer cell line. Cancer Res., 61: 7071-7078, 2001.
30. No. 9964. In: Merck Index, Ed. 11.
31. Vlahos, C. J., Matter, W. F., Hui, K. Y., and Brown, R. F. A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1- benzopyran-4-one (LY294002). J. Biol. Chem., 269: 5241-5248, 1994.
32. Parker, S. L., Tong, T., Bolden, S., and Wingo, P. A. Cancer statistics, 1997. CA Cancer J. Clin., 47: 5-27, 1997. (Pubitemid 27050847)
33. Kim, H. G., Kassis, J., Souto, J. C., Turner, T., and Wells, A. EGF receptor signaling in prostate morphogenesis and tumorigenesis. Histol. Histopathol., 14: 1175-1182, 1999. (Pubitemid 29447459)
34. Grimberg, A., and Cohen, P. Role of insulin-like growth factors and their binding proteins in growth control and carcinogenesis. J. Cell Physiol., 183: 1-9, 2000. (Pubitemid 30130219)
35. Miki, K., Xu, M., Gupta, A., Ba, Y., Tan, Y., Al-Refaie, W., Bouvet, M., Makuuchi, M., Moossa, A. R., and Hoffman, R. M. Methioninase cancer gene therapy with selenomethionine as suicide prodrug substrate. Cancer Res., 61: 6805-6810, 2001. (Pubitemid 32896504)
36. Gopalakrishna, R., Chen, Z. H., and Gundimeda, U. Selenocompounds induce a redox modulation of protein kinase C in the cell, compartmentally independent from cytosolic glutathione: its role in inhibition of tumor promotion. Arch. Biochem. Biophys., 348: 37-48, 1997. (Pubitemid 27514668)
37. Park, H. S., Huh, S. H., Kim, Y., Shim, J., Lee, S. H., Park, I. S., Jung, Y. K., Kim, I. Y., and Choi, E. J. Selenite negatively regulates caspase-3 through a redox mechanism. J. Biol. Chem., 275: 8487-8491, 2000. (Pubitemid 30180195)