Can procalcitonin levels indicate the need for adjunctive therapies in sepsis?

International Journal of Antimicrobial Agents

Volumn 46, Issue , 2015, Pages S13-S18

  Becze, Zsolt ^a   Molnár, Zsolt ^b   Fazakas, János ^c  

^a Outpatient Clinic   (Hungary)

^b UNIVERSITY OF SZEGED   (Hungary)

^c SEMMELWEIS UNIVERSITY   (Hungary)

Author keywords

Cytokines; Immunoglobulins; Procalcitonin; Sepsis; Systemic inflammatory response syndrome

Indexed keywords

ANTIBIOTIC AGENT; C REACTIVE PROTEIN; IMMUNOGLOBULIN; IMMUNOGLOBULIN G; PROCALCITONIN; ANTIINFECTIVE AGENT; BIOLOGICAL MARKER; CALCA PROTEIN, HUMAN; CALCITONIN; CALCITONIN GENE RELATED PEPTIDE; PROTEIN PRECURSOR;

ANTIBIOTIC THERAPY; ARTICLE; BLOOD FILTER; COMPLEMENT SYSTEM; CRITICALLY ILL PATIENT; CYTOKINE STORM; DISEASE MARKER; EVIDENCE BASED MEDICINE; HUMAN; IMMUNE RESPONSE; INFECTION; INFLAMMATION; INTENSIVE CARE UNIT; NONHUMAN; OUTCOME ASSESSMENT; PATHOPHYSIOLOGY; PERSONALIZED MEDICINE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BLOOD LEVEL; RANDOMIZED CONTROLLED TRIAL (TOPIC); SEPSIS; SIGNAL TRANSDUCTION; SURGICAL PATIENT; BLOOD; DRUG MONITORING; DRUG THERAPY; PROCEDURES;

ANTI-BACTERIAL AGENTS; BIOMARKERS; CALCITONIN; CALCITONIN GENE-RELATED PEPTIDE; DRUG MONITORING; DRUG THERAPY; HUMANS; PROTEIN PRECURSORS; SEPSIS;

EID: 84949486224     PISSN: 09248579     EISSN: 18727913     Source Type: Journal    
DOI: 10.1016/j.ijantimicag.2015.11.002     Document Type: Article

References (63)

1. K.M. Kaukonen, M. Bailey, S. Suzuki, D. Pilcher, and R. Bellomo Mortality related to severe sepsis and septic shock among critically ill patients in Australia and New Zealand, 2000-2012 JAMA 311 2014 1308 1316
2. D.F. Gaieski, J.M. Edwards, M.J. Kallan, and B.G. Carr Benchmarking the incidence and mortality of severe sepsis in the United States Crit Care Med 41 2013 1167 1174
3. C.M. Torio, and R.M. Andrews National inpatient hospital costs: the most expensive conditions by payer, 2011: statistical brief #160. Healthcare Cost and Utilization Project (HCUP) Statistical Briefs 2006-2013 US Agency for Health Care Policy and Research Rockville, MD http://hcup-us.ahrq.gov/reports/statbriefs/sb160.jsp [accessed 21.10.15]
4. G.A. Ospina-Tascon, G.L. Buchele, and J.L. Vincent Multicenter, randomized, controlled trials evaluating mortality in intensive care: doomed to fail? Crit Care Med 36 2008 1311 1322
5. J.L. Vincent We should abandon randomized controlled trials in the intensive care unit Crit Care Med 38 Suppl. 2010 S534 S538
6. R.P. Dellinger, M.M. Levy, A. Rhodes, D. Annane, H. Gerlach, S.M. Opal, and et al. Surviving Sepsis Campaign Guidelines Committee including The Pediatric Subgroup. Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock, 2012 Intensive Care Med 39 2013 165 228
7. S.H. Hoeboer, P.J. van der Geest, D. Nieboer, and A.B.J. Groeneveld The diagnostic accuracy of procalcitonin for bacteraemia: a systematic review and meta-analysis Clin Microbiol Infect 21 2015 474 481
8. M. Harrison, and C.D. Collins Is procalcitonin-guided antimicrobial use cost-effective in adult patients with suspected bacterial infection and sepsis? Infect Control Hosp Epidemiol 36 2015 265 272
9. Y.Z. Zhang, and S. Singh Antibiotic stewardship programmes in intensive care units: why, how, and where are they leading us World J Crit Care Med 4 2015 13 28
10. M.M. Alejandria, M.A.D. Lansang, L.F. Dans, and J.B. Mantaring III Intravenous immunoglobulin for treating sepsis, severe sepsis and septic shock Cochrane Database Syst Rev 9 2013 CD001090
11. T. Szakmany, B. Hauser, and P. Radermacher N-acetylcysteine for sepsis and systemic inflammatory response in adults Cochrane Database Syst Rev 9 2012 CD006616
12. C.A. Lukaszewicz, and D. Payen Purification methods: a way to treat severe acute inflammation related to sepsis? Crit Care 17 2013 159
13. R.C. Bone, C.J. Fisher Jr., T.P. Clemmer, G.J. Slotman, C.A. Metz, and R.A. Balk A controlled clinical trial of high-dose methylprednisolone in the treatment of severe sepsis and septic shock N Engl J Med 317 1987 653 658
14. R.C. Bone, C.J. Fisher Jr., T.P. Clemmer, G.J. Slotman, C.A. Metz, and R.A. Balk Sepsis syndrome: a valid clinical entity. Methylprednisolone Severe Sepsis Study Group Crit Care Med 17 1989 389 393
15. American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference: definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis Crit Care Med 20 1992 864 874
16. J.L. Vincent, S.M. Opal, J.C. Marshall, and K.J. Tracey Sepsis definitions: time for change Lancet 381 2013 774 775
17. J. Harder, J.M. Schröder, and R. Gläser The skin surface as antimicrobial barrier: present concepts and future outlooks Exp Dermatol 22 2013 1 5
18. A. Baroni, E. Buommino, V. De Gregorio, E. Ruocco, V. Ruocco, and R. Wolf Structure and function of the epidermis related to barrier properties Clin Dermatol 30 2012 257 262
19. R. Rudraraju, B.G. Jones, S.L. Surman, R.E. Sealy, P.G. Thomas, and J.L. Hurwitz Respiratory tract epithelial cells express retinaldehyde dehydrogenase ALDH1A and enhance IgA production by stimulated B cells in the presence of vitamin A PLOS ONE 9 2014 86554
20. T. Pelaseyed, J.H. Bergström, J.K. Gustafsson, A. Ermund, G.M. Birchenough, A. Schütte, and et al. The mucus and mucins of the goblet cells and enterocytes provide the first defense line of the gastrointestinal tract and interact with the immune system Immunol Rev 260 2014 8 20
21. M. Ghosh Secreted mucosal antimicrobials in the female reproductive tract that are important to consider for HIV prevention Am J Reprod Immunol 71 2014 575 588
22. M. Kompoti, A. Michopoulos, M. Michalia, P.M. Clouva-Molyvdas, A.E. Germenis, and M. Speletas Genetic polymorphisms of innate and adaptive immunity as predictors of outcome in critically ill patients Immunobiology 220 2015 414 421
23. L.M. Sompayrac How the immune system works 4th ed. 2012 Wiley-Blackwell
24. Q. Zhang, M. Raoof, Y. Chen, Y. Sumi, T. Sursal, W. Junger, and et al. Circulating mitochondrial DAMPs cause inflammatory responses to injury Nature 464 2010 104 107
25. A. Kumar, D. Roberts, K.E. Wood, B. Light, J.E. Parrillo, S. Sharma, and et al. Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock Crit Care Med 34 2006 1589 1596
26. C. Fitting, M. Parlato, M. Adib-Conquy, N. Memain, F. Philippart, B. Misset, and et al. DNAemia detection by multiplex PCR and biomarkers for infection in systemic inflammatory response syndrome patients PLoS ONE 7 2012 e38916
27. C. Leli, A. Cardaccia, M. Ferranti, A. Cesarini, F. D'Alò, C. Ferri, and et al. Procalcitonin better than C-reactive protein, erythrocyte sedimentation rate, and white blood cell count in predicting DNAemia in patients with sepsis Scand J Infect Dis 46 2014 745 752
28. M.W. Pletz, N. Wellinghausen, and T. Welte Will polymerase chain reaction (PCR)-based diagnostics improve outcome in septic patients? A clinical view Intensive Care Med 37 2011 1069 1076
29. T. Brenner, T. Fleming, F. Uhle, S. Silaff, F. Schmitt, E. Salgado, and et al. Methylglyoxal as a new biomarker in patients with septic shock: an observational clinical study Crit Care 18 2014 683
30. C. Pierrakos, and J.L. Vincent Sepsis biomarkers: a review Crit Care 14 2010 R15
31. M. Meisner Procalcitonin - biochemistry and clinical diagnosis 2010 Uni-Med Verlag Ag
32. P. Dandona, D. Nix, M.F. Wilson, A. Aljada, J. Love, M. Assicot, and et al. Procalcitonin increase after endotoxin injection in normal subjects J Clin Endocrinol Metab 79 1994 1605 1608
33. J. Garnacho-Montero, M.J. Huici-Moreno, A. Gutiérrez-Pizarraya, I. López, J.A. Márquez-Vácaro, H. Macher, and et al. Prognostic and diagnostic value of eosinopenia, C-reactive protein, procalcitonin, and circulating cell-free DNA in critically ill patients admitted with suspicion of sepsis Crit Care 18 2014 R116
34. B. Müller, K.L. Becker, H. Schächinger, P.R. Rickenbacher, P.R. Huber, W. Zimmerli, and et al. Calcitonin precursors are reliable markers of sepsis in a medical intensive care unit Crit Care Med 28 2000 977 983
35. M. Christ-Crain, D. Jaccard-Stolz, R. Bingisser, M.M. Gencay, P.R. Huber, M. Tamm, and et al. Effect of procalcitonin-guided treatment on antibiotic use and outcome in lower respiratory tract infections: cluster-randomised, single-blinded intervention trial Lancet 363 2004 600 607
36. L. Bouadma, C.E. Luyt, F. Tubach, C. Cracco, A. Alvarez, C. Schwebel, et al. PRORATA Trial Group Use of procalcitonin to reduce patients' exposure to antibiotics in intensive care units (PRORATA trial): a multicentre randomised controlled trial Lancet 375 2010 463 474
37. C. Clec'h, J.P. Fosse, P. Karoubi, F. Vincent, I. Chouahi, L. Hamza, and et al. Differential diagnostic value of procalcitonin in surgical and medical patients with septic shock Crit Care Med 34 2006 102 107
38. O. Mimoz, J.F. Benoist, A.R. Edouard, M. Assicot, C. Bohuon, and K. Samii Procalcitonin and C-reactive protein during the early posttraumatic systemic inflammatory response syndrome Intensive Care Med 24 1998 185 188
39. C. Sponholz, Y. Sakr, K. Reinhart, and F. Brunkhorst Diagnostic value and prognostic implications of serum procalcitonin after cardiac surgery: a systematic review of the literature Crit Care 10 2006 R145
40. F.M. Brunkhorst, A.L. Clark, Z.F. Forycki, and S.D. Anker Pyrexia, procalcitonin, immune activation and survival in cardiogenic shock: the potential importance of bacterial translocation Int J Cardiol 72 1999 3 10
41. A. Kaczmarek, P. Vandenabeele, and D.V. Krysko Necroptosis: the release of damage-associated molecular patterns and its physiological relevance Immunity 38 2013 209 223
42. B. Uzzan, R. Cohen, P. Nicolas, M. Cucherat, and G.Y. Perret Procalcitonin as a diagnostic test for sepsis in critically ill adults and after surgery or trauma: a systematic review and meta-analysis Crit Care Med 34 2006 1996 2003
43. M. Meisner, K. Tschaikowsky, A. Hutzler, C. Schick, and J. Schüttler Postoperative plasma concentrations of procalcitonin after different types of surgery Intensive Care Med 24 1998 680 684
44. D.N. Amin, J.C. Pruitt, and P. Schuetz Influence of major cardiopulmonary surgery on serum levels of procalcitonin and other inflammatory markers Anaesth Intensive Care 40 2012 760 766
45. P.E. Charles, C. Tinel, S. Barbar, S. Aho, S. Prin, J.M. Doise, and et al. Procalcitonin kinetics within the first days of sepsis: relationship with the appropriateness of antibiotic therapy and the outcome Crit Care 13 2009 R38
46. J. Leentjens, M. Kox, R.M. Koch, F. Preijers, L.A. Joosten, J.G. van der Hoeven, and et al. Reversal of immunoparalysis in humans in vivo: a double-blind, placebo-controlled, randomized pilot study Am J Respir Crit Care Med 186 2012 838 845
47. B.M. Rau, I. Frigerio, M.W. Büchler, K. Wegscheider, C. Bassi, P.A. Puolakkainen, and et al. Evaluation of procalcitonin for predicting septic multiorgan failure and overall prognosis in secondary peritonitis: a prospective, international multicenter study Arch Surg 142 2007 134 142
48. I. Tsangaris, D. Plachouras, D. Kavatha, G.M. Gourgoulis, A. Tsantes, P. Kopterides, and et al. Diagnostic and prognostic value of procalcitonin among febrile critically ill patients with prolonged ICU stay BMC Infect Dis 9 2009 213
49. N. Öveges, D. Trásy, M.F. Németh, K. Tánczos, A. Osztroluczki, J. Fazakas, and et al. Increasing procalcitonin kinetics may be a good indicator of infection in critically ill patients Lives 2014. Linking innovation vision excellence & science 27th annual congress 27 September-1 October 2014, Barcelona, Spain 2014 European Society of Intensive Care Medicine Brussels, Belgium [poster 0982]
50. M.R. Ehrenstein, and C.A. Notley The importance of natural IgM: scavenger, protector and regulator Nat Rev Immunol 10 2010 778 786
51. S. Oesser, C. Schulze, and J. Seifert Protective capacity of a IgM/IgA-enriched polyclonal immunoglobulin-G preparation in endotoxemia Res Exp Med (Berl) 198 1999 325 339
52. Z. Molnár, A. Nierhaus, and F. Esen Sepsis mechanisms and therapies - immunoglobulins in sepsis: which patients will benefit the most? J.-L. Vincent, Annual update in intensive care and emergency medicine 2013 2013 Springer-Verlag Berlin-Heidelberg 145 153
53. T. Taniguchi Cytokine adsorbing columns Contrib Nephrol 166 2010 134 141
54. A. Spittler, M. Razenberger, H. Kupper, M. Kaul, W. Hackl, G. Boltz-Nitulescu, and et al. Relationship between interleukin-6 plasma concentration in patients with sepsis, monocyte phenotype, monocyte phagocytic properties, and cytokine production Clin Infect Dis 31 2000 1338 1342
55. R. de Pablo, J. Monserrat, E. Reyes, D. Diaz-Martin, M. Rodriguez Zapata, F. Carballo, and et al. Mortality in patients with septic shock correlates with anti-inflammatory but not pro-inflammatory immunomodulatory molecules J Intensive Care Med 26 2011 125 132
56. C.R. Vocelka, K.M. Jones, K.M. Mikhova, R.M. Ebisu, A. Shar, J.A. Kellum, and et al. Role of cytokine hemoadsorption in cardiopulmonary bypass-induced ventricular dysfunction in a porcine model J Extra Corpor Technol 45 2013 220 227
57. Z.Y. Peng, M.J. Carter, and J.A. Kellum Effects of hemoadsorption on cytokine removal and short-term survival in septic rats Crit Care Med 36 2008 1573 1577
58. M. Wiegele, and C.G. Krenn Cytosorb™ in a patient with Legionella pneumonia-associated rhabdomyolysis ASAIO J 61 2015 14 16
59. R. Basu, S. Pathak, J. Goyal, R. Chaudhry, R.B. Goel, and A. Barwal Use of a novel hemoadsorption device for cytokine removal as adjuvant therapy in a patient with septic shock with multi-organ dysfunction: a case study Indian J Crit Care Med 18 2014 822 824
60. J.A. Kellum, R. Venkataraman, D. Powner, M. Elder, G. Hergenroeder, and M. Carter Feasibility study of cytokine removal by hemoadsorption in brain-dead humans Crit Care Med 36 2008 268 272
61. M.J. Wilhelm, J. Pratschke, F. Beato, M. Taal, M. Kusaka, W.W. Hancock, and et al. Activation of the heart by donor brain death accelerates acute rejection after transplantation Circulation 102 2000 2426 2433
62. H. Hetz, R. Berger, P. Recknagel, and H. Steltzer Septic shock secondary to β-hemolytic Streptococcus-induced necrotizing fasciitis treated with a novel cytokine adsorption therapy Int J Artif Organs 37 2014 422 426
63. D. Trasy, M. Nemeth, A. Osztroluczki, K. Tanczos, N. Oveges, P. Hankovszky, and et al. Early procalcitonin kinetics may indicate effective empirical antibiotic therapy within hours after starting treatment (a pilot study) Intensive Care Med 39 Suppl. 2 2013 P0233