Procalcitonin better than C-reactive protein, erythrocyte sedimentation rate, and white blood cell count in predicting DNAemia in patients with sepsis

Scandinavian Journal of Infectious Diseases

Volumn 46, Issue 11, 2014, Pages 745-752

  Leli, Christian ^a   Cardaccia, Angela ^a   Ferranti, Marta ^a   Cesarini, Angelica ^a   D'alò, Francesco ^a   Ferri, Carla ^b   Cenci, Elio ^a   Mencacci, Antonella ^a  

^a UNIVERSITY OF PERUGIA   (Italy)

^b SANTA MARIA DELLA MISERICORDIA HOSPITAL   (Italy)

Author keywords

C reactive protein; Erythrocyte sedimentation rate; Procalcitonin; Real time PCR; Sepsis

Indexed keywords

C REACTIVE PROTEIN; PROCALCITONIN; BACTERIAL DNA; BIOLOGICAL MARKER; CALCITONIN; PROTEIN PRECURSOR;

ADULT; AGED; AREA UNDER THE CURVE; ARTICLE; BACTEREMIA; COMPARATIVE EFFECTIVENESS; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DIAGNOSTIC TEST ACCURACY STUDY; DNAEMIA; ERYTHROCYTE SEDIMENTATION RATE; FEMALE; HUMAN; LEUKOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; PREDICTION; PROTEIN BLOOD LEVEL; REAL TIME POLYMERASE CHAIN REACTION; RECEIVER OPERATING CHARACTERISTIC; RETROSPECTIVE STUDY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEPSIS; BLOOD; MICROBIOLOGY; MIDDLE AGED; VERY ELDERLY;

AGED; AGED, 80 AND OVER; BACTEREMIA; BIOLOGICAL MARKERS; BLOOD SEDIMENTATION; C-REACTIVE PROTEIN; CALCITONIN; DNA, BACTERIAL; FEMALE; HUMANS; LEUKOCYTE COUNT; MALE; MIDDLE AGED; PROTEIN PRECURSORS; REAL-TIME POLYMERASE CHAIN REACTION; RETROSPECTIVE STUDIES; ROC CURVE;

EID: 84911999621     PISSN: 00365548     EISSN: 16511980     Source Type: Journal    
DOI: 10.3109/00365548.2014.936493     Document Type: Article

References (41)

1. Dellinger RP, Levy M M, Rhodes A, Annane D, Gerlach H , Opal SM, et al. Surviving Sepsis Campaign Guidelines Committee including The Pediatric Subgroup. Surviving Sepsis Campaign: international guidelines for management of severe sepsiSand septic shock, 2012. Intensive Care Med 2013;39:165-228
2. Mayr F B, Yende S, Angus D C. E pidemiologYof severe sepsis. Virulence 2014;5:4-11
3. Bloos F, Reinhart K. Rapid diagnosis of sepsis. Virulence 2014;5:154-60
4. Bauer M, Reinhart K. Molecular diagnostics of sepsis- where are we today?. Int J Med Microbiol 2010;300:411-13
5. Reinhart K, Bauer M, Riedemann N C, Hartog CS. New approaches to sepsis: molecular diagnosticSand biomarkers. Clin Microbiol Rev 2012;25:609-34
6. Yanagihara K, Kitagawa Y, TomonagAm, Tsukasaki K , Kohno S, Seki M, et al. Evaluation of pathogen detection from clinical samples by real-time polymerase chain reaction using a sepsis pathogen DNA detection kit. Crit Care 2010;14:R159
7. Obara H, AikawAn, HasegawAn, Hori S, Ikeda Y , Kobayashi Y, et al. The role of a real-time PCR technology for rapid detection and identifi cation of bacterial and fungal pathogens in whole-blood samples. J Infect Chemother 2011;17:327-33
8. Pasqualini L, Mencacci A, Leli C, Montagna P, Cardaccia A , Cenci E, et al. Diagnostic performance of Amultiple realtime PCR assay in patients with suspected sepsis hospitalized in an internal medicine ward. J Clin Microbiol 2012;50:1285-8
9. herne V, Nelovkov A, K ü tt M, IVanovAm. Diagnostic performance and therapeutic impact of LightCycler Septi- Fast assay in patients with suspected sepsis. Eur J MicrobioLimmunol (Bp) 2013;3:68-76
10. Navarro E, Segura J C, Castañ o M J, Solera J. Use of real-time quantitative polymerase chain reaction to monitor the evolution of BrucellAmelitensis DNA load during therapy and post-therapy follow-up in patients with brucellosis. Clin Infect Dis 2006;42:1266-73
11. øv steb ø R, Brandtzaeg P, Brusletto B, Haug KB, L ande K , H ø iby EA, et al. Use of robotized DNA isolation and realtime PCR to quantify and identify close correlation between levels of NeisseriAmeningitidis DNA and lipopolysaccharides in plasma and cerebrospinal fl uid from patients with systemic meningococcal disease. J Clin Microbiol 2004;42:2980-7
12. Peters RP, Van Agtmael MA, G ierveld S, Danner SA , Groeneveld AB, Vandenbroucke-Grauls CM, et al. Quantitative detection of Staphylococcus aureuSanDenterococcus faecalis DNA in blood to diagnose bacteremia in patients in the intensive care unit. J Clin Microbiol 2007;45:3641-6
13. Kibe S, Adams K, Barlow G. DiagnostiCand prognostic biomarkers of sepsis in critical care. J Antimicrob Chemother 2011:66:ii33-40
14. Riedel S. Procalcitonin and the role of biomarkers in the diagnosiSand management of sepsis. Diagn MicrobioLinfect Dis 2012;73:221-7
15. Schuetz P, Albrich W, Mueller B. Procalcitonin for diagnosis of infection and guide to antibiotic decisions: past, present and future. BMC Med 2011;9:107
16. Barati M, Alinejad F, Bahar MA, Tabrisi M S, Shamshiri AR , Bodouhi NO, et al. Comparison of WBC, ESR, CRP and PCT serum levels in septiCand non-septic burn cases. Burns 2008;34:770-4
17. Chirouze C, Schuhmacher H, Rabaud C, Gil H, Khayat N , Estavoyer JM, et al. Low serum procalcitonin level accurately predicts the absence of bacteremia in adult patients with acute fever. Clin Infect Dis 2002;35:156-61
18. Mencacci A, Leli C, Cardaccia A, Meucci M, Moretti A , D ALò F, et al. Procalcitonin predicts real-time PCR results in blood samples from patients with suspected sepsis. PLoS One 2012;7:e53279
19. Bone RC, Balk RA, Cerra FB, Dellinger RP, Fein AM , Knaus WA, et al. ACCP/SCCM Consensus Conference Committee. Definitions for sepsiSand organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/SocietYof Critical Care Medicine. 1992. Chest 2009;136:e28
20. Lehmann LE, Hunfeld KP, E mrich T, Haberhausen G , Wissing H, Hoeft A, et al. Amultiplex real-time PCR assay for rapid detection and differentiation of 25 bacterial and fungal pathogens from whole blood samples. Med MicrobioLimmunol 2008;197:313-24
21. Weinstein MP. B lood culture contamination: persisting problemSand partial progress. J Clin Microbiol 2003;41:2275-8
22. Limper M, De Kruif MD, Duits A J, Brandjes DP , Van Gorp EC. The diagnostic role of procalcitonin and other biomarkers in discriminating infectious from non-infectious fever. J Infect 2010;60:409-16
23. Uusitalo-Seppä l ä R, Koskinen P, Leino A, Peuravuori H , Vahlberg T, Rintala EM. Early detection of severe sepsis in the emergency room: diagnostic value of plasma C-reactive protein, procalcitonin, and interleukin-6. Scand J Infect Dis 2011;43:883-90
24. Jeong S, Park Y, Cho Y, Kim H S. Diagnostic utilities of procalcitonin and C-reactive protein for the prediction of bacteremia determined by blood culture. Clin ChiMacta 2012;413:1731-6
25. Schuetz P, Suter-Widmer I, Chaudri A, Christ-Crain M , Zimmerli W, Mueller B. Procalcitonin-Guided Antibiotic Therapy and Hospitalization in Patients with Lower Respiratory Tract Infections (ProHOSP) Study Group. Prognostic value of procalcitonin in community-acquired pneumonia. Eur Respir J 2011;37:384-92
26. Gilbert D N. Procalcitonin as a biomarker in respiratory tract infection. Clin Infect Dis 2011;52:S346-50
27. Lehmann LE, Hunfeld KP, S teinbrucker M, Brade V , Book M, Seifert H, et al. Improved detection of blood stream pathogens by real-time PCR in severe sepsis. Intensive Care Med 2010;36:49-56
28. Chang SS, H sieh WH, Liu TS, Lee SH, Wang CH, Chou HC, et al. Multiplex PCR system for rapid detection of pathogens in patients with presumed sepsis a systemic revieWand meta-analysis. PLoS One 2013;8:e62323
29. Paolucci M, Stanzani M, Melchionda F, Tolomelli G , Castellani G, Landini MP, et al. Routine use of a real-time polymerase chain reaction method for detection of bloodstream infections in neutropaenic patients. Diagn MicrobioLinfect Dis 2013;75:130-4
30. Simon L, Gauvin F, Amre DK, Saint-Louis P, Lacroix, J. Serum procalcitonin and C-reactive protein levels as markers of bacteriaLinfection: a systematic revieWand meta-analysis. Clin Infect Dis 2004;39:206-17
31. Mü ller F, Christ-Crain M, Bregenzer T, Krause M , Zimmerli W, Mueller B, et al.; ProHOSP Study Group. Procalcitonin levels predict bacteremia in patients with community- acquired pneumonia: a prospective cohort trial. Chest 2010;138:121-9
32. Van Nieuwkoop C1, Bonten TN, Van t Wout JW, Kuijper EJ, Groeneveld GH, Becker MJ, et al. Procalcitonin refLects bacteremia and bacterial load in urosepsis syndrome: a prospective observational study. Crit Care 2010;14:R206
33. Schuetz P, Mueller B, Trampuz A. S erum procalcitonin for discrimination of blood contamination from bloodstream infection due to coagulase-negative staphylococci. Infection 2007;35:352-5
34. Lucignano B, Ranno S, Liesenfeld O, Pizzorno B , Putignani L, Bernaschi P, et al. Multiplex PCR allows rapid and accurate diagnosis of bloodstream infections in newbornSand children with suspected sepsis. J Clin Microbiol 2011;49:2252-8
35. Vince A, Lepej SZ, Barsi B, Dusek D, Mitrovi ć Z , Serventi-Seiwerth R, et al. LightCycler SeptiFast assay as a tool for the rapid diagnosis of sepsis in patients during antimicrobial therapy. J Med Microbiol 2008;57:1306-7
36. Monneret G, Labaune JM, Isaac C, Bienvenu F, Putet G , Bienvenu J. Procalcitonin and C-reactive protein levels in neonataLinfections. Acta Paediatr 1997;86:209-12
37. Dandona P, Nix D, Wilson MF, Aljada A, Love J, Assicot M, et al. Procalcitonin increase after endotoxin injection in normal subjects. J Clin Endocrinol Metab 1994;79:1605-8
38. Brunkhorst FM, Heinz U, Forycki ZF. K inetics of procalcitonin in iatrogenic sepsis. Intensive Care Med 1998;24 : 888-9
39. Kim K E, Han J Y. E valuation of the clinical performance of an automated procalcitonin assay for the quantitative detection of bloodstream infection. Korean J Lab Med 2010;30 : 153-9
40. Lee C C, Hong M Y, Lee N Y, Chen P L, Chang C M , Ko WC. Pitfalls in using serum C-reactive protein to predict bacteremia in febrile adults in the ED. Am J Emerg Med 2012;30:562-9
41. Cho SY, Choi JH. Biomarkers of sepsis. Infect Chemother 2014;46:1-12