The diagnostic accuracy of procalcitonin for bacteraemia: A systematic review and meta-analysis

Clinical Microbiology and Infection

Volumn 21, Issue 5, 2015, Pages 474-481

  Hoeboer, S H ^a   van der Geest, P J ^a   Nieboer, D ^a   Groeneveld, A B J ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

Bacteraemia; Diagnostic accuracy; Infection; Meta analysis; Procalcitonin; Sensitivity and specificity

Indexed keywords

BIOLOGICAL MARKER; PROCALCITONIN; CALCITONIN; PROTEIN PRECURSOR;

ARTICLE; BACTEREMIA; BLOOD CULTURE; BLOOD LEVEL; BLOODSTREAM INFECTION; DATA BASE; DIAGNOSTIC ACCURACY; DIAGNOSTIC TEST ACCURACY STUDY; HUMAN; IMMUNOCOMPROMISED PATIENT; INTENSIVE CARE; META ANALYSIS; NEUTROPENIA; PRIORITY JOURNAL; QUALITY CONTROL; RECEIVER OPERATING CHARACTERISTIC; SYSTEMATIC REVIEW; ADOLESCENT; ADULT; AGED; BLOOD; CHILD; EVALUATION STUDY; FEMALE; MALE; MIDDLE AGED; SENSITIVITY AND SPECIFICITY; VERY ELDERLY;

BACTERIA (MICROORGANISMS);

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; BACTEREMIA; BIOMARKERS; CALCITONIN; CHILD; FEMALE; HUMANS; MALE; MIDDLE AGED; PROTEIN PRECURSORS; ROC CURVE; SENSITIVITY AND SPECIFICITY;

EID: 84930516300     PISSN: 1198743X     EISSN: 14690691     Source Type: Journal    
DOI: 10.1016/j.cmi.2014.12.026     Document Type: Article

References (56)

1. Kumar A., Roberts D., Wood K.E., et al. Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock. Crit Care Med 2006, 34:1589-1596.
2. Wang H.E., Szychowski J.M., Griffin R., et al. Long-term mortality after community-acquired sepsis: a longitudinal population-based cohort study. BMJ Open 2014, 4:e004283.
3. Dellinger R.P., Levy M.M., Rhodes A., et al. Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock, 2012. Intensive Care Med 2013, 39:165-228.
4. Kopterides P., Siempos, Tsangaris I., et al. Procalcitonin-guided algorithms of antibiotic therapy in the intensive care unit: a systematic review and meta-analysis of randomized controlled trials. Crit Care Med 2010, 38:2229-2241.
5. Bone R.C., Balk R.A., Cerra F.B., et al. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. Chest 1992, 101:1644-1655.
6. Harbarth S., Holeckova K., Froidevaux C., et al. Diagnostic value of procalcitonin, interleukin-6, and interleukin-8 in critically ill patients admitted with suspected sepsis. Am J Respir Crit Care Med 2001, 164:396-402.
7. Pettila V., Hynninen M., Takkunen O., et al. Predictive value of procalcitonin and interleukin 6 in critically ill patients with suspected sepsis. Intensive Care Med 2002, 28:1220-1225.
8. Hensler T., Sauerland S., Lefering R., et al. The clinical value of procalcitonin and neopterin in predicting sepsis and organ failure after major trauma. Shock 2003, 20:420-426.
9. Riedel S. Procalcitonin and the role of biomarkers in the diagnosis and management of sepsis. Diagn Microbiol Infect Dis 2012, 73:221-227.
10. Wang H., Yin F., Shen D.X., et al. Predictive value of procalcitonin for excluding bloodstream infection: results of a retrospective study and utility of a rapid, quantitative test for procalcitonin. JInt Med Res 2013, 41:1671-1681.
11. Uzzan B., et al. Procalcitonin as a diagnostic test for sepsis in critically ill adults and after surgery or trauma: a systematic review and meta-analysis. Crit Care Med 2006, 34:1996-2003.
12. Tang B.M., Eslick G.D., Craig J.C., et al. Accuracy of procalcitonin for sepsis diagnosis in critically ill patients: systematic review and meta-analysis. Lancet Infect Dis 2007, 7:210-217.
13. Sakr Y., Sponholz C., Tuche F., Brunkhorst F., Reinhart K. The role of procalcitonin in febrile neutropenic patients: review of the literature. Infection 2008, 36:396-407.
14. Yu Z., Liu J., Sun Q., Qiu Y., Han S., Guo X. The accuracy of the procalcitonin test for the diagnosis of neonatal sepsis: a meta-analysis. Scand J Infect Dis 2010, 42:723-733.
15. Mann E.A., Wood G.L., Wade C.E. Use of procalcitonin for the detection of sepsis in the critically ill burn patient: a systematic review of the literature. Burns 2011, 37:549-558.
16. Vouloumanou E.K., Plessa E., Karageorgopoulos D.E., Mantadakis E., Falagas M.E. Serum procalcitonin as a diagnostic marker for neonatal sepsis: a systematic review and meta-analysis. Intensive Care Med 2011, 5:2174-2178.
17. Haeulser G.M., Carlesse F., Phililips R.S. An updated systematic review and meta-analysis of the predictive value of serum biomarkers in the assessment of fever during neutropenia in children with cancer. Pediatr Infect Dis J 2013, 10:e390-e396.
18. Wacker C., Prkno A., Brunkhorst F.M., Schlattmann P. Procalcitonin as a diagnostic marker for sepsis: a systematic review and meta-analysis. Lancet Infect Dis 2013, 13:426-435.
19. Bates D.W., Sands K., Miller E., et al. Predicting bacteremia in patients with sepsis syndrome. Academic Medical Center Consortium Sepsis Project Working Group. JInfect Dis 1997, 176:1538-1551.
20. Sands K.E., Bates D.W., Lanken P.N., et al. Epidemiology of sepsis syndrome in 8 academic medical centers. JAMA 1997, 278:234-240.
21. Magadia R.R., Weinstein M.P. Laboratory diagnosis of bacteremia and fungemia. Infect Dis Clin North Am 2001, 15:1009-1024.
22. Flayhart D., Borek A.P., Wakefield T., Dick J., Carroll K.C. Comparison of BACTEC PLUS blood culture media to BacT/Alert FA blood culture media for detection of bacterial pathogens in samples containing therapeutic levels of antibiotics. JClin Microbiol 2007, 45:816-821.
23. Muller F., Christ-Crain M., Bregenzer T., et al. Procalcitonin levels predict bacteremia in patients with community-acquired pneumonia: a prospective cohort trial. Chest 2010, 138:121-129.
24. Kim M.H., Lim G., Kang S.Y., Lee W.I., Suh J.T., Lee H.J. Utility of procalcitonin as an early diagnostic marker of bacteremia in patients with acute fever. Yonsei Med J 2011, 52:276-281.
25. Lai C.C., Chen S.Y., Wang C.Y., et al. Diagnostic value of procalcitonin for bacterial infection in elderly patients in the emergency department. JAm Geriatr Soc 2010, 58:518-522.
26. Schuetz P., Mueller B., Trampuz A. Serum procalcitonin for discrimination of blood contamination from bloodstream infection due to coagulase-negative staphylococci. Infection 2007, 35:352-355.
27. Riedel S., Melendez J.H., An A.T., Rosenbaum J.E., Zenilman J.M. Procalcitonin as a marker for the detection of bacteremia and sepsis in the emergency department. Am J Clin Pathol 2011, 135:182-189.
28. Simon L., Gauvin F., Amre D.K., Saint-Louis P., Lacroix J. Serum procalcitonin and C-reactive protein levels as markers of bacterial infection: a systematic review and meta-analysis. Clin Infect Dis 2004, 39:206-217.
29. Van den Breul, Thompson M.J., Haj-Hassan T., et al. Diagnostic value of laboratory tests in identifying serious infections in febrile children: systematic review. BMJ 2011, 342:d3082.
30. Lin S.G., Hou T.Y., Huang D.H., et al. Role of procalcitonin in the diagnosis of severe infection in pediatric patients with fever and neutropenia-a systemic review and meta-analysis. Pediatr Infect Dis J 2012, 31:e182-e188.
31. Wu J.Y., Lee S.H., Shen C.J., et al. Use of serum procalcitonin to detect bacterial infection in patients with autoimmune diseases: a systematic review and meta-analysis. Arthritis Rheum 2012, 64:3034-3042.
32. Yo C.H., Hsieh P.S., Lee S.H., et al. Comparison of the test characteristics of procalcitonin to C-reactive protein and leukocytosis for the detection of serious bacterial infections in children presenting with fever without source: a systematic review and meta-analysis. Ann Emerg Med 2012, 60:591-600.
33. Dou Y.H., Du J.K., Liu H.L., Shong X.D. The role of procalcitonin in the identification of invasive fungal infection-a systemic review and meta-analysis. Diagn Microbiol Infect Dis 2013, 76:464-469.
34. Lee S.H., Chan R.C., Wu J.Y., Chen H.W., Chang S.S., Lee C.C. Diagnostic value of procalcitonin for bacterial infection in elderly patients-a systemic review and meta-analysis. Int J Clin Pract 2013, 67:1350-1357.
35. Shen C.J., Wu M.S., Lin K.H., et al. The use of procalcitonin in the diagnosis of bone and joint infection: a systemic review and meta-analysis. Eur J Clin Microbiol Infect Dis 2013, 32:807-814.
36. Yu C.W., Juan L.I., Hsu S.C., Chen C.K., Wu C.W., Lee C.C., et al. Role of procalcitonin in the diagnosis of infective endocarditis: a meta-analysis. Am J Emerg Med 2013, 31:935-941.
37. Huang S.L., Lee H.C., Yu C.M., et al. Value of procalcitonin in differentiating pulmonary tuberculosis from other pulmonary infections: a meta-analysis. Int J Tuberc Lung Dis 2014, 18:470-477.
38. Pfister R., Kochanek M., Leygeber T., et al. Procalcitonin for diagnosis of bacterial pneumonia in critically ill patients during 2009 H1N1 influenza pandemic: a prospective cohort study, systematic review and individual patient data meta-analysis. Crit Care 2014, 10:R44.
39. Lin K.H., Wang F.L., Wu M.S., et al. Serum procalcitonin and C-reactive protein levels as markers of bacterial infection in patients with liver cirrhosis: a systematic review and meta-analysis. Diagn Microbiol Infect Dis 2014, 80:72-78.
40. Jones A.E., Fiechtl J.F., Brown M.D., Ballew J.J., Kline J.A. Procalcitonin test in the diagnosis of bacteremia: a meta-analysis. Ann Emerg Med 2007, 50:34-41.
41. Liberati A., Altman D.G., Tetzlaff J., et al. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration. BMJ 2009, 339:b2700.
42. Whiting P., Rutjes A.W., Reitsma J.B., Bossuyt P.M., Kleijnen J. The development of QUADAS: a tool for the quality assessment of studies of diagnostic accuracy included in systematic reviews. BMC Med Res Methodol 2003, 3:25.
43. Leeflang M.M., Deeks J.J., Gatsonis C., Bossuyt P.M. Systematic reviews of diagnostic test accuracy. Ann Intern Med 2008, 149:889-897.
44. Harbord R.M., Whiting P. metandi: meta-analysis of diagnostic accuracy using hierarchical logistic regression. Stata J 2009, 9:211-229.
45. Reitsma J.B., Glas A.S., Rutjes A.W., Scholten R.J., Bossuyt P.M., Zwinderman A.H. Bivariate analysis of sensitivity and specificity produces informative summary measures in diagnostic reviews. JClin Epidemiol 2005, 58:982-990.
46. Lai C.C., Tan C.K., Chen S.Y., et al. Diagnostic value of procalcitonin for bacteremia in patients with bacterial infection at the emergency department. JInfect 2010, 61:512-515.
47. Fazili T., Endy T., Javaid W., et al. Role of procalcitonin in guiding antibiotic therapy. Am J Health Syst Pharm 2012, 69:2057-2061.
48. Quenot J.P., Luyt C.E., Roche N., et al. Role of biomarkers in the management of antibiotic therapy: an expert panel review II: clinical use of biomarkers for initiation or discontinuation of antibiotic therapy. Ann Int Care 2013, 3:21.
49. Tape TG. Interpreting diagnostic tests. Available online at: Accessed 12.10.14. http://gim.unmc.edu/dxtests/Default.htm.
50. Deeks J.J., Macaskill P., Irwig L. The performance of tests of publication bias and other sample size effects in systematic reviews of diagnostic test accuracy was assessed. JClin Epidemiol 2005, 58:882-893.
51. Schuetz P., Albrich W., Mueller B. Procalcitonin for diagnosis of infection and guide to antibiotic decisions: past, present and future. BMC Med 2011, 9:107.
52. Guinard-Barbier S., Grabar S., Chenevier-Gobeaux C., et al. Is mid-regional pro-atrial natriuretic peptide (MRproANP) an accurate marker of bacteremia in pyelonephritis?. Biomarkers 2011, 16:355-363.
53. Hoenigl M., Raggam R.B., Wagner J., et al. Diagnostic accuracy of soluble urokinase plasminogen activator receptor (suPAR) for prediction of bacteremia in patients with systemic inflammatory response syndrome. Clin Biochem 2013, 46:225-229.
54. Menendez R., Sahuquillo-Arce J.M., Reyes S., et al. Cytokine activation patterns and biomarkers are influenced by microorganisms in community-acquired pneumonia. Chest 2012, 141:1537-1545.
55. Park J.H., Wee J.H., Choi S.P., Oh S.H. The value of procalcitonin level in community-acquired pneumonia in the ED. Am J Emerg Med 2012, 30:1248-1254.
56. Theodorou V.P., Papaioannou V.E., Tripsianis G.A., et al. Procalcitonin and procalcitonin kinetics for diagnosis and prognosis of intravascular catheter-related bloodstream infections in selected critically ill patients: a prospective observational study. BMC Infect Dis 2012, 12:247.