메뉴 건너뛰기




Volumn 45, Issue 6, 2016, Pages 876-881

Intratumor Heterogeneity of KRAS Mutation Status in Pancreatic Ductal Adenocarcinoma Is Associated with Smaller Lesions

Author keywords

intratumor heterogeneity; KRAS; pancreatic ductal adenocarcinoma; subclonality

Indexed keywords

K RAS PROTEIN; KRAS PROTEIN, HUMAN; PROTEIN P21;

EID: 84949472002     PISSN: 08853177     EISSN: 15364828     Source Type: Journal    
DOI: 10.1097/MPA.0000000000000562     Document Type: Article
Times cited : (9)

References (34)
  • 2
    • 0024292722 scopus 로고
    • Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes
    • Almoguera C Shibata D Forrester K Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes. Cell. 1988; 53: 549-554.
    • (1988) Cell , vol.53 , pp. 549-554
    • Almoguera, C.1    Shibata, D.2    Forrester, K.3
  • 3
    • 52149123619 scopus 로고    scopus 로고
    • Core signaling pathways in human pancreatic cancers revealed by global genomic analyses
    • Jones S Zhang X Parsons DW Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Science. 2008; 321: 1801-1806.
    • (2008) Science , vol.321 , pp. 1801-1806
    • Jones, S.1    Zhang, X.2    Parsons, D.W.3
  • 4
    • 84924056345 scopus 로고    scopus 로고
    • Whole genomes redefine the mutational landscape of pancreatic cancer
    • Waddell N Pajic M Patch AM Whole genomes redefine the mutational landscape of pancreatic cancer. Nature. 2015; 518: 495-501.
    • (2015) Nature , vol.518 , pp. 495-501
    • Waddell, N.1    Pajic, M.2    Patch, A.M.3
  • 5
    • 78049398107 scopus 로고    scopus 로고
    • Distant metastasis occurs late during the genetic evolution of pancreatic cancer
    • Yachida S Jones S Bozic I Distant metastasis occurs late during the genetic evolution of pancreatic cancer. Nature. 2010; 467: 1114-1117.
    • (2010) Nature , vol.467 , pp. 1114-1117
    • Yachida, S.1    Jones, S.2    Bozic, I.3
  • 6
    • 0031459206 scopus 로고    scopus 로고
    • Prevalence of activating K-ras mutations in the evolutionary stages of neoplasia in intraductal papillary mucinous tumors of the pancreas
    • Z'graggen K Rivera JA Compton CC Prevalence of activating K-ras mutations in the evolutionary stages of neoplasia in intraductal papillary mucinous tumors of the pancreas. Ann Surg. 1997; 226: 491-498.
    • (1997) Ann Surg , vol.226 , pp. 491-498
    • Z'Graggen, K.1    Rivera, J.A.2    Compton, C.C.3
  • 7
    • 45349107664 scopus 로고    scopus 로고
    • Sensitive and quantitative detection of KRAS2 gene mutations in pancreatic duct juice differentiates patients with pancreatic cancer from chronic pancreatitis, potential for early detection
    • Shi C Fukushima N Abe T Sensitive and quantitative detection of KRAS2 gene mutations in pancreatic duct juice differentiates patients with pancreatic cancer from chronic pancreatitis, potential for early detection. Cancer Biol Ther. 2008; 7: 353-360.
    • (2008) Cancer Biol Ther , vol.7 , pp. 353-360
    • Shi, C.1    Fukushima, N.2    Abe, T.3
  • 8
    • 84863012865 scopus 로고    scopus 로고
    • Oncogenic KRAS is required for both the initiation and maintenance of pancreatic cancer in mice
    • Collins MA Bednar F Zhang Y Oncogenic KRAS is required for both the initiation and maintenance of pancreatic cancer in mice. J Clin Invest. 2012; 122: 639-653.
    • (2012) J Clin Invest , vol.122 , pp. 639-653
    • Collins, M.A.1    Bednar, F.2    Zhang, Y.3
  • 9
    • 84870709449 scopus 로고    scopus 로고
    • Metastatic pancreatic cancer is dependent on oncogenic Kras in mice
    • Collins MA Brisset JC Zhang Y Metastatic pancreatic cancer is dependent on oncogenic Kras in mice. PLoS One. 2012; 7: e49707.
    • (2012) PLoS One , vol.7 , pp. e49707
    • Collins, M.A.1    Brisset, J.C.2    Zhang, Y.3
  • 10
    • 84860321700 scopus 로고    scopus 로고
    • Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism
    • Ying H Kimmelman AC Lyssiotis CA Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism. Cell. 2012; 149: 656-670.
    • (2012) Cell , vol.149 , pp. 656-670
    • Ying, H.1    Kimmelman, A.C.2    Lyssiotis, C.A.3
  • 11
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • Hanahan D Weinberg RA. Hallmarks of cancer: the next generation. Cell. 2011; 144: 646-674.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 12
    • 84875884456 scopus 로고    scopus 로고
    • Cellular heterogeneity and molecular evolution in cancer
    • Almendro V Marusyk A Polyak K. Cellular heterogeneity and molecular evolution in cancer. Annu Rev Pathol. 2013; 8: 277-302.
    • (2013) Annu Rev Pathol , vol.8 , pp. 277-302
    • Almendro, V.1    Marusyk, A.2    Polyak, K.3
  • 13
    • 80052571361 scopus 로고    scopus 로고
    • LNA-based PCR clamping enrichment assay for the identification of KRAS mutations
    • Efrati E Elkin H Peerless Y LNA-based PCR clamping enrichment assay for the identification of KRAS mutations. Cancer Biomark. 2010; 8: 89-94.
    • (2010) Cancer Biomark , vol.8 , pp. 89-94
    • Efrati, E.1    Elkin, H.2    Peerless, Y.3
  • 15
    • 84875634162 scopus 로고    scopus 로고
    • Integrative Genomics Viewer (IGV): High-performance genomics data visualization and exploration
    • Thorvaldsdóttir H Robinson JT Mesirov JP. Integrative Genomics Viewer (IGV): high-performance genomics data visualization and exploration. Brief Bioinform. 2013; 14: 178-192.
    • (2013) Brief Bioinform , vol.14 , pp. 178-192
    • Thorvaldsdóttir, H.1    Robinson, J.T.2    Mesirov, J.3
  • 16
    • 84862777152 scopus 로고    scopus 로고
    • Presence of somatic mutations in most early-stage pancreatic intraepithelial neoplasia
    • Kanda M Matthaei H Wu J Presence of somatic mutations in most early-stage pancreatic intraepithelial neoplasia. Gastroenterology. 2012; 142: 730.e9-733.e9.
    • (2012) Gastroenterology , vol.142 , pp. 730e9-733e9
    • Kanda, M.1    Matthaei, H.2    Wu, J.3
  • 17
    • 84888087317 scopus 로고    scopus 로고
    • Intra-tumor heterogeneity: Lessons from microbial evolution and clinical implications
    • de Bruin EC Taylor TB Swanton C. Intra-tumor heterogeneity: lessons from microbial evolution and clinical implications. Genome Med. 2013; 5: 101.
    • (2013) Genome Med , vol.5 , pp. 101
    • De Bruin, E.C.1    Taylor, T.B.2    Swanton, C.3
  • 18
    • 84884365015 scopus 로고    scopus 로고
    • The causes and consequences of genetic heterogeneity in cancer evolution
    • Burrell RA McGranahan N Bartek J The causes and consequences of genetic heterogeneity in cancer evolution. Nature. 2013; 501: 338-345.
    • (2013) Nature , vol.501 , pp. 338-345
    • Burrell, R.A.1    McGranahan, N.2    Bartek, J.3
  • 19
    • 84884407337 scopus 로고    scopus 로고
    • Tumour heterogeneity in the clinic
    • Bedard PL Hansen AR Ratain MJ Tumour heterogeneity in the clinic. Nature. 2013; 501: 355-364.
    • (2013) Nature , vol.501 , pp. 355-364
    • Bedard, P.L.1    Hansen, A.R.2    Ratain, M.J.3
  • 20
    • 79955833377 scopus 로고    scopus 로고
    • Discordant human epidermal growth factor receptor 2 and hormone receptor status in primary and metastatic breast cancer and response to trastuzumab
    • Chang HJ Han SW Oh DY Discordant human epidermal growth factor receptor 2 and hormone receptor status in primary and metastatic breast cancer and response to trastuzumab. Jpn J Clin Oncol. 2011; 41: 593-599.
    • (2011) Jpn J Clin Oncol , vol.41 , pp. 593-599
    • Chang, H.J.1    Han, S.W.2    Oh, D.Y.3
  • 21
    • 70849093383 scopus 로고    scopus 로고
    • Prognostic impact of discordance between triple-receptor measurements in primary and recurrent breast cancer
    • Liedtke C Broglio K Moulder S Prognostic impact of discordance between triple-receptor measurements in primary and recurrent breast cancer. Ann Oncol. 2009; 20: 1953-1958.
    • (2009) Ann Oncol , vol.20 , pp. 1953-1958
    • Liedtke, C.1    Broglio, K.2    Moulder, S.3
  • 22
    • 43649099401 scopus 로고    scopus 로고
    • Intratumor heterogeneity of epidermal growth factor receptor mutations in lung cancer and its correlation to the response to gefitinib
    • Taniguchi K Okami J Kodama K Intratumor heterogeneity of epidermal growth factor receptor mutations in lung cancer and its correlation to the response to gefitinib. Cancer Sci. 2008; 99: 929-935.
    • (2008) Cancer Sci , vol.99 , pp. 929-935
    • Taniguchi, K.1    Okami, J.2    Kodama, K.3
  • 23
    • 84924359778 scopus 로고    scopus 로고
    • Spatial and temporal heterogeneity in high-grade serous ovarian cancer: A phylogenetic analysis
    • Schwarz RF Ng CK Cooke SL Spatial and temporal heterogeneity in high-grade serous ovarian cancer: a phylogenetic analysis. PLoS Med. 2015; 12: e1001789.
    • (2015) PLoS Med , vol.12 , pp. e1001789
    • Schwarz, R.F.1    Ng, C.K.2    Cooke, S.L.3
  • 24
    • 84907808265 scopus 로고    scopus 로고
    • Intratumor heterogeneity in localized lung adenocarcinomas delineated by multiregion sequencing
    • Zhang J Fujimoto J Zhang J Intratumor heterogeneity in localized lung adenocarcinomas delineated by multiregion sequencing. Science. 2014; 346: 256-259.
    • (2014) Science , vol.346 , pp. 256-259
    • Zhang, J.1    Fujimoto, J.2    Zhang, J.3
  • 25
    • 84924388105 scopus 로고    scopus 로고
    • Intra-tumor genetic heterogeneity and mortality in head and neck cancer: Analysis of data from the Cancer Genome Atlas
    • Mroz EA Tward AD Hammon RJ Intra-tumor genetic heterogeneity and mortality in head and neck cancer: analysis of data from the Cancer Genome Atlas. PLoS Med. 2015; 12: e1001786.
    • (2015) PLoS Med , vol.12 , pp. e1001786
    • Mroz, E.A.1    Tward, A.D.2    Hammon, R.J.3
  • 26
    • 84874102335 scopus 로고    scopus 로고
    • Evolution and impact of subclonal mutations in chronic lymphocytic leukemia
    • Landau DA Carter SL Stojanov P Evolution and impact of subclonal mutations in chronic lymphocytic leukemia. Cell. 2013; 152: 714-726.
    • (2013) Cell , vol.152 , pp. 714-726
    • Landau, D.A.1    Carter, S.L.2    Stojanov, P.3
  • 27
    • 84867121875 scopus 로고    scopus 로고
    • Intratumor heterogeneity: Evolution through space and time
    • Swanton C. Intratumor heterogeneity: evolution through space and time. Cancer Res. 2012; 72: 4875-4882.
    • (2012) Cancer Res , vol.72 , pp. 4875-4882
    • Swanton, C.1
  • 28
    • 80855165133 scopus 로고    scopus 로고
    • Molecular morphometric analysis shows relative intra-tumoural homogeneity for KRAS mutations in colorectal cancer
    • Farber L Efrati E Elkin H Molecular morphometric analysis shows relative intra-tumoural homogeneity for KRAS mutations in colorectal cancer. Virchows Arch. 2011; 459: 487-493.
    • (2011) Virchows Arch , vol.459 , pp. 487-493
    • Farber, L.1    Efrati, E.2    Elkin, H.3
  • 29
    • 84908889764 scopus 로고    scopus 로고
    • Adenoma and carcinoma components in colonic tumors show discordance for KRAS mutation
    • Hershkovitz D Simon E Bick T Adenoma and carcinoma components in colonic tumors show discordance for KRAS mutation. Hum Pathol. 2014; 45: 1866-1871.
    • (2014) Hum Pathol , vol.45 , pp. 1866-1871
    • Hershkovitz, D.1    Simon, E.2    Bick, T.3
  • 30
    • 82555194053 scopus 로고    scopus 로고
    • KRAS mutant allele-specific imbalance in lung adenocarcinoma
    • Chiosea SI Sherer CK Jelic T KRAS mutant allele-specific imbalance in lung adenocarcinoma. Mod Pathol. 2011; 24: 1571-1577.
    • (2011) Mod Pathol , vol.24 , pp. 1571-1577
    • Chiosea, S.I.1    Sherer, C.K.2    Jelic, T.3
  • 31
    • 84885018386 scopus 로고    scopus 로고
    • KRAS mutant allele-specific imbalance is associated with worse prognosis in pancreatic cancer and progression to undifferentiated carcinoma of the pancreas
    • Krasinskas AM Moser AJ Saka B KRAS mutant allele-specific imbalance is associated with worse prognosis in pancreatic cancer and progression to undifferentiated carcinoma of the pancreas. Mod Pathol. 2013; 26: 1346-1354.
    • (2013) Mod Pathol , vol.26 , pp. 1346-1354
    • Krasinskas, A.M.1    Moser, A.J.2    Saka, B.3
  • 32
    • 84924954711 scopus 로고    scopus 로고
    • KRAS mutant allele-specific imbalance (MASI) assessment in routine samples of patients with metastatic colorectal cancer
    • Malapelle U Sgariglia R De Stefano A KRAS mutant allele-specific imbalance (MASI) assessment in routine samples of patients with metastatic colorectal cancer. J Clin Pathol. 2015; 68: 265-269.
    • (2015) J Clin Pathol , vol.68 , pp. 265-269
    • Malapelle, U.1    Sgariglia, R.2    De Stefano, A.3
  • 33
    • 78049380554 scopus 로고    scopus 로고
    • The patterns and dynamics of genomic instability in metastatic pancreatic cancer
    • Campbell PJ Yachida S Mudie LJ The patterns and dynamics of genomic instability in metastatic pancreatic cancer. Nature. 2010; 467: 1109-1113.
    • (2010) Nature , vol.467 , pp. 1109-1113
    • Campbell, P.J.1    Yachida, S.2    Mudie, L.J.3
  • 34
    • 84892158506 scopus 로고    scopus 로고
    • Clinical next-generation sequencing successfully applied to fine-needle aspirations of pulmonary and pancreatic neoplasms
    • Young G Wang K He J Clinical next-generation sequencing successfully applied to fine-needle aspirations of pulmonary and pancreatic neoplasms. Cancer Cytopathol. 2013; 121: 688-694.
    • (2013) Cancer Cytopathol , vol.121 , pp. 688-694
    • Young, G.1    Wang, K.2    He, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.