ER chaperone BiP/GRP78 is required for myelinating cell survival and provides protection during experimental autoimmune encephalomyelitis

Journal of Neuroscience

Volumn 35, Issue 48, 2015, Pages 15921-15933

  Hussien, Yassir ^a   Podojil, Joseph R ^b   Robinson, Andrew P ^b   Lee, Amy S ^c   Miller, Steven D ^b   Popko, Brian ^a  

^a UNIVERSITY OF CHICAGO   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

^c UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

ER stress; Mouse models; Protein homeostasis; Unfolded protein response

Indexed keywords

GLUCOSE REGULATED PROTEIN 78; X BOX BINDING PROTEIN 1; 2',3' CYCLIC NUCLEOTIDE 3' PHOSPHODIESTERASE; BAX-INHIBITING PEPTIDE, BIP; CNP PROTEIN, MOUSE; CYTOKINE; DDIT3 PROTEIN, MOUSE; FREUND ADJUVANT; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; MYELIN OLIGODENDROCYTE GLYCOPROTEIN; MYELIN OLIGODENDROCYTE GLYCOPROTEIN (35-55); MYELIN PROTEIN; OLIGOPEPTIDE; PEPTIDE FRAGMENT;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; ELECTRON MICROSCOPY; ENDOPLASMIC RETICULUM STRESS; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; FLOW CYTOMETRY; IMMUNOHISTOCHEMISTRY; MOUSE; MYELINATION; NERVOUS SYSTEM DEVELOPMENT; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; RNA ISOLATION; SCORING SYSTEM; SIGNAL TRANSDUCTION; TUNEL ASSAY; WESTERN BLOTTING; ANIMAL; C57BL MOUSE; CHEMICALLY INDUCED; DISEASE MODEL; DRUG EFFECTS; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; ENDOPLASMIC RETICULUM; FEMALE; GENE EXPRESSION REGULATION; GENETICS; IMMUNOLOGY; METABOLISM; MYELIN SHEATH; NEWBORN; OLIGODENDROGLIA; PATHOLOGY; PATHOPHYSIOLOGY; PERIPHERAL NERVE; ULTRASTRUCTURE;

2',3'-CYCLIC NUCLEOTIDE 3'-PHOSPHODIESTERASE; ANIMALS; ANIMALS, NEWBORN; CELL SURVIVAL; CYTOKINES; DISEASE MODELS, ANIMAL; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; ENDOPLASMIC RETICULUM; FEMALE; FREUND'S ADJUVANT; GENE EXPRESSION REGULATION, DEVELOPMENTAL; MICE; MICE, INBRED C57BL; MYELIN PROTEINS; MYELIN SHEATH; MYELIN-OLIGODENDROCYTE GLYCOPROTEIN; OLIGODENDROGLIA; OLIGOPEPTIDES; PEPTIDE FRAGMENTS; PERIPHERAL NERVES; TRANSCRIPTION FACTOR CHOP;

EID: 84949431700     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.0693-15.2015     Document Type: Article

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