Recent advances for FLAP inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 25, Issue 13, 2015, Pages 2607-2612

  Pettersen, Daniel ^a   Davidsson, Öjvind ^a   Whatling, Carl ^a  

^a ASTRAZENECA R AND D   (Sweden)

Author keywords

5 LO; Cardiovascular; FLAP; Inflammatory; Leukotrienes

Indexed keywords

3 [3 TERT BUTYLTHIO 1 (4 CHLOROBENZYL) 5 ISOPROPYL 2 INDOLYL] 2,2 DIMETHYLPROPIONIC ACID; 4,4 BIS[4 (2 QUINOLYLMETHOXY)PHENYL]PENTANOIC ACID; ABT 040; AM 103; ARACHIDONATE 5 LIPOXYGENASE ACTIVATING PROTEIN INHIBITOR; ATRELEUTON; AZD 6642; BENZIMIDAZOLE DERIVATIVE; BI 665915; CYTOCHROME P450 2C9; CYTOCHROME P450 3A4; FIBOFLAPON; IBUPROFEN; LEUKOTRIENE; LEUKOTRIENE RECEPTOR BLOCKING AGENT; MONTELUKAST; PRANLUKAST; QUIFLAPON; UNCLASSIFIED DRUG; VELIFLAPON; ZAFIRLUKAST;

ACUTE CORONARY SYNDROME; ARTICLE; ASTHMA; ATHEROSCLEROTIC PLAQUE; BINDING AFFINITY; BRONCHOCONSTRICTION; CARDIOVASCULAR DISEASE; DISEASE COURSE; DRUG INDICATION; DRUG SOLUBILITY; EYE INFLAMMATION; HAPLOTYPE; HEART INFARCTION; HEART MUSCLE ISCHEMIA; HUMAN; IC50; INFLAMMATORY DISEASE; LIPOPHILICITY; METABOLIC STABILITY; MOLECULAR WEIGHT; NONHUMAN; PHARMACOPHORE; PHASE 1 CLINICAL TRIAL (TOPIC); PHASE 2 CLINICAL TRIAL (TOPIC); PHASE 3 CLINICAL TRIAL (TOPIC); PLASMA PROTEIN BINDING; RESPIRATORY TRACT DISEASE; ANIMAL; ATHEROSCLEROSIS; CHEMICAL STRUCTURE; CHEMISTRY; DRUG DESIGN; DRUG DEVELOPMENT; INFLAMMATION; METABOLISM;

5-LIPOXYGENASE-ACTIVATING PROTEIN INHIBITORS; ANIMALS; ASTHMA; ATHEROSCLEROSIS; DRUG DESIGN; DRUG DISCOVERY; HUMANS; INFLAMMATION; LEUKOTRIENES; MOLECULAR STRUCTURE;

EID: 84949324426     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2015.04.090     Document Type: Review

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