Substituted 2,2-bisaryl-bicycloheptanes as novel and potent inhibitors of 5-lipoxygenase activating protein

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 6, 2008, Pages 2023-2027

  Macdonald, Dwight ^a   Brideau, Christine ^a   Chan, Chi Chung ^a   Falgueyret, Jean Pierre ^a   Frenette, Richard ^a   Guay, Jocelyne ^a   Hutchinson, John H ^a   Perrier, Hélène ^a   Prasit, Peptiboon ^a   Riendeau, Denis ^a   Tagari, Philip ^a   Thérien, Michel ^a   Young, Robert N ^a   Girard, Yves ^a  

^a MERCK FROSST CENTRE FOR THERAPEUTIC RESEARCH   (Canada)

Author keywords

5 LO; Asthma; Atherosclerosis; FLAP; Inflammatory bowel disease; LT; Psoriasis; Rheumatoid arthritis

Indexed keywords

3 [3 TERT BUTYLTHIO 1 (4 CHLOROBENZYL) 5 (2 QUINOLINYLMETHOXY) 2 INDOLYL] 2,2 DIMETHYLPROPIONIC ACID; 5 BENZOTHIAZOLYLMETHOXY 2 PYRIDINYLCARBAMATE DERIVATIVE; ARACHIDONATE 5 LIPOXYGENASE ACTIVATING PROTEIN; CALCIUM IONOPHORE; CARBENE; CYCLOHEPTANE DERIVATIVE; LEUKOTRIENE B4; LEUKOTRIENE E4; LIPOXYGENASE INHIBITOR; NITROGEN; POLYCYCLIC AROMATIC HYDROCARBON DERIVATIVE; UNCLASSIFIED DRUG; URETHAN;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOG; DRUG POTENCY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; INHIBITION KINETICS; NEUTROPHIL; NONHUMAN; RAGWEED; STRUCTURE ACTIVITY RELATION;

AMBROSIA; ANIMALS; ARACHIDONATE 5-LIPOXYGENASE; BICYCLO COMPOUNDS; CARRIER PROTEINS; DOGS; HEPTANES; HUMANS; INDOLES; IODINE RADIOISOTOPES; LEUKOTRIENE D4; LIPOXYGENASE INHIBITORS; MEMBRANE PROTEINS; MOLECULAR STRUCTURE; NEUTROPHILS; QUINOLINES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

AMBROSIA; CANIS FAMILIARIS;

EID: 40749090775     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.01.105     Document Type: Article

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