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Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 12, 2012, Pages 4133-4138

Evaluation of endo- and exo-aryl-substitutions and central scaffold modifications on diphenyl substituted alkanes as 5-lipoxygenase activating protein inhibitors

(20) Chu, Lin a Armstrong, Helen M a Chang, Linda L a Cheng, Amy F a Colwell, Lawrence a Cui, Jisong a Evans, Jilly a Galka, Amy a Goulet, Mark T a,b Hayes, Nancy a Lo, Jane a Menke, John a Ok, Hyun O a Ondeyka, Debra L a Patel, Minal a Quaker, Grace M a Sings, Heather a,c Witkin, Stephanie L a Zhao, Annie a Ujjainwalla, Feroze a

a MERCK RESEARCH LABORATORIES (United States)

b Department: DPS Strategic Operations ^* (United States)

c Department: Global Scientific and Medical Publications (United States)

Author keywords

5 Lipoxygenase activating protein; Antiasthmatic; FLAP inhibitors

Indexed keywords

LIPOXYGENASE INHIBITOR;

ANIMAL CELL; ARTICLE; CHEMICAL MODIFICATION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; MAXIMUM PLASMA CONCENTRATION; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION;

5-LIPOXYGENASE-ACTIVATING PROTEIN INHIBITORS; 5-LIPOXYGENASE-ACTIVATING PROTEINS; ALKANES; ANIMALS; ANTI-ALLERGIC AGENTS; BENZENE DERIVATIVES; HUMANS; INHIBITORY CONCENTRATION 50; INJECTIONS, INTRAVENOUS; NEUTROPHILS; RATS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84861573873 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2012.04.064 Document Type: Article

Times cited : (21)

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