Inhibition of host cell translation elongation by Legionella pneumophila blocks the host cell unfolded protein response

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 49, 2015, Pages E6790-6797

  Hempstead, Andrew D ^a,b   Isberg, Ralph R ^a  

^a TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b William A Hin ton State Laboratory Institute   (United States)

Author keywords

Legionella; Translation inhibition; Unfolded protein response

Indexed keywords

BACTERIAL ENZYME; CYCLOHEXIMIDE; GLUCOSYLTRANSFERASE; LEGIONELLA PNEUMOPHILA GLUCOSYLTRANSFERASE 3; MESSENGER RNA; PATTERN RECOGNITION RECEPTOR; PROTEIN IRE1; PROTEIN SYNTHESIS INHIBITOR; RAPAMYCIN; TOLL LIKE RECEPTOR; UNCLASSIFIED DRUG; X BOX BINDING PROTEIN 1; DNA BINDING PROTEIN; ERN1 PROTEIN, HUMAN; PROTEIN SERINE THREONINE KINASE; REGULATORY FACTOR X TRANSCRIPTION FACTOR; RIBONUCLEASE; TRANSCRIPTION FACTOR; XBP1 PROTEIN, HUMAN;

ANIMAL CELL; ARTICLE; BACTERIAL TRANSLOCATION; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; HOST CELL; HUMAN; HUMAN CELL; INNATE IMMUNITY; LEGIONELLA PNEUMOPHILA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SYNTHESIS INHIBITION; RNA SPLICING; RNA TRANSLATION; SIGNAL TRANSDUCTION; TRANSLATION ELONGATION; U937 CELL LINE; UNFOLDED PROTEIN RESPONSE; GENETICS; PHYSIOLOGY; PROTEIN SYNTHESIS;

CYCLOHEXIMIDE; DNA-BINDING PROTEINS; ENDORIBONUCLEASES; HUMANS; LEGIONELLA PNEUMOPHILA; PROTEIN BIOSYNTHESIS; PROTEIN-SERINE-THREONINE KINASES; REGULATORY FACTOR X TRANSCRIPTION FACTORS; TRANSCRIPTION FACTORS; UNFOLDED PROTEIN RESPONSE; X-BOX BINDING PROTEIN 1;

EID: 84949309775     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1508716112     Document Type: Article

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