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Volumn 112, Issue 49, 2015, Pages 15142-15147

Myeloid differentiation architecture of leukocyte transcriptome dynamics in perceived social isolation

Author keywords

Health; Inflammation; Loneliness; Social genomics

Indexed keywords

GAMMA INTERFERON; GLUCOCORTICOID; INTERFERON; TRANSCRIPTOME;

EID: 84949309766     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1514249112     Document Type: Article
Times cited : (196)

References (56)
  • 1
    • 77955071715 scopus 로고    scopus 로고
    • Social relationships and mortality risk: A meta-analytic review
    • Holt-Lunstad J, Smith TB, Layton JB (2010) Social relationships and mortality risk: A meta-analytic review. PLoS Med 7(7):e1000316.
    • (2010) PLoS Med , vol.7 , Issue.7 , pp. e1000316
    • Holt-Lunstad, J.1    Smith, T.B.2    Layton, J.B.3
  • 2
    • 84857452967 scopus 로고    scopus 로고
    • Loneliness, health, and mortality in old age: A national longitudinal study
    • Luo Y, Hawkley LC, Waite LJ, Cacioppo JT (2012) Loneliness, health, and mortality in old age: A national longitudinal study. Soc Sci Med 74(6):907-914.
    • (2012) Soc Sci Med , vol.74 , Issue.6 , pp. 907-914
    • Luo, Y.1    Hawkley, L.C.2    Waite, L.J.3    Cacioppo, J.T.4
  • 5
    • 84924917995 scopus 로고    scopus 로고
    • Loneliness across phylogeny and a call for comparative studies and animal models
    • Cacioppo JT, et al. (2015) Loneliness across phylogeny and a call for comparative studies and animal models. Perspect Psychol Sci 10(2):202-212.
    • (2015) Perspect Psychol Sci , vol.10 , Issue.2 , pp. 202-212
    • Cacioppo, J.T.1
  • 6
    • 70349185342 scopus 로고    scopus 로고
    • Perceived social isolation and cognition
    • Cacioppo JT, Hawkley LC (2009) Perceived social isolation and cognition. Trends Cogn Sci 13(10):447-454.
    • (2009) Trends Cogn Sci , vol.13 , Issue.10 , pp. 447-454
    • Cacioppo, J.T.1    Hawkley, L.C.2
  • 7
    • 84885355333 scopus 로고    scopus 로고
    • Social stress up-regulates inflammatory gene expression in the leukocyte transcriptome via β-adrenergic induction of myelopoiesis
    • Powell ND, et al. (2013) Social stress up-regulates inflammatory gene expression in the leukocyte transcriptome via β-adrenergic induction of myelopoiesis. Proc Natl Acad Sci USA 110(41):16574-16579.
    • (2013) Proc Natl Acad Sci USA , vol.110 , Issue.41 , pp. 16574-16579
    • Powell, N.D.1
  • 8
    • 84904023285 scopus 로고    scopus 로고
    • Chronic variable stress activates hematopoietic stem cells
    • Heidt T, et al. (2014) Chronic variable stress activates hematopoietic stem cells. Nat Med 20(7):754-758.
    • (2014) Nat Med , vol.20 , Issue.7 , pp. 754-758
    • Heidt, T.1
  • 10
    • 84908568806 scopus 로고    scopus 로고
    • A behavioral taxonomy of loneliness in humans and rhesus monkeys (Macaca mulatta
    • Capitanio JP, Hawkley LC, Cole SW, Cacioppo JT (2014) A behavioral taxonomy of loneliness in humans and rhesus monkeys (Macaca mulatta). PLoS One 9(10):e110307.
    • (2014) PLoS One , vol.9 , Issue.10 , pp. e110307
    • Capitanio, J.P.1    Hawkley, L.C.2    Cole, S.W.3    Cacioppo, J.T.4
  • 11
    • 35848951495 scopus 로고    scopus 로고
    • Social regulation of gene expression in human leukocytes
    • Cole SW, et al. (2007) Social regulation of gene expression in human leukocytes. Genome Biol 8(9):R189.
    • (2007) Genome Biol , vol.8 , Issue.9 , pp. R189
    • Cole, S.W.1
  • 12
    • 79952587441 scopus 로고    scopus 로고
    • Transcript origin analysis identifies antigen-presenting cells as primary targets of socially regulated gene expression in leukocytes
    • Cole SW, Hawkley LC, Arevalo JM, Cacioppo JT (2011) Transcript origin analysis identifies antigen-presenting cells as primary targets of socially regulated gene expression in leukocytes. Proc Natl Acad Sci USA 108(7):3080-3085.
    • (2011) Proc Natl Acad Sci USA , vol.108 , Issue.7 , pp. 3080-3085
    • Cole, S.W.1    Hawkley, L.C.2    Arevalo, J.M.3    Cacioppo, J.T.4
  • 13
    • 84865629341 scopus 로고    scopus 로고
    • Mindfulness-based stress reduction training reduces loneliness and pro-inflammatory gene expression in older adults: A small randomized controlled trial
    • Creswell JD, et al. (2012) Mindfulness-based stress reduction training reduces loneliness and pro-inflammatory gene expression in older adults: A small randomized controlled trial. Brain Behav Immun 26(7):1095-1101.
    • (2012) Brain Behav Immun , vol.26 , Issue.7 , pp. 1095-1101
    • Creswell, J.D.1
  • 14
    • 33747039463 scopus 로고    scopus 로고
    • Loneliness is a unique predictor of age-related differences in systolic blood pressure
    • Hawkley LC, Masi CM, Berry JD, Cacioppo JT (2006) Loneliness is a unique predictor of age-related differences in systolic blood pressure. Psychol Aging 21(1):152-164.
    • (2006) Psychol Aging , vol.21 , Issue.1 , pp. 152-164
    • Hawkley, L.C.1    Masi, C.M.2    Berry, J.D.3    Cacioppo, J.T.4
  • 15
    • 0141865550 scopus 로고    scopus 로고
    • Loneliness in everyday life: Cardiovascular activity, psychosocial context, and health behaviors
    • Hawkley LC, Burleson MH, Berntson GG, Cacioppo JT (2003) Loneliness in everyday life: Cardiovascular activity, psychosocial context, and health behaviors. J Pers Soc Psychol 85(1):105-120.
    • (2003) J Pers Soc Psychol , vol.85 , Issue.1 , pp. 105-120
    • Hawkley, L.C.1    Burleson, M.H.2    Berntson, G.G.3    Cacioppo, J.T.4
  • 16
    • 1642295763 scopus 로고    scopus 로고
    • Loneliness and neuroendo-crine, cardiovascular, and inflammatory stress responses in middle-aged men and women
    • Steptoe A, Owen N, Kunz-Ebrecht SR, Brydon L (2004) Loneliness and neuroendo-crine, cardiovascular, and inflammatory stress responses in middle-aged men and women. Psychoneuroendocrinology 29(5):593-611.
    • (2004) Psychoneuroendocrinology , vol.29 , Issue.5 , pp. 593-611
    • Steptoe, A.1    Owen, N.2    Kunz-Ebrecht, S.R.3    Brydon, L.4
  • 17
    • 33747046908 scopus 로고    scopus 로고
    • Loneliness as a specific risk factor for depressive symptoms: Cross-sectional and longitudinal analyses
    • Cacioppo JT, Hughes ME, Waite LJ, Hawkley LC, Thisted RA (2006) Loneliness as a specific risk factor for depressive symptoms: Cross-sectional and longitudinal analyses. Psychol Aging 21(1):140-151.
    • (2006) Psychol Aging , vol.21 , Issue.1 , pp. 140-151
    • Cacioppo, J.T.1    Hughes, M.E.2    Waite, L.J.3    Hawkley, L.C.4    Thisted, R.A.5
  • 18
    • 77951878127 scopus 로고    scopus 로고
    • Inflammation and social experience: An inflammatory challenge induces feelings of social disconnection in addition to depressed mood
    • Eisenberger NI, Inagaki TK, Mashal NM, Irwin MR (2010) Inflammation and social experience: An inflammatory challenge induces feelings of social disconnection in addition to depressed mood. Brain Behav Immun 24(4):558-563.
    • (2010) Brain Behav Immun , vol.24 , Issue.4 , pp. 558-563
    • Eisenberger, N.I.1    Inagaki, T.K.2    Mashal, N.M.3    Irwin, M.R.4
  • 19
    • 80052091705 scopus 로고    scopus 로고
    • Reciprocal regulation of the neural and innate immune systems
    • Irwin MR, Cole SW (2011) Reciprocal regulation of the neural and innate immune systems. Nat Rev Immunol 11(9):625-632.
    • (2011) Nat Rev Immunol , vol.11 , Issue.9 , pp. 625-632
    • Irwin, M.R.1    Cole, S.W.2
  • 20
    • 84855174215 scopus 로고    scopus 로고
    • Inflammation selectively enhances amygdala activity to socially threatening images
    • Inagaki TK, Muscatell KA, Irwin MR, Cole SW, Eisenberger NI (2012) Inflammation selectively enhances amygdala activity to socially threatening images. Neuroimage 59(4):3222-3226.
    • (2012) Neuroimage , vol.59 , Issue.4 , pp. 3222-3226
    • Inagaki, T.K.1    Muscatell, K.A.2    Irwin, M.R.3    Cole, S.W.4    Eisenberger, N.I.5
  • 21
    • 84927723020 scopus 로고    scopus 로고
    • Social instability and immunity in rhesus monkeys: The role of the sympathetic nervous system
    • Capitanio JP, Cole SW (2015) Social instability and immunity in rhesus monkeys: the role of the sympathetic nervous system. Philos Trans R Soc Lond B Biol Sci 370(1669): 370.
    • (2015) Philos Trans R Soc Lond B Biol Sci , vol.370 , Issue.1669 , pp. 370
    • Capitanio, J.P.1    Cole, S.W.2
  • 22
    • 50249183432 scopus 로고    scopus 로고
    • Social regulation of leukocyte homeostasis: The role of glucocorticoid sensitivity
    • Cole SW (2008) Social regulation of leukocyte homeostasis: The role of glucocorticoid sensitivity. Brain Behav Immun 22(7):1049-1055.
    • (2008) Brain Behav Immun , vol.22 , Issue.7 , pp. 1049-1055
    • Cole, S.W.1
  • 23
    • 0034976589 scopus 로고    scopus 로고
    • Social stress induces glucocorticoid resistance in macrophages
    • Stark JL, et al. (2001) Social stress induces glucocorticoid resistance in macrophages. Am J Physiol Regul Integr Comp Physiol 280(6):R1799-R1805.
    • (2001) Am J Physiol Regul Integr Comp Physiol , vol.280 , Issue.6 , pp. R1799-R1805
    • Stark, J.L.1
  • 24
    • 68849088302 scopus 로고    scopus 로고
    • Social stress desensitizes lymphocytes to regulation by endogenous glucocorticoids: Insights from in vivo cell trafficking dynamics in rhesus macaques
    • Cole SW, Mendoza SP, Capitanio JP (2009) Social stress desensitizes lymphocytes to regulation by endogenous glucocorticoids: Insights from in vivo cell trafficking dynamics in rhesus macaques. Psychosom Med 71(6):591-597.
    • (2009) Psychosom Med , vol.71 , Issue.6 , pp. 591-597
    • Cole, S.W.1    Mendoza, S.P.2    Capitanio, J.P.3
  • 25
    • 79955780432 scopus 로고    scopus 로고
    • β-Adrenergic receptor antagonism prevents anxiety-like behavior and microglial reactivity induced by repeated social defeat
    • Wohleb ES, et al. (2011) β-Adrenergic receptor antagonism prevents anxiety-like behavior and microglial reactivity induced by repeated social defeat. J Neurosci 31(17):6277-6288.
    • (2011) J Neurosci , vol.31 , Issue.17 , pp. 6277-6288
    • Wohleb, E.S.1
  • 26
    • 84865634389 scopus 로고    scopus 로고
    • Beta adrenergic blockade decreases the immunomodulatory effects of social disruption stress
    • Hanke ML, Powell ND, Stiner LM, Bailey MT, Sheridan JF (2012) Beta adrenergic blockade decreases the immunomodulatory effects of social disruption stress. Brain Behav Immun 26(7):1150-1159.
    • (2012) Brain Behav Immun , vol.26 , Issue.7 , pp. 1150-1159
    • Hanke, M.L.1    Powell, N.D.2    Stiner, L.M.3    Bailey, M.T.4    Sheridan, J.F.5
  • 27
    • 84919365614 scopus 로고    scopus 로고
    • Human social genomics
    • Cole SW (2014) Human social genomics. PLoS Genet 10(8):e1004601.
    • (2014) PLoS Genet , vol.10 , Issue.8 , pp. e1004601
    • Cole, S.W.1
  • 28
    • 0036830003 scopus 로고    scopus 로고
    • Chronic psychological stress and the regulation of pro-inflammatory cytokines: A glucocorticoid-resistance model
    • Miller GE, Cohen S, Ritchey AK (2002) Chronic psychological stress and the regulation of pro-inflammatory cytokines: A glucocorticoid-resistance model. Health Psychol 21(6):531-541.
    • (2002) Health Psychol , vol.21 , Issue.6 , pp. 531-541
    • Miller, G.E.1    Cohen, S.2    Ritchey, A.K.3
  • 29
    • 33845291521 scopus 로고    scopus 로고
    • Cytokine-effects on glucocorticoid receptor function: Relevance to glucocorticoid resistance and the pathophysiology and treatment of major depression
    • Pace TW, Hu F, Miller AH (2007) Cytokine-effects on glucocorticoid receptor function: relevance to glucocorticoid resistance and the pathophysiology and treatment of major depression. Brain Behav Immun 21(1):9-19.
    • (2007) Brain Behav Immun , vol.21 , Issue.1 , pp. 9-19
    • Pace, T.W.1    Hu, F.2    Miller, A.H.3
  • 30
    • 48149093475 scopus 로고    scopus 로고
    • A functional genomic fingerprint of chronic stress in humans: Blunted glucocorticoid and increased NF-kappaB signaling
    • Miller GE, et al. (2008) A functional genomic fingerprint of chronic stress in humans: Blunted glucocorticoid and increased NF-kappaB signaling. Biol Psychiatry 64(4): 266-272.
    • (2008) Biol Psychiatry , vol.64 , Issue.4 , pp. 266-272
    • Miller, G.E.1
  • 31
    • 70149101327 scopus 로고    scopus 로고
    • Low early-life social class leaves a biological residue manifested by decreased glucocorticoid and increased proinflammatory signaling
    • Miller GE, et al. (2009) Low early-life social class leaves a biological residue manifested by decreased glucocorticoid and increased proinflammatory signaling. Proc Natl Acad Sci USA 106(34):14716-14721.
    • (2009) Proc Natl Acad Sci USA , vol.106 , Issue.34 , pp. 14716-14721
    • Miller, G.E.1
  • 32
    • 84924029983 scopus 로고    scopus 로고
    • Greater inflammatory activity and blunted glucocorticoid signaling in monocytes of chronically stressed caregivers
    • Miller GE, et al. (2014) Greater inflammatory activity and blunted glucocorticoid signaling in monocytes of chronically stressed caregivers. Brain Behav Immun 41: 191-199.
    • (2014) Brain Behav Immun , vol.41 , pp. 191-199
    • Miller, G.E.1
  • 33
    • 85014119974 scopus 로고    scopus 로고
    • Monocyte trafficking to the brain with stress and inflammation: A novel axis of immune-to-brain communication that influences mood and behavior
    • Wohleb ES, McKim DB, Sheridan JF, Godbout JP (2014) Monocyte trafficking to the brain with stress and inflammation: A novel axis of immune-to-brain communication that influences mood and behavior. Front Neurosci 8:447.
    • (2014) Front Neurosci , vol.8 , pp. 447
    • Wohleb, E.S.1    McKim, D.B.2    Sheridan, J.F.3    Godbout, J.P.4
  • 34
    • 37249094173 scopus 로고    scopus 로고
    • From inflammation to sickness and depression: When the immune system subjugates the brain
    • Dantzer R, O'Connor JC, Freund GG, Johnson RW, Kelley KW (2008) From inflammation to sickness and depression: When the immune system subjugates the brain. Nat Rev Neurosci 9(1):46-56.
    • (2008) Nat Rev Neurosci , vol.9 , Issue.1 , pp. 46-56
    • Dantzer, R.1    O'Connor, J.C.2    Freund, G.G.3    Johnson, R.W.4    Kelley, K.W.5
  • 35
    • 57749188081 scopus 로고    scopus 로고
    • From social structure factors to perceptions of relationship quality and loneliness: The Chicago Health, Aging, and Social Relations Study
    • Hawkley LC, et al. (2008) From social structure factors to perceptions of relationship quality and loneliness: The Chicago Health, Aging, and Social Relations Study. J Gerontol Soc Sci 63B(6):S375-S384.
    • (2008) J Gerontol Soc Sci , vol.63 B , Issue.6 , pp. S375-S384
    • Hawkley, L.C.1
  • 36
    • 84875985398 scopus 로고    scopus 로고
    • Blood-informative transcripts define nine common axes of peripheral blood gene expression
    • Preininger M, et al. (2013) Blood-informative transcripts define nine common axes of peripheral blood gene expression. PLoS Genet 9(3):e1003362.
    • (2013) PLoS Genet , vol.9 , Issue.3 , pp. e1003362
    • Preininger, M.1
  • 37
    • 84858754792 scopus 로고    scopus 로고
    • Increased risk of mortality associated with social isolation in older men: Only when feeling lonely? Results from the Amsterdam Study of the Elderly (AMSTEL
    • Holwerda TJ, et al. (2012) Increased risk of mortality associated with social isolation in older men: only when feeling lonely? Results from the Amsterdam Study of the Elderly (AMSTEL). Psychol Med 42(4):843-853.
    • (2012) Psychol Med , vol.42 , Issue.4 , pp. 843-853
    • Holwerda, T.J.1
  • 38
    • 84902199255 scopus 로고    scopus 로고
    • Loneliness and mortality among older adults in China
    • Luo Y, Waite LJ (2014) Loneliness and mortality among older adults in China. J Gerontol B Psychol Sci Soc Sci 69(4):633-645.
    • (2014) J Gerontol B Psychol Sci Soc Sci , vol.69 , Issue.4 , pp. 633-645
    • Luo, Y.1    Waite, L.J.2
  • 39
    • 0032528508 scopus 로고    scopus 로고
    • Norepinephrine accelerates HIV replication via protein kinase A-dependent effects on cytokine production
    • Cole SW, Korin YD, Fahey JL, Zack JA (1998) Norepinephrine accelerates HIV replication via protein kinase A-dependent effects on cytokine production. J Immunol 161(2):610-616.
    • (1998) J Immunol , vol.161 , Issue.2 , pp. 610-616
    • Cole, S.W.1    Korin, Y.D.2    Fahey, J.L.3    Zack, J.A.4
  • 40
    • 33749535668 scopus 로고    scopus 로고
    • Adrenergic inhibition of innate anti-viral response: PKA blockade of Type i interferon gene transcription mediates catechol-amine support for HIV-1 replication
    • Collado-Hidalgo A, Sung C, Cole S (2006) Adrenergic inhibition of innate anti-viral response: PKA blockade of Type I interferon gene transcription mediates catechol-amine support for HIV-1 replication. Brain Behav Immun 20(6):552-563.
    • (2006) Brain Behav Immun , vol.20 , Issue.6 , pp. 552-563
    • Collado-Hidalgo, A.1    Sung, C.2    Cole, S.3
  • 41
    • 84870752459 scopus 로고    scopus 로고
    • Differential TNF production by monocyte subsets under physical stress: Blunted mobilization of proinflammatory monocytes in pre-hypertensive individuals
    • Dimitrov S, et al. (2013) Differential TNF production by monocyte subsets under physical stress: Blunted mobilization of proinflammatory monocytes in pre-hypertensive individuals. Brain Behav Immun 27(1):101-108.
    • (2013) Brain Behav Immun , vol.27 , Issue.1 , pp. 101-108
    • Dimitrov, S.1
  • 42
    • 33750802947 scopus 로고    scopus 로고
    • Loneliness within a nomological net: An evolutionary perspective
    • Cacioppo JT, et al. (2006) Loneliness within a nomological net: An evolutionary perspective. J Res Pers 40:1054-1085.
    • (2006) J Res Pers , vol.40 , pp. 1054-1085
    • Cacioppo, J.T.1
  • 44
    • 84882392732 scopus 로고    scopus 로고
    • A functional genomic perspective on human well-being
    • Fredrickson BL, et al. (2013) A functional genomic perspective on human well-being. Proc Natl Acad Sci USA 110(33):13684-13689.
    • (2013) Proc Natl Acad Sci USA , vol.110 , Issue.33 , pp. 13684-13689
    • Fredrickson, B.L.1
  • 45
    • 84961290841 scopus 로고    scopus 로고
    • Psychological well-being and the human conserved transcriptional response to adversity
    • Fredrickson BL, et al. (2015) Psychological well-being and the human conserved transcriptional response to adversity. PLoS One 10(3):e0121839.
    • (2015) PLoS One , vol.10 , Issue.3 , pp. e0121839
    • Fredrickson, B.L.1
  • 46
    • 84860130525 scopus 로고    scopus 로고
    • Social environment is associated with gene regulatory variation in the rhesus macaque immune system
    • Tung J, et al. (2012) Social environment is associated with gene regulatory variation in the rhesus macaque immune system. Proc Natl Acad Sci USA 109(17):6490-6495.
    • (2012) Proc Natl Acad Sci USA , vol.109 , Issue.17 , pp. 6490-6495
    • Tung, J.1
  • 47
    • 11144358198 scopus 로고    scopus 로고
    • A gene atlas of the mouse and human protein-encoding tran-scriptomes
    • Su AI, et al. (2004) A gene atlas of the mouse and human protein-encoding tran-scriptomes. Proc Natl Acad Sci USA 101(16):6062-6067.
    • (2004) Proc Natl Acad Sci USA , vol.101 , Issue.16 , pp. 6062-6067
    • Su, A.I.1
  • 48
    • 21344446363 scopus 로고    scopus 로고
    • Immune response in silico (IRIS): Immune-specific genes identified from a compendium of microarray expression data
    • Abbas AR, et al. (2005) Immune response in silico (IRIS): Immune-specific genes identified from a compendium of microarray expression data. Genes Immun 6(4):319-331.
    • (2005) Genes Immun , vol.6 , Issue.4 , pp. 319-331
    • Abbas, A.R.1
  • 49
    • 77449102329 scopus 로고    scopus 로고
    • Comparison of gene expression profiles between human and mouse monocyte subsets
    • Ingersoll MA, et al. (2010) Comparison of gene expression profiles between human and mouse monocyte subsets. Blood 115(3):e10-e19.
    • (2010) Blood , vol.115 , Issue.3 , pp. e10-e19
    • Ingersoll, M.A.1
  • 50
    • 15944429669 scopus 로고    scopus 로고
    • Expression-based monitoring of transcription factor activity: The TELiS database
    • Cole SW, Yan W, Galic Z, Arevalo J, Zack JA (2005) Expression-based monitoring of transcription factor activity: The TELiS database. Bioinformatics 21(6):803-810.
    • (2005) Bioinformatics , vol.21 , Issue.6 , pp. 803-810
    • Cole, S.W.1    Yan, W.2    Galic, Z.3    Arevalo, J.4    Zack, J.A.5
  • 51
    • 34548096953 scopus 로고    scopus 로고
    • Social stress enhances sympathetic innervation of primate lymph nodes: Mechanisms and implications for viral pathogenesis
    • Sloan EK, et al. (2007) Social stress enhances sympathetic innervation of primate lymph nodes: Mechanisms and implications for viral pathogenesis. J Neurosci 27(33): 8857-8865.
    • (2007) J Neurosci , vol.27 , Issue.33 , pp. 8857-8865
    • Sloan, E.K.1
  • 52
    • 0035835505 scopus 로고    scopus 로고
    • Real-time TaqMan PCR as a specific and more sensitive alternative to the branched-chain DNA assay for quantitation of simian immunodeficiency virus RNA
    • Leutenegger CM, et al. (2001) Real-time TaqMan PCR as a specific and more sensitive alternative to the branched-chain DNA assay for quantitation of simian immunodeficiency virus RNA. AIDS Res Hum Retroviruses 17(3):243-251.
    • (2001) AIDS Res Hum Retroviruses , vol.17 , Issue.3 , pp. 243-251
    • Leutenegger, C.M.1
  • 53
    • 0031060156 scopus 로고    scopus 로고
    • Plasma viremia in macaques infected with simian immunodeficiency virus: Plasma viral load early in infection predicts survival
    • Watson A, et al. (1997) Plasma viremia in macaques infected with simian immunodeficiency virus: Plasma viral load early in infection predicts survival. J Virol 71(1):284-290.
    • (1997) J Virol , vol.71 , Issue.1 , pp. 284-290
    • Watson, A.1
  • 54
    • 18744433053 scopus 로고    scopus 로고
    • Targeted lymph-node immunization with whole inactivated simian immunodeficiency virus (SIV) or envelope and core subunit antigen vaccines does not reliably protect rhesus macaques from vaginal challenge with SIVmac251
    • Lü X, et al. (1998) Targeted lymph-node immunization with whole inactivated simian immunodeficiency virus (SIV) or envelope and core subunit antigen vaccines does not reliably protect rhesus macaques from vaginal challenge with SIVmac251. AIDS 12(1): 1-10.
    • (1998) AIDS , vol.12 , Issue.1 , pp. 1-10
    • Lü, X.1


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