Inflammation selectively enhances amygdala activity to socially threatening images

NeuroImage

Volumn 59, Issue 4, 2012, Pages 3222-3226

  Inagaki, Tristen K ^a   Muscatell, Keely A ^a   Irwin, Michael R ^b   Cole, Steve W ^b,c   Eisenberger, Naomi I ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Amygdala; Cytokines; Functional magnetic resonance imaging; Inflammation; Social; Social withdrawal

Indexed keywords

CYTOKINE; ENDOTOXIN;

ADULT; AMYGDALOID NUCLEUS; ARTICLE; AVOIDANCE BEHAVIOR; BLOOD SAMPLING; BRAIN FUNCTION; CONTROLLED STUDY; DISEASE ACTIVITY; FEMALE; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HUMAN; HUMAN EXPERIMENT; IMAGE ANALYSIS; INFLAMMATION; MALE; NORMAL HUMAN; PATTERN RECOGNITION; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PSYCHOSOCIAL WITHDRAWAL; THREAT;

ADOLESCENT; ADULT; AMYGDALA; DOUBLE-BLIND METHOD; FEAR; FEMALE; HUMANS; INFLAMMATION; MAGNETIC RESONANCE IMAGING; MALE; SOCIAL DISTANCE; YOUNG ADULT;

EID: 84855174215     PISSN: 10538119     EISSN: 10959572     Source Type: Journal    
DOI: 10.1016/j.neuroimage.2011.10.090     Document Type: Article

References (30)

1. Adolphs R., Russell J.A., Tranel D. A role for the human amygdala in recognizing emotional arousal from unpleasant stimuli. Psychol. Sci. 1999, 10:167-171.
2. Andreasen A.S., Krabbe K.S., Krogh-Madsen R., Taudorf S., Pedersen B.K., Møller K. Human endotoxemia as a model of systemic inflammation. Curr. Med. Chem. 2008, 15:1697-1705.
3. Blackford J.U., Avery S.N., Cowan R.L., Shelton R.C., Zald D.H. Sustained amygdala response to both novel and newly familiar faces characterizes inhibited temperament. Soc. Cogn. Affect. Neurosci. 2010, 5:1-9.
4. Blair K., Shaywitz J., Smith B.W., Rhodes R., Geraci M., Jones M., McCaffrey D., Vythilingam M., Finger E., Mondillo K., Jacobs M., Charney D.S., Blair R.J., Drevets W.C., Pine D.S. Response to emotional expressions in generalized social phobia and generalized anxiety disorder: evidence for separate disorders. Am. J. Psychiatry 2008, 165:1193-1202.
5. Brett M., Anton J., Valabregue R., Poline J. Region of interest analysis using an SPM toolbox. Abstract presented at the 8th International Conference on Functional Mapping of the Human Brain, June 2-6, 2002, Sendai, Japan. Available on CD-ROM in NeuroImage 2002, Vol. 16. No 2.
6. Brühl A.B., Rufer M., Delsignore A., Kaffenberger T., Jäncke L., Herwig U. Neural correlates of altered general emotion processing in social anxiety disorder. Brain Res. 2011, 1378:72-83.
7. Cole S.W. The complexity of dynamic host networks. Complex Systems Science in BioMedicine 2006, 605-629. Kluwer Academic, New York. T.S. Deisboeck, J.Y. Kresh (Eds.).
8. Dantzer R., O'Connor J.C., Freund G.G., Johnson R.W., Kelley K.W. From inflammation to sickness and depression: when the immune system subjugates the brain. Nat. Rev. Neurosci. 2008, 9:46-56.
9. Eisenberger N.I., Inagaki T.K., Rameson L.T., Mashal N.M., Irwin M.R. An fMRI study of cytokine-induced depressed mood and social pain: the role of sex differences. NeuroImage 2009, 47:881-890.
10. Eisenberger N.I., Berkman E.T., Inagaki T.K., Rameson L.T., Mashal N.M., Irwin M.R. Inflammation-induced anhedonia: endotoxin reduces ventral striatum responses to reward. Biol. Psychiatry 2010, 68:748-754.
11. Eisenberger N.I., Inagaki T.K., Mashal N.M., Irwin M.R. Inflammation and social experience: an inflammatory challenge induces feelings of social disconnection. Brain Beh. Imm. 2010, 24:558-563.
12. Evans K.C., Wright C.I., Wedig M.M., Gold A.L., Pollack M.H., Rauch S.L. A functional MRI study of amygdala responses to angry schematic faces in social anxiety disorder. Depress. Anxiety 2008, 25:496-505.
13. Feinstein J.S., Adolphs R., Damasio A., Tranel D. The human amygdala and the induction and experience of fear. Curr. Biol. 2011, 21:34-38.
14. Frenois F., Moreau M., O'Connor J., Lawson M., Micon C., Lestage J., Kelley K.W., Dantzer R., Castanon N. Lipopolysaccharide induces delayed FosB/DeltaFosB immunostaining within the mouse extended amygdala, hippocampus and hypothalamus, that parallel the expression of depressive-like behavior. Psychoneuroendocrinology 2007, 32:516-531.
15. Hariri A.R., Tessitore A., Mattay V.S., Fera F., Weinberger D.R. The amygdala response to emotional stimuli: a comparison of faces and scenes. NeuroImage 2002, 17:317-323.
16. Hart B.L. Biological basis of the behavior of sick animals. Neurosci. Biobehav. Rev. 1988, 12:123-137.
17. Krabbe K.S., Reichenberg A., Yirmiya R., Smed A., Pedersen B.K., Bruunsgaard H. Low-dose endotoxemia and human neuropsychological functions. Brain Behav. Immunol. 2005, 19:453-460.
18. Lang P.J., Bradley M.M., Cuthbert B.N. International Affective Picture System (IAPS): Instruction Manual and Affective Ratings 1999, University of Florida, The Center for Research in Psychophysiology, Gainsville.
19. Marvel F.A., Chen C.C., Badr N., Gaykema R.P., Goehler L.E. Reversible inactivation of the dorsal vagal complex blocks lipopolysaccharide-induced social withdrawal and c-Fos expression in central autonomic nuclei. Brain Behav. Immunol. 2004, 18:123-134.
20. Morris J.S., Frith C.D., Perrett D.I., Rowland D., Young A.W., Calder A.J., Dolan R.J. A differential neural response to the human amygdala to fearful and happy facial expressions. Nature 1996, 383:812-815.
21. Phan K.L., Fitzgerald D.A., Nathan P.J., Tancer M.E. Association between amygdala hyperactivity to harsh faces and severity of social anxiety in generalized social phobia. Biol. Psychiatry 2006, 59:424-429.
22. Reichenberg A., Yirmiya R., Schuld A., Kraus T., Haack M., Morag A., Pollmächer T. Cytokine-associated emotional and cognitive disturbances in humans. Arch. Gen. Psychiatry 2001, 58:445-452.
23. Schwartz C.E., Wright C.I., Shin L.M., Kagan J., Rauch S.L. Inhibited and uninhibited infants "grown up": adult amygdalar response to novelty. Science 2003, 300:1952-1953.
24. Suffredini A.F., O'Grady N.P. Pathophysiological responses to endotoxin in humans. Endotoxin in Health Diseases 1999, 817-830. Marcel Dekker Inc., New York. D. Morrison (Ed.).
25. Suffredini A.F., Hochstein H.D., McMahon F.G. Dose-related inflammatory effects of intravenous endotoxin in humans: evaluation of a new clinical lot of Escherichia coli O:113 endotoxin. J. Infect. Dis. 1999, 179:1278-1282.
26. Tottenham N., Tanaka J.W., Leon A.C., McCarry T., Nurse M., Hare T.A., Marcus D.J., Westerlund A., Casey B.J., Nelson C. The NimStim set of facial expressions: judgments from untrained research participants. Psychiatry Res. 2009, 168:242-249.
27. Tzourio-Mazoyer N., Landeau B., Papathanassiou D., Crivello F., Etard O., Delcroix N., Mazoyer B., Joliot B. Automated anatomical labeling of the MNI MRI single-subject brain. NeuroImage 2002, 15:273-289.
28. Whalen P.J., Shin L.M., McInerney S.C., Fischer H., Wright C.I., Rauch S.L. A functional MRI study of human amygdala responses to facial expressions of fear vs. anger. Emotion 2001, 1:70-83.
29. Wright C.E., Strike P.C., Brydon I., Steptoe A. Acute inflammation and negative mood: mediation by cytokine activation. Brain Behav. Immunol. 2005, 19:345-350.
30. Yoon K.L., Fitzgerald D.A., Angstadt M., McCarron R.A., Phan K.L. Amygdala reactivity to emotional faces at high and low intensity in generalized social phobia: a 4-Tesla functional MRI study. Psychiatry Res. 2007, 154:93-98.