Intravitreal delivery of a novel AAV vector targets ON bipolar cells and restores visual function in a mouse model of complete congenital stationary night blindness

Human Molecular Genetics

Volumn 24, Issue 21, 2015, Pages 6229-6239

  Scalabrino, Miranda L ^a   Boye, Sanford L ^a   Fransen, Kathryn M H ^b   Noel, Jennifer M ^b   Dyka, Frank M ^a   Min, Seok Hong ^a   Ruan, Qing ^a   De Leeuw, Charles N ^d,e   Simpson, Elizabeth M ^d,e   Gregg, Ronald G ^c   McCall, Maureen A ^b   Peachey, Neal S ^f,g,h   Boye, Shannon E ^a  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^b University of Louisville School of Medicine   (United States)

^c UNIVERSITY OF LOUISVILLE   (United States)

^d UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^e UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^f LOUIS STOKES CLEVELAND VA MEDICAL CENTER   (United States)

^g LERNER RESEARCH INSTITUTE   (United States)

^h CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PARVOVIRUS VECTOR; NYCTALOPIN PROTEIN, MOUSE; PROTEOGLYCAN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; B WAVE; CONTROLLED STUDY; ELECTRORETINOGRAM; GENE EXPRESSION; MOUSE; NIGHT BLINDNESS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RETINA BIPOLAR GANGLION CELL; TRANSGENE; VIRAL GENE DELIVERY SYSTEM; VISION; ANIMAL; C57BL MOUSE; DEPENDOPARVOVIRUS; DISEASE MODEL; EYE DISEASE; GENE VECTOR; GENETIC TRANSFECTION; GENETICS; HUMAN; INTRAVITREAL DRUG ADMINISTRATION; METABOLISM; MUTATION; MYOPIA; PROMOTER REGION; RETINA; X CHROMOSOME LINKED DISORDER;

ANIMALS; DEPENDOVIRUS; DISEASE MODELS, ANIMAL; EYE DISEASES, HEREDITARY; GENETIC DISEASES, X-LINKED; GENETIC VECTORS; HUMANS; INTRAVITREAL INJECTIONS; MICE; MICE, INBRED C57BL; MUTATION; MYOPIA; NIGHT BLINDNESS; PROMOTER REGIONS, GENETIC; PROTEOGLYCANS; RETINA; RETINAL BIPOLAR CELLS; TRANSFECTION; TRANSGENES; VISION, OCULAR;

EID: 84949238699     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddv341     Document Type: Article

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