G226, a new epipolythiodioxopiperazine derivative, triggers DNA damage and apoptosis in human cancer cells in vitro via ROS generation

Acta Pharmacologica Sinica

Volumn 35, Issue 12, 2014, Pages 1546-1555

  He, Peng Xing ^a   Zhang, Jie ^c   Che, Yong Sheng ^b   He, Qiao Jun ^a   Chen, Yi ^c   Ding, Jian ^c  

^a ZHEJIANG UNIVERSITY   (China)

^b BEIJING INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY   (China)

^c INSTITUTE OF GEOLOGY AND GEOPHYSICS   (China)

Author keywords

11 deoxyverticillin A; anti cancer agent; antioxidant; apoptosis; DNA damage; epipolythiodioxopiperazine; G226; ROS; Topo II

Indexed keywords

ANTINEOPLASTIC AGENT; ANTIOXIDANT; DNA TOPOISOMERASE; DNA TOPOISOMERASE (ATP HYDROLYSING); G 226; HYDROGEN PEROXIDE; OXIDE; PIPERAZINE DERIVATIVE; REACTIVE OXYGEN METABOLITE; SUPEROXIDE; UNCLASSIFIED DRUG; DISULFIDE; DNA BINDING PROTEIN; DNA TOPOISOMERASE II ALPHA; G226 COMPOUND; GYRASE INHIBITOR; H2AFX PROTEIN, HUMAN; HISTONE; PIPERAZINEDIONE; TUMOR ANTIGEN;

ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CANCER CELL CULTURE; CELL PROLIFERATION ASSAY; DNA DAMAGE; DOSE RESPONSE; DRUG CYTOTOXICITY; DRUG STRUCTURE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IC50; IN VITRO STUDY; WESTERN BLOTTING; CELL CYCLE; CELL PROLIFERATION; CELL SURVIVAL; DRUG EFFECTS; GENETICS; HCT116 CELL LINE; HL 60 CELL LINE; HT 29 CELL LINE; METABOLISM; NEOPLASM; OXIDATIVE STRESS; PATHOLOGY; PHOSPHORYLATION;

ANTIGENS, NEOPLASM; ANTIOXIDANTS; APOPTOSIS; CELL CYCLE; CELL PROLIFERATION; CELL SURVIVAL; DIKETOPIPERAZINES; DISULFIDES; DNA DAMAGE; DNA TOPOISOMERASES, TYPE II; DNA-BINDING PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; HCT116 CELLS; HISTONES; HL-60 CELLS; HT29 CELLS; HUMANS; INHIBITORY CONCENTRATION 50; NEOPLASMS; OXIDATIVE STRESS; PHOSPHORYLATION; PIPERAZINES; REACTIVE OXYGEN SPECIES; TOPOISOMERASE II INHIBITORS;

EID: 84949116075     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2014.105     Document Type: Article

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