메뉴 건너뛰기




Volumn 68, Issue 2, 2015, Pages 513-519

Glucose, glycolysis and lymphocyte responses

Author keywords

B cell; c Myc; Galactose; GAPDH; Glucose; Glycolysis; Granzyme B; HIF1 ; IFN ; Lymphocyte; Metabolism; mTORC1; Natural Killer cell; Oxidative phosphorylation; Review; T cell

Indexed keywords

ADENOSINE TRIPHOSPHATE; GLUCOSE; GLYCOLYTIC ENZYME; MESSENGER RNA;

EID: 84949084914     PISSN: 01615890     EISSN: 18729142     Source Type: Journal    
DOI: 10.1016/j.molimm.2015.07.034     Document Type: Article
Times cited : (142)

References (50)
  • 1
    • 67650074206 scopus 로고    scopus 로고
    • MTOR regulates memory CD8 T-cell differentiation
    • Araki K., et al. mTOR regulates memory CD8 T-cell differentiation. Nature 2009, 460(7251):108-112.
    • (2009) Nature , vol.460 , Issue.7251 , pp. 108-112
    • Araki, K.1
  • 2
    • 84867801805 scopus 로고    scopus 로고
    • Protein kinase Cbeta is critical for the metabolic switch to glycolysis following B-cell antigen receptor engagement
    • Blair D., Dufort F.J., Chiles T.C. Protein kinase Cbeta is critical for the metabolic switch to glycolysis following B-cell antigen receptor engagement. Biochem J. 2012, 448(1):165-169.
    • (2012) Biochem J. , vol.448 , Issue.1 , pp. 165-169
    • Blair, D.1    Dufort, F.J.2    Chiles, T.C.3
  • 3
    • 84898606445 scopus 로고    scopus 로고
    • Metabolic reprogramming is required for antibody production that is suppressed in anergic but exaggerated in chronically BAFF-exposed B cells
    • Caro-Maldonado A., et al. Metabolic reprogramming is required for antibody production that is suppressed in anergic but exaggerated in chronically BAFF-exposed B cells. J. Immunol. 2014, 192(8):3626-3636.
    • (2014) J. Immunol. , vol.192 , Issue.8 , pp. 3626-3636
    • Caro-Maldonado, A.1
  • 4
    • 84861969926 scopus 로고    scopus 로고
    • Insights into RNA biology from an atlas of mammalian mRNA-binding proteins
    • Castello A., et al. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell 2012, 149(6):1393-1406.
    • (2012) Cell , vol.149 , Issue.6 , pp. 1393-1406
    • Castello, A.1
  • 5
    • 17044422629 scopus 로고    scopus 로고
    • Glucose availability regulates IFN-gamma production and p70S6 kinase activation in CD8+ effector T cells
    • Cham C.M., Gajewski T.F. Glucose availability regulates IFN-gamma production and p70S6 kinase activation in CD8+ effector T cells. J. Immunol. 2005, 174(8):4670-4677.
    • (2005) J. Immunol. , vol.174 , Issue.8 , pp. 4670-4677
    • Cham, C.M.1    Gajewski, T.F.2
  • 6
    • 55249114228 scopus 로고    scopus 로고
    • Glucose deprivation inhibits multiple key gene expression events and effector functions in CD8+ T cells
    • Cham C.M., et al. Glucose deprivation inhibits multiple key gene expression events and effector functions in CD8+ T cells. Eur. J. Immunol. 2008, 38(9):2438-2450.
    • (2008) Eur. J. Immunol. , vol.38 , Issue.9 , pp. 2438-2450
    • Cham, C.M.1
  • 7
    • 84878831880 scopus 로고    scopus 로고
    • Posttranscriptional control of T cell effector function by aerobic glycolysis
    • Chang C.H., et al. Posttranscriptional control of T cell effector function by aerobic glycolysis. Cell 2013, 153(6):1239-1251.
    • (2013) Cell , vol.153 , Issue.6 , pp. 1239-1251
    • Chang, C.H.1
  • 8
    • 84906274052 scopus 로고    scopus 로고
    • C-Myc-induced transcription factor AP4 is required for host protection mediated by CD8+ T cells
    • Chou C., et al. c-Myc-induced transcription factor AP4 is required for host protection mediated by CD8+ T cells. Nat. Immunol. 2014, 15(9):884-893.
    • (2014) Nat. Immunol. , vol.15 , Issue.9 , pp. 884-893
    • Chou, C.1
  • 9
    • 0029760743 scopus 로고    scopus 로고
    • Specific interaction in vitro and in vivo of glyceraldehyde-3-phosphate dehydrogenase and LA protein with cis-acting RNAs of human parainfluenza virus type 3
    • De B.P., et al. Specific interaction in vitro and in vivo of glyceraldehyde-3-phosphate dehydrogenase and LA protein with cis-acting RNAs of human parainfluenza virus type 3. J. Biol. Chem. 1996, 271(40):24728-24735.
    • (1996) J. Biol. Chem. , vol.271 , Issue.40 , pp. 24728-24735
    • De, B.P.1
  • 10
    • 66949173728 scopus 로고    scopus 로고
    • The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment
    • Delgoffe G.M., et al. The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment. Immunity 2009, 30(6):832-844.
    • (2009) Immunity , vol.30 , Issue.6 , pp. 832-844
    • Delgoffe, G.M.1
  • 11
    • 79952985551 scopus 로고    scopus 로고
    • The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2
    • Delgoffe G.M., et al. The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2. Nat. Immunol. 2011, 12(4):295-303.
    • (2011) Nat. Immunol. , vol.12 , Issue.4 , pp. 295-303
    • Delgoffe, G.M.1
  • 12
    • 84908123523 scopus 로고    scopus 로고
    • MTORC1-dependent metabolic reprogramming is a prerequisite for NK cell effector function
    • Donnelly R.P., et al. mTORC1-dependent metabolic reprogramming is a prerequisite for NK cell effector function. J. Immunol. 2014, 193(9):4477-4484.
    • (2014) J. Immunol. , vol.193 , Issue.9 , pp. 4477-4484
    • Donnelly, R.P.1
  • 13
    • 66649128115 scopus 로고    scopus 로고
    • Intrathymic proliferation wave essential for Valpha14+ natural killer T cell development depends on c-Myc
    • Dose M., et al. Intrathymic proliferation wave essential for Valpha14+ natural killer T cell development depends on c-Myc. Proc. Natl. Acad. Sci. U. S. A. 2009, 106(21):8641-8646.
    • (2009) Proc. Natl. Acad. Sci. U. S. A. , vol.106 , Issue.21 , pp. 8641-8646
    • Dose, M.1
  • 14
    • 33744462050 scopus 로고    scopus 로고
    • Antigen receptor-mediated changes in glucose metabolism in B lymphocytes: role of phosphatidylinositol 3-kinase signaling in the glycolytic control of growth
    • Doughty C.A., et al. Antigen receptor-mediated changes in glucose metabolism in B lymphocytes: role of phosphatidylinositol 3-kinase signaling in the glycolytic control of growth. Blood 2006, 107(11):4458-4465.
    • (2006) Blood , vol.107 , Issue.11 , pp. 4458-4465
    • Doughty, C.A.1
  • 15
    • 38449099803 scopus 로고    scopus 로고
    • Cutting edge: IL-4-mediated protection of primary B lymphocytes from apoptosis via Stat6-dependent regulation of glycolytic metabolism
    • Dufort F.J., et al. Cutting edge: IL-4-mediated protection of primary B lymphocytes from apoptosis via Stat6-dependent regulation of glycolytic metabolism. J. Immunol. 2007, 179(8):4953-4957.
    • (2007) J. Immunol. , vol.179 , Issue.8 , pp. 4953-4957
    • Dufort, F.J.1
  • 16
    • 78650645408 scopus 로고    scopus 로고
    • Temporal differences in the dependency on phosphoinositide-dependent kinase 1 distinguish the development of invariant Valpha14 NKT cells and conventional T cells
    • Finlay D.K., et al. Temporal differences in the dependency on phosphoinositide-dependent kinase 1 distinguish the development of invariant Valpha14 NKT cells and conventional T cells. J. Immunol. 2010, 185(10):5973-5982.
    • (2010) J. Immunol. , vol.185 , Issue.10 , pp. 5973-5982
    • Finlay, D.K.1
  • 17
    • 84871861969 scopus 로고    scopus 로고
    • PDK1 regulation of mTOR and hypoxia-inducible factor 1 integrate metabolism and migration of CD8+ T cells
    • Finlay D.K., et al. PDK1 regulation of mTOR and hypoxia-inducible factor 1 integrate metabolism and migration of CD8+ T cells. J. Exp. Med. 2012, 209(13):2441-2453.
    • (2012) J. Exp. Med. , vol.209 , Issue.13 , pp. 2441-2453
    • Finlay, D.K.1
  • 18
    • 0029920614 scopus 로고    scopus 로고
    • The Leloir pathway: a mechanistic imperative for three enzymes to change the stereochemical configuration of a single carbon in galactose
    • Frey P.A. The Leloir pathway: a mechanistic imperative for three enzymes to change the stereochemical configuration of a single carbon in galactose. FASEB J. 1996, 10(4):461-470.
    • (1996) FASEB J. , vol.10 , Issue.4 , pp. 461-470
    • Frey, P.A.1
  • 19
    • 84859140799 scopus 로고    scopus 로고
    • Metabolic pathways in T cell fate and function
    • Gerriets V.A., Rathmell J.C. Metabolic pathways in T cell fate and function. Trends Immunol. 2012, 33(4):168-173.
    • (2012) Trends Immunol. , vol.33 , Issue.4 , pp. 168-173
    • Gerriets, V.A.1    Rathmell, J.C.2
  • 20
    • 84886721392 scopus 로고    scopus 로고
    • Rapid effector function of memory CD8+ T cells requires an immediate-early glycolytic switch
    • Gubser P.M., et al. Rapid effector function of memory CD8+ T cells requires an immediate-early glycolytic switch. Nat. Immunol. 2013, 14(10):1064-1072.
    • (2013) Nat. Immunol. , vol.14 , Issue.10 , pp. 1064-1072
    • Gubser, P.M.1
  • 21
    • 2042546096 scopus 로고    scopus 로고
    • Balancing acts: molecular control of mammalian iron metabolism
    • Hentze M.W., Muckenthaler M.U., Andrews N.C. Balancing acts: molecular control of mammalian iron metabolism. Cell 2004, 117(3):285-297.
    • (2004) Cell , vol.117 , Issue.3 , pp. 285-297
    • Hentze, M.W.1    Muckenthaler, M.U.2    Andrews, N.C.3
  • 22
    • 0018077453 scopus 로고
    • Aerobic glycolysis and lymphocyte transformation
    • Hume D.A., et al. Aerobic glycolysis and lymphocyte transformation. Biochem. J. 1978, 174(3):703-709.
    • (1978) Biochem. J. , vol.174 , Issue.3 , pp. 703-709
    • Hume, D.A.1
  • 23
    • 84904057246 scopus 로고    scopus 로고
    • The glucose transporter Glut1 is selectively essential for CD4+ T cell activation and effector function
    • Macintyre A.N., et al. The glucose transporter Glut1 is selectively essential for CD4+ T cell activation and effector function. Cell Metab. 2014, 20(1):61-72.
    • (2014) Cell Metab. , vol.20 , Issue.1 , pp. 61-72
    • Macintyre, A.N.1
  • 24
    • 84886720433 scopus 로고    scopus 로고
    • The transcription factor IRF4 is essential for TCR affinity-mediated metabolic programming and clonal expansion of T cells
    • Man K., et al. The transcription factor IRF4 is essential for TCR affinity-mediated metabolic programming and clonal expansion of T cells. Nat. Immunol. 2013, 14(11):1155-1165.
    • (2013) Nat. Immunol. , vol.14 , Issue.11 , pp. 1155-1165
    • Man, K.1
  • 25
    • 84904725488 scopus 로고    scopus 로고
    • The metabolic checkpoint kinase mTOR is essential for IL- signaling during the development and activation of NK cells
    • Marcais A., et al. The metabolic checkpoint kinase mTOR is essential for IL- signaling during the development and activation of NK cells. Nat. Immunol. 2014, 15(8):749-757.
    • (2014) Nat. Immunol. , vol.15 , Issue.8 , pp. 749-757
    • Marcais, A.1
  • 26
    • 79953172571 scopus 로고    scopus 로고
    • Cutting edge: distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4++ T cell subsets
    • Michalek R.D., et al. Cutting edge: distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4++ T cell subsets. J. Immunol. 2011, 186(6):3299-3303.
    • (2011) J. Immunol. , vol.186 , Issue.6 , pp. 3299-3303
    • Michalek, R.D.1
  • 27
    • 67649958251 scopus 로고    scopus 로고
    • The GAIT system: a gatekeeper of inflammatory gene expression
    • Mukhopadhyay R., et al. The GAIT system: a gatekeeper of inflammatory gene expression. Trends Biochem. Sci. 2009, 34(7):324-331.
    • (2009) Trends Biochem. Sci. , vol.34 , Issue.7 , pp. 324-331
    • Mukhopadhyay, R.1
  • 28
    • 0028816615 scopus 로고
    • Glyceraldehyde-3-phosphate dehydrogenase selectively binds AU-rich RNA in the NAD(+)-binding region (Rossmann fold)
    • Nagy E., Rigby W.F. Glyceraldehyde-3-phosphate dehydrogenase selectively binds AU-rich RNA in the NAD(+)-binding region (Rossmann fold). J. Biol. Chem. 1995, 270(6):2755-2763.
    • (1995) J. Biol. Chem. , vol.270 , Issue.6 , pp. 2755-2763
    • Nagy, E.1    Rigby, W.F.2
  • 29
    • 84911132031 scopus 로고    scopus 로고
    • Bcl-6 directly represses the gene program of the glycolysis pathway
    • Oestreich K.J., et al. Bcl-6 directly represses the gene program of the glycolysis pathway. Nat. Immunol. 2014, 15(10):957-964.
    • (2014) Nat. Immunol. , vol.15 , Issue.10 , pp. 957-964
    • Oestreich, K.J.1
  • 30
    • 84876758617 scopus 로고    scopus 로고
    • Metabolic pathways in immune cell activation and quiescence
    • Pearce E.L., Pearce E.J. Metabolic pathways in immune cell activation and quiescence. Immunity 2013, 38(4):633-643.
    • (2013) Immunity , vol.38 , Issue.4 , pp. 633-643
    • Pearce, E.L.1    Pearce, E.J.2
  • 31
    • 67650096912 scopus 로고    scopus 로고
    • Enhancing CD8 T-cell memory by modulating fatty acid metabolism
    • Pearce E.L., et al. Enhancing CD8 T-cell memory by modulating fatty acid metabolism. Nature 2009, 460(7251):103-107.
    • (2009) Nature , vol.460 , Issue.7251 , pp. 103-107
    • Pearce, E.L.1
  • 32
    • 84903277871 scopus 로고    scopus 로고
    • Integrating canonical and metabolic signalling programmes in the regulation of T cell responses
    • Pollizzi K.N., Powell J.D. Integrating canonical and metabolic signalling programmes in the regulation of T cell responses. Nat. Rev. Immunol. 2014, 14(7):435-446.
    • (2014) Nat. Rev. Immunol. , vol.14 , Issue.7 , pp. 435-446
    • Pollizzi, K.N.1    Powell, J.D.2
  • 33
    • 84856244509 scopus 로고    scopus 로고
    • Regulation of immune responses by mTOR
    • Powell J.D., et al. Regulation of immune responses by mTOR. Annu. Rev. Immunol. 2011.
    • (2011) Annu. Rev. Immunol.
    • Powell, J.D.1
  • 34
    • 84876454059 scopus 로고    scopus 로고
    • AMPKalpha1: a glucose sensor that controls CD8 T-cell memory
    • Rolf J., et al. AMPKalpha1: a glucose sensor that controls CD8 T-cell memory. Eur. J. Immunol. 2013, 43(4):889-896.
    • (2013) Eur. J. Immunol. , vol.43 , Issue.4 , pp. 889-896
    • Rolf, J.1
  • 35
    • 84924388189 scopus 로고    scopus 로고
    • Essential role for autophagy during invariant NKT cell development
    • Salio M., et al. Essential role for autophagy during invariant NKT cell development. Proc. Natl. Acad. Sci. U. S. A. 2014, 111(52):E5678-E5687.
    • (2014) Proc. Natl. Acad. Sci. U. S. A. , vol.111 , Issue.52 , pp. E5678-E5687
    • Salio, M.1
  • 36
    • 0021131044 scopus 로고
    • Inhibition of human natural killer activity by 2-deoxy--glucose and other sugars
    • Schlesinger M., Bekesi J.G. Inhibition of human natural killer activity by 2-deoxy--glucose and other sugars. J. Clin. Lab. Immunol. 1984, 15(1):19-26.
    • (1984) J. Clin. Lab. Immunol. , vol.15 , Issue.1 , pp. 19-26
    • Schlesinger, M.1    Bekesi, J.G.2
  • 37
    • 0029927267 scopus 로고    scopus 로고
    • Specific interaction of glyceraldehyde 3-phosphate dehydrogenase with the 5'-nontranslated RNA of hepatitis A virus
    • Schultz D.E., Hardin C.C., Lemon S.M. Specific interaction of glyceraldehyde 3-phosphate dehydrogenase with the 5'-nontranslated RNA of hepatitis A virus. J. Biol. Chem. 1996, 271(24):14134-14142.
    • (1996) J. Biol. Chem. , vol.271 , Issue.24 , pp. 14134-14142
    • Schultz, D.E.1    Hardin, C.C.2    Lemon, S.M.3
  • 38
    • 79960369458 scopus 로고    scopus 로고
    • HIF1alpha-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells
    • Shi L.Z., et al. HIF1alpha-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells. J. Exp. Med. 2011, 208(7):1367-1376.
    • (2011) J. Exp. Med. , vol.208 , Issue.7 , pp. 1367-1376
    • Shi, L.Z.1
  • 39
    • 84896869317 scopus 로고    scopus 로고
    • Mechanistic target of rapamycin complex 1 is critical for invariant natural killer T-cell development and effector function
    • Shin J., et al. Mechanistic target of rapamycin complex 1 is critical for invariant natural killer T-cell development and effector function. Proc. Natl. Acad. Sci. U. S. A. 2014, 111(8):E776-E783.
    • (2014) Proc. Natl. Acad. Sci. U. S. A. , vol.111 , Issue.8 , pp. E776-E783
    • Shin, J.1
  • 40
    • 84876514626 scopus 로고    scopus 로고
    • Control of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation
    • Sinclair L.V., et al. Control of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation. Nat. Immunol. 2013, 14(5):500-508.
    • (2013) Nat. Immunol. , vol.14 , Issue.5 , pp. 500-508
    • Sinclair, L.V.1
  • 41
    • 84885055994 scopus 로고    scopus 로고
    • Inhibiting glycolytic metabolism enhances CD8+ T cell memory and antitumor function
    • Sukumar M., et al. Inhibiting glycolytic metabolism enhances CD8+ T cell memory and antitumor function. J. Clin. Invest. 2013, 123(10):4479-4488.
    • (2013) J. Clin. Invest. , vol.123 , Issue.10 , pp. 4479-4488
    • Sukumar, M.1
  • 42
    • 84883423963 scopus 로고    scopus 로고
    • CD8 memory T cells have a bioenergetic advantage that underlies their rapid recall ability
    • van der Windt G.J., et al. CD8 memory T cells have a bioenergetic advantage that underlies their rapid recall ability. Proc. Natl. Acad. Sci. U. S. A. 2013, 110(35):14336-14341.
    • (2013) Proc. Natl. Acad. Sci. U. S. A. , vol.110 , Issue.35 , pp. 14336-14341
    • van der Windt, G.J.1
  • 43
    • 66249108601 scopus 로고    scopus 로고
    • Understanding the Warburg effect: the metabolic requirements of cell proliferation
    • Vander Heiden M.G., Cantley L.C., Thompson C.B. Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 2009, 324(5930):1029-1033.
    • (2009) Science , vol.324 , Issue.5930 , pp. 1029-1033
    • Vander Heiden, M.G.1    Cantley, L.C.2    Thompson, C.B.3
  • 44
    • 0017153683 scopus 로고
    • Aerobic glycolysis during lymphocyte proliferation
    • Wang T., Marquardt C., Foker J. Aerobic glycolysis during lymphocyte proliferation. Nature 1976, 261(5562):702-705.
    • (1976) Nature , vol.261 , Issue.5562 , pp. 702-705
    • Wang, T.1    Marquardt, C.2    Foker, J.3
  • 45
    • 84255199079 scopus 로고    scopus 로고
    • The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation
    • Wang R., et al. The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation. Immunity 2011, 35(6):871-882.
    • (2011) Immunity , vol.35 , Issue.6 , pp. 871-882
    • Wang, R.1
  • 47
    • 12444279265 scopus 로고
    • On the origin of cancer cells
    • Warburg O. On the origin of cancer cells. Science 1956, 123(3191):309-314.
    • (1956) Science , vol.123 , Issue.3191 , pp. 309-314
    • Warburg, O.1
  • 48
    • 84908120735 scopus 로고    scopus 로고
    • Cutting edge: Discrete functions of mTOR signaling in invariant NKT cell development and NKT17 fate decision
    • Wei J., Yang K., Chi H. Cutting edge: Discrete functions of mTOR signaling in invariant NKT cell development and NKT17 fate decision. J. Immunol. 2014, 193(9):4297-4301.
    • (2014) J. Immunol. , vol.193 , Issue.9 , pp. 4297-4301
    • Wei, J.1    Yang, K.2    Chi, H.3
  • 49
    • 0032529511 scopus 로고    scopus 로고
    • Identification of glyceraldehyde-3-phosphate dehydrogenase as a cellular protein that binds to the hepatitis B virus posttranscriptional regulatory element
    • Zang W.Q., et al. Identification of glyceraldehyde-3-phosphate dehydrogenase as a cellular protein that binds to the hepatitis B virus posttranscriptional regulatory element. Virology 1998, 248(1):46-52.
    • (1998) Virology , vol.248 , Issue.1 , pp. 46-52
    • Zang, W.Q.1
  • 50
    • 84905976831 scopus 로고    scopus 로고
    • Mammalian target of rapamycin complex 1 orchestrates invariant NKT cell differentiation and effector function
    • Zhang L., et al. Mammalian target of rapamycin complex 1 orchestrates invariant NKT cell differentiation and effector function. J. Immunol. 2014, 193(4):1759-1765.
    • (2014) J. Immunol. , vol.193 , Issue.4 , pp. 1759-1765
    • Zhang, L.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.