Gedunin and azadiradione: Human pancreatic alpha-amylase inhibiting limonoids from neem (Azadirachta indica) as anti-diabetic agents

PLoS ONE

Volumn 10, Issue 10, 2015, Pages

  Ponnusamy, Sudha ^a   Haldar, Saikat ^b   Mulani, Fayaj ^b   Zinjarde, Smita ^a   Thulasiram, Hirekodathakallu ^b   RaviKumar, Ameeta ^a  

^a UNIVERSITY OF PUNE   (India)

^b NATIONAL CHEMICAL LABORATORY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLASE; ANTIDIABETIC AGENT; AZADIRADIONE; GEDUNIN; LIMONOID; MALTOPENTAOSE; OLIGOSACCHARIDE; STARCH; TRYPTOPHAN; TYROSINE; UNCLASSIFIED DRUG; GLYCOSIDASE INHIBITOR; PLANT EXTRACT;

ACINAR CELL; ANIMAL CELL; AR42J CELL LINE; ARTICLE; AZADIRACHTA INDICA; BIOLOGICAL ACTIVITY; CHEMICAL INTERACTION; CIRCULAR DICHROISM; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG MECHANISM; DRUG SCREENING; DRUG STRUCTURE; ENZYME INHIBITION; FLUORESCENCE; HUMAN; IC50; IN VITRO STUDY; LIGAND BINDING; MICHAELIS MENTEN KINETICS; MOLECULAR DOCKING; NONHUMAN; RAT; STOICHIOMETRY; THERMODYNAMICS; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL LINE; CHEMISTRY; DIABETES MELLITUS; ENZYMOLOGY; MOLECULAR MODEL;

ALPHA-AMYLASES; ANIMALS; AZADIRACHTA; CELL LINE; DIABETES MELLITUS; GLYCOSIDE HYDROLASE INHIBITORS; HUMANS; HYPOGLYCEMIC AGENTS; LIMONINS; MODELS, MOLECULAR; MOLECULAR DOCKING SIMULATION; PLANT EXTRACTS; RATS;

EID: 84949008992     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0140113     Document Type: Article

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