Inhibitory effect of Azadirachta indica A. Juss leaf extract on the activities of α-Amylase and α-Glucosidase

Pakistan Journal of Biological Sciences

Volumn 16, Issue 21, 2013, Pages 1358-1362

  Kazeem, M I ^a   Dansu, T V ^a   Adeola, S A ^a  

^a LAGOS STATE UNIVERSITY   (Nigeria)

Author keywords

amylase; glucosidase; Azadirachta indica; Diabetes mellitus; Flavonoids

Indexed keywords

ALPHA GLUCOSIDASE; AMYLASE; ANTIDIABETIC AGENT; ENZYME INHIBITOR; FLAVONOID; PLANT EXTRACT; SACCHAROMYCES CEREVISIAE PROTEIN; SAPONIN; TANNIN DERIVATIVE;

ARTICLE; AZADIRACHTA INDICA; CHEMISTRY; DIABETES MELLITUS; DRUG ANTAGONISM; DRUG EFFECT; HYPERGLYCEMIA; KINETICS; METABOLISM; PLANT LEAF; SACCHAROMYCES CEREVISIAE;

ALPHA-AMYLASES; ALPHA-GLUCOSIDASES; AZADIRACHTA; DIABETES MELLITUS; ENZYME INHIBITORS; FLAVONOIDS; HYPERGLYCEMIA; HYPOGLYCEMIC AGENTS; KINETICS; PLANT EXTRACTS; PLANT LEAVES; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SAPONINS; TANNINS;

AZADIRACHTA INDICA;

EID: 84876768363     PISSN: 10288880     EISSN: 18125735     Source Type: Journal    
DOI: 10.3923/pjbs.2013.1358.1362     Document Type: Article

References (21)

1. Ali, H., P.J. Houghton and A. Soumyanath, 2006. α-Amylase inhibitory activity of some Malaysian plants used to treat diabetes; with particular reference to Phyllantus amarus. J. Ethnopharmacol., 107: 449-455.
2. Andrade, A., J. Becerra-Jimenez and R. Cardenas-Vazquez, 2005. The antioxidant property of tannin. J. Ethnopharmacol., 116: 27-32.
3. Bhat, M., S.K. Kothiwale, A.R. Tirmale, S.Y. Bhargava and B.N. Joshi, 2009. Antidiabetic Properties of Azadirachta indica andBougainvillea spectabilis: In Vivo studies in murine diabetes model. Evid. Based Complement Alternat Med., 10.1093/ecam/nep033 http://ecam.oxfordjournals.org/cgi/content/abstract/nep033
4. Cheng, A.Y. and I.G. Fantus, 2005. Oral antihyperglycemic therapy for type 2 diabetes mellitus. CMAJ, 172: 213-226.
5. Dholi, S.K., R. Raparla and S.K. Mankala, 2011. In vivo antidiabetic evaluation of Neem leaf extract in alloxan induced rats. Kannappan Nagappan, J. Appl. Pharmaceutical Sci., 1: 100-105.
6. Eloff, J.N., 1998. Which extractant should be used for the screening and isolation of antimicrobial components from plants. J. Ethnopharmacol., 60: 1-8.
7. Grover, J.K., S. Yadav and V. Vats, 2002. Medicinal plants of India with anti-diabetic potential. J. Ethnopharmacol., 81: 81-100.
8. International Diabetes Federation, 2009. The Diabetes Atlas. 4th Edn., International Diabetes Federation, Brussels.
9. Kim, Y. M., Y. K. Jeong, M.H. Wang, W.Y. Lee and H.I. Rhee, 2005. Inhibitory effect of pine extract on alpha-glucosidase activity and postprandial hyperglycemia. Nutrition, 21: 756-761.
10. Klein, G., J. Kim, K. Himmeldirk, Y. Cao and X. Chen, 2007. Antidiabetes and anti-obesity activity of Lagerstroemia speciosa. Evidence-Based Complement Alternat. Med., 4: 401-407.
11. Kwon, Y.I., E. Apostolidis, Y.C. Kim and K. Shetty, 2007. Health benefits of traditional corn, beans and pumpkin In vitrostudies for hyperglycemia and hypertension management. J. Med. Foods, 10: 266-275.
12. Mayur, B., S. Sandesh, S. Shruti and S. Sung-Yum, 2010. Antioxidant and α-glucosidase inhibitory properties of Carpesium abrotanoides L. J. Med. Plant Res., 4: 1547-1553.
13. McCue, P.P. and K. Shetty, 2004. Inhibitory effects of rosmarinic acid extracts on porcine pancreatic amylase in vitro. Asia Pac. J. Clin. Nutr., 13: 101-106.
14. Mukherjee, P.K., K. Maiti, K. Mukherjee and P.J. Houghton, 2006. Leads from Indian medicinal plants with hypoglycemic potentials. J. Ethnopharmacol., 106: 1-28.
15. Oboh, G., A.J. Akinyemi, A.O. Ademiluyi and S.A. Adefegha, 2010. Inhibitory effects of aqueous extract of two varieties of ginger on some key enzymes linked to type-2 diabetes In vitro. J. Food Nutr. Res., 49: 14-20.
16. Siddiqui, B.S., M. Rasheed, F. Ilyas, T. Gulzar, R.M. Tariq and S.N. Naqvi, 2004. Analysis of insecticidal Azadirachta indica A. Juss fractions. Z Naturforsch C, 59: 104-112.
17. Sofowara, A., 2006. Medical Plants and Traditional Medicine in Africa. Spectrum Books Ltd., Ibadan, ISBN: 9789780295417, Pages: 289.
18. Song, Y., J.E. Manson, J.E. Buring, D. Howard and S. Liu, 2005. Associations of dietary flavonoids with risk of type 2 diabetes and markers of insulin resistance and systemic inflammation in women: A prospective study and cross-sectional analysis. J. Am. Coll. Nutr., 24: 376-384.
19. Sudha, P., S.S. Zinjarde, S.Y. Bhargava and A.R. Kumar, 2011. Potent α-amylase inhibitory activity of Indian Ayurvedic medicinal plants. BMC Complementary Altern. Med., Vol. 11 10.1186/1472-6882-11-5
20. Tarling, C.A., K. Woods, R. Zhang, H.C. Brastianos, G.D. Brayer, R.J. Andersen and S.G. Withers, 2008. The search for novel human pancreatic α-Amylase inhibitors: High-throughput screening of terrestrial and marine natural product extracts. Chem. Bio. Chem., 9: 433-438.
21. Trease, A. and W.C. Evans, 1996. Pharmacognosy. 14th Edn., W.B. Saunders Company, Ltd., London