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Volumn 9, Issue , 2015, Pages 95-103

Glioblastoma stem cells as a new therapeutic target for glioblastoma

Author keywords

Glioblastoma stem cell; Hypoxia; Mutation; Stem cell; Therapy

Indexed keywords

BMI1 PROTEIN; BONE MORPHOGENETIC PROTEIN; CD133 ANTIGEN; CD15 ANTIGEN; EPIDERMAL GROWTH FACTOR; HEAT SHOCK PROTEIN 90; HYPOXIA INDUCIBLE FACTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; ISOCITRATE DEHYDROGENASE 1; MAMMALIAN TARGET OF RAPAMYCIN; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 2; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; MYC PROTEIN; NESTIN; OCTAMER TRANSCRIPTION FACTOR 4; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; SONIC HEDGEHOG PROTEIN; STAGE SPECIFIC EMBRYO ANTIGEN 1; STAT PROTEIN; TRANSCRIPTION FACTOR EZH2; TRANSCRIPTION FACTOR NANOG; TRANSCRIPTION FACTOR SOX2; TRANSFORMING GROWTH FACTOR BETA; UNINDEXED DRUG; VASCULOTROPIN; VASCULOTROPIN RECEPTOR; WNT PROTEIN;

EID: 84948981558     PISSN: None     EISSN: 11795549     Source Type: Journal    
DOI: 10.4137/CMO.S30271     Document Type: Article
Times cited : (45)

References (63)
  • 1
    • 70350225829 scopus 로고    scopus 로고
    • The hypoxic microenvironment maintains glioblastoma stem cells and promotes reprogramming towards a cancer stem cell phenotype
    • Heddleston JM, Li Z, McLendon RE, Hjelmeland AB, Rich JN. The hypoxic microenvironment maintains glioblastoma stem cells and promotes reprogramming towards a cancer stem cell phenotype. Cell Cycle. 2009;8(20):3274-84.
    • (2009) Cell Cycle. , vol.8 , Issue.20 , pp. 3274-3284
    • Heddleston, J.M.1    Li, Z.2    McLendon, R.E.3    Hjelmeland, A.B.4    Rich, J.N.5
  • 2
    • 84876487189 scopus 로고    scopus 로고
    • Targeting cancer stem cells for treatment of glioblastoma multiforme
    • Cho D, Lin S, Yang W, et al. Targeting cancer stem cells for treatment of glioblastoma multiforme. Cell Transplant. 2013;22:731-9.
    • (2013) Cell Transplant. , vol.22 , pp. 731-739
    • Cho, D.1    Lin, S.2    Yang, W.3
  • 3
    • 84948988356 scopus 로고    scopus 로고
    • Signaling pathways in glioblastoma cancer stem cells: A role of Stat3 as a potential therapeutic target
    • Kanno H, Miyake S, Nakanowatari S. Signaling pathways in glioblastoma cancer stem cells: a role of Stat3 as a potential therapeutic target. Austin J Cancer Clin Res. 2015;2(2):1030.
    • (2015) Austin J Cancer Clin Res. , vol.2 , Issue.2 , pp. 1030
    • Kanno, H.1    Miyake, S.2    Nakanowatari, S.3
  • 4
    • 84882891680 scopus 로고    scopus 로고
    • Glioblastoma cancer stem cells-From concept to clinical application
    • Stopschinski BE, Beier CP, Beier D. Glioblastoma cancer stem cells-From concept to clinical application. Cancer Lett. 2013;338:32-40.
    • (2013) Cancer Lett. , vol.338 , pp. 32-40
    • Stopschinski, B.E.1    Beier, C.P.2    Beier, D.3
  • 5
    • 84888322374 scopus 로고    scopus 로고
    • Therapy targets in glioblastoma and cancer stem cells: Lessons from hematopoietic neoplasm
    • Cruceru ML, Neagu M, Demoulin JB, Constantinescu SN. Therapy targets in glioblastoma and cancer stem cells: lessons from hematopoietic neoplasm. J Cell Mol Med. 2013;17(10):1218-35.
    • (2013) J Cell Mol Med. , vol.17 , Issue.10 , pp. 1218-1235
    • Cruceru, M.L.1    Neagu, M.2    Demoulin, J.B.3    Constantinescu, S.N.4
  • 6
    • 79953189403 scopus 로고    scopus 로고
    • Cancer stem cells in glioblastoma-molecular signaling and therapeutic targeting
    • Huang Z, Cheng L, Guryanova OA, Wu Q, Bao S. Cancer stem cells in glioblastoma-molecular signaling and therapeutic targeting. Protein Cell. 2010;1(7):638-55.
    • (2010) Protein Cell. , vol.1 , Issue.7 , pp. 638-655
    • Huang, Z.1    Cheng, L.2    Guryanova, O.A.3    Wu, Q.4    Bao, S.5
  • 7
    • 72449210651 scopus 로고    scopus 로고
    • Glioma stem cells: Cell culture, markers and targets for new combination therapies
    • Dec 1
    • Gilbert CA, Ross AH. Glioma stem cells: cell culture, markers and targets for new combination therapies. J Cell Biochem. 2009 Dec 1;108(5):1031-8.
    • (2009) J Cell Biochem. , vol.108 , Issue.5 , pp. 1031-1038
    • Gilbert, C.A.1    Ross, A.H.2
  • 8
    • 84900011318 scopus 로고    scopus 로고
    • Stem cell niches in glioblastoma: A neuropathological view
    • Schiffer D, Mellai M, Annovazzi L, et al. Stem cell niches in glioblastoma: a neuropathological view. Biomed Res Int. 2014;2014:725921.
    • (2014) Biomed Res Int. , vol.2014
    • Schiffer, D.1    Mellai, M.2    Annovazzi, L.3
  • 9
    • 84970919297 scopus 로고    scopus 로고
    • Hypoxia signaling pathways in cancer metabolism: The importance of co-selecting interconnected physiological pathways
    • Masson N, Ratcliffe PJ. Hypoxia signaling pathways in cancer metabolism: the importance of co-selecting interconnected physiological pathways. Cancer Metab. 2014;2014(2):3.
    • (2014) Cancer Metab. , vol.2014 , Issue.2 , pp. 3
    • Masson, N.1    Ratcliffe, P.J.2
  • 10
    • 84856014884 scopus 로고    scopus 로고
    • Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia
    • Metallo CM, Gameiro PA, Bell EL, et al. Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia. Nature. 2011;481(7381):380-4.
    • (2011) Nature. , vol.481 , Issue.7381 , pp. 380-384
    • Metallo, C.M.1    Gameiro, P.A.2    Bell, E.L.3
  • 11
    • 77952330272 scopus 로고    scopus 로고
    • Intratumoral hypoxic gradient drives stem cells distribution and MGMT expression in glioblastoma
    • Pistollato F, Abbadi S, Rampazzo E, et al. Intratumoral hypoxic gradient drives stem cells distribution and MGMT expression in glioblastoma. Stem Cells. 2010;28:851-62.
    • (2010) Stem Cells. , vol.28 , pp. 851-862
    • Pistollato, F.1    Abbadi, S.2    Rampazzo, E.3
  • 12
    • 65049084510 scopus 로고    scopus 로고
    • Distinct pools of cancer stem-like cells coexist within human glioblastomas and display different tumorigenicity and independent genomic evolution
    • Piccirillo SG, Combi R, Cajola L, et al. Distinct pools of cancer stem-like cells coexist within human glioblastomas and display different tumorigenicity and independent genomic evolution. Oncogene. 2009;28:1807-11.
    • (2009) Oncogene. , vol.28 , pp. 1807-1811
    • Piccirillo, S.G.1    Combi, R.2    Cajola, L.3
  • 13
    • 79953865922 scopus 로고    scopus 로고
    • Proinflammatory gene expression in solid glioblastoma microenvironment and in hypoxic stem cells from human glioblastoma
    • Tafani M, Di Vito M, Frati A, et al. Proinflammatory gene expression in solid glioblastoma microenvironment and in hypoxic stem cells from human glioblastoma. J Neuroinflammation. 2011;8:32.
    • (2011) J Neuroinflammation. , vol.8 , pp. 32
    • Tafani, M.1    Di Vito, M.2    Frati, A.3
  • 14
    • 84873410837 scopus 로고    scopus 로고
    • Glioblastoma cancer stem cells: Role of the microenvironment and therapeutic targeting
    • Persana L, Rampazzo E, Basso G, Viola G. Glioblastoma cancer stem cells: role of the microenvironment and therapeutic targeting. Biochem Pharmacol. 2013;85:612-22.
    • (2013) Biochem Pharmacol. , vol.85 , pp. 612-622
    • Persana, L.1    Rampazzo, E.2    Basso, G.3    Viola, G.4
  • 16
    • 9244241576 scopus 로고    scopus 로고
    • Identification of human brain tumour initiating cells
    • Singh SK, Hawkins CI, Clarke D, et al. Identification of human brain tumour initiating cells. Nature. 2004;432:396-401.
    • (2004) Nature. , vol.432 , pp. 396-401
    • Singh, S.K.1    Hawkins, C.I.2    Clarke, D.3
  • 17
    • 65349115320 scopus 로고    scopus 로고
    • SSEA-1 is an enrichment marker for tumor-initiating cells in human glioblastoma
    • [cell surface markers were used]
    • Son MJ, Woolard K, Nam DH, Lee J, Fine HA. SSEA-1 is an enrichment marker for tumor-initiating cells in human glioblastoma. Cell Stem Cell. 2009;4:440-52. [cell surface markers were used].
    • (2009) Cell Stem Cell. , vol.4 , pp. 440-452
    • Son, M.J.1    Woolard, K.2    Nam, D.H.3    Lee, J.4    Fine, H.A.5
  • 18
    • 84926076998 scopus 로고    scopus 로고
    • Stem cell signature in glioblastoma: Therapeutic development for a moving target
    • Nakano I. Stem cell signature in glioblastoma: therapeutic development for a moving target. J Neurosurg. 2015;122(2):324-30.
    • (2015) J Neurosurg. , vol.122 , Issue.2 , pp. 324-330
    • Nakano, I.1
  • 19
    • 0026448862 scopus 로고
    • The role of CD15-(Le(X))-related carbohydrates in neutrophil adhesion
    • Kerr MA, Stocks SC. The role of CD15-(Le(X))-related carbohydrates in neutrophil adhesion. Histochem J. 1992;24:811-26.
    • (1992) Histochem J. , vol.24 , pp. 811-826
    • Kerr, M.A.1    Stocks, S.C.2
  • 20
    • 0037194887 scopus 로고    scopus 로고
    • LeX/ssea-1 is expressed by adult mouse CNS stem cells, identifying them as nonependymal
    • Capela A, Temple S. LeX/ssea-1 is expressed by adult mouse CNS stem cells, identifying them as nonependymal. Neuron. 2002;35:865-75.
    • (2002) Neuron. , vol.35 , pp. 865-875
    • Capela, A.1    Temple, S.2
  • 21
    • 33644980252 scopus 로고    scopus 로고
    • LeX is expressed by principle progenitor cells in the embryonic nervous system, is secreted into their environment and binds Wnt-1
    • Capela A, Temple S. LeX is expressed by principle progenitor cells in the embryonic nervous system, is secreted into their environment and binds Wnt-1. Dev Biol. 2006;291:300-13.
    • (2006) Dev Biol. , vol.291 , pp. 300-313
    • Capela, A.1    Temple, S.2
  • 23
    • 84862297341 scopus 로고    scopus 로고
    • Current strategies for identification of glioma stem cells: Adequate or unsatisfactory?
    • Brescia P, Richichi C, Pelicci G. Current strategies for identification of glioma stem cells: adequate or unsatisfactory? J Oncol. 2012;2012:376894.
    • (2012) J Oncol. , vol.2012
    • Brescia, P.1    Richichi, C.2    Pelicci, G.3
  • 24
    • 85051604946 scopus 로고    scopus 로고
    • Identification of glioma stem cells: What is already known and how far do still need to go? The biomarkers dilemma
    • Bresvia P, Richichi C, Pelicci G. Identification of glioma stem cells: what is already known and how far do still need to go? The biomarkers dilemma. J Carcinog Mutagen. 2011;S1:003.
    • (2011) J Carcinog Mutagen. , vol.S1
    • Bresvia, P.1    Richichi, C.2    Pelicci, G.3
  • 25
    • 84942894679 scopus 로고    scopus 로고
    • Musashi proteins in neural stem/progenitor cells
    • Dr. Tao Sun, ed. InTech
    • Horisawa K, Yanagawa H. Musashi proteins in neural stem/progenitor cells. In: Dr. Tao Sun, ed. Neural Stem Cells and Therapy. InTech; 2012. Available at http://www.intechopen.com/books/neural-stem-cells-and-therapy/musashi-proteins-in-eural-stem-progenitor-cells.
    • (2012) Neural Stem Cells and Therapy.
    • Horisawa, K.1    Yanagawa, H.2
  • 26
    • 84949026805 scopus 로고    scopus 로고
    • [Homo sapiens (human)] Gene ID: 4440, updated on February 1
    • MSI1 musashi RNA-binding protein 1 [Homo sapiens (human)] Gene ID: 4440, updated on February 1, 2015.
    • (2015) MSI1 musashi RNA-binding protein 1
  • 27
    • 84915785461 scopus 로고    scopus 로고
    • Glioblastoma stem cells: Molecular characteristics and therapeutic implications
    • Bayin NS, Modrek AS, Placantonakis DG. Glioblastoma stem cells: molecular characteristics and therapeutic implications. World J Stem Cells. 2014;6(2):230-8.
    • (2014) World J Stem Cells. , vol.6 , Issue.2 , pp. 230-238
    • Bayin, N.S.1    Modrek, A.S.2    Placantonakis, D.G.3
  • 28
    • 77954218647 scopus 로고    scopus 로고
    • Potential therapeutic implications of cancer stem cells in glioblastoma
    • Cheng L, Bao S, Rich JN. Potential therapeutic implications of cancer stem cells in glioblastoma. Biochem Pharmacol. 2010;80:654-65.
    • (2010) Biochem Pharmacol. , vol.80 , pp. 654-665
    • Cheng, L.1    Bao, S.2    Rich, J.N.3
  • 29
    • 84883682803 scopus 로고    scopus 로고
    • Constitutive activation of signal transducer and activator of transcription 3 (STAT3) and nuclear factor κB signaling in glioblastoma cancer stem cells regulates the Notch pathway
    • Garner JM, Fan M, Yang CH, et al. Constitutive activation of signal transducer and activator of transcription 3 (STAT3) and nuclear factor κB signaling in glioblastoma cancer stem cells regulates the Notch pathway. J Biol Chem. 2013;288:26167-76.
    • (2013) J Biol Chem. , vol.288 , pp. 26167-26176
    • Garner, J.M.1    Fan, M.2    Yang, C.H.3
  • 30
    • 84859778293 scopus 로고    scopus 로고
    • mTOR signaling in growth control and disease
    • Laplante M, Sabatini DM. mTOR signaling in growth control and disease. Cell. 2012;149(2):274-93.
    • (2012) Cell. , vol.149 , Issue.2 , pp. 274-293
    • Laplante, M.1    Sabatini, D.M.2
  • 31
    • 84891513783 scopus 로고    scopus 로고
    • The mTORC1/mTORC2 inhibitor AZD2014 enhances the radiosensitivity of glioblastoma stem-like cells
    • Kahn J, Hayman TJ, Jamal M, et al. The mTORC1/mTORC2 inhibitor AZD2014 enhances the radiosensitivity of glioblastoma stem-like cells. Neuro Oncol. 2014;16(1):29-37.
    • (2014) Neuro Oncol. , vol.16 , Issue.1 , pp. 29-37
    • Kahn, J.1    Hayman, T.J.2    Jamal, M.3
  • 32
    • 84876276597 scopus 로고    scopus 로고
    • First-in-human phase I trial of the dual mTORC1 and mTORC2 inhibitor AZD2014 in solid tumors
    • abstr3004
    • Banerji U, Dean EJ, Gonzalez M, et al. First-in-human phase I trial of the dual mTORC1 and mTORC2 inhibitor AZD2014 in solid tumors. J Clin Oncol. 2012;30(suppl):abstr3004.
    • (2012) J Clin Oncol. , vol.30
    • Banerji, U.1    Dean, E.J.2    Gonzalez, M.3
  • 33
    • 84874506372 scopus 로고    scopus 로고
    • Hsp90: Structure and function
    • Jackson SE. Hsp90: structure and function. Top Curr Chem. 2012;2013(328):155-240.
    • (2012) Top Curr Chem. , vol.2013 , Issue.328 , pp. 155-240
    • Jackson, S.E.1
  • 34
    • 65949102292 scopus 로고    scopus 로고
    • In vivo gene delivery by embryonic-stem-cell-derived astrocytes for malignant gliomas
    • Uzzaman M, Keller G, Germano IM. In vivo gene delivery by embryonic-stem-cell-derived astrocytes for malignant gliomas. Neuro Oncol. 2009;11(2):102-8.
    • (2009) Neuro Oncol. , vol.11 , Issue.2 , pp. 102-108
    • Uzzaman, M.1    Keller, G.2    Germano, I.M.3
  • 37
    • 0034169521 scopus 로고    scopus 로고
    • Neural precursor cells for delivery of replication-conditional hsv-1 vectors to intracerebral gliomas
    • Herrlinger U, Woiciechowski C, Sena-Esteves M, et al. Neural precursor cells for delivery of replication-conditional hsv-1 vectors to intracerebral gliomas. Mol Ther. 2000;1:347-57.
    • (2000) Mol Ther. , vol.1 , pp. 347-357
    • Herrlinger, U.1    Woiciechowski, C.2    Sena-Esteves, M.3
  • 38
    • 47749128298 scopus 로고    scopus 로고
    • Stem cell protein BMI-1 is an independent marker for poor prognosis in oligodendroglial tumours
    • Häyry V, Tynninen O, Haapasalo HK, et al. Stem cell protein BMI-1 is an independent marker for poor prognosis in oligodendroglial tumours. Neuropathol Appl Neurobiol. 2008;34:555-63.
    • (2008) Neuropathol Appl Neurobiol. , vol.34 , pp. 555-563
    • Häyry, V.1    Tynninen, O.2    Haapasalo, H.K.3
  • 39
    • 76749158386 scopus 로고    scopus 로고
    • Inhibition of tumorigenicity and enhancement of radiochemosensitivity in head and neck squamous cell cancer-derived ALDH1-positive cells by knockdown of Bmi-1
    • Chen YC, Chang CJ, Hsu HS, et al. Inhibition of tumorigenicity and enhancement of radiochemosensitivity in head and neck squamous cell cancer-derived ALDH1-positive cells by knockdown of Bmi-1. Oral Oncol. 2010;46:158-65.
    • (2010) Oral Oncol. , vol.46 , pp. 158-165
    • Chen, Y.C.1    Chang, C.J.2    Hsu, H.S.3
  • 40
    • 0345169950 scopus 로고    scopus 로고
    • PTEN gene mutation and high MIB-1 labeling index may contribute to dissemination in patients with glioblastoma
    • Kato H, Fujimura M, Kumabe T, Ishioka C, Kanamaru R, Yoshimoto T. PTEN gene mutation and high MIB-1 labeling index may contribute to dissemination in patients with glioblastoma. J Clin Neurosci. 2004;11:37-41.
    • (2004) J Clin Neurosci. , vol.11 , pp. 37-41
    • Kato, H.1    Fujimura, M.2    Kumabe, T.3    Ishioka, C.4    Kanamaru, R.5    Yoshimoto, T.6
  • 41
    • 83355166283 scopus 로고    scopus 로고
    • Inhibition of cancer stem cell-like properties and reduced chemoradioresistance of glioblastoma using micro RNA145 with cationic polyurethane-short branch PEI
    • Yang YP, Chien Y, Chiou GY, et al. Inhibition of cancer stem cell-like properties and reduced chemoradioresistance of glioblastoma using micro RNA145 with cationic polyurethane-short branch PEI. Biomaterials. 2012;33:1462-76.
    • (2012) Biomaterials. , vol.33 , pp. 1462-1476
    • Yang, Y.P.1    Chien, Y.2    Chiou, G.Y.3
  • 42
    • 84883438714 scopus 로고    scopus 로고
    • The timing of neural stem cell-based virotherapy is critical for optimal therapeutic efficacy when applied with radiation and chemotherapy for the treatment of glioblastoma
    • Tobias AL, Thaci B, Auffinger B, et al. The timing of neural stem cell-based virotherapy is critical for optimal therapeutic efficacy when applied with radiation and chemotherapy for the treatment of glioblastoma. Stem Cells Transl Med. 2013;2(9):655-66.
    • (2013) Stem Cells Transl Med. , vol.2 , Issue.9 , pp. 655-666
    • Tobias, A.L.1    Thaci, B.2    Auffinger, B.3
  • 43
    • 84928746155 scopus 로고    scopus 로고
    • Targeted therapy of glioblastoma stem-like cells and tumor non-stem cells using cetuximab conjugated in iron-oxide nanoparticles
    • Kaluzova M, Bouras A, Machaidze R, Hadjipanayis CG. Targeted therapy of glioblastoma stem-like cells and tumor non-stem cells using cetuximab conjugated in iron-oxide nanoparticles. Oncotarget. 2015;6:8788-806.
    • (2015) Oncotarget. , vol.6 , pp. 8788-8806
    • Kaluzova, M.1    Bouras, A.2    McHaidze, R.3    Hadjipanayis, C.G.4
  • 44
    • 84891754509 scopus 로고    scopus 로고
    • Double suicide gene therapy using human neural stem cells against glioblastoma: Double safety measures
    • Lee JY, Lee DH, Kim HA, et al. Double suicide gene therapy using human neural stem cells against glioblastoma: double safety measures. J Neurooncol. 2014;116(1):49-57.
    • (2014) J Neurooncol. , vol.116 , Issue.1 , pp. 49-57
    • Lee, J.Y.1    Lee, D.H.2    Kim, H.A.3
  • 45
    • 79952281817 scopus 로고    scopus 로고
    • L1CAM regulates DNA damage checkpoint response of glioblastoma stem cells through NBS1
    • Cheng L, Wu Q, Huang Z, et al. L1CAM regulates DNA damage checkpoint response of glioblastoma stem cells through NBS1. EMBO J. 2011;30(5):800-13.
    • (2011) EMBO J. , vol.30 , Issue.5 , pp. 800-813
    • Cheng, L.1    Wu, Q.2    Huang, Z.3
  • 46
    • 80053058993 scopus 로고    scopus 로고
    • Direct in vivo evidence for tumor propagation by glioblastoma cancer stem cells
    • Lathia JD, Gallagher J, Myers JT, et al. Direct in vivo evidence for tumor propagation by glioblastoma cancer stem cells. PLoS One. 2011;6(9):e24807.
    • (2011) PLoS One. , vol.6 , Issue.9
    • Lathia, J.D.1    Gallagher, J.2    Myers, J.T.3
  • 47
    • 4944250781 scopus 로고    scopus 로고
    • Isolation and characterization of tumorigenic, stem-like neural precursors from human glioblastoma
    • Galli R, Binda E, Orfanelli U, et al. Isolation and characterization of tumorigenic, stem-like neural precursors from human glioblastoma. Cancer Res. 2004;64(19):7011-21.
    • (2004) Cancer Res. , vol.64 , Issue.19 , pp. 7011-7021
    • Galli, R.1    Binda, E.2    Orfanelli, U.3
  • 48
    • 84908584286 scopus 로고    scopus 로고
    • Sustained radiosensitization of hypoxic glioma cells after oxygen pretreatment in an animal model of glioblastoma and in vitro models of tumor hypoxia
    • Clarke RH, Moosa S, Anzivino M, et al. Sustained radiosensitization of hypoxic glioma cells after oxygen pretreatment in an animal model of glioblastoma and in vitro models of tumor hypoxia. PLoS One. 2014;9(10):e111199.
    • (2014) PLoS One. , vol.9 , Issue.10
    • Clarke, R.H.1    Moosa, S.2    Anzivino, M.3
  • 49
    • 35949002429 scopus 로고    scopus 로고
    • Malignant astrocytic glioma: Genetics, biology and paths to treatment
    • Furnari FB, Fenton T, Bachoo RM, et al. Malignant astrocytic glioma: genetics, biology and paths to treatment. Genes Dev. 2007;21:2683-710.
    • (2007) Genes Dev. , vol.21 , pp. 2683-2710
    • Furnari, F.B.1    Fenton, T.2    Bachoo, R.M.3
  • 50
    • 48249125791 scopus 로고    scopus 로고
    • Malignant gliomas in adults
    • Wen PY, Kesari S. Malignant gliomas in adults. N Engl J Med. 2008;359:492-507.
    • (2008) N Engl J Med. , vol.359 , pp. 492-507
    • Wen, P.Y.1    Kesari, S.2
  • 51
    • 80052677148 scopus 로고    scopus 로고
    • Prognostic significance of IDH-1 and MGMT in patients with glioblastoma: One step forward, and one step back?
    • Combs ES, Rieken S, Wick W, et al. Prognostic significance of IDH-1 and MGMT in patients with glioblastoma: one step forward, and one step back? Radiat Oncol. 2011;13(6):115.
    • (2011) Radiat Oncol. , vol.13 , Issue.6 , pp. 115
    • Combs, E.S.1    Rieken, S.2    Wick, W.3
  • 52
    • 84912121230 scopus 로고    scopus 로고
    • IDH1 mutations is prognostic marker for primary glioblastoma multiforme but MGMT hypermethylation is not prognostic for primary glioblastoma multiforme
    • Kalkan R, Atli Eİ, Özdemir M, et al. IDH1 mutations is prognostic marker for primary glioblastoma multiforme but MGMT hypermethylation is not prognostic for primary glioblastoma multiforme. Gene. 2015;554(1):81-6.
    • (2015) Gene. , vol.554 , Issue.1 , pp. 81-86
    • Kalkan, R.1    Atli, E.İ.2    Özdemir, M.3
  • 53
    • 33745198882 scopus 로고    scopus 로고
    • Chemotherapy resistance of glioblastoma stem cells
    • Eramo A, Ricci-Vitiani L, Zeuner A, et al. Chemotherapy resistance of glioblastoma stem cells. Cell Death Differ. 2006;13:1238-41.
    • (2006) Cell Death Differ. , vol.13 , pp. 1238-1241
    • Eramo, A.1    Ricci-Vitiani, L.2    Zeuner, A.3
  • 54
    • 48649104080 scopus 로고    scopus 로고
    • Temozolomide preferentially depletes cancer stem cells in glioblastoma
    • Beier D, Rohrl S, Pillai DR, et al. Temozolomide preferentially depletes cancer stem cells in glioblastoma. Cancer Res. 2008;68:5706-15.
    • (2008) Cancer Res. , vol.68 , pp. 5706-5715
    • Beier, D.1    Rohrl, S.2    Pillai, D.R.3
  • 55
    • 33845671339 scopus 로고    scopus 로고
    • Analysis of gene expression and chemoresistance of CD133+cancer stem cells in glioblastoma
    • Liu G, Yuan X, Zeng Z, et al. Analysis of gene expression and chemoresistance of CD133+cancer stem cells in glioblastoma. Mol Cancer. 2006;5:67.
    • (2006) Mol Cancer. , vol.5 , pp. 67
    • Liu, G.1    Yuan, X.2    Zeng, Z.3
  • 56
    • 79953287708 scopus 로고    scopus 로고
    • IDH1 R132H decreases proliferation of glioma cell lines in vitro and in vivo
    • Bralten LB, Kloosterhof NK, Balvers R, et al. IDH1 R132H decreases proliferation of glioma cell lines in vitro and in vivo. Ann Neurol. 2011;69:455-63.
    • (2011) Ann Neurol. , vol.69 , pp. 455-463
    • Bralten, L.B.1    Kloosterhof, N.K.2    Balvers, R.3
  • 57
    • 83355163405 scopus 로고    scopus 로고
    • Evidence for sequenced molecular evolution of IDH1 mutant glioblastoma from a distinct cell of origin
    • Lai A, Kharbanda S, Pope WB, et al. Evidence for sequenced molecular evolution of IDH1 mutant glioblastoma from a distinct cell of origin. J Clin Oncol. 2011;29(34):4482-90.
    • (2011) J Clin Oncol. , vol.29 , Issue.34 , pp. 4482-4490
    • Lai, A.1    Kharbanda, S.2    Pope, W.B.3
  • 58
    • 34249332411 scopus 로고    scopus 로고
    • CD133(+) and CD133(-) glioblastoma-derived cancer stem cells show differential growth characteristics and molecular profiles
    • Beier D, Hau P, Proescholdt M, et al. CD133(+) and CD133(-) glioblastoma-derived cancer stem cells show differential growth characteristics and molecular profiles. Cancer Res. 2007;67:4010-5.
    • (2007) Cancer Res. , vol.67 , pp. 4010-4015
    • Beier, D.1    Hau, P.2    Proescholdt, M.3
  • 59
    • 80053588700 scopus 로고    scopus 로고
    • Expression and regulation of AC133 and CD133 in glioblastoma
    • Campos B, Zeng L, Daotrong PH, et al. Expression and regulation of AC133 and CD133 in glioblastoma. Glia. 2011;59:1974-86.
    • (2011) Glia. , vol.59 , pp. 1974-1986
    • Campos, B.1    Zeng, L.2    Daotrong, P.H.3
  • 60
    • 84858738034 scopus 로고    scopus 로고
    • Identification of cancer stem cells from human glioblastomas: Growth and differentiation capabilities and CD133/prominin-1 expression
    • Gambelli F, Sasdelli F, Manini I, et al. Identification of cancer stem cells from human glioblastomas: growth and differentiation capabilities and CD133/prominin-1 expression. Cell Biol Int. 2012;36:29-38.
    • (2012) Cell Biol Int. , vol.36 , pp. 29-38
    • Gambelli, F.1    Sasdelli, F.2    Manini, I.3
  • 62
    • 84866340817 scopus 로고    scopus 로고
    • Hypoxia and hypoxia-inducible factors in glioblastoma multiforme progression and therapeutic implications
    • Yang L, Lin C, Wang L, Guo H, Wang X. Hypoxia and hypoxia-inducible factors in glioblastoma multiforme progression and therapeutic implications. Exp Cell Res. 2012;318(19):2417-26.
    • (2012) Exp Cell Res. , vol.318 , Issue.19 , pp. 2417-2426
    • Yang, L.1    Lin, C.2    Wang, L.3    Guo, H.4    Wang, X.5
  • 63
    • 84874786113 scopus 로고    scopus 로고
    • Hypoxia enhances stemness of cancer stem cells in glioblastoma: An in vitro study
    • Li P, Zhou C, Xu L, Xiao H. Hypoxia enhances stemness of cancer stem cells in glioblastoma: an in vitro study. Int J Med Sci. 2013;10(4):399-407.
    • (2013) Int J Med Sci. , vol.10 , Issue.4 , pp. 399-407
    • Li, P.1    Zhou, C.2    Xu, L.3    Xiao, H.4


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