Structural basis for ligand recognition and functional selectivity at angiotensin receptor

Journal of Biological Chemistry

Volumn 290, Issue 49, 2015, Pages 29127-29139

  Zhang, Haitao ^a   Unal, Hamiyet ^b,c   Desnoyer, Russell ^b   Han, Gye Won ^a   Patel, Nilkanth ^a   Katritch, Vsevolod ^a   Karnik, Sadashiva S ^b   Cherezov, Vadim ^a   Stevens, Raymond C ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b LERNER RESEARCH INSTITUTE   (United States)

^c ERCIYES UNIVERSITY   (Turkey)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; BINDING SITES; BINS; BLOOD PRESSURE; DRUG PRODUCTS; LIGANDS; PEPTIDES; PRESSURE REGULATORS; SCAFFOLDS;

CLINICAL SETTINGS; DOCKING SIMULATIONS; HYPERTENSIVE DRUG; INVERSE AGONISTS; LIGAND RECOGNITION; SITE DIRECTED MUTAGENESIS; SPECIFIC INTERACTION; THERAPEUTIC EFFICACY;

CRYSTAL STRUCTURE;

ANGIOTENSIN 1 RECEPTOR; CALCIUM ION; CARBOXYL GROUP; EPROSARTAN; LOSARTAN; OLMESARTAN; SODIUM ION; ANTIHYPERTENSIVE AGENT; IMIDAZOLE DERIVATIVE; ION; LIGAND; OLIGOPEPTIDE; PROTEIN BINDING; SARCOSINE-ARGINYL-VALYL-TYROSYL-ISOLEUCYL-HISTIDYL-PROLYL-ALANINE; SODIUM; TETRAZOLE DERIVATIVE;

ALLOSTERISM; AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; BINDING SITE; CALCIUM CELL LEVEL; CHEMICAL PARAMETERS; COMPLEX FORMATION; CONTROLLED STUDY; COS 1 CELL LINE; CRYSTAL STRUCTURE; FUNCTIONAL SELECTIVITY; HYDROGEN BOND; LIGAND BINDING; LIGAND RECOGNITION; MOLECULAR DOCKING; MOLECULAR INTERACTION; MOLECULAR RECOGNITION; PRIORITY JOURNAL; PROTEIN CONFORMATION; RECEPTOR BLOCKING; SITE DIRECTED MUTAGENESIS; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; X RAY CRYSTALLOGRAPHY; ANIMAL; BINDING COMPETITION; CELL LINE; CELL MEMBRANE; CHEMISTRY; CHLOROCEBUS AETHIOPS; COMPUTER SIMULATION; COS CELL LINE; HUMAN; METABOLISM; MUTATION; PROTEIN TERTIARY STRUCTURE; SF9 CELL LINE;

ALLOSTERIC SITE; ANIMALS; ANTIHYPERTENSIVE AGENTS; BINDING, COMPETITIVE; CELL LINE; CELL MEMBRANE; CERCOPITHECUS AETHIOPS; COMPUTER SIMULATION; COS CELLS; CRYSTALLOGRAPHY, X-RAY; HUMANS; IMIDAZOLES; IONS; LIGANDS; MUTAGENESIS, SITE-DIRECTED; MUTATION; OLIGOPEPTIDES; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECEPTOR, ANGIOTENSIN, TYPE 1; SF9 CELLS; SODIUM; TETRAZOLES;

EID: 84948960472     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.689000     Document Type: Article

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