-
1
-
-
0344622606
-
The serial cultivation of human diploid cell strains
-
Hayflick, L. & Moorhead, P. S. The serial cultivation of human diploid cell strains. Exp. Cell Res. 25, 585-621 (1961).
-
(1961)
Exp. Cell Res.
, vol.25
, pp. 585-621
-
-
Hayflick, L.1
Moorhead, P.S.2
-
2
-
-
0025279931
-
Telomeres shorten during ageing of human fibroblasts
-
Harley, C. B., Futcher, A. B. & Greider, C. W. Telomeres shorten during ageing of human fibroblasts. Nature 345, 458-460 (1990).
-
(1990)
Nature
, vol.345
, pp. 458-460
-
-
Harley, C.B.1
Futcher, A.B.2
Greider, C.W.3
-
4
-
-
0028564951
-
Specific association of human telomerase activity with immortal cells and cancer
-
Kim, N. W. et al. Specific association of human telomerase activity with immortal cells and cancer. Science 266, 2011-2015 (1994).
-
(1994)
Science
, vol.266
, pp. 2011-2015
-
-
Kim, N.W.1
-
5
-
-
0029894237
-
Telomere length regulation
-
Greider, C. W. Telomere length regulation. Annu. Rev. Biochem. 65, 337-365 (1996).
-
(1996)
Annu. Rev. Biochem.
, vol.65
, pp. 337-365
-
-
Greider, C.W.1
-
6
-
-
0030819894
-
Telomerase catalytic subunit homologs from fission yeast and human
-
Nakamura, T. M. et al. Telomerase catalytic subunit homologs from fission yeast and human. Science 277, 955-959 (1997).
-
(1997)
Science
, vol.277
, pp. 955-959
-
-
Nakamura, T.M.1
-
7
-
-
0029096515
-
The RNA component of human telomerase
-
Feng, J. et al. The RNA component of human telomerase. Science 269, 1236-1241 (1995).
-
(1995)
Science
, vol.269
, pp. 1236-1241
-
-
Feng, J.1
-
8
-
-
0025877846
-
Inhibition of telomerase by G-quartet DNA structures
-
Zahler, A. M., Williamson, J. R., Cech, T. R. & Prescott, D. M. Inhibition of telomerase by G-quartet DNA structures. Nature 350, 718-720 (1991).
-
(1991)
Nature
, vol.350
, pp. 718-720
-
-
Zahler, A.M.1
Williamson, J.R.2
Cech, T.R.3
Prescott, D.M.4
-
9
-
-
0032554620
-
Effect of DNA secondary structure on human telomerase activity
-
Fletcher, T. M., Sun, D., Salazar, M. & Hurley, L. H. Effect of DNA secondary structure on human telomerase activity. Biochemistry 37, 5536-5541 (1998).
-
(1998)
Biochemistry
, vol.37
, pp. 5536-5541
-
-
Fletcher, T.M.1
Sun, D.2
Salazar, M.3
Hurley, L.H.4
-
10
-
-
37049004147
-
Targeting telomeres and telomerase
-
De Cian, A. et al. Targeting telomeres and telomerase. Biochimie 90, 131-155 (2008).
-
(2008)
Biochimie
, vol.90
, pp. 131-155
-
-
De Cian, A.1
-
11
-
-
47649124369
-
G-quadruplexes: Targets in anticancer drug design
-
Ou, T. M. et al. G-quadruplexes: targets in anticancer drug design. Chem Med Chem 3, 690-713 (2008).
-
(2008)
Chem Med Chem
, vol.3
, pp. 690-713
-
-
Ou, T.M.1
-
12
-
-
84875048234
-
Structure and stability of human telomeric G-quadruplex with preclinical 9-amino acridines
-
Ferreira, R. et al. Structure and stability of human telomeric G-quadruplex with preclinical 9-amino acridines. PloS one 8, e57701 (2013).
-
(2013)
PloS One
, vol.8
, pp. e57701
-
-
Ferreira, R.1
-
13
-
-
0032718247
-
The development of telomerase inhibitors: The G-quartet approach
-
Mergny, J. L. et al. The development of telomerase inhibitors: the G-quartet approach. Anti-cancer Drug Des. 14, 327-339 (1999).
-
(1999)
Anti-cancer Drug Des.
, vol.14
, pp. 327-339
-
-
Mergny, J.L.1
-
14
-
-
0032739776
-
Recent advances in the development of telomerase inhibitors for the treatment of cancer
-
Perry, P. J. & Jenkins, T. C. Recent advances in the development of telomerase inhibitors for the treatment of cancer. Expert Opin. Investig. Drugs 8, 1981-2008 (1999).
-
(1999)
Expert Opin. Investig. Drugs
, vol.8
, pp. 1981-2008
-
-
Perry, P.J.1
Jenkins, T.C.2
-
15
-
-
0034065866
-
DNA G-quadruplexes, telomere-specific proteins and telomere-associated enzymes as potential targets for new anticancer drugs
-
Raymond, E. et al. DNA G-quadruplexes, telomere-specific proteins and telomere-associated enzymes as potential targets for new anticancer drugs. Invest. New Drugs 18, 123-137 (2000).
-
(2000)
Invest. New Drugs
, vol.18
, pp. 123-137
-
-
Raymond, E.1
-
16
-
-
0036562687
-
Telomere maintenance as a target for anticancer drug discovery
-
Neidle, S. & Parkinson, G. Telomere maintenance as a target for anticancer drug discovery. Nat. Rev. Drug Discov. 1, 383-393 (2002).
-
(2002)
Nat. Rev. Drug Discov.
, vol.1
, pp. 383-393
-
-
Neidle, S.1
Parkinson, G.2
-
17
-
-
32044461141
-
Natural and synthetic G-quadruplex interactive berberine derivatives
-
Franceschin, M. et al. Natural and synthetic G-quadruplex interactive berberine derivatives. Bioorg. Med. Chem. Lett. 16, 1707-1711 (2006).
-
(2006)
Bioorg. Med. Chem. Lett.
, vol.16
, pp. 1707-1711
-
-
Franceschin, M.1
-
18
-
-
84862587840
-
Spectroscopic, molecular modeling, and NMR-spectroscopic investigation of the binding mode of the natural alkaloids berberine and sanguinarine to human telomeric G-quadruplex DNA
-
Bessi, I. et al. Spectroscopic, molecular modeling, and NMR-spectroscopic investigation of the binding mode of the natural alkaloids berberine and sanguinarine to human telomeric G-quadruplex DNA. ACS Chem. Biol. 7, 1109-1119 (2012).
-
(2012)
ACS Chem. Biol.
, vol.7
, pp. 1109-1119
-
-
Bessi, I.1
-
19
-
-
81455123778
-
Polymorphic nucleic acid binding of bioactive isoquinoline alkaloids and their role in cancer
-
Maiti, M. & Kumar, G. S. Polymorphic nucleic Acid binding of bioactive isoquinoline alkaloids and their role in cancer. J. Nucleic Acids 2010 (2010).
-
(2010)
J. Nucleic Acids
, vol.2010
-
-
Maiti, M.1
Kumar, G.S.2
-
20
-
-
79951716375
-
Interaction of berberine, palmatine, coralyne, and sanguinarine to quadruplex DNA: A comparative spectroscopic and calorimetric study
-
Bhadra, K. & Kumar, G. S. Interaction of berberine, palmatine, coralyne, and sanguinarine to quadruplex DNA: a comparative spectroscopic and calorimetric study. Biochim. Biophys. Acta 1810, 485-496 (2011).
-
(2011)
Biochim. Biophys. Acta
, vol.1810
, pp. 485-496
-
-
Bhadra, K.1
Kumar, G.S.2
-
21
-
-
77956931066
-
Probing the binding affinity of small-molecule natural products to the G-quadruplex in C-myc oncogene by electrospray ionization mass spectrometry
-
Liu, Y., Zheng, B., Xu, X. & Yuan, G. Probing the binding affinity of small-molecule natural products to the G-quadruplex in C-myc oncogene by electrospray ionization mass spectrometry. Rapid. Commun. Mass Spectrom. 24, 3072-3075 (2010).
-
(2010)
Rapid. Commun. Mass Spectrom.
, vol.24
, pp. 3072-3075
-
-
Liu, Y.1
Zheng, B.2
Xu, X.3
Yuan, G.4
-
22
-
-
0032497405
-
NMR-based model of a telomerase-inhibiting compound bound to G-quadruplex DNA
-
Fedoroff, O. Y. et al. NMR-Based model of a telomerase-inhibiting compound bound to G-quadruplex DNA. Biochemistry 37, 12367-12374 (1998).
-
(1998)
Biochemistry
, vol.37
, pp. 12367-12374
-
-
Fedoroff, O.Y.1
-
23
-
-
84890589307
-
Flavonoids from achyrocline satureioides: Promising biomolecules for anticancer therapy
-
Carini, J. P., Klamt, F. & Bassani, V. L. Flavonoids from Achyrocline satureioides: promising biomolecules for anticancer therapy. RSC Advances 4, 3131 (2014).
-
(2014)
RSC Advances
, vol.4
, pp. 3131
-
-
Carini, J.P.1
Klamt, F.2
Bassani, V.L.3
-
24
-
-
0017691720
-
Mutagenic activity of quercetin and related compounds
-
Bjeldanes, L. F. & Chang, G. W. Mutagenic activity of quercetin and related compounds. Science 197, 577-578 (1977).
-
(1977)
Science
, vol.197
, pp. 577-578
-
-
Bjeldanes, L.F.1
Chang, G.W.2
-
25
-
-
0022517987
-
Genetic toxicology of flavonoids: The role of metabolic conditions in the induction of reverse mutation, SOS functions and sister-chromatid exchanges
-
Rueff, J. et al. Genetic toxicology of flavonoids: the role of metabolic conditions in the induction of reverse mutation, SOS functions and sister-chromatid exchanges. Mutagenesis 1, 179-183 (1986).
-
(1986)
Mutagenesis
, vol.1
, pp. 179-183
-
-
Rueff, J.1
-
26
-
-
0037246317
-
Anti- and pro-oxidant activity of rutin and quercetin derivatives
-
Kessler, M., Ubeaud, G. & Jung, L. Anti- and pro-oxidant activity of rutin and quercetin derivatives. J. Pharm. Pharmacol. 55, 131-142 (2003).
-
(2003)
J. Pharm. Pharmacol.
, vol.55
, pp. 131-142
-
-
Kessler, M.1
Ubeaud, G.2
Jung, L.3
-
27
-
-
0036711591
-
Luteolin, an emerging anti-cancer flavonoid, poisons eukaryotic DNA topoisomerase I
-
Chowdhury, A. R. et al. Luteolin, an emerging anti-cancer flavonoid, poisons eukaryotic DNA topoisomerase I. Biochem. J. 366, 653-661 (2002).
-
(2002)
Biochem. J.
, vol.366
, pp. 653-661
-
-
Chowdhury, A.R.1
-
28
-
-
0035253312
-
Detrimental effect of cancer preventive phytochemicals silymarin, genistein and epigallocatechin 3-gallate on epigenetic events in human prostate carcinoma DU145 cells
-
Bhatia, N. & Agarwal, R. Detrimental effect of cancer preventive phytochemicals silymarin, genistein and epigallocatechin 3-gallate on epigenetic events in human prostate carcinoma DU145 cells. Prostate 46, 98-107 (2001).
-
(2001)
Prostate
, vol.46
, pp. 98-107
-
-
Bhatia, N.1
Agarwal, R.2
-
29
-
-
0036434544
-
The interaction of quercetin with human serum albumin: A fluorescence spectroscopic study
-
Sengupta, B. & Sengupta, P. K. The interaction of quercetin with human serum albumin: a fluorescence spectroscopic study. Biochem. Biophys. Res. Commun. 299, 400-403 (2002).
-
(2002)
Biochem. Biophys. Res. Commun.
, vol.299
, pp. 400-403
-
-
Sengupta, B.1
Sengupta, P.K.2
-
30
-
-
0141543861
-
Reduction of genistein clastogenicity in Chinese hamster V79 cells by daidzein and other flavonoids
-
Snyder, R. D. & Gillies, P. J. Reduction of genistein clastogenicity in Chinese hamster V79 cells by daidzein and other flavonoids. Food Chem. Toxicol. 41, 1291-1298 (2003).
-
(2003)
Food Chem. Toxicol.
, vol.41
, pp. 1291-1298
-
-
Snyder, R.D.1
Gillies, P.J.2
-
31
-
-
0038807711
-
Flavonoids: Promising anticancer agents
-
Ren, W., Qiao, Z., Wang, H., Zhu, L. & Zhang, L. Flavonoids: promising anticancer agents. Med. Res. Rev. 23, 519-534 (2003).
-
(2003)
Med. Res. Rev.
, vol.23
, pp. 519-534
-
-
Ren, W.1
Qiao, Z.2
Wang, H.3
Zhu, L.4
Zhang, L.5
-
32
-
-
0032815147
-
Comparative analysis of the effects of flavonoids on proliferation, cytotoxicity, and apoptosis in human colon cancer cell lines
-
Kuntz, S., Wenzel, U. & Daniel, H. Comparative analysis of the effects of flavonoids on proliferation, cytotoxicity, and apoptosis in human colon cancer cell lines. Eur. J. Nutr. 38, 133-142 (1999).
-
(1999)
Eur. J. Nutr.
, vol.38
, pp. 133-142
-
-
Kuntz, S.1
Wenzel, U.2
Daniel, H.3
-
33
-
-
42749088247
-
Flavones and flavonols exert cytotoxic effects on a human oesophageal adenocarcinoma cell line (OE33) by causing G2/M arrest and inducing apoptosis
-
Zhang, Q., Zhao, X. H. & Wang, Z. J. Flavones and flavonols exert cytotoxic effects on a human oesophageal adenocarcinoma cell line (OE33) by causing G2/M arrest and inducing apoptosis. Food Chem. Toxicol. 46, 2042-2053 (2008).
-
(2008)
Food Chem. Toxicol.
, vol.46
, pp. 2042-2053
-
-
Zhang, Q.1
Zhao, X.H.2
Wang, Z.J.3
-
34
-
-
0038701811
-
Telomerase inhibition as cancer therapy
-
Saretzki, G. Telomerase inhibition as cancer therapy. Cancer Lett. 194, 209-219 (2003).
-
(2003)
Cancer Lett.
, vol.194
, pp. 209-219
-
-
Saretzki, G.1
-
35
-
-
0000313119
-
Flavonoid-DNA interaction studied with flow linear dichroism technique
-
Solimani, R. et al. Flavonoid-DNA Interaction Studied with Flow Linear Dichroism Technique. J. Agric. Food Chem. 43, 876-882 (1995).
-
(1995)
J. Agric. Food Chem.
, vol.43
, pp. 876-882
-
-
Solimani, R.1
-
36
-
-
0029947431
-
Quercetin and DNA in solution: Analysis of the dynamics of their interaction with a linear dichroism study
-
Solimani, R. Quercetin and DNA in solution: analysis of the dynamics of their interaction with a linear dichroism study. Int. J. Biol. Macromol. 18, 287-295 (1996).
-
(1996)
Int. J. Biol. Macromol.
, vol.18
, pp. 287-295
-
-
Solimani, R.1
-
37
-
-
34548688164
-
An overview of DNA and RNA bindings to antioxidant flavonoids
-
Kanakis, C. D., Tarantilis, P. A., Polissiou, M. G., Diamantoglou, S. & Tajmir-Riahi, H. A. An overview of DNA and RNA bindings to antioxidant flavonoids. Cell Biochem. Biophys. 49, 29-36 (2007).
-
(2007)
Cell Biochem. Biophys.
, vol.49
, pp. 29-36
-
-
Kanakis, C.D.1
Tarantilis, P.A.2
Polissiou, M.G.3
Diamantoglou, S.4
Tajmir-Riahi, H.A.5
-
38
-
-
67650904960
-
The characterisation of flavone-DNA isoform interactions as a basis for anticancer drug development
-
Ragazzon, P. A., Bradshaw, T., Matthews, C., Iley, J. & Missailidis, S. The characterisation of flavone-DNA isoform interactions as a basis for anticancer drug development. Anticancer Res. 29, 2273-2283 (2009).
-
(2009)
Anticancer Res.
, vol.29
, pp. 2273-2283
-
-
Ragazzon, P.A.1
Bradshaw, T.2
Matthews, C.3
Iley, J.4
Missailidis, S.5
-
39
-
-
33646833241
-
Spectroscopic studies of the interaction between quercetin and G-quadruplex DNA
-
Sun, H. et al. Spectroscopic studies of the interaction between quercetin and G-quadruplex DNA. Bioorg. Med. Chem. Lett. 16, 3586-3589 (2006).
-
(2006)
Bioorg. Med. Chem. Lett.
, vol.16
, pp. 3586-3589
-
-
Sun, H.1
-
40
-
-
0034846868
-
Antioxidant and antiradical activities of flavonoids
-
Burda, S. & Oleszek, W. Antioxidant and antiradical activities of flavonoids. J. Agric. Food Chem. 49, 2774-2779 (2001).
-
(2001)
J. Agric. Food Chem.
, vol.49
, pp. 2774-2779
-
-
Burda, S.1
Oleszek, W.2
-
41
-
-
0010383446
-
Spectroscopic investigation of differential binding modes of. DELTA.- and. LAMBDA.-Ru(bpy)2(ppz)2+ with calf thymus DNA
-
Tysoe, S. A., Morgan, R. J., Baker, A. D. & Strekas, T. C. Spectroscopic investigation of differential binding modes of. DELTA.- and. LAMBDA.-Ru(bpy)2(ppz)2+ with calf thymus DNA. J. Phys. Chem. 97, 1707-1711 (1993).
-
(1993)
J. Phys. Chem.
, vol.97
, pp. 1707-1711
-
-
Tysoe, S.A.1
Morgan, R.J.2
Baker, A.D.3
Strekas, T.C.4
-
42
-
-
0344687284
-
Electrochemical investigation on interaction between DNA with quercetin and Eu-Qu3 complex
-
Kang, J. et al. Electrochemical investigation on interaction between DNA with quercetin and Eu-Qu3 complex. J. Inorg. Biochem. 98, 79-86 (2004).
-
(2004)
J. Inorg. Biochem.
, vol.98
, pp. 79-86
-
-
Kang, J.1
-
43
-
-
33646943863
-
Human telomeric sequence forms a hybrid-type intramolecular G-quadruplex structure with mixed parallel/antiparallel strands in potassium solution
-
Ambrus, A. et al. Human telomeric sequence forms a hybrid-type intramolecular G-quadruplex structure with mixed parallel/antiparallel strands in potassium solution. Nucleic Acids Res. 34, 2723-2735 (2006).
-
(2006)
Nucleic Acids Res.
, vol.34
, pp. 2723-2735
-
-
Ambrus, A.1
-
44
-
-
0141905867
-
Structure of the parallel-stranded DNA quadruplex d(TTAGGGT)4 containing the human telomeric repeat: Evidence for A-tetrad formation from NMR and molecular dynamics simulations
-
Gavathiotis, E. & Searle, M. S. Structure of the parallel-stranded DNA quadruplex d(TTAGGGT)4 containing the human telomeric repeat: evidence for A-tetrad formation from NMR and molecular dynamics simulations. Org. Biomol. Chem. 1, 1650-1656 (2003).
-
(2003)
Org. Biomol. Chem.
, vol.1
, pp. 1650-1656
-
-
Gavathiotis, E.1
Searle, M.S.2
-
45
-
-
0032030327
-
DNA tetraplex formation in the control region of c-myc
-
Simonsson, T., Pecinka, P. & Kubista, M. DNA tetraplex formation in the control region of c-myc. Nucleic Acids Res. 26, 1167-1172 (1998).
-
(1998)
Nucleic Acids Res.
, vol.26
, pp. 1167-1172
-
-
Simonsson, T.1
Pecinka, P.2
Kubista, M.3
-
46
-
-
33751020853
-
Quadruplex DNA: Sequence, topology and structure
-
Burge, S., Parkinson, G. N., Hazel, P., Todd, A. K. & Neidle, S. Quadruplex DNA: sequence, topology and structure. Nucleic Acids Res. 34, 5402-5415 (2006).
-
(2006)
Nucleic Acids Res.
, vol.34
, pp. 5402-5415
-
-
Burge, S.1
Parkinson, G.N.2
Hazel, P.3
Todd, A.K.4
Neidle, S.5
-
47
-
-
0027971685
-
A novel K(+)-dependent DNA synthesis arrest site in a commonly occurring sequence motif in eukaryotes
-
Woodford, K. J., Howell, R. M. & Usdin, K. A novel K(+)-dependent DNA synthesis arrest site in a commonly occurring sequence motif in eukaryotes. J. Biol. Chem. 269, 27029-27035 (1994).
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 27029-27035
-
-
Woodford, K.J.1
Howell, R.M.2
Usdin, K.3
-
48
-
-
0032497405
-
NMR-based model of a telomerase-inhibiting compound bound to G-quadruplex DNA†
-
Fedoroff, O. Y. et al. NMR-Based Model of a Telomerase-Inhibiting Compound Bound to G-Quadruplex DNA†. Biochemistry 37, 12367-12374 (1998).
-
(1998)
Biochemistry
, vol.37
, pp. 12367-12374
-
-
Fedoroff, O.Y.1
-
49
-
-
77951978938
-
Spectroscopic study on the binding of porphyrins to (G(4)T(4)G(4))4 parallel G-quadruplex
-
Wei, C., Wang, J. & Zhang, M. Spectroscopic study on the binding of porphyrins to (G(4)T(4)G(4))4 parallel G-quadruplex. Biophys. Chem. 148, 51-55 (2010).
-
(2010)
Biophys. Chem.
, vol.148
, pp. 51-55
-
-
Wei, C.1
Wang, J.2
Zhang, M.3
-
50
-
-
0343359244
-
Investigation of exchange processes by two-dimensional NMR spectroscopy
-
Jeener, J., Meier, B. H., Bachmann, P. & Ernst, R. R. Investigation of exchange processes by two-dimensional NMR spectroscopy. J. Chem. Phys. 71, 4546-4553 (1979).
-
(1979)
J. Chem. Phys.
, vol.71
, pp. 4546-4553
-
-
Jeener, J.1
Meier, B.H.2
Bachmann, P.3
Ernst, R.R.4
-
51
-
-
67650500988
-
CHARMM: The biomolecular simulation program
-
Brooks, B. R. et al. CHARMM: the biomolecular simulation program. J. Comput. Chem. 30, 1545-1614 (2009).
-
(2009)
J. Comput. Chem.
, vol.30
, pp. 1545-1614
-
-
Brooks, B.R.1
-
52
-
-
0004016501
-
Comparison of simple potential functions for simulating liquid water
-
Jorgensen, W. L., Chandrasekhar, J., Madura, J. D., Impey, R. W. & Klein, M. L. Comparison of simple potential functions for simulating liquid water. J. Chem. Phys. 79, 926-935 (1983).
-
(1983)
J. Chem. Phys.
, vol.79
, pp. 926-935
-
-
Jorgensen, W.L.1
Chandrasekhar, J.2
Madura, J.D.3
Impey, R.W.4
Klein, M.L.5
-
53
-
-
33846823909
-
Particle mesh ewald: An N·log(N) method for ewald sums in large systems
-
Darden, T., York, D. & Pedersen, L. Particle mesh Ewald: An N·log(N) method for Ewald sums in large systems. J. Chem. Phys. 98, 10089-10092 (1993).
-
(1993)
J. Chem. Phys.
, vol.98
, pp. 10089-10092
-
-
Darden, T.1
York, D.2
Pedersen, L.3
-
54
-
-
33646940952
-
Numerical integration of the cartesian equations of motion of a system with constraints: Molecular dynamics of n-alkanes
-
Ryckaert, J.-P., Ciccotti, G. & Berendsen, H. J. C. Numerical integration of the cartesian equations of motion of a system with constraints: molecular dynamics of n-alkanes. J. Comput. Phys. 23, 327-341 (1977).
-
(1977)
J. Comput. Phys.
, vol.23
, pp. 327-341
-
-
Ryckaert, J.-P.1
Ciccotti, G.2
Berendsen, H.J.C.3
|