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Volumn 13, Issue 1, 2015, Pages

Future perspectives in melanoma research: Meeting report from the "Melanoma Bridge": Napoli, December 3rd-6th 2014

(37)  Ascierto, Paolo A a   Atkins, Michael b   Bifulco, Carlo c   Botti, Gerardo a   Cochran, Alistair d   Davies, Michael e   Demaria, Sandra f   Dummer, Reinhard g   Ferrone, Soldano h   Formenti, Silvia f   Gajewski, Thomas F i   Garbe, Claus j   Khleif, Samir k   Kiessling, Rolf l   Lo, Roger d   Lorigan, Paul m   Arthur, Grant Mc n   Masucci, Giuseppe o   Melero, Ignacio p   Mihm, Martin q   more..


Author keywords

[No Author keywords available]

Indexed keywords

B RAF KINASE; BINIMETINIB; CANCER VACCINE; CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE 6; CYCLIN DEPENDENT KINASE INHIBITOR 2A; CYCLOPHOSPHAMIDE; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4 ANTIBODY; INITIATION FACTOR 2ALPHA; MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE; NIVOLUMAB; PHOSPHATIDYLINOSITOL 3 KINASE; PROGRAMMED DEATH 1 LIGAND 1; PROTEIN KINASE B; PROTEIN TYROSINE KINASE; VASCULOTROPIN RECEPTOR; VEMURAFENIB; TUMOR MARKER;

EID: 84948948183     PISSN: None     EISSN: 14795876     Source Type: Journal    
DOI: 10.1186/s12967-015-0736-1     Document Type: Article
Times cited : (12)

References (149)
  • 1
    • 84864059882 scopus 로고    scopus 로고
    • Tumor-infiltrating lymphocyte grade is an independent predictor of sentinel lymph node status and survival in patients with cutaneous melanoma
    • Azimi F, Scolyer RA, Rumcheva P, et al. Tumor-infiltrating lymphocyte grade is an independent predictor of sentinel lymph node status and survival in patients with cutaneous melanoma. J Clin Oncol. 2012;30(21):2678-83.
    • (2012) J Clin Oncol , vol.30 , Issue.21 , pp. 2678-2683
    • Azimi, F.1    Scolyer, R.A.2    Rumcheva, P.3
  • 2
    • 0033579934 scopus 로고    scopus 로고
    • Tumor regressions observed in patients with metastatic melanoma treated with an antigenic peptide encoded by gene MAGE-3 and presented by HLA-A1
    • Marchand M, van Baren N, Weynants P, et al. Tumor regressions observed in patients with metastatic melanoma treated with an antigenic peptide encoded by gene MAGE-3 and presented by HLA-A1. Int J Cancer. 1999;80(2):219-30.
    • (1999) Int J Cancer , vol.80 , Issue.2 , pp. 219-230
    • Marchand, M.1    Baren, N.2    Weynants, P.3
  • 3
    • 45549103395 scopus 로고    scopus 로고
    • Functions of anti-MAGE T-cells induced in melanoma patients under different vaccination modalities
    • Connerotte T, Van Pel A, Godelaine D, et al. Functions of anti-MAGE T-cells induced in melanoma patients under different vaccination modalities. Cancer Res. 2008;68(10):3931-40.
    • (2008) Cancer Res , vol.68 , Issue.10 , pp. 3931-3940
    • Connerotte, T.1    Pel, A.2    Godelaine, D.3
  • 4
    • 79957831345 scopus 로고    scopus 로고
    • gp100 peptide vaccine and interleukin-2 in patients with advanced melanoma
    • Schwartzentruber DJ, Lawson DH, Richards JM, et al. gp100 peptide vaccine and interleukin-2 in patients with advanced melanoma. N Engl J Med. 2011;364(22):2119-27.
    • (2011) N Engl J Med , vol.364 , Issue.22 , pp. 2119-2127
    • Schwartzentruber, D.J.1    Lawson, D.H.2    Richards, J.M.3
  • 5
    • 84866458433 scopus 로고    scopus 로고
    • Dendritic cell-based vaccination in metastatic melanoma patients: phase II clinical trial
    • Oshita C, Takikawa M, Kume A, et al. Dendritic cell-based vaccination in metastatic melanoma patients: phase II clinical trial. Oncol Rep. 2012;28(4):1131-8.
    • (2012) Oncol Rep , vol.28 , Issue.4 , pp. 1131-1138
    • Oshita, C.1    Takikawa, M.2    Kume, A.3
  • 6
    • 84886698315 scopus 로고    scopus 로고
    • Innate and adaptive immune cells in the tumor microenvironment
    • Gajewski TF, Schreiber H, Fu YX. Innate and adaptive immune cells in the tumor microenvironment. Nat Immunol. 2013;14(10):1014-22.
    • (2013) Nat Immunol , vol.14 , Issue.10 , pp. 1014-1022
    • Gajewski, T.F.1    Schreiber, H.2    Fu, Y.X.3
  • 7
    • 84881246114 scopus 로고    scopus 로고
    • A randomized phase II trial of multiepitope vaccination with melanoma peptides for cytotoxic T cells and helper T cells for patients with metastatic melanoma (E1602)
    • Slingluff CL Jr, Lee S, Zhao F, et al. A randomized phase II trial of multiepitope vaccination with melanoma peptides for cytotoxic T cells and helper T cells for patients with metastatic melanoma (E1602). Clin Cancer Res. 2013;19(15):4228-38.
    • (2013) Clin Cancer Res , vol.19 , Issue.15 , pp. 4228-4238
    • Slingluff, C.L.1    Lee, S.2    Zhao, F.3
  • 8
    • 79955624415 scopus 로고    scopus 로고
    • Vaccine therapy for metastatic melanoma: systematic review and meta-analysis of clinical trials
    • Chi M, Dudek AZ. Vaccine therapy for metastatic melanoma: systematic review and meta-analysis of clinical trials. Melanoma Res. 2011;21(3):165-74.
    • (2011) Melanoma Res , vol.21 , Issue.3 , pp. 165-174
    • Chi, M.1    Dudek, A.Z.2
  • 9
    • 84863794013 scopus 로고    scopus 로고
    • DERMA phase III trial of MAGE-A3 antigen-specific cancer immunotherapeutic (ASCI) as adjuvant therapy in patients with MAGE-A3-positive resected stage III melanoma
    • Kirkwood JM, Dreno B, Hauschild A, et al. DERMA phase III trial of MAGE-A3 antigen-specific cancer immunotherapeutic (ASCI) as adjuvant therapy in patients with MAGE-A3-positive resected stage III melanoma. J Clin Oncol. 2011;29:(suppl; abstr TPS232).
    • (2011) J Clin Oncol. , vol.29
    • Kirkwood, J.M.1    Dreno, B.2    Hauschild, A.3
  • 10
    • 84856706929 scopus 로고    scopus 로고
    • Phenotype, function and clinical implications of myeloid-derived suppressor cells in cancer patients
    • Filipazzi P, Huber V, Rivoltini L. Phenotype, function and clinical implications of myeloid-derived suppressor cells in cancer patients. Cancer Immunol Immunother. 2012;61(2):255-63.
    • (2012) Cancer Immunol Immunother , vol.61 , Issue.2 , pp. 255-263
    • Filipazzi, P.1    Huber, V.2    Rivoltini, L.3
  • 11
    • 84918828514 scopus 로고    scopus 로고
    • Genetic basis for clinical response to CTLA-4 blockade in melanoma
    • Snyder A, Makarov V, Merghoub T, et al. Genetic basis for clinical response to CTLA-4 blockade in melanoma. N Engl J Med. 2014;371(23):2189-99.
    • (2014) N Engl J Med , vol.371 , Issue.23 , pp. 2189-2199
    • Snyder, A.1    Makarov, V.2    Merghoub, T.3
  • 12
    • 84939267894 scopus 로고    scopus 로고
    • Melanoma's next top model, it is in the air
    • Widmer DS, Eichhoff OM, Dummer R, et al. Melanoma's next top model, it is in the air. Exp Dermatol. 2015;24(9):659-60.
    • (2015) Exp Dermatol , vol.24 , Issue.9 , pp. 659-660
    • Widmer, D.S.1    Eichhoff, O.M.2    Dummer, R.3
  • 13
    • 84891893623 scopus 로고    scopus 로고
    • A novel AKT1 mutant amplifies an adaptive melanoma response to BRAF inhibition
    • Shi H, Hong A, Kong X, et al. A novel AKT1 mutant amplifies an adaptive melanoma response to BRAF inhibition. Cancer Discov. 2014;4(1):69-79.
    • (2014) Cancer Discov , vol.4 , Issue.1 , pp. 69-79
    • Shi, H.1    Hong, A.2    Kong, X.3
  • 14
    • 84891898344 scopus 로고    scopus 로고
    • Acquired resistance and clonal evolution in melanoma during BRAF inhibitor therapy
    • Shi H, Hugo W, Kong X, et al. Acquired resistance and clonal evolution in melanoma during BRAF inhibitor therapy. Cancer Discov. 2014;4(1):80-93.
    • (2014) Cancer Discov , vol.4 , Issue.1 , pp. 80-93
    • Shi, H.1    Hugo, W.2    Kong, X.3
  • 15
    • 84920394727 scopus 로고    scopus 로고
    • Improved overall survival in melanoma with combined dabrafenib and trametinib
    • Robert C, Karaszewska B, Schachter J, et al. Improved overall survival in melanoma with combined dabrafenib and trametinib. N Engl J Med. 2015;372(1):30-9.
    • (2015) N Engl J Med , vol.372 , Issue.1 , pp. 30-39
    • Robert, C.1    Karaszewska, B.2    Schachter, J.3
  • 16
    • 84927513281 scopus 로고    scopus 로고
    • Health-related quality of life impact in a randomised phase III study of the combination of dabrafenib and trametinib versus dabrafenib monotherapy in patients with BRAF V600 metastatic melanoma
    • Schadendorf D, Amonkar MM, Stroyakovskiy D, et al. Health-related quality of life impact in a randomised phase III study of the combination of dabrafenib and trametinib versus dabrafenib monotherapy in patients with BRAF V600 metastatic melanoma. Eur J Cancer. 2015;51(7):833-40.
    • (2015) Eur J Cancer , vol.51 , Issue.7 , pp. 833-840
    • Schadendorf, D.1    Amonkar, M.M.2    Stroyakovskiy, D.3
  • 17
    • 84938739283 scopus 로고    scopus 로고
    • Dabrafenib and trametinib versus dabrafenib and placebo for Val600 BRAF-mutant melanoma: a multicentre, double-blind, phase 3 randomised controlled trial
    • Long GV, Stroyakovskiy D, Gogas H, et al. Dabrafenib and trametinib versus dabrafenib and placebo for Val600 BRAF-mutant melanoma: a multicentre, double-blind, phase 3 randomised controlled trial. Lancet. 2015;386(9992):444-51.
    • (2015) Lancet , vol.386 , Issue.9992 , pp. 444-451
    • Long, G.V.1    Stroyakovskiy, D.2    Gogas, H.3
  • 18
    • 84908245075 scopus 로고    scopus 로고
    • Combined vemurafenib and cobimetinib in BRAF-mutated melanoma
    • Larkin J, Ascierto PA, Dreno B, et al. Combined vemurafenib and cobimetinib in BRAF-mutated melanoma. N Engl J Med. 2014;371(20):1867-76.
    • (2014) N Engl J Med , vol.371 , Issue.20 , pp. 1867-1876
    • Larkin, J.1    Ascierto, P.A.2    Dreno, B.3
  • 19
    • 84945199346 scopus 로고    scopus 로고
    • Vemurafenib and cobimetinib potently inhibit pS6 signaling in BRAFV600 mutation-positive locally advanced or metastatic melanoma from BRIM7 study
    • Yan Y, McArthur GA, Gajewski T, et al. Vemurafenib and cobimetinib potently inhibit pS6 signaling in BRAFV600 mutation-positive locally advanced or metastatic melanoma from BRIM7 study. Annals Oncol. 2014;25(suppl; abstr 1093D).
    • (2014) Annals Oncol. , vol.25
    • Yan, Y.1    McArthur, G.A.2    Gajewski, T.3
  • 20
    • 84897933246 scopus 로고    scopus 로고
    • Response of BRAF-mutant melanoma to BRAF inhibition is mediated by a network of transcriptional regulators of glycolysis
    • Parmenter TJ, Kleinschmidt M, Kinross KM, et al. Response of BRAF-mutant melanoma to BRAF inhibition is mediated by a network of transcriptional regulators of glycolysis. Cancer Discov. 2014;4(4):423-33.
    • (2014) Cancer Discov , vol.4 , Issue.4 , pp. 423-433
    • Parmenter, T.J.1    Kleinschmidt, M.2    Kinross, K.M.3
  • 21
    • 84948977889 scopus 로고    scopus 로고
    • The PI3K inhibitor PX-866 displays anti-invasive and cytotoxic effects in combination with PLX4720 in melanoma cells in vitro and in vivo
    • Shannan B, Krepler C, Rajan G, et al. The PI3K inhibitor PX-866 displays anti-invasive and cytotoxic effects in combination with PLX4720 in melanoma cells in vitro and in vivo. Pigment Cell Melanoma Res. 2013;26:1000.
    • (2013) Pigment Cell Melanoma Res , vol.26 , pp. 1000
    • Shannan, B.1    Krepler, C.2    Rajan, G.3
  • 22
    • 84155171313 scopus 로고    scopus 로고
    • Correlation of NRAS mutations with clinical response to high-dose IL-2 in patients with advanced melanoma
    • Joseph RW, Sullivan RJ, Harrell R, et al. Correlation of NRAS mutations with clinical response to high-dose IL-2 in patients with advanced melanoma. J Immunother. 2012;35(1):66-72.
    • (2012) J Immunother , vol.35 , Issue.1 , pp. 66-72
    • Joseph, R.W.1    Sullivan, R.J.2    Harrell, R.3
  • 23
    • 84961546746 scopus 로고    scopus 로고
    • Impact of NRAS mutations for patients with advanced melanoma treated with immune therapies
    • Johnson DB, Lovly CM, Flavin M, et al. Impact of NRAS mutations for patients with advanced melanoma treated with immune therapies. Cancer Immunol Res. 2015;3(3):288-95.
    • (2015) Cancer Immunol Res , vol.3 , Issue.3 , pp. 288-295
    • Johnson, D.B.1    Lovly, C.M.2    Flavin, M.3
  • 24
    • 84875235432 scopus 로고    scopus 로고
    • MEK162 for patients with advanced melanoma harbouring NRAS or Val600 BRAF mutations: a non-randomised, open-label phase 2 study
    • Ascierto PA, Schadendorf D, Berking C, et al. MEK162 for patients with advanced melanoma harbouring NRAS or Val600 BRAF mutations: a non-randomised, open-label phase 2 study. Lancet Oncol. 2013;14(3):249-56.
    • (2013) Lancet Oncol , vol.14 , Issue.3 , pp. 249-256
    • Ascierto, P.A.1    Schadendorf, D.2    Berking, C.3
  • 25
    • 84912110744 scopus 로고    scopus 로고
    • A phase IB/II study of LEE011 in combination with Binimetinib (MEK162) in patients with advanced NRAS-mutant melanoma: early encouraging clinical activity
    • Sosman JA, Kittaneh M, Lolkema MP, et al. A phase IB/II study of LEE011 in combination with Binimetinib (MEK162) in patients with advanced NRAS-mutant melanoma: early encouraging clinical activity. J Clin Oncol. 2014;32:5s(suppl; abstr 9009).
    • (2014) J Clin Oncol. , vol.32 5S
    • Sosman, J.A.1    Kittaneh, M.2    Lolkema, M.P.3
  • 26
    • 73349128709 scopus 로고    scopus 로고
    • Integrated molecular and clinical analysis of AKT activation in metastatic melanoma
    • Davies MA, Stemke-Hale K, Lin E, et al. Integrated molecular and clinical analysis of AKT activation in metastatic melanoma. Clin Cancer Res. 2009;15(24):7538-46.
    • (2009) Clin Cancer Res , vol.15 , Issue.24 , pp. 7538-7546
    • Davies, M.A.1    Stemke-Hale, K.2    Lin, E.3
  • 27
    • 84909634322 scopus 로고    scopus 로고
    • Complete loss of PTEN protein expression correlates with shorter time to brain metastasis and survival in stage IIIB/C melanoma patients with BRAFV600 mutations
    • Bucheit AD, Chen G, Siroy A, et al. Complete loss of PTEN protein expression correlates with shorter time to brain metastasis and survival in stage IIIB/C melanoma patients with BRAFV600 mutations. Clin Cancer Res. 2014;20(21):5527-36.
    • (2014) Clin Cancer Res , vol.20 , Issue.21 , pp. 5527-5536
    • Bucheit, A.D.1    Chen, G.2    Siroy, A.3
  • 28
    • 84909578490 scopus 로고    scopus 로고
    • Molecular profiling of patient-matched brain and extracranial melanoma metastases implicates the PI3K pathway as a therapeutic target
    • Chen G, Chakravarti N, Aardalen K, et al. Molecular profiling of patient-matched brain and extracranial melanoma metastases implicates the PI3K pathway as a therapeutic target. Clin Cancer Res. 2014;20(21):5537-46.
    • (2014) Clin Cancer Res , vol.20 , Issue.21 , pp. 5537-5546
    • Chen, G.1    Chakravarti, N.2    Aardalen, K.3
  • 29
    • 78449275389 scopus 로고    scopus 로고
    • Basal and treatment-induced activation of AKT mediates resistance to cell death by AZD6244 (ARRY-142886) in Braf-mutant human cutaneous melanoma cells
    • Gopal YN, Deng W, Woodman SE, et al. Basal and treatment-induced activation of AKT mediates resistance to cell death by AZD6244 (ARRY-142886) in Braf-mutant human cutaneous melanoma cells. Cancer Res. 2010;70(21):8736-47.
    • (2010) Cancer Res , vol.70 , Issue.21 , pp. 8736-8747
    • Gopal, Y.N.1    Deng, W.2    Woodman, S.E.3
  • 30
    • 84918582539 scopus 로고    scopus 로고
    • Inhibition of mTORC1/2 overcomes resistance to MAPK pathway inhibitors mediated by PGC1alpha and oxidative phosphorylation in melanoma
    • Gopal YN, Rizos H, Chen G, et al. Inhibition of mTORC1/2 overcomes resistance to MAPK pathway inhibitors mediated by PGC1alpha and oxidative phosphorylation in melanoma. Cancer Res. 2014;74(23):7037-47.
    • (2014) Cancer Res , vol.74 , Issue.23 , pp. 7037-7047
    • Gopal, Y.N.1    Rizos, H.2    Chen, G.3
  • 31
    • 84886047746 scopus 로고    scopus 로고
    • The evolution of melanoma resistance reveals therapeutic opportunities
    • Das Thakur M, Stuart DD. The evolution of melanoma resistance reveals therapeutic opportunities. Cancer Res. 2013;73(20):6106-10.
    • (2013) Cancer Res. , vol.73 , Issue.20 , pp. 6106-6110
    • Das Thakur, M.1    Stuart, D.D.2
  • 32
    • 84944474511 scopus 로고    scopus 로고
    • Combination of antibodies directed against different ErbB3 surface epitopes prevents the establishment of resistance to BRAF/MEK inhibitors in melanoma
    • Fattore L, Malpicci D, Marra E, et al. Combination of antibodies directed against different ErbB3 surface epitopes prevents the establishment of resistance to BRAF/MEK inhibitors in melanoma. Oncotarget. 2015;6(28):24823-41.
    • (2015) Oncotarget , vol.6 , Issue.28 , pp. 24823-24841
    • Fattore, L.1    Malpicci, D.2    Marra, E.3
  • 33
    • 62549147841 scopus 로고    scopus 로고
    • Persistent elimination of ErbB-2/HER2-overexpressing tumors using combinations of monoclonal antibodies: relevance of receptor endocytosis
    • Ben-Kasus T, Schechter B, Lavi S, et al. Persistent elimination of ErbB-2/HER2-overexpressing tumors using combinations of monoclonal antibodies: relevance of receptor endocytosis. Proc Natl Acad Sci USA. 2009;106(9):3294-9.
    • (2009) Proc Natl Acad Sci USA , vol.106 , Issue.9 , pp. 3294-3299
    • Ben-Kasus, T.1    Schechter, B.2    Lavi, S.3
  • 34
    • 85048517157 scopus 로고    scopus 로고
    • Grp94-specific monoclonal antibody to counteract BRAF inhibitor resistance in BRAFV600E melanoma
    • Sabbatino F, Favoino E, Wang Y, et al. Grp94-specific monoclonal antibody to counteract BRAF inhibitor resistance in BRAFV600E melanoma. J Transl Med. 2015;13(Suppl 1):K12.
    • (2015) J Transl Med , vol.13 , pp. K12
    • Sabbatino, F.1    Favoino, E.2    Wang, Y.3
  • 35
    • 39149104690 scopus 로고    scopus 로고
    • Meta-analysis of phase II cooperative group trials in metastatic stage IV melanoma to determine progression-free and overall survival benchmarks for future phase II trials
    • Korn EL, Liu PY, Lee SJ, et al. Meta-analysis of phase II cooperative group trials in metastatic stage IV melanoma to determine progression-free and overall survival benchmarks for future phase II trials. J Clin Oncol. 2008;26(4):527-34.
    • (2008) J Clin Oncol , vol.26 , Issue.4 , pp. 527-534
    • Korn, E.L.1    Liu, P.Y.2    Lee, S.J.3
  • 36
    • 0033024863 scopus 로고    scopus 로고
    • High-dose recombinant interleukin 2 therapy for patients with metastatic melanoma: analysis of 270 patients treated between 1985 and 1993
    • Atkins MB, Lotze MT, Dutcher JP, et al. High-dose recombinant interleukin 2 therapy for patients with metastatic melanoma: analysis of 270 patients treated between 1985 and 1993. J Clin Oncol. 1999;17(7):2105-16.
    • (1999) J Clin Oncol , vol.17 , Issue.7 , pp. 2105-2116
    • Atkins, M.B.1    Lotze, M.T.2    Dutcher, J.P.3
  • 37
    • 79959772576 scopus 로고    scopus 로고
    • Ipilimumab plus dacarbazine for previously untreated metastatic melanoma
    • Robert C, Thomas L, Bondarenko I, et al. Ipilimumab plus dacarbazine for previously untreated metastatic melanoma. N Engl J Med. 2011;364(26):2517-26.
    • (2011) N Engl J Med , vol.364 , Issue.26 , pp. 2517-2526
    • Robert, C.1    Thomas, L.2    Bondarenko, I.3
  • 38
    • 79959776574 scopus 로고    scopus 로고
    • BRIM-2: an open-label, multicenter phase II study of vemurafenib in previously treated patients with BRAF V600E mutation-positive metastatic melanoma
    • Ribas A, Kim KB, Schuchter M, et al. BRIM-2: an open-label, multicenter phase II study of vemurafenib in previously treated patients with BRAF V600E mutation-positive metastatic melanoma. J Clin Oncol. 2011;29:(suppl; abstr 8509).
    • (2011) J Clin Oncol. , vol.29
    • Ribas, A.1    Kim, K.B.2    Schuchter, M.3
  • 39
    • 84901340078 scopus 로고    scopus 로고
    • Outcomes of patients with metastatic melanoma treated with immunotherapy prior to or after BRAF inhibitors
    • Ackerman A, Klein O, McDermott DF, et al. Outcomes of patients with metastatic melanoma treated with immunotherapy prior to or after BRAF inhibitors. Cancer. 2014;120(11):1695-701.
    • (2014) Cancer , vol.120 , Issue.11 , pp. 1695-1701
    • Ackerman, A.1    Klein, O.2    McDermott, D.F.3
  • 40
    • 84863116743 scopus 로고    scopus 로고
    • Survival in BRAF V600-mutant advanced melanoma treated with vemurafenib
    • Sosman JA, Kim KB, Schuchter L, et al. Survival in BRAF V600-mutant advanced melanoma treated with vemurafenib. N Engl J Med. 2012;366(8):707-14.
    • (2012) N Engl J Med , vol.366 , Issue.8 , pp. 707-714
    • Sosman, J.A.1    Kim, K.B.2    Schuchter, L.3
  • 41
    • 84865068182 scopus 로고    scopus 로고
    • Updated overall survival (OS) results for BRIM-3, a phase III randomized, open-label, multicenter trial comparing BRAF inhibitor vemurafenib (vem) with dacarbazine (DTIC) in previously untreated patients with BRAFV600E-mutated melanoma
    • Chapman PB, Hauschild A, Robert C, et al. Updated overall survival (OS) results for BRIM-3, a phase III randomized, open-label, multicenter trial comparing BRAF inhibitor vemurafenib (vem) with dacarbazine (DTIC) in previously untreated patients with BRAFV600E-mutated melanoma. J Clin Oncol. 2012;30(suppl; abstr 8502).
    • (2012) J Clin Oncol. , vol.30
    • Chapman, P.B.1    Hauschild, A.2    Robert, C.3
  • 42
    • 84898729758 scopus 로고    scopus 로고
    • Sequential treatment with ipilimumab and BRAF inhibitors in patients with metastatic melanoma: data from the Italian cohort of the ipilimumab expanded access program
    • Ascierto PA, Simeone E, Sileni VC, et al. Sequential treatment with ipilimumab and BRAF inhibitors in patients with metastatic melanoma: data from the Italian cohort of the ipilimumab expanded access program. Cancer Invest. 2014;32(4):144-9.
    • (2014) Cancer Invest , vol.32 , Issue.4 , pp. 144-149
    • Ascierto, P.A.1    Simeone, E.2    Sileni, V.C.3
  • 43
    • 84874872137 scopus 로고    scopus 로고
    • BRAF inhibition is associated with enhanced melanoma antigen expression and a more favorable tumor microenvironment in patients with metastatic melanoma
    • Frederick DT, Piris A, Cogdill AP, et al. BRAF inhibition is associated with enhanced melanoma antigen expression and a more favorable tumor microenvironment in patients with metastatic melanoma. Clin Cancer Res. 2013;19(5):1225-31.
    • (2013) Clin Cancer Res , vol.19 , Issue.5 , pp. 1225-1231
    • Frederick, D.T.1    Piris, A.2    Cogdill, A.P.3
  • 44
    • 84948948487 scopus 로고    scopus 로고
    • Investigating the role of exosomes in conferring drug resistance in melanoma
    • Vella LJ, Coleman B, Behren A, et al. Investigating the role of exosomes in conferring drug resistance in melanoma. Pigment Cell Melanoma Res. 2013;26:1009.
    • (2013) Pigment Cell Melanoma Res , vol.26 , pp. 1009
    • Vella, L.J.1    Coleman, B.2    Behren, A.3
  • 45
    • 84917743888 scopus 로고    scopus 로고
    • Combinatorial effect of dabrafenib, trametinib, and adoptive cell transfer (ACT) in an immune-competent murine model of BRAFV600E mutant melanoma
    • Hu-Lieskovan S, Mok S, Robert Faja L, et al. Combinatorial effect of dabrafenib, trametinib, and adoptive cell transfer (ACT) in an immune-competent murine model of BRAFV600E mutant melanoma. J Clin Oncol. 2014;32:5s(suppl; abstr 2512).
    • (2014) J Clin Oncol. , vol.32 5S
    • Hu-Lieskovan, S.1    Mok, S.2    Robert Faja, L.3
  • 46
    • 84880277245 scopus 로고    scopus 로고
    • Clinical activity, safety, and biomarkers of MPDL3280A, an engineered PD-L1 antibody in patients with locally advanced or metastatic melanoma (mM).
    • Hamid O, Sosman JA, Lawrence DP, et al. Clinical activity, safety, and biomarkers of MPDL3280A, an engineered PD-L1 antibody in patients with locally advanced or metastatic melanoma (mM). J Clin Oncol. 2013;31(suppl; abstr 9010).
    • (2013) J Clin Oncol. , vol.31
    • Hamid, O.1    Sosman, J.A.2    Lawrence, D.P.3
  • 47
    • 84875785905 scopus 로고    scopus 로고
    • Hepatotoxicity with combination of vemurafenib and ipilimumab
    • Ribas A, Hodi FS, Callahan M, et al. Hepatotoxicity with combination of vemurafenib and ipilimumab. N Engl J Med. 2013;368(14):1365-6.
    • (2013) N Engl J Med , vol.368 , Issue.14 , pp. 1365-1366
    • Ribas, A.1    Hodi, F.S.2    Callahan, M.3
  • 48
    • 84912135461 scopus 로고    scopus 로고
    • Phase 1 study of the BRAF inhibitor dabrafenib (D) with or without the MEK inhibitor trametinib (T) in combination with ipilimumab (Ipi) for V600E/K mutation-positive unresectable or metastatic melanoma (MM)
    • Puzanov I, Callahan MK, Linette GP, et al. Phase 1 study of the BRAF inhibitor dabrafenib (D) with or without the MEK inhibitor trametinib (T) in combination with ipilimumab (Ipi) for V600E/K mutation-positive unresectable or metastatic melanoma (MM). J Clin Oncol. 2014;32:5s(suppl; abstr 2511).
    • (2014) J Clin Oncol. , vol.32 5S
    • Puzanov, I.1    Callahan, M.K.2    Linette, G.P.3
  • 49
    • 84939258997 scopus 로고    scopus 로고
    • Severe gastrointestinal toxicity with administration of trametinib in combination with dabrafenib and ipilimumab
    • Minor DR, Puzanov I, Callahan MK, et al. Severe gastrointestinal toxicity with administration of trametinib in combination with dabrafenib and ipilimumab. Pigment Cell Melanoma Res. 2015;28(5):611-2.
    • (2015) Pigment Cell Melanoma Res , vol.28 , Issue.5 , pp. 611-612
    • Minor, D.R.1    Puzanov, I.2    Callahan, M.K.3
  • 50
    • 84862882003 scopus 로고    scopus 로고
    • Tumor immunotherapy directed at PD-1
    • Ribas A. Tumor immunotherapy directed at PD-1. N Engl J Med. 2012;366(26):2517-9.
    • (2012) N Engl J Med , vol.366 , Issue.26 , pp. 2517-2519
    • Ribas, A.1
  • 51
    • 77954801079 scopus 로고    scopus 로고
    • Improved survival with ipilimumab in patients with metastatic melanoma
    • Hodi FS, O'Day SJ, McDermott DF, et al. Improved survival with ipilimumab in patients with metastatic melanoma. N Engl J Med. 2010;363(8):711-23.
    • (2010) N Engl J Med , vol.363 , Issue.8 , pp. 711-723
    • Hodi, F.S.1    O'Day, S.J.2    McDermott, D.F.3
  • 52
    • 84859158384 scopus 로고    scopus 로고
    • Targeting the PD-1/B7-H1(PD-L1) pathway to activate anti-tumor immunity
    • Topalian SL, Drake CG, Pardoll DM. Targeting the PD-1/B7-H1(PD-L1) pathway to activate anti-tumor immunity. Curr Opin Immunol. 2012;24(2):207-12.
    • (2012) Curr Opin Immunol , vol.24 , Issue.2 , pp. 207-212
    • Topalian, S.L.1    Drake, C.G.2    Pardoll, D.M.3
  • 53
    • 84940374206 scopus 로고    scopus 로고
    • Long-term survival of ipilimumab-naive patients (pts) with advanced melanoma (MEL) treated with nivolumab (anti-PD-1; BMS-936558, ONO-4538) in a phase 1 trial
    • Hodi FS, Kluger HM, Sznol M, et al. Long-term survival of ipilimumab-naive patients (pts) with advanced melanoma (MEL) treated with nivolumab (anti-PD-1; BMS-936558, ONO-4538) in a phase 1 trial. Pigment Cell Melanoma Res. 2014;27:1199.
    • (2014) Pigment Cell Melanoma Res , vol.27 , pp. 1199
    • Hodi, F.S.1    Kluger, H.M.2    Sznol, M.3
  • 54
    • 84931083080 scopus 로고    scopus 로고
    • Nivolumab versus chemotherapy in patients with advanced melanoma who progressed after anti-CTLA-4 treatment (CheckMate 037): a randomised, controlled, open-label, phase 3 trial
    • Weber JS, D'Angelo SP, Minor D, et al. Nivolumab versus chemotherapy in patients with advanced melanoma who progressed after anti-CTLA-4 treatment (CheckMate 037): a randomised, controlled, open-label, phase 3 trial. Lancet Oncol. 2015;16(4):375-84.
    • (2015) Lancet Oncol , vol.16 , Issue.4 , pp. 375-384
    • Weber, J.S.1    D'Angelo, S.P.2    Minor, D.3
  • 55
    • 84879777241 scopus 로고    scopus 로고
    • Nivolumab plus ipilimumab in advanced melanoma
    • Wolchok JD, Kluger H, Callahan MK, et al. Nivolumab plus ipilimumab in advanced melanoma. N Engl J Med. 2013;369(2):122-33.
    • (2013) N Engl J Med , vol.369 , Issue.2 , pp. 122-133
    • Wolchok, J.D.1    Kluger, H.2    Callahan, M.K.3
  • 56
    • 84908664534 scopus 로고    scopus 로고
    • Ipilimumab plus sargramostim vs ipilimumab alone for treatment of metastatic melanoma: a randomized clinical trial
    • Hodi FS, Lee S, McDermott DF, et al. Ipilimumab plus sargramostim vs ipilimumab alone for treatment of metastatic melanoma: a randomized clinical trial. JAMA. 2014;312(17):1744-53.
    • (2014) JAMA , vol.312 , Issue.17 , pp. 1744-1753
    • Hodi, F.S.1    Lee, S.2    McDermott, D.F.3
  • 57
    • 15944410592 scopus 로고    scopus 로고
    • Inhibition of CD4(+)25+ T regulatory cell function implicated in enhanced immune response by low-dose cyclophosphamide
    • Lutsiak ME, Semnani RT, De Pascalis R, et al. Inhibition of CD4(+)25+ T regulatory cell function implicated in enhanced immune response by low-dose cyclophosphamide. Blood. 2005;105(7):2862-8.
    • (2005) Blood , vol.105 , Issue.7 , pp. 2862-2868
    • Lutsiak, M.E.1    Semnani, R.T.2    Pascalis, R.3
  • 58
    • 84865416551 scopus 로고    scopus 로고
    • B7-DC-Ig enhances vaccine effect by a novel mechanism dependent on PD-1 expression level on T cell subsets
    • Mkrtichyan M, Najjar YG, Raulfs EC, et al. B7-DC-Ig enhances vaccine effect by a novel mechanism dependent on PD-1 expression level on T cell subsets. J Immunol. 2012;189(5):2338-47.
    • (2012) J Immunol , vol.189 , Issue.5 , pp. 2338-2347
    • Mkrtichyan, M.1    Najjar, Y.G.2    Raulfs, E.C.3
  • 59
    • 84948952482 scopus 로고    scopus 로고
    • Immune combinational therapy targeting OX40 and IDO synergistically enhances efficacy of a cancer vaccine
    • Berrong Z, Ahmad S, Abu Eid R, et al. Immune combinational therapy targeting OX40 and IDO synergistically enhances efficacy of a cancer vaccine. J Immunother Cancer. 2014;2(suppl 3):P226.
    • (2014) J Immunother Cancer. , vol.2 , pp. P226
    • Berrong, Z.1    Ahmad, S.2    Abu Eid, R.3
  • 60
    • 67649432744 scopus 로고    scopus 로고
    • Inhibitors of indoleamine-2,3-dioxygenase for cancer therapy: can we see the wood for the trees?
    • Lob S, Konigsrainer A, Rammensee HG, et al. Inhibitors of indoleamine-2,3-dioxygenase for cancer therapy: can we see the wood for the trees? Nat Rev Cancer. 2009;9(6):445-52.
    • (2009) Nat Rev Cancer , vol.9 , Issue.6 , pp. 445-452
    • Lob, S.1    Konigsrainer, A.2    Rammensee, H.G.3
  • 61
    • 1242315588 scopus 로고    scopus 로고
    • Ionizing radiation inhibition of distant untreated tumors (abscopal effect) is immune mediated
    • Demaria S, Ng B, Devitt ML, et al. Ionizing radiation inhibition of distant untreated tumors (abscopal effect) is immune mediated. Int J Radiat Oncol Biol Phys. 2004;58(3):862-70.
    • (2004) Int J Radiat Oncol Biol Phys , vol.58 , Issue.3 , pp. 862-870
    • Demaria, S.1    Ng, B.2    Devitt, M.L.3
  • 62
    • 84937525789 scopus 로고    scopus 로고
    • Local radiotherapy and granulocyte-macrophage colony-stimulating factor to generate abscopal responses in patients with metastatic solid tumours: a proof-of-principle trial
    • Golden EB, Chhabra A, Chachoua A, et al. Local radiotherapy and granulocyte-macrophage colony-stimulating factor to generate abscopal responses in patients with metastatic solid tumours: a proof-of-principle trial. Lancet Oncol. 2015;16(7):795-803.
    • (2015) Lancet Oncol , vol.16 , Issue.7 , pp. 795-803
    • Golden, E.B.1    Chhabra, A.2    Chachoua, A.3
  • 63
    • 84880093055 scopus 로고    scopus 로고
    • Radiation as an immunological adjuvant: current evidence on dose and fractionation
    • Demaria S, Formenti SC. Radiation as an immunological adjuvant: current evidence on dose and fractionation. Front Oncol. 2012;2:153.
    • (2012) Front Oncol , vol.2 , pp. 153
    • Demaria, S.1    Formenti, S.C.2
  • 64
    • 51549088023 scopus 로고    scopus 로고
    • Radiation-induced CXCL16 release by breast cancer cells attracts effector T cells
    • Matsumura S, Wang B, Kawashima N, et al. Radiation-induced CXCL16 release by breast cancer cells attracts effector T cells. J Immunol. 2008;181(5):3099-107.
    • (2008) J Immunol , vol.181 , Issue.5 , pp. 3099-3107
    • Matsumura, S.1    Wang, B.2    Kawashima, N.3
  • 65
    • 84867182261 scopus 로고    scopus 로고
    • Suppressing T cell motility induced by anti-CTLA-4 monotherapy improves antitumor effects
    • Ruocco MG, Pilones KA, Kawashima N, et al. Suppressing T cell motility induced by anti-CTLA-4 monotherapy improves antitumor effects. J Clin Invest. 2012;122(10):3718-30.
    • (2012) J Clin Invest , vol.122 , Issue.10 , pp. 3718-3730
    • Ruocco, M.G.1    Pilones, K.A.2    Kawashima, N.3
  • 66
    • 59449094876 scopus 로고    scopus 로고
    • Invariant natural killer T cells regulate breast cancer response to radiation and CTLA-4 blockade
    • Pilones KA, Kawashima N, Yang AM, et al. Invariant natural killer T cells regulate breast cancer response to radiation and CTLA-4 blockade. Clin Cancer Res. 2009;15(2):597-606.
    • (2009) Clin Cancer Res , vol.15 , Issue.2 , pp. 597-606
    • Pilones, K.A.1    Kawashima, N.2    Yang, A.M.3
  • 67
    • 84977177265 scopus 로고    scopus 로고
    • Invariant natural killer T cells regulate anti-tumor immunity by controlling the population of dendritic cells in tumor and draining lymph nodes
    • Pilones KA, Aryankalayil J, Babb JS, et al. Invariant natural killer T cells regulate anti-tumor immunity by controlling the population of dendritic cells in tumor and draining lymph nodes. J Immunother Cancer. 2014;2(1):37.
    • (2014) J Immunother Cancer , vol.2 , Issue.1 , pp. 37
    • Pilones, K.A.1    Aryankalayil, J.2    Babb, J.S.3
  • 68
    • 84902517894 scopus 로고    scopus 로고
    • Radiation fosters dose-dependent and chemotherapy-induced immunogenic cell death
    • Golden EB, Frances D, Pellicciotta I, et al. Radiation fosters dose-dependent and chemotherapy-induced immunogenic cell death. Oncoimmunology. 2014;3:e28518.
    • (2014) Oncoimmunology , vol.3 , pp. e28518
    • Golden, E.B.1    Frances, D.2    Pellicciotta, I.3
  • 69
    • 69949085196 scopus 로고    scopus 로고
    • Fractionated but not single-dose radiotherapy induces an immune-mediated abscopal effect when combined with anti-CTLA-4 antibody
    • Dewan MZ, Galloway AE, Kawashima N, et al. Fractionated but not single-dose radiotherapy induces an immune-mediated abscopal effect when combined with anti-CTLA-4 antibody. Clin Cancer Res. 2009;15(17):5379-88.
    • (2009) Clin Cancer Res , vol.15 , Issue.17 , pp. 5379-5388
    • Dewan, M.Z.1    Galloway, A.E.2    Kawashima, N.3
  • 70
    • 12244252335 scopus 로고    scopus 로고
    • Immune-mediated inhibition of metastases after treatment with local radiation and CTLA-4 blockade in a mouse model of breast cancer
    • Demaria S, Kawashima N, Yang AM, et al. Immune-mediated inhibition of metastases after treatment with local radiation and CTLA-4 blockade in a mouse model of breast cancer. Clin Cancer Res. 2005;11(2 Pt 1):728-34.
    • (2005) Clin Cancer Res , vol.11 , Issue.2 , pp. 728-734
    • Demaria, S.1    Kawashima, N.2    Yang, A.M.3
  • 71
    • 84857815877 scopus 로고    scopus 로고
    • Immunologic correlates of the abscopal effect in a patient with melanoma
    • Postow MA, Callahan MK, Barker CA, et al. Immunologic correlates of the abscopal effect in a patient with melanoma. N Engl J Med. 2012;366(10):925-31.
    • (2012) N Engl J Med , vol.366 , Issue.10 , pp. 925-931
    • Postow, M.A.1    Callahan, M.K.2    Barker, C.A.3
  • 72
    • 85003053854 scopus 로고    scopus 로고
    • An abscopal response to radiation and ipilimumab in a patient with metastatic non-small cell lung cancer
    • Golden EB, Demaria S, Schiff PB, et al. An abscopal response to radiation and ipilimumab in a patient with metastatic non-small cell lung cancer. Cancer Immunol Res. 2013;1(6):365-72.
    • (2013) Cancer Immunol Res , vol.1 , Issue.6 , pp. 365-372
    • Golden, E.B.1    Demaria, S.2    Schiff, P.B.3
  • 73
    • 84901641673 scopus 로고    scopus 로고
    • Ipilimumab versus placebo after radiotherapy in patients with metastatic castration-resistant prostate cancer that had progressed after docetaxel chemotherapy (CA184-043): a multicentre, randomised, double-blind, phase 3 trial
    • Kwon ED, Drake CG, Scher HI, et al. Ipilimumab versus placebo after radiotherapy in patients with metastatic castration-resistant prostate cancer that had progressed after docetaxel chemotherapy (CA184-043): a multicentre, randomised, double-blind, phase 3 trial. Lancet Oncol. 2014;15(7):700-12.
    • (2014) Lancet Oncol , vol.15 , Issue.7 , pp. 700-712
    • Kwon, E.D.1    Drake, C.G.2    Scher, H.I.3
  • 74
    • 84929377774 scopus 로고    scopus 로고
    • Is classical stereotactic radiotherapy the optimal partner for immunotherapy?
    • 347, 387.
    • Formenti SC. Is classical stereotactic radiotherapy the optimal partner for immunotherapy? Oncology (Williston Park). 2015;29(5):340, 347, 387.
    • (2015) Oncology (Williston Park). , vol.29 , Issue.5 , pp. 340
    • Formenti, S.C.1
  • 75
    • 26244456936 scopus 로고    scopus 로고
    • Topical imiquimod to treat recurrent breast cancer
    • Hengge UR, Roth S, Tannapfel A. Topical imiquimod to treat recurrent breast cancer. Breast Cancer Res Treat. 2005;94(1):93-4.
    • (2005) Breast Cancer Res Treat , vol.94 , Issue.1 , pp. 93-94
    • Hengge, U.R.1    Roth, S.2    Tannapfel, A.3
  • 76
    • 84871217036 scopus 로고    scopus 로고
    • Topical TLR7 agonist imiquimod can induce immune-mediated rejection of skin metastases in patients with breast cancer
    • Adams S, Kozhaya L, Martiniuk F, et al. Topical TLR7 agonist imiquimod can induce immune-mediated rejection of skin metastases in patients with breast cancer. Clin Cancer Res. 2012;18(24):6748-57.
    • (2012) Clin Cancer Res , vol.18 , Issue.24 , pp. 6748-6757
    • Adams, S.1    Kozhaya, L.2    Martiniuk, F.3
  • 77
    • 84929366910 scopus 로고    scopus 로고
    • TGFbeta is a master regulator of radiation therapy-induced antitumor immunity
    • Vanpouille-Box C, Diamond JM, Pilones KA, et al. TGFbeta is a master regulator of radiation therapy-induced antitumor immunity. Cancer Res. 2015;75(11):2232-42.
    • (2015) Cancer Res , vol.75 , Issue.11 , pp. 2232-2242
    • Vanpouille-Box, C.1    Diamond, J.M.2    Pilones, K.A.3
  • 78
    • 63449088194 scopus 로고    scopus 로고
    • Palettes of vaccines and immunostimulatory monoclonal antibodies for combination
    • Melero I, Martinez-Forero I, Dubrot J, et al. Palettes of vaccines and immunostimulatory monoclonal antibodies for combination. Clin Cancer Res. 2009;15(5):1507-9.
    • (2009) Clin Cancer Res , vol.15 , Issue.5 , pp. 1507-1509
    • Melero, I.1    Martinez-Forero, I.2    Dubrot, J.3
  • 79
    • 84867052405 scopus 로고    scopus 로고
    • Immunotherapeutic synergy between anti-CD137 mAb and intratumoral administration of a cytopathic Semliki Forest virus encoding IL-12
    • Quetglas JI, Dubrot J, Bezunartea J, et al. Immunotherapeutic synergy between anti-CD137 mAb and intratumoral administration of a cytopathic Semliki Forest virus encoding IL-12. Mol Ther. 2012;20(9):1664-75.
    • (2012) Mol Ther , vol.20 , Issue.9 , pp. 1664-1675
    • Quetglas, J.I.1    Dubrot, J.2    Bezunartea, J.3
  • 80
    • 84962219179 scopus 로고    scopus 로고
    • Virotherapy with a Semliki Forest virus-based vector encoding IL12 synergizes with PD-1/PD-L1 blockade
    • Quetglas JI, Labiano S, Aznar MA, et al. Virotherapy with a Semliki Forest virus-based vector encoding IL12 synergizes with PD-1/PD-L1 blockade. Cancer Immunol Res. 2015;3(5):449-54.
    • (2015) Cancer Immunol Res , vol.3 , Issue.5 , pp. 449-454
    • Quetglas, J.I.1    Labiano, S.2    Aznar, M.A.3
  • 81
    • 84893730461 scopus 로고    scopus 로고
    • Final trial report of sentinel-node biopsy versus nodal observation in melanoma
    • Morton DL, Thompson JF, Cochran AJ, et al. Final trial report of sentinel-node biopsy versus nodal observation in melanoma. N Engl J Med. 2014;370(7):599-609.
    • (2014) N Engl J Med , vol.370 , Issue.7 , pp. 599-609
    • Morton, D.L.1    Thompson, J.F.2    Cochran, A.J.3
  • 82
    • 84904394363 scopus 로고    scopus 로고
    • Number of excised lymph nodes as a quality assurance measure for lymphadenectomy in melanoma
    • Rossi CR, Mozzillo N, Maurichi A, et al. Number of excised lymph nodes as a quality assurance measure for lymphadenectomy in melanoma. JAMA Surg. 2014;149(7):700-6.
    • (2014) JAMA Surg , vol.149 , Issue.7 , pp. 700-706
    • Rossi, C.R.1    Mozzillo, N.2    Maurichi, A.3
  • 83
    • 0033869666 scopus 로고    scopus 로고
    • Lung metastases from melanoma: when is surgical treatment warranted?
    • Leo F, Cagini L, Rocmans P, et al. Lung metastases from melanoma: when is surgical treatment warranted? Br J Cancer. 2000;83(5):569-72.
    • (2000) Br J Cancer , vol.83 , Issue.5 , pp. 569-572
    • Leo, F.1    Cagini, L.2    Rocmans, P.3
  • 84
    • 0029059360 scopus 로고
    • Resection and adjuvant immunotherapy for melanoma metastatic to the lung and thorax
    • Tafra L, Dale PS, Wanek LA, et al. Resection and adjuvant immunotherapy for melanoma metastatic to the lung and thorax. J Thorac Cardiovasc Surg. 1995;110(1):119-28 (discussion 129).
    • (1995) J Thorac Cardiovasc Surg , vol.110 , Issue.1 , pp. 119-128
    • Tafra, L.1    Dale, P.S.2    Wanek, L.A.3
  • 85
    • 0025899090 scopus 로고
    • Improved survival after resection of pulmonary metastases from malignant melanoma
    • Gorenstein LA, Putnam JB, Natarajan G, et al. Improved survival after resection of pulmonary metastases from malignant melanoma. Ann Thorac Surg. 1991;52(2):204-10.
    • (1991) Ann Thorac Surg , vol.52 , Issue.2 , pp. 204-210
    • Gorenstein, L.A.1    Putnam, J.B.2    Natarajan, G.3
  • 86
    • 0030480471 scopus 로고    scopus 로고
    • Surgical treatment of malignant melanoma
    • Karakousis CP. Surgical treatment of malignant melanoma. Surg Clin North Am. 1996;76(6):1299-312.
    • (1996) Surg Clin North Am , vol.76 , Issue.6 , pp. 1299-1312
    • Karakousis, C.P.1
  • 87
    • 0026550697 scopus 로고
    • Analysis of 945 cases of pulmonary metastatic melanoma
    • Harpole DH Jr, Johnson CM, Wolfe WG, et al. Analysis of 945 cases of pulmonary metastatic melanoma. J Thorac Cardiovasc Surg. 1992;103(4):743-8 (discussion 748-750).
    • (1992) J Thorac Cardiovasc Surg. , vol.103 , Issue.4 , pp. 743-748
    • Harpole, D.H.1    Johnson, C.M.2    Wolfe, W.G.3
  • 88
    • 0036791943 scopus 로고    scopus 로고
    • The surgical management of metastatic melanoma
    • Allen PJ, Coit DG. The surgical management of metastatic melanoma. Ann Surg Oncol. 2002;9(8):762-70.
    • (2002) Ann Surg Oncol , vol.9 , Issue.8 , pp. 762-770
    • Allen, P.J.1    Coit, D.G.2
  • 89
    • 4444370752 scopus 로고    scopus 로고
    • Contemporary surgical treatment of advanced-stage melanoma
    • Essner R, Lee JH, Wanek LA, et al. Contemporary surgical treatment of advanced-stage melanoma. Arch Surg. 2004;139(9):961-6 (discussion 966-967).
    • (2004) Arch Surg. , vol.139 , Issue.9 , pp. 961-966
    • Essner, R.1    Lee, J.H.2    Wanek, L.A.3
  • 90
    • 41549122882 scopus 로고    scopus 로고
    • Prognosis and determinants of outcome following locoregional or distant recurrence in patients with cutaneous melanoma
    • Francken AB, Accortt NA, Shaw HM, et al. Prognosis and determinants of outcome following locoregional or distant recurrence in patients with cutaneous melanoma. Ann Surg Oncol. 2008;15(5):1476-84.
    • (2008) Ann Surg Oncol , vol.15 , Issue.5 , pp. 1476-1484
    • Francken, A.B.1    Accortt, N.A.2    Shaw, H.M.3
  • 91
    • 33750364347 scopus 로고    scopus 로고
    • Complete metastasectomy in patients with stage IV metastatic melanoma
    • Ollila DW. Complete metastasectomy in patients with stage IV metastatic melanoma. Lancet Oncol. 2006;7(11):919-24.
    • (2006) Lancet Oncol , vol.7 , Issue.11 , pp. 919-924
    • Ollila, D.W.1
  • 92
    • 84888390679 scopus 로고    scopus 로고
    • Long-lasting response to electrochemotherapy in melanoma patients with cutaneous metastasis
    • Caraco C, Mozzillo N, Marone U, et al. Long-lasting response to electrochemotherapy in melanoma patients with cutaneous metastasis. BMC Cancer. 2013;13:564.
    • (2013) BMC Cancer , vol.13 , pp. 564
    • Caraco, C.1    Mozzillo, N.2    Marone, U.3
  • 93
    • 84944463986 scopus 로고    scopus 로고
    • Assessing a novel immuno-oncology-based combination therapy: ipilimumab plus electrochemotherapy
    • Mozzillo N, Simeone E, Benedetto L, et al. Assessing a novel immuno-oncology-based combination therapy: ipilimumab plus electrochemotherapy. Oncoimmunology. 2015;4(6):e1008842.
    • (2015) Oncoimmunology , vol.4 , Issue.6 , pp. e1008842
    • Mozzillo, N.1    Simeone, E.2    Benedetto, L.3
  • 94
    • 77957723967 scopus 로고    scopus 로고
    • Upregulation of Tim-3 and PD-1 expression is associated with tumor antigen-specific CD8+ T cell dysfunction in melanoma patients
    • Fourcade J, Sun Z, Benallaoua M, et al. Upregulation of Tim-3 and PD-1 expression is associated with tumor antigen-specific CD8+ T cell dysfunction in melanoma patients. J Exp Med. 2010;207(10):2175-86.
    • (2010) J Exp Med , vol.207 , Issue.10 , pp. 2175-2186
    • Fourcade, J.1    Sun, Z.2    Benallaoua, M.3
  • 95
    • 84863393290 scopus 로고    scopus 로고
    • CD8(+) T cells specific for tumor antigens can be rendered dysfunctional by the tumor microenvironment through upregulation of the inhibitory receptors BTLA and PD-1
    • Fourcade J, Sun Z, Pagliano O, et al. CD8(+) T cells specific for tumor antigens can be rendered dysfunctional by the tumor microenvironment through upregulation of the inhibitory receptors BTLA and PD-1. Cancer Res. 2012;72(4):887-96.
    • (2012) Cancer Res , vol.72 , Issue.4 , pp. 887-896
    • Fourcade, J.1    Sun, Z.2    Pagliano, O.3
  • 96
    • 84894266990 scopus 로고    scopus 로고
    • PD-1 and Tim-3 regulate the expansion of tumor antigen-specific CD8(+) T cells induced by melanoma vaccines
    • Fourcade J, Sun Z, Pagliano O, et al. PD-1 and Tim-3 regulate the expansion of tumor antigen-specific CD8(+) T cells induced by melanoma vaccines. Cancer Res. 2014;74(4):1045-55.
    • (2014) Cancer Res , vol.74 , Issue.4 , pp. 1045-1055
    • Fourcade, J.1    Sun, Z.2    Pagliano, O.3
  • 97
    • 84942890083 scopus 로고    scopus 로고
    • IL10 and PD-1 cooperate to limit the activity of tumor-specific CD8+ T cells
    • Sun Z, Fourcade J, Pagliano O, et al. IL10 and PD-1 cooperate to limit the activity of tumor-specific CD8+ T cells. Cancer Res. 2015;75(8):1635-44.
    • (2015) Cancer Res , vol.75 , Issue.8 , pp. 1635-1644
    • Sun, Z.1    Fourcade, J.2    Pagliano, O.3
  • 98
    • 84872841412 scopus 로고    scopus 로고
    • Tumor exome analysis reveals neoantigen-specific T-cell reactivity in an ipilimumab-responsive melanoma
    • van Rooij N, van Buuren MM, Philips D, et al. Tumor exome analysis reveals neoantigen-specific T-cell reactivity in an ipilimumab-responsive melanoma. J Clin Oncol. 2013;31(32):e439-42.
    • (2013) J Clin Oncol , vol.31 , Issue.32 , pp. e439-e442
    • Rooij, N.1    Buuren, M.M.2    Philips, D.3
  • 99
    • 33746887327 scopus 로고    scopus 로고
    • Comparative analysis of regulatory and effector T cells in progressively growing versus rejecting tumors of similar origins
    • Bui JD, Uppaluri R, Hsieh CS, et al. Comparative analysis of regulatory and effector T cells in progressively growing versus rejecting tumors of similar origins. Cancer Res. 2006;66(14):7301-9.
    • (2006) Cancer Res , vol.66 , Issue.14 , pp. 7301-7309
    • Bui, J.D.1    Uppaluri, R.2    Hsieh, C.S.3
  • 100
    • 84888347277 scopus 로고    scopus 로고
    • Adjuvants that improve the ratio of antigen-specific effector to regulatory T cells enhance tumor immunity
    • Perret R, Sierro SR, Botelho NK, et al. Adjuvants that improve the ratio of antigen-specific effector to regulatory T cells enhance tumor immunity. Cancer Res. 2013;73(22):6597-608.
    • (2013) Cancer Res , vol.73 , Issue.22 , pp. 6597-6608
    • Perret, R.1    Sierro, S.R.2    Botelho, N.K.3
  • 101
    • 79954594763 scopus 로고    scopus 로고
    • Differentiation associated regulation of microRNA expression in vivo in human CD8+ T cell subsets
    • Salaun B, Yamamoto T, Badran B, et al. Differentiation associated regulation of microRNA expression in vivo in human CD8+ T cell subsets. J Transl Med. 2011;9:44.
    • (2011) J Transl Med , vol.9 , pp. 44
    • Salaun, B.1    Yamamoto, T.2    Badran, B.3
  • 102
    • 84876746489 scopus 로고    scopus 로고
    • MicroRNA-155 is required for effector CD8+ T cell responses to virus infection and cancer
    • Dudda JC, Salaun B, Ji Y, et al. MicroRNA-155 is required for effector CD8+ T cell responses to virus infection and cancer. Immunity. 2013;38(4):742-53.
    • (2013) Immunity , vol.38 , Issue.4 , pp. 742-753
    • Dudda, J.C.1    Salaun, B.2    Ji, Y.3
  • 103
    • 79955495231 scopus 로고    scopus 로고
    • Association of IFN-gamma signal transduction defects with impaired HLA class I antigen processing in melanoma cell lines
    • Respa A, Bukur J, Ferrone S, et al. Association of IFN-gamma signal transduction defects with impaired HLA class I antigen processing in melanoma cell lines. Clin Cancer Res. 2011;17(9):2668-78.
    • (2011) Clin Cancer Res , vol.17 , Issue.9 , pp. 2668-2678
    • Respa, A.1    Bukur, J.2    Ferrone, S.3
  • 104
    • 0037174674 scopus 로고    scopus 로고
    • Cancer regression and autoimmunity in patients after clonal repopulation with antitumor lymphocytes
    • Dudley ME, Wunderlich JR, Robbins PF, et al. Cancer regression and autoimmunity in patients after clonal repopulation with antitumor lymphocytes. Science. 2002;298(5594):850-4.
    • (2002) Science , vol.298 , Issue.5594 , pp. 850-854
    • Dudley, M.E.1    Wunderlich, J.R.2    Robbins, P.F.3
  • 105
    • 79960299888 scopus 로고    scopus 로고
    • Durable complete responses in heavily pretreated patients with metastatic melanoma using T-cell transfer immunotherapy
    • Rosenberg SA, Yang JC, Sherry RM, et al. Durable complete responses in heavily pretreated patients with metastatic melanoma using T-cell transfer immunotherapy. Clin Cancer Res. 2011;17(13):4550-7.
    • (2011) Clin Cancer Res , vol.17 , Issue.13 , pp. 4550-4557
    • Rosenberg, S.A.1    Yang, J.C.2    Sherry, R.M.3
  • 106
    • 84883472041 scopus 로고    scopus 로고
    • Adoptive transfer of tumor-infiltrating lymphocytes in patients with metastatic melanoma: intent-to-treat analysis and efficacy after failure to prior immunotherapies
    • Besser MJ, Shapira-Frommer R, Itzhaki O, et al. Adoptive transfer of tumor-infiltrating lymphocytes in patients with metastatic melanoma: intent-to-treat analysis and efficacy after failure to prior immunotherapies. Clin Cancer Res. 2013;19(17):4792-800.
    • (2013) Clin Cancer Res , vol.19 , Issue.17 , pp. 4792-4800
    • Besser, M.J.1    Shapira-Frommer, R.2    Itzhaki, O.3
  • 107
    • 84871207055 scopus 로고    scopus 로고
    • Specific lymphocyte subsets predict response to adoptive cell therapy using expanded autologous tumor-infiltrating lymphocytes in metastatic melanoma patients
    • Radvanyi LG, Bernatchez C, Zhang M, et al. Specific lymphocyte subsets predict response to adoptive cell therapy using expanded autologous tumor-infiltrating lymphocytes in metastatic melanoma patients. Clin Cancer Res. 2012;18(24):6758-70.
    • (2012) Clin Cancer Res , vol.18 , Issue.24 , pp. 6758-6770
    • Radvanyi, L.G.1    Bernatchez, C.2    Zhang, M.3
  • 108
    • 84875663346 scopus 로고    scopus 로고
    • Co-stimulation through 4-1BB/CD137 improves the expansion and function of CD8(+) melanoma tumor-infiltrating lymphocytes for adoptive T-cell therapy
    • Chacon JA, Wu RC, Sukhumalchandra P, et al. Co-stimulation through 4-1BB/CD137 improves the expansion and function of CD8(+) melanoma tumor-infiltrating lymphocytes for adoptive T-cell therapy. PLoS One. 2013;8(4):e60031.
    • (2013) PLoS One , vol.8 , Issue.4 , pp. e60031
    • Chacon, J.A.1    Wu, R.C.2    Sukhumalchandra, P.3
  • 109
    • 84916597538 scopus 로고    scopus 로고
    • Activation and propagation of tumor-infiltrating lymphocytes on clinical-grade designer artificial antigen-presenting cells for adoptive immunotherapy of melanoma
    • Forget MA, Malu S, Liu H, et al. Activation and propagation of tumor-infiltrating lymphocytes on clinical-grade designer artificial antigen-presenting cells for adoptive immunotherapy of melanoma. J Immunother. 2014;37(9):448-60.
    • (2014) J Immunother , vol.37 , Issue.9 , pp. 448-460
    • Forget, M.A.1    Malu, S.2    Liu, H.3
  • 110
    • 84925247513 scopus 로고    scopus 로고
    • A phase I clinical trial combining dendritic cell vaccination with adoptive T cell transfer in patients with stage IV melanoma
    • Poschke I, Lovgren T, Adamson L, et al. A phase I clinical trial combining dendritic cell vaccination with adoptive T cell transfer in patients with stage IV melanoma. Cancer Immunol Immunother. 2014;63(10):1061-71.
    • (2014) Cancer Immunol Immunother , vol.63 , Issue.10 , pp. 1061-1071
    • Poschke, I.1    Lovgren, T.2    Adamson, L.3
  • 111
    • 77953141534 scopus 로고    scopus 로고
    • Immature immunosuppressive CD14 + HLA-DR-/low cells in melanoma patients are Stat3hi and overexpress CD80, CD83, and DC-sign
    • Poschke I, Mougiakakos D, Hansson J, et al. Immature immunosuppressive CD14 + HLA-DR-/low cells in melanoma patients are Stat3hi and overexpress CD80, CD83, and DC-sign. Cancer Res. 2010;70(11):4335-45.
    • (2010) Cancer Res , vol.70 , Issue.11 , pp. 4335-4345
    • Poschke, I.1    Mougiakakos, D.2    Hansson, J.3
  • 112
    • 84905455438 scopus 로고    scopus 로고
    • Inhibition of tumor-derived prostaglandin-e2 blocks the induction of myeloid-derived suppressor cells and recovers natural killer cell activity
    • Mao Y, Sarhan D, Steven A, et al. Inhibition of tumor-derived prostaglandin-e2 blocks the induction of myeloid-derived suppressor cells and recovers natural killer cell activity. Clin Cancer Res. 2014;20(15):4096-106.
    • (2014) Clin Cancer Res , vol.20 , Issue.15 , pp. 4096-4106
    • Mao, Y.1    Sarhan, D.2    Steven, A.3
  • 113
    • 84862330080 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells impair the quality of dendritic cell vaccines
    • Poschke I, Mao Y, Adamson L, et al. Myeloid-derived suppressor cells impair the quality of dendritic cell vaccines. Cancer Immunol Immunother. 2012;61(6):827-38.
    • (2012) Cancer Immunol Immunother , vol.61 , Issue.6 , pp. 827-838
    • Poschke, I.1    Mao, Y.2    Adamson, L.3
  • 114
    • 58849100439 scopus 로고    scopus 로고
    • Transduction with the antioxidant enzyme catalase protects human T cells against oxidative stress
    • Ando T, Mimura K, Johansson CC, et al. Transduction with the antioxidant enzyme catalase protects human T cells against oxidative stress. J Immunol. 2008;181(12):8382-90.
    • (2008) J Immunol , vol.181 , Issue.12 , pp. 8382-8390
    • Ando, T.1    Mimura, K.2    Johansson, C.C.3
  • 115
    • 84896523643 scopus 로고    scopus 로고
    • Ipilimumab treatment results in an early decrease in the frequency of circulating granulocytic myeloid-derived suppressor cells as well as their Arginase1 production
    • Pico de Coana Y, Poschke I, Gentilcore G, et al. Ipilimumab treatment results in an early decrease in the frequency of circulating granulocytic myeloid-derived suppressor cells as well as their Arginase1 production. Cancer Immunol Res. 2013;1(3):158-62.
    • (2013) Cancer Immunol Res , vol.1 , Issue.3 , pp. 158-162
    • Pico de Coana, Y.1    Poschke, I.2    Gentilcore, G.3
  • 116
    • 84923019006 scopus 로고    scopus 로고
    • T cells expressing CD19 chimeric antigen receptors for acute lymphoblastic leukaemia in children and young adults: a phase 1 dose-escalation trial
    • Lee DW, Kochenderfer JN, Stetler-Stevenson M, et al. T cells expressing CD19 chimeric antigen receptors for acute lymphoblastic leukaemia in children and young adults: a phase 1 dose-escalation trial. Lancet. 2015;385(9967):517-28.
    • (2015) Lancet , vol.385 , Issue.9967 , pp. 517-528
    • Lee, D.W.1    Kochenderfer, J.N.2    Stetler-Stevenson, M.3
  • 117
    • 84890827981 scopus 로고    scopus 로고
    • Donor-derived CD19-targeted T cells cause regression of malignancy persisting after allogeneic hematopoietic stem cell transplantation
    • Kochenderfer JN, Dudley ME, Carpenter RO, et al. Donor-derived CD19-targeted T cells cause regression of malignancy persisting after allogeneic hematopoietic stem cell transplantation. Blood. 2013;122(25):4129-39.
    • (2013) Blood , vol.122 , Issue.25 , pp. 4129-4139
    • Kochenderfer, J.N.1    Dudley, M.E.2    Carpenter, R.O.3
  • 118
    • 84904097189 scopus 로고    scopus 로고
    • Current concepts in the diagnosis and management of cytokine release syndrome
    • Lee DW, Gardner R, Porter DL, et al. Current concepts in the diagnosis and management of cytokine release syndrome. Blood. 2014;124(2):188-95.
    • (2014) Blood , vol.124 , Issue.2 , pp. 188-195
    • Lee, D.W.1    Gardner, R.2    Porter, D.L.3
  • 119
    • 84891749600 scopus 로고    scopus 로고
    • Tumor-infiltrating lymphocytes and their significance in melanoma prognosis
    • Schatton T, Scolyer RA, Thompson JF, et al. Tumor-infiltrating lymphocytes and their significance in melanoma prognosis. Methods Mol Biol. 2014;1102:287-324.
    • (2014) Methods Mol Biol , vol.1102 , pp. 287-324
    • Schatton, T.1    Scolyer, R.A.2    Thompson, J.F.3
  • 120
    • 0024814687 scopus 로고
    • Model predicting survival in stage I melanoma based on tumor progression
    • Clark WH Jr, Elder DE, Dt Guerry, et al. Model predicting survival in stage I melanoma based on tumor progression. J Natl Cancer Inst. 1989;81(24):1893-904.
    • (1989) J Natl Cancer Inst , vol.81 , Issue.24 , pp. 1893-1904
    • Clark, W.H.1    Elder, D.E.2    Dt, G.3
  • 121
    • 79952724400 scopus 로고    scopus 로고
    • SOX2 and nestin expression in human melanoma: an immunohistochemical and experimental study
    • Laga AC, Zhan Q, Weishaupt C, et al. SOX2 and nestin expression in human melanoma: an immunohistochemical and experimental study. Exp Dermatol. 2011;20(4):339-45.
    • (2011) Exp Dermatol , vol.20 , Issue.4 , pp. 339-345
    • Laga, A.C.1    Zhan, Q.2    Weishaupt, C.3
  • 122
    • 84922481838 scopus 로고    scopus 로고
    • Nestin depletion induces melanoma matrix metalloproteinases and invasion
    • Lee CW, Zhan Q, Lezcano C, et al. Nestin depletion induces melanoma matrix metalloproteinases and invasion. Lab Invest. 2014;94(12):1382-95.
    • (2014) Lab Invest , vol.94 , Issue.12 , pp. 1382-1395
    • Lee, C.W.1    Zhan, Q.2    Lezcano, C.3
  • 123
    • 84936953099 scopus 로고    scopus 로고
    • Melanoma-intrinsic beta-catenin signalling prevents anti-tumour immunity
    • Spranger S, Bao R, Gajewski TF. Melanoma-intrinsic beta-catenin signalling prevents anti-tumour immunity. Nature. 2015;523(7559):231-5.
    • (2015) Nature , vol.523 , Issue.7559 , pp. 231-235
    • Spranger, S.1    Bao, R.2    Gajewski, T.F.3
  • 124
    • 84912120595 scopus 로고    scopus 로고
    • STING-dependent cytosolic DNA sensing mediates innate immune recognition of immunogenic tumors
    • Woo SR, Fuertes MB, Corrales L, et al. STING-dependent cytosolic DNA sensing mediates innate immune recognition of immunogenic tumors. Immunity. 2014;41(5):830-42.
    • (2014) Immunity , vol.41 , Issue.5 , pp. 830-842
    • Woo, S.R.1    Fuertes, M.B.2    Corrales, L.3
  • 125
    • 84929705879 scopus 로고    scopus 로고
    • Direct activation of STING in the tumor microenvironment leads to potent and systemic tumor regression and immunity
    • Corrales L, Glickman LH, McWhirter SM, et al. Direct activation of STING in the tumor microenvironment leads to potent and systemic tumor regression and immunity. Cell Rep. 2015;11(7):1018-30.
    • (2015) Cell Rep , vol.11 , Issue.7 , pp. 1018-1030
    • Corrales, L.1    Glickman, L.H.2    McWhirter, S.M.3
  • 126
    • 84912128872 scopus 로고    scopus 로고
    • STING-dependent cytosolic DNA sensing promotes radiation-induced type I Interferon-dependent antitumor immunity in immunogenic tumors
    • Deng L, Liang H, Xu M, et al. STING-dependent cytosolic DNA sensing promotes radiation-induced type I Interferon-dependent antitumor immunity in immunogenic tumors. Immunity. 2014;41(5):843-52.
    • (2014) Immunity , vol.41 , Issue.5 , pp. 843-852
    • Deng, L.1    Liang, H.2    Xu, M.3
  • 127
    • 33749319703 scopus 로고    scopus 로고
    • Type, density, and location of immune cells within human colorectal tumors predict clinical outcome
    • Galon J, Costes A, Sanchez-Cabo F, et al. Type, density, and location of immune cells within human colorectal tumors predict clinical outcome. Science. 2006;313(5795):1960-4.
    • (2006) Science , vol.313 , Issue.5795 , pp. 1960-1964
    • Galon, J.1    Costes, A.2    Sanchez-Cabo, F.3
  • 128
    • 79952093380 scopus 로고    scopus 로고
    • Histopathologic-based prognostic factors of colorectal cancers are associated with the state of the local immune reaction
    • Mlecnik B, Tosolini M, Kirilovsky A, et al. Histopathologic-based prognostic factors of colorectal cancers are associated with the state of the local immune reaction. J Clin Oncol. 2011;29(6):610-8.
    • (2011) J Clin Oncol , vol.29 , Issue.6 , pp. 610-618
    • Mlecnik, B.1    Tosolini, M.2    Kirilovsky, A.3
  • 129
    • 84880704621 scopus 로고    scopus 로고
    • The continuum of cancer immunosurveillance: prognostic, predictive, and mechanistic signatures
    • Galon J, Angell HK, Bedognetti D, et al. The continuum of cancer immunosurveillance: prognostic, predictive, and mechanistic signatures. Immunity. 2013;39(1):11-26.
    • (2013) Immunity , vol.39 , Issue.1 , pp. 11-26
    • Galon, J.1    Angell, H.K.2    Bedognetti, D.3
  • 130
    • 84885724091 scopus 로고    scopus 로고
    • Spatiotemporal dynamics of intratumoral immune cells reveal the immune landscape in human cancer
    • Bindea G, Mlecnik B, Tosolini M, et al. Spatiotemporal dynamics of intratumoral immune cells reveal the immune landscape in human cancer. Immunity. 2013;39(4):782-95.
    • (2013) Immunity , vol.39 , Issue.4 , pp. 782-795
    • Bindea, G.1    Mlecnik, B.2    Tosolini, M.3
  • 131
    • 73349142719 scopus 로고    scopus 로고
    • In situ cytotoxic and memory T cells predict outcome in patients with early-stage colorectal cancer
    • Pages F, Kirilovsky A, Mlecnik B, et al. In situ cytotoxic and memory T cells predict outcome in patients with early-stage colorectal cancer. J Clin Oncol. 2009;27(35):5944-51.
    • (2009) J Clin Oncol , vol.27 , Issue.35 , pp. 5944-5951
    • Pages, F.1    Kirilovsky, A.2    Mlecnik, B.3
  • 132
    • 84890280907 scopus 로고    scopus 로고
    • Towards the introduction of the 'Immunoscore' in the classification of malignant tumours
    • Galon J, Mlecnik B, Bindea G, et al. Towards the introduction of the 'Immunoscore' in the classification of malignant tumours. J Pathol. 2014;232(2):199-209.
    • (2014) J Pathol , vol.232 , Issue.2 , pp. 199-209
    • Galon, J.1    Mlecnik, B.2    Bindea, G.3
  • 133
    • 84930703457 scopus 로고    scopus 로고
    • Abstracts of the Melanoma Bridge Meeting 2014, December 3-6, 2014, Naples, Italy
    • K1-P16
    • Abstracts of the Melanoma Bridge Meeting 2014, December 3-6, 2014, Naples, Italy. J Transl Med. 2015;13(Suppl 1):K1-P16.
    • (2015) J Transl Med. , vol.13
  • 134
    • 84948581918 scopus 로고    scopus 로고
    • Immunoscore: a new possible approach for melanoma classification
    • Capone M, Madonna G, Sebastiao N, et al. Immunoscore: a new possible approach for melanoma classification. J Immunother Cancer. 2014;2(Suppl 3):P193.
    • (2014) J Immunother Cancer. , vol.2 , pp. P193
    • Capone, M.1    Madonna, G.2    Sebastiao, N.3
  • 135
    • 84941022331 scopus 로고    scopus 로고
    • Density of tumor-infiltrating lymphocytes correlates with extent of brain edema and overall survival time in patients with brain metastases
    • (in press).
    • Berghoff AS, Fuchs E, Ricken G, et al. Density of tumor-infiltrating lymphocytes correlates with extent of brain edema and overall survival time in patients with brain metastases. Oncoimmunology. 2015 (in press).
    • (2015) Oncoimmunology.
    • Berghoff, A.S.1    Fuchs, E.2    Ricken, G.3
  • 136
    • 84859128199 scopus 로고    scopus 로고
    • Colocalization of inflammatory response with B7-h1 expression in human melanocytic lesions supports an adaptive resistance mechanism of immune escape
    • 127ra137.
    • Taube JM, Anders RA, Young GD, et al. Colocalization of inflammatory response with B7-h1 expression in human melanocytic lesions supports an adaptive resistance mechanism of immune escape. Sci Transl Med. 2012;4(127):127ra137.
    • (2012) Sci Transl Med. , vol.4 , Issue.127
    • Taube, J.M.1    Anders, R.A.2    Young, G.D.3
  • 137
    • 84942887332 scopus 로고    scopus 로고
    • Differential expression of immune-regulatory genes associated with PD-L1 display in melanoma: implications for PD-1 pathway blockade
    • Taube JM, Young GD, McMiller TL, et al. Differential expression of immune-regulatory genes associated with PD-L1 display in melanoma: implications for PD-1 pathway blockade. Clin Cancer Res. 2015;21(17):3969-76.
    • (2015) Clin Cancer Res , vol.21 , Issue.17 , pp. 3969-3976
    • Taube, J.M.1    Young, G.D.2    McMiller, T.L.3
  • 138
    • 84862859820 scopus 로고    scopus 로고
    • Safety, activity, and immune correlates of anti-PD-1 antibody in cancer
    • Topalian SL, Hodi FS, Brahmer JR, et al. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N Engl J Med. 2012;366(26):2443-54.
    • (2012) N Engl J Med , vol.366 , Issue.26 , pp. 2443-2454
    • Topalian, S.L.1    Hodi, F.S.2    Brahmer, J.R.3
  • 140
    • 84904024273 scopus 로고    scopus 로고
    • Association of PD-1, PD-1 ligands, and other features of the tumor immune microenvironment with response to anti-PD-1 therapy
    • Taube JM, Klein A, Brahmer JR, et al. Association of PD-1, PD-1 ligands, and other features of the tumor immune microenvironment with response to anti-PD-1 therapy. Clin Cancer Res. 2014;20(19):5064-74.
    • (2014) Clin Cancer Res , vol.20 , Issue.19 , pp. 5064-5074
    • Taube, J.M.1    Klein, A.2    Brahmer, J.R.3
  • 141
    • 84920956732 scopus 로고    scopus 로고
    • PD-1 blockade induces responses by inhibiting adaptive immune resistance
    • Tumeh PC, Harview CL, Yearley JH, et al. PD-1 blockade induces responses by inhibiting adaptive immune resistance. Nature. 2014;515(7528):568-71.
    • (2014) Nature , vol.515 , Issue.7528 , pp. 568-571
    • Tumeh, P.C.1    Harview, C.L.2    Yearley, J.H.3
  • 142
    • 84860110928 scopus 로고    scopus 로고
    • The stable traits of melanoma genetics: an alternate approach to target discovery
    • Spivey TL, De Giorgi V, Zhao Y, et al. The stable traits of melanoma genetics: an alternate approach to target discovery. BMC Genom. 2012;13:156.
    • (2012) BMC Genom , vol.13 , pp. 156
    • Spivey, T.L.1    Giorgi, V.2    Zhao, Y.3
  • 143
    • 78651446131 scopus 로고    scopus 로고
    • Mutations in GNA11 in uveal melanoma
    • Van Raamsdonk CD, Griewank KG, Crosby MB, et al. Mutations in GNA11 in uveal melanoma. N Engl J Med. 2010;363(23):2191-9.
    • (2010) N Engl J Med , vol.363 , Issue.23 , pp. 2191-2199
    • Raamsdonk, C.D.1    Griewank, K.G.2    Crosby, M.B.3
  • 144
    • 84879466800 scopus 로고    scopus 로고
    • Conjunctival melanomas harbor BRAF and NRAS mutations and copy number changes similar to cutaneous and mucosal melanomas
    • Griewank KG, Westekemper H, Murali R, et al. Conjunctival melanomas harbor BRAF and NRAS mutations and copy number changes similar to cutaneous and mucosal melanomas. Clin Cancer Res. 2013;19(12):3143-52.
    • (2013) Clin Cancer Res , vol.19 , Issue.12 , pp. 3143-3152
    • Griewank, K.G.1    Westekemper, H.2    Murali, R.3
  • 145
    • 84907063471 scopus 로고    scopus 로고
    • Systemic treatment of metastatic uveal melanoma: review of literature and future perspectives
    • Buder K, Gesierich A, Gelbrich G, et al. Systemic treatment of metastatic uveal melanoma: review of literature and future perspectives. Cancer Med. 2013;2(5):674-86.
    • (2013) Cancer Med , vol.2 , Issue.5 , pp. 674-686
    • Buder, K.1    Gesierich, A.2    Gelbrich, G.3
  • 146
    • 84893849823 scopus 로고    scopus 로고
    • Genetic alterations and personalized medicine in melanoma: progress and future prospects
    • djt435.
    • Griewank KG, Scolyer RA, Thompson JF, et al. Genetic alterations and personalized medicine in melanoma: progress and future prospects. J Natl Cancer Inst. 2014;106(2):djt435.
    • (2014) J Natl Cancer Inst. , vol.106 , Issue.2
    • Griewank, K.G.1    Scolyer, R.A.2    Thompson, J.F.3
  • 147
    • 0031757416 scopus 로고    scopus 로고
    • High expression of immunotherapy candidate proteins gp100, MART-1, tyrosinase and TRP-1 in uveal melanoma
    • de Vries TJ, Trancikova D, Ruiter DJ, et al. High expression of immunotherapy candidate proteins gp100, MART-1, tyrosinase and TRP-1 in uveal melanoma. Br J Cancer. 1998;78(9):1156-61.
    • (1998) Br J Cancer , vol.78 , Issue.9 , pp. 1156-1161
    • Vries, T.J.1    Trancikova, D.2    Ruiter, D.J.3
  • 148
    • 84887087345 scopus 로고    scopus 로고
    • Efficacy and safety of ipilimumab in patients with pre-treated, uveal melanoma
    • Maio M, Danielli R, Chiarion-Sileni V, et al. Efficacy and safety of ipilimumab in patients with pre-treated, uveal melanoma. Ann Oncol. 2013;24(11):2911-5.
    • (2013) Ann Oncol , vol.24 , Issue.11 , pp. 2911-2915
    • Maio, M.1    Danielli, R.2    Chiarion-Sileni, V.3
  • 149
    • 84924543977 scopus 로고    scopus 로고
    • Phase II DeCOG-study of ipilimumab in pretreated and treatment-naive patients with metastatic uveal melanoma
    • Zimmer L, Vaubel J, Mohr P, et al. Phase II DeCOG-study of ipilimumab in pretreated and treatment-naive patients with metastatic uveal melanoma. PLoS One. 2015;10(3):e0118564.
    • (2015) PLoS One , vol.10 , Issue.3 , pp. e0118564
    • Zimmer, L.1    Vaubel, J.2    Mohr, P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.