-
1
-
-
12444279265
-
On the origin of cancer cells
-
Warburg O: On the origin of cancer cells. Science 123: 309-314, 1956.
-
(1956)
Science
, vol.123
, pp. 309-314
-
-
Warburg, O.1
-
2
-
-
0036262039
-
Low mitochondrial respiratory chain content correlates with tumor aggressiveness in renal cell carcinoma
-
Simonnet H, Alazard N, Pfeiffer K, Gallou C, Béroud C, Demont J, Bouvier R, Schägger H and Godinot C: Low mitochondrial respiratory chain content correlates with tumor aggressiveness in renal cell carcinoma. Carcinogenesis 23: 759-768, 2002.
-
(2002)
Carcinogenesis
, vol.23
, pp. 759-768
-
-
Simonnet, H.1
Alazard, N.2
Pfeiffer, K.3
Gallou, C.4
Béroud, C.5
Demont, J.6
Bouvier, R.7
Schägger, H.8
Godinot, C.9
-
3
-
-
84863552719
-
Cyclosporine A inhibits breast cancer cell growth by downregulating the expression of pyruvate kinase subtype M2
-
Jiang K, He B, Lai L, Chen Q, Liu Y, Guo Q and Wang Q: Cyclosporine A inhibits breast cancer cell growth by downregulating the expression of pyruvate kinase subtype M2. Int J Mol Med 30: 302-308, 2012.
-
(2012)
Int J Mol Med
, vol.30
, pp. 302-308
-
-
Jiang, K.1
He, B.2
Lai, L.3
Chen, Q.4
Liu, Y.5
Guo, Q.6
Wang, Q.7
-
4
-
-
84856692165
-
Clotrimazole preferentially inhibits human breast cancer cell proliferation, viability and glycolysis
-
Furtado CM, Marcondes MC, Sola-Penna M, de Souza ML and Zancan P: Clotrimazole preferentially inhibits human breast cancer cell proliferation, viability and glycolysis. PLoS One 7: e30462, 2012.
-
(2012)
Plos One
, vol.7
-
-
Furtado, C.M.1
Marcondes, M.C.2
Sola-Penna, M.3
De Souza, M.L.4
Zancan, P.5
-
5
-
-
82155192703
-
MUC1-C oncoprotein regulates glycolysis and pyruvate kinase M2 activity in cancer cells
-
Kosugi M, Ahmad R, Alam M, Uchida Y and Kufe D: MUC1-C oncoprotein regulates glycolysis and pyruvate kinase M2 activity in cancer cells. PLoS One 6: e28234, 2011.
-
(2011)
Plos One
, vol.6
-
-
Kosugi, M.1
Ahmad, R.2
Alam, M.3
Uchida, Y.4
Kufe, D.5
-
6
-
-
0032520197
-
The allosteric regulation of pyruvate kinase by fructose-1,6-bisphosphate
-
Jurica MS, Mesecar A, Heath PJ, Shi W, Nowak T and Stoddard BL: The allosteric regulation of pyruvate kinase by fructose-1,6-bisphosphate. Structure 6: 195-210, 1998.
-
(1998)
Structure
, vol.6
, pp. 195-210
-
-
Jurica, M.S.1
Mesecar, A.2
Heath, P.J.3
Shi, W.4
Nowak, T.5
Stoddard, B.L.6
-
7
-
-
40749163248
-
The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth
-
Christofk HR, Vander Heiden MG, Harris MH, Ramanathan A, Gerszten RE, Wei R, Fleming MD, Schreiber SL and Cantley LC: The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth. Nature 452: 230-233, 2008.
-
(2008)
Nature
, vol.452
, pp. 230-233
-
-
Christofk, H.R.1
Vander Heiden, M.G.2
Harris, M.H.3
Ramanathan, A.4
Gerszten, R.E.5
Wei, R.6
Fleming, M.D.7
Schreiber, S.L.8
Cantley, L.C.9
-
8
-
-
40749099894
-
Pyruvate kinase M2 is a phosphotyrosine-binding protein
-
Christofk HR, Vander Heiden MG, Wu N, Asara JM and Cantley LC: Pyruvate kinase M2 is a phosphotyrosine-binding protein. Nature 452: 181-186, 2008.
-
(2008)
Nature
, vol.452
, pp. 181-186
-
-
Christofk, H.R.1
Vander Heiden, M.G.2
Wu, N.3
Asara, J.M.4
Cantley, L.C.5
-
9
-
-
82555170271
-
Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation
-
Yang W, Xia Y, Ji H, Zheng Y, Liang J, Huang W, Gao X, Aldape K and Lu Z: Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation. Nature 480: 118-122, 2011.
-
(2011)
Nature
, vol.480
, pp. 118-122
-
-
Yang, W.1
Xia, Y.2
Ji, H.3
Zheng, Y.4
Liang, J.5
Huang, W.6
Gao, X.7
Aldape, K.8
Lu, Z.9
-
10
-
-
82755166890
-
Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses
-
Anastasiou D, Poulogiannis G, Asara JM, Boxer MB, Jiang JK, Shen M, Bellinger G, Sasaki AT, Locasale JW, Auld DS, et al: Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses. Science 334: 1278-1283, 2011.
-
(2011)
Science
, vol.334
, pp. 1278-1283
-
-
Anastasiou, D.1
Poulogiannis, G.2
Asara, J.M.3
Boxer, M.B.4
Jiang, J.K.5
Shen, M.6
Bellinger, G.7
Sasaki, A.T.8
Locasale, J.W.9
Auld, D.S.10
-
11
-
-
84856913587
-
Pyruvate kinase M2-specific siRNA induces apoptosis and tumor regression
-
Goldberg MS and Sharp PA: Pyruvate kinase M2-specific siRNA induces apoptosis and tumor regression. J Exp Med 209: 217-224, 2012.
-
(2012)
J Exp Med
, vol.209
, pp. 217-224
-
-
Goldberg, M.S.1
Sharp, P.A.2
-
12
-
-
79952232216
-
Global cancer statistics
-
Jemal A, Bray F, Center MM, Ferlay J, Ward E and Forman D: Global cancer statistics. CA Cancer J Clin 61: 69-90, 2011.
-
(2011)
CA Cancer J Clin
, vol.61
, pp. 69-90
-
-
Jemal, A.1
Bray, F.2
Center, M.M.3
Ferlay, J.4
Ward, E.5
Forman, D.6
-
13
-
-
84879512941
-
Pyruvate kinase M2 plays a dual role on regulation of the EGF/EGFR signaling via E-cadherin-dependent manner in gastric cancer cells
-
Wang LY, Liu YP, Chen LG, Chen YL, Tan L, Liu JJ, Jazag A, Ren JL and Guleng B: Pyruvate kinase M2 plays a dual role on regulation of the EGF/EGFR signaling via E-cadherin-dependent manner in gastric cancer cells. PLoS One 8: e67542, 2013.
-
(2013)
Plos One
, vol.8
-
-
Wang, L.Y.1
Liu, Y.P.2
Chen, L.G.3
Chen, Y.L.4
Tan, L.5
Liu, J.J.6
Jazag, A.7
Ren, J.L.8
Guleng, B.9
-
14
-
-
84871499320
-
Overexpression of the M2 isoform of pyruvate kinase is an adverse prognostic factor for signet ring cell gastric cancer
-
Lim JY, Yoon SO, Seol SY, Hong SW, Kim JW, Choi SH and Cho JY: Overexpression of the M2 isoform of pyruvate kinase is an adverse prognostic factor for signet ring cell gastric cancer. World J Gastroenterol 18: 4037-4043, 2012.
-
(2012)
World J Gastroenterol
, vol.18
, pp. 4037-4043
-
-
Lim, J.Y.1
Yoon, S.O.2
Seol, S.Y.3
Hong, S.W.4
Kim, J.W.5
Choi, S.H.6
Cho, J.Y.7
-
15
-
-
84862685621
-
Pyruvate kinase M2 promotes the growth of gastric cancer cells via regulation of Bcl-xL expression at transcriptional level
-
Kwon OH, Kang TW, Kim JH, Kim M, Noh SM, Song KS, Yoo HS, Kim WH, Xie Z, Pocalyko D, et al: Pyruvate kinase M2 promotes the growth of gastric cancer cells via regulation of Bcl-xL expression at transcriptional level. Biochem Biophys Res Commun 423: 38-44, 2012.
-
(2012)
Biochem Biophys Res Commun
, vol.423
, pp. 38-44
-
-
Kwon, O.H.1
Kang, T.W.2
Kim, J.H.3
Kim, M.4
Noh, S.M.5
Song, K.S.6
Yoo, H.S.7
Kim, W.H.8
Xie, Z.9
Pocalyko, D.10
-
16
-
-
33748474260
-
Pharmacokinetic drug interaction profiles of proton pump inhibitors
-
Blume H, Donath F, Warnke A and Schug BS: Pharmacokinetic drug interaction profiles of proton pump inhibitors. Drug Saf 29: 769-784, 2006.
-
(2006)
Drug Saf
, vol.29
, pp. 769-784
-
-
Blume, H.1
Donath, F.2
Warnke, A.3
Schug, B.S.4
-
17
-
-
84863822889
-
Effects of pantoprazole as a HIF-1α inhibitor on human gastric adenocarcinoma sgc-7901 cells
-
Shen Y, Wu Y, Chen M, Shen W, Huang S, Zhang L and Zou X: Effects of pantoprazole as a HIF-1α inhibitor on human gastric adenocarcinoma sgc-7901 cells. Neoplasma 59: 142-149, 2012.
-
(2012)
Neoplasma
, vol.59
, pp. 142-149
-
-
Shen, Y.1
Wu, Y.2
Chen, M.3
Shen, W.4
Huang, S.5
Zhang, L.6
Zou, X.7
-
18
-
-
84919871646
-
Loss of SNAIL inhibits cellular growth and metabolism through the miR-128-mediated RPS6KB1/HIF-1α/PKM2 signaling pathway in prostate cancer cells
-
Tao T, Li G, Dong Q, Liu D, Liu C, Han D, Huang Y, Chen S, Xu B and Chen M: Loss of SNAIL inhibits cellular growth and metabolism through the miR-128-mediated RPS6KB1/HIF-1α/PKM2 signaling pathway in prostate cancer cells. Tumour Biol 35: 8543-8550, 2014.
-
(2014)
Tumour Biol
, vol.35
, pp. 8543-8550
-
-
Tao, T.1
Li, G.2
Dong, Q.3
Liu, D.4
Liu, C.5
Han, D.6
Huang, Y.7
Chen, S.8
Xu, B.9
Chen, M.10
-
19
-
-
11144226693
-
Selective induction of apoptosis with proton pump inhibitor in gastric cancer cells
-
Yeo M, Kim DK, Kim YB, Oh TY, Lee JE, Cho SW, Kim HC and Hahm KB: Selective induction of apoptosis with proton pump inhibitor in gastric cancer cells. Clin Cancer Res 10: 8687-8696, 2004.
-
(2004)
Clin Cancer Res
, vol.10
, pp. 8687-8696
-
-
Yeo, M.1
Kim, D.K.2
Kim, Y.B.3
Oh, T.Y.4
Lee, J.E.5
Cho, S.W.6
Kim, H.C.7
Hahm, K.B.8
-
20
-
-
0036176751
-
Positron emission tomography scanning: Current and future applications
-
Czernin J and Phelps ME: Positron emission tomography scanning: Current and future applications. Annu Rev Med 53: 89-112, 2002.
-
(2002)
Annu Rev Med
, vol.53
, pp. 89-112
-
-
Czernin, J.1
Phelps, M.E.2
-
21
-
-
0036717382
-
Molecular imaging of cancer with positron emission tomography
-
Gambhir SS: Molecular imaging of cancer with positron emission tomography. Nat Rev Cancer 2: 683-693, 2002.
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 683-693
-
-
Gambhir, S.S.1
-
22
-
-
77954164403
-
Silencing of pkm2 increases the efficacy of docetaxel in human lung cancer xenografts in mice
-
Shi HS, Li D, Zhang J, Wang YS, Yang L, Zhang HL, Wang XH, Mu B, Wang W, Ma Y et al: Silencing of pkm2 increases the efficacy of docetaxel in human lung cancer xenografts in mice. Cancer Sci 101: 1447-1453, 2010.
-
(2010)
Cancer Sci
, vol.101
, pp. 1447-1453
-
-
Shi, H.S.1
Li, D.2
Zhang, J.3
Wang, Y.S.4
Yang, L.5
Zhang, H.L.6
Wang, X.H.7
Mu, B.8
Wang, W.9
Ma, Y.10
-
23
-
-
84872174405
-
M2 isoform of pyruvate kinase is dispensable for tumor maintenance and growth
-
Cortés-Cros M, Hemmerlin C, Ferretti S, Zhang J, Gounarides JS, Yin H, Muller A, Haberkorn A, Chene P, Sellers WR and Hofmann F: M2 isoform of pyruvate kinase is dispensable for tumor maintenance and growth. Proc Natl Acad Sci USA 110: 489-494, 2013.
-
(2013)
Proc Natl Acad Sci USA
, vol.110
, pp. 489-494
-
-
Cortés-Cros, M.1
Hemmerlin, C.2
Ferretti, S.3
Zhang, J.4
Gounarides, J.S.5
Yin, H.6
Muller, A.7
Haberkorn, A.8
Chene, P.9
Sellers, W.R.10
Hofmann, F.11
-
24
-
-
84861090758
-
Reversal effects of pantoprazole on multidrug resistance in human gastric adenocarcinoma cells by down-regulating the V-ATPases/mTOR/HIF-1α/P-gp and MRP1 signaling pathway in vitro and in vivo
-
Chen M, Huang SL, Zhang XQ, Zhang B, Zhu H, Yang VW and Zou XP: Reversal effects of pantoprazole on multidrug resistance in human gastric adenocarcinoma cells by down-regulating the V-ATPases/mTOR/HIF-1α/P-gp and MRP1 signaling pathway in vitro and in vivo. J Cell Biochem 113: 2474-2487, 2012.
-
(2012)
J Cell Biochem
, vol.113
, pp. 2474-2487
-
-
Chen, M.1
Huang, S.L.2
Zhang, X.Q.3
Zhang, B.4
Zhu, H.5
Yang, V.W.6
Zou, X.P.7
-
25
-
-
68949098403
-
Pyruvate kinase isoenzyme M2 is a glycolytic sensor differentially regulating cell proliferation, cell size and apoptotic cell death dependent on glucose supply
-
Spoden GA, Rostek U, Lechner S, Mitterberger M, Mazurek S and Zwerschke W: Pyruvate kinase isoenzyme M2 is a glycolytic sensor differentially regulating cell proliferation, cell size and apoptotic cell death dependent on glucose supply. Exp Cell Res 315: 2765-2774, 2009.
-
(2009)
Exp Cell Res
, vol.315
, pp. 2765-2774
-
-
Spoden, G.A.1
Rostek, U.2
Lechner, S.3
Mitterberger, M.4
Mazurek, S.5
Zwerschke, W.6
-
26
-
-
78751606536
-
Efficacy of RNAi targeting of pyruvate kinase M2 combined with cisplatin in a lung cancer model
-
Guo W, Zhang Y, Chen T, Wang Y, Xue J, Zhang Y, Xiao W, Mo X and Lu Y: Efficacy of RNAi targeting of pyruvate kinase M2 combined with cisplatin in a lung cancer model. J Cancer Res Clin Oncol 137: 65-72, 2011.
-
(2011)
J Cancer Res Clin Oncol
, vol.137
, pp. 65-72
-
-
Guo, W.1
Zhang, Y.2
Chen, T.3
Wang, Y.4
Xue, J.5
Zhang, Y.6
Xiao, W.7
Mo, X.8
Lu, Y.9
-
27
-
-
44949224444
-
Isotype-specific inhibitors of the glycolytic key regulator pyruvate kinase subtype M2 moderately decelerate tumor cell proliferation
-
Spoden GA, Mazurek S, Morandell D, Bacher N, Ausserlechner MJ, Jansen-Dürr P, Eigenbrodt E and Zwerschke W: Isotype-specific inhibitors of the glycolytic key regulator pyruvate kinase subtype M2 moderately decelerate tumor cell proliferation. Int J Cancer 123: 312-321, 2008.
-
(2008)
Int J Cancer
, vol.123
, pp. 312-321
-
-
Spoden, G.A.1
Mazurek, S.2
Morandell, D.3
Bacher, N.4
Ausserlechner, M.J.5
Jansen-Dürr, P.6
Eigenbrodt, E.7
Zwerschke, W.8
-
28
-
-
84856860890
-
Targeting glucose metabolism for cancer therapy
-
Hamanaka RB and Chandel NS: Targeting glucose metabolism for cancer therapy. J Exp Med 209: 211-215, 2012.
-
(2012)
J Exp Med
, vol.209
, pp. 211-215
-
-
Hamanaka, R.B.1
Chandel, N.S.2
-
29
-
-
84867559423
-
Pyruvate kinase M2: Multiple faces for conferring benefits on cancer cells
-
Tamada M, Suematsu M and Saya H: Pyruvate kinase M2: Multiple faces for conferring benefits on cancer cells. Clin Cancer Res 18: 5554-5561, 2012.
-
(2012)
Clin Cancer Res
, vol.18
, pp. 5554-5561
-
-
Tamada, M.1
Suematsu, M.2
Saya, H.3
-
30
-
-
79952749503
-
Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth
-
Sun Q, Chen X, Ma J, Peng H, Wang F, Zha X, Wang Y, Jing Y, Yang H, Chen R et al: Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth. Proc Natl Acad Sci USA 108: 4129-4134, 2011.
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, pp. 4129-4134
-
-
Sun, Q.1
Chen, X.2
Ma, J.3
Peng, H.4
Wang, F.5
Zha, X.6
Wang, Y.7
Jing, Y.8
Yang, H.9
Chen, R.10
-
31
-
-
67349244880
-
A novel benzimidazole analogue inhibits the hypoxia-inducible factor (HIF)-1 pathway
-
Won MS, Im N, Park S, Boovanahalli SK, Jin Y, Jin X, Chung KS, Kang M, Lee K, Park SK et al: A novel benzimidazole analogue inhibits the hypoxia-inducible factor (HIF)-1 pathway. Biochem Biophys Res Commun 385: 16-21, 2009.
-
(2009)
Biochem Biophys Res Commun
, vol.385
, pp. 16-21
-
-
Won, M.S.1
Im, N.2
Park, S.3
Boovanahalli, S.K.4
Jin, Y.5
Jin, X.6
Chung, K.S.7
Kang, M.8
Lee, K.9
Park, S.K.10
|